Fernando Vásquez Pacheco - Academia.edu (original) (raw)
Papers by Fernando Vásquez Pacheco
Tenemos mucha competencia lo que hará difícil el ganar mercado si no tenemos un producto competit... more Tenemos mucha competencia lo que hará difícil el ganar mercado si no tenemos un producto competitivo y bien diferenciado de los demás de su especie. Enero 9: el gerente emite la Orden de producción # 001 Para la elaboración de 30000 litros de Vino Durazno Materia Prima *2100 lts. Alcohol 96°*675 lts de base de vino *9 Kg. durazno a. *5,06 Kg. Durazo M.
In Crescendo, 2016
El presente trabajo de investigación, tuvo como problemática estudiar las causas de la evasión tr... more El presente trabajo de investigación, tuvo como problemática estudiar las causas de la evasión tributaria y su efecto en la economía del Perú 2014 – Rubro Servicios. Para tal caso se utilizó la Metodología de Revisión Bibliográfica y Documental, con la finalidad de recolectar información que nos permita abordar el tema objeto de estudio basados en indagar los mecanismos más recurrentes en nuestro país para evadir tributos, conocer además los segmentos y comportamientos tributarios de los contribuyentes que evaden sus responsabilidades y buscan alternativas que afectan la economía del país y los entes fiscalizadores que representan al Estado Peruano. La investigación ha conllevado a enterarnos de múltiples causas de evasión tributaria, que aqueja a nuestro país y afecta en la recaudación fiscal. El marco teórico nos ha servido para entender, comprender los lineamientos que giran alrededor de la sociedad, las políticas económicas que posee el Estado para recaudar ingresos y como utili...
Journal of Geochemical Exploration, 2010
The quartz veins containing scheelite from Fonte Santa mine cut the Lower Ordovician quartzites. ... more The quartz veins containing scheelite from Fonte Santa mine cut the Lower Ordovician quartzites. A muscovite-biotite granite (G1) and a muscovite granite (G2), both S-type, crop out close to the Fonte Santa mine and are related to the Moncorvo-Bemposta shear zone. The most altered samples of G2 show intense muscovitization and microclinization and contain chlorite, columbite-tantalite, wolframite, W-ixiolite and Feoxides. The tin-bearing granites contain 18 ppm (G1) and 73 ppm (G2) Sn. The most altered samples of G2 correspond to a tungsten granite. The quartz veins contain muscovite, chlorite, tourmaline, scheelite, pyrrhotite, pyrite, sphalerite, chalcopyrite, galena, arsenopyrite, iron oxides, Fe-sulfates, phosphates of Pb, Fe and Al. The Fonte Santa mine area was exploited for W between 1942 and 1982. At the end of November 2006, a flood event damaged the tailings dam of Fonte Santa mine, releasing contaminated material and increasing contaminant levels in water within the area of influence of the mine. The waters related to the Fonte Santa mine are poorly mineralized, with electrical conductivity < 965 µS / cm, and of a mixed type or HCO 3 and SO 4 2types. Most pH values (5.0 8.5) indicate that there is no significant acidic drainage in the region, as found in other areas. More acidic values (pH = 3.4) were found in the mine's lagoon. Waters associated with mineralized veins and old mine activities have Fe and Mn concentrations that forbid their use for human consumption and agriculture. Natural Na, Mg and K water contents are associated with the alteration of albite, chlorite and muscovite of country rock, while Ca with the W-bearing quartz veins. Weathering agents are carbonic and sulphuric acids and the latter has a strong influence in areas draining fine-grained mine tailings.
In Crescendo, 2015
La presente investigación tuvo como objetivo general determinar y describir la influencia del imp... more La presente investigación tuvo como objetivo general determinar y describir la influencia del impuesto a la renta en la liquidez de las micro y pequeñas empresas (MYPES) industriales de Chimbote, en el año 2014. El diseño de la investigación fue no experimental, retrospectivo, correlacional y de nivel cuantitativo. La información se recabó de una muestra de 50 MYPES escogida de manera dirigida de una población de 187, a quienes se les aplicó un cuestionario de 27 preguntas cerradas utilizando la técnica de la encuesta; obteniéndose los siguientes resultados: El 78 % de las MYPES encuestadas vienen funcionando entre 6 o más años en el sector industrial; el 92 % tienen entre 3 a 15 años como empresa y el 42 % se dedican a actividades relacionadas con la pesca. Por otro lado, el 70 % de las MYPES encuestadas han pagado el impuesto a la renta en el año 2014 y el 30 % no. Asimismo, para el 74 %, el pago del impuesto a la renta ha reducido la liquidez de sus empresas y el 76 % tienen prob...
In Crescendo Ciencias Contables & Administrativas, May 10, 2016
Rem: Revista Escola de Minas, 2013
Two simple methods of aquifer vulnerability assessment were used in this study: the GOD and AVI m... more Two simple methods of aquifer vulnerability assessment were used in this study: the GOD and AVI methods. The main purpose was to appraise their faithfulness as exploratory techniques, and their applicability to the scale of a small watershed. The study area was the Sordo River Basin (area: 50 km2), located in the Northeast of Portugal. To measure accuracy, model results were compared with vulnerability maps previously obtained for the basin, but using the standard DRASTIC model. Results of the GOD method were a map dominated by class "low vulnerability" where parameter O (overlying strata) imprinted its signature, very similar to the DRASTIC map but with smaller resolution. The method was considered valuable for exploration of primary factors of aquifer vulnerability (e.g. discrimination between water table and confined aquifers) but not for description of secondary factors (e.g. nuances in the degree of confinement). The application of the AVI method was proven inefficien...
Science of The Total Environment, 2015
• Compare techniques of factor weighting in DRASTIC modeling • Evaluate the impact of changing th... more • Compare techniques of factor weighting in DRASTIC modeling • Evaluate the impact of changing the weighting technique on the vulnerability index • Model the vulnerability of a large group of aquifer systems in continental Portugal
Brazilian Journal of Physics, 2006
In this work, the influence of the substrate bias on the crystalline structure and surface compos... more In this work, the influence of the substrate bias on the crystalline structure and surface composition of Ti6Al4V thin films prepared by rf magnetron sputtering were studied. Samples were grown onto two different types of substrates: AISI 420 steel and common glass using a Ti6Al4V (99.9 %) target. Substrate bias was varied from-100V to-200 V. Samples were characterized by X-ray diffraction (XRD), Energy Dispersive X-ray Analysis (EDX), Scanning Electron Microscopy (SEM), and X-Ray Photoelectron Spectroscopy (XPS). It was observed that the increase of the substrate voltage improved the crystallinity of the deposited films. The stoichiometry of the deposited thin films was studied by EDX and found to be slightly different from that of the target material. Finally, the passive film spontaneously formed on the deposited films upon exposure to the laboratory atmosphere was studied by XPS. The composition of the passive film is rather complex since it contains several forms of oxidized titanium and vanadium as well as Al 2 O 3 .
In Crescendo Ciencias Contables & Administrativas, May 10, 2016
Applied Geochemistry, 2006
To quantify and explain the contributions by pollution and chemical weathering to their compositi... more To quantify and explain the contributions by pollution and chemical weathering to their composition, we studied the chemistries of springs and surface waters in the mountainous part of the Vouga River basin. Water samples were collected during a number of consecutive summer campaigns. Recharge rates were derived from monitored discharge rates within the basin. Very large contributions by meteoric, agricultural and domestic sources to the water chemistries were found, identified by the chloride, sulfate and nitrate concentrations: on average only 1/4 to 1/3 of the solutes could be attributed to chemical weathering. Two petrologic units characterize the river basin: granites and metasediments. The waters collected within metasediment units are distinct from those in granite terrain by a higher magnesium (Mg) concentration. On that basis, it could be estimated that the Rio Vouga, when leaving the mountainous part of the basin, has for some 2/5 a signature determined by chemical weathering in the metasediments. The dominant primary minerals subject to chemical weathering are plagioclase (Pl) and biotite (in granite) or plagioclase and chlorite (in metasediment). Kaolinite, gibbsite and vermiculite are the major weathering products where annual precipitation (P) > 1000 mm⋅y-1 , and kaolinite, vermiculite and smectite where P was lower. Using an algorithm based on the ratio of dissolved silica to bicarbonate, the contributions of chemical weathering of primary minerals could be unraveled. The results show that in granite the export rate (as mol⋅ha-1 ⋅y-1 ⋅wt.%mineral-1) of oligoclase (Pl with An 10−30) was 5.0 ± 2.6 and of biotite 3.2 ± 2.6, while in metasediment these rates for albite (Pl with An 0-10) are 16.5 ± 8.9 and for chlorite are 0.5 ± 0.5. The observed decrease of dissolved silica in surface waters relative to springs was ascribed to (summer) uptake by aquatic biota.
Computers & Geosciences, 1998
Cluster Analysis has numerous scientific and practical applications. This paper presents a comput... more Cluster Analysis has numerous scientific and practical applications. This paper presents a computer program to find an adequate (natural) number of clusters and to isolate anomalous samples in a data set. The program stands on an algorithm that is based on the mathematical concept of equivalence class and uses the framework of the graph theory to identify equivalence classes in multivariate data bases. This type of clustering algorithm is particularly useful when one is dealing with groundwater data sets, because anomalies are frequent in these sets, and because the number of groups that is present is often impossible to estimate; it will depend on the combined effect of many factors, including geology, morphology, climate and pollution. As an example of the utility of this program, a set of groundwater samples is clustered, and the average chemistry of nine identified equivalence classes is related to weathering reactions of plagioclase in a Portuguese granitoid area.
Medicina Clínica, 2016
España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex... more España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (basel
Medicina Clínica, 2016
España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex... more España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (basel
Applied Geochemistry, 2006
In the Szigetvár area, SW Hungary, shallow groundwaters draining upper Pleistocene loess and Holo... more In the Szigetvár area, SW Hungary, shallow groundwaters draining upper Pleistocene loess and Holocene sediments are considerably contaminated by domestic effluents and leachates of farmland fertilizers. The loess contains calcite and dolomite, but gypsum was not recognized in these sediments. The anthropogenic inputs contain significant amounts of calcium and sulfate. The calcium from these anthropogenic inputs is promoting calcite growth, with concomitant consumption of carbonate alkalinity, undersaturation of the system with respect to dolomite, and dolomite dissolution; in brief, is driving "dedolomitization reactions". Geochemical arguments supporting the occurrence of "dedolomitization reactions" in the area are provided by the results of mass balance and thermodynamic analyses. The mass balances predicted the weather sequence dolomite > calcite > plagioclase > K-feldspar, at odds with widely accepted sequences of weatherability where calcite is the first mineral in the row. The exchange between calcite and dolomite can be a side effect of "dedolomitization reactions" because they cause precipitation of calcite. The thermodynamic prerequisites for "dedolomitization reactions" are satisfied by most local groundwaters (70%) since they are supersaturated (or in equilibrium) with respect to calcite, undersaturated (or in equilibrium) with respect to dolomite, and undersaturated with respect to gypsum. The calcium vs. sulfate and magnesium vs. sulfate trends are also compatible with homologous trends resulting from "dedolomitization reactions".
Journal of Hydrology, 2012
Journal of Hydrology, 2006
A weathering study of a fractured environment composed of granites and metasediments was conducte... more A weathering study of a fractured environment composed of granites and metasediments was conducted in Trás-os-Montes and Alto Douro (north of Portugal) and covered the hydrographic basin of Sordo river. Within the basin, a number of perennial springs were monitored for discharge rate, which allowed for the estimation of annual recharges. A small area of the basin was characterized for parameters such as hydraulic conductivity and effective porosity, which, in combination with the previously calculated recharges, allowed for the calculation of a fracture surface area. The monitored springs were also sampled and analyzed for major inorganic compounds, and using a mole balance model the chemistry of the water samples was explained by weathering to kaolinite of albiteoligoclase plus biotite (granites) or of albite plus chlorite (metasediments). The number of moles of dissolved primary minerals (e.g. albite) could be calculated using this method. These mass transfers were then multiplied by the spring's median discharge rate and divided by the fracture surface area to obtain a weathering rate. Another weathering rate was determined, but using a BET surface area as normalizing factor. Comparing both rates with a representative record of laboratory as well as of field-based weathering rates, it has been noted that rates normalized by the BET were, as expected, similar to commonly reported field-based rates, whereas rates normalized by the fracture surface area were unexpectedly relatively close to laboratory rates (one order of magnitude smaller). The monitored springs are of the fracture artesian type, which means that water emerging at the spring site flowed preferentially through joints and fractures and that weathering took place predominantly at their walls. Consequently, it was concluded that the most realistic weathering rates are those normalized by the fracture surface area, and as a corollary that the gap between laboratory and field weathering rates might not be as wide as usually is reported to be.
Inf. psiquiatr, 1992
Base de dados : LILACS. Pesquisa : 113653 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 113653 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 113653. ...
Tenemos mucha competencia lo que hará difícil el ganar mercado si no tenemos un producto competit... more Tenemos mucha competencia lo que hará difícil el ganar mercado si no tenemos un producto competitivo y bien diferenciado de los demás de su especie. Enero 9: el gerente emite la Orden de producción # 001 Para la elaboración de 30000 litros de Vino Durazno Materia Prima *2100 lts. Alcohol 96°*675 lts de base de vino *9 Kg. durazno a. *5,06 Kg. Durazo M.
In Crescendo, 2016
El presente trabajo de investigación, tuvo como problemática estudiar las causas de la evasión tr... more El presente trabajo de investigación, tuvo como problemática estudiar las causas de la evasión tributaria y su efecto en la economía del Perú 2014 – Rubro Servicios. Para tal caso se utilizó la Metodología de Revisión Bibliográfica y Documental, con la finalidad de recolectar información que nos permita abordar el tema objeto de estudio basados en indagar los mecanismos más recurrentes en nuestro país para evadir tributos, conocer además los segmentos y comportamientos tributarios de los contribuyentes que evaden sus responsabilidades y buscan alternativas que afectan la economía del país y los entes fiscalizadores que representan al Estado Peruano. La investigación ha conllevado a enterarnos de múltiples causas de evasión tributaria, que aqueja a nuestro país y afecta en la recaudación fiscal. El marco teórico nos ha servido para entender, comprender los lineamientos que giran alrededor de la sociedad, las políticas económicas que posee el Estado para recaudar ingresos y como utili...
Journal of Geochemical Exploration, 2010
The quartz veins containing scheelite from Fonte Santa mine cut the Lower Ordovician quartzites. ... more The quartz veins containing scheelite from Fonte Santa mine cut the Lower Ordovician quartzites. A muscovite-biotite granite (G1) and a muscovite granite (G2), both S-type, crop out close to the Fonte Santa mine and are related to the Moncorvo-Bemposta shear zone. The most altered samples of G2 show intense muscovitization and microclinization and contain chlorite, columbite-tantalite, wolframite, W-ixiolite and Feoxides. The tin-bearing granites contain 18 ppm (G1) and 73 ppm (G2) Sn. The most altered samples of G2 correspond to a tungsten granite. The quartz veins contain muscovite, chlorite, tourmaline, scheelite, pyrrhotite, pyrite, sphalerite, chalcopyrite, galena, arsenopyrite, iron oxides, Fe-sulfates, phosphates of Pb, Fe and Al. The Fonte Santa mine area was exploited for W between 1942 and 1982. At the end of November 2006, a flood event damaged the tailings dam of Fonte Santa mine, releasing contaminated material and increasing contaminant levels in water within the area of influence of the mine. The waters related to the Fonte Santa mine are poorly mineralized, with electrical conductivity < 965 µS / cm, and of a mixed type or HCO 3 and SO 4 2types. Most pH values (5.0 8.5) indicate that there is no significant acidic drainage in the region, as found in other areas. More acidic values (pH = 3.4) were found in the mine's lagoon. Waters associated with mineralized veins and old mine activities have Fe and Mn concentrations that forbid their use for human consumption and agriculture. Natural Na, Mg and K water contents are associated with the alteration of albite, chlorite and muscovite of country rock, while Ca with the W-bearing quartz veins. Weathering agents are carbonic and sulphuric acids and the latter has a strong influence in areas draining fine-grained mine tailings.
In Crescendo, 2015
La presente investigación tuvo como objetivo general determinar y describir la influencia del imp... more La presente investigación tuvo como objetivo general determinar y describir la influencia del impuesto a la renta en la liquidez de las micro y pequeñas empresas (MYPES) industriales de Chimbote, en el año 2014. El diseño de la investigación fue no experimental, retrospectivo, correlacional y de nivel cuantitativo. La información se recabó de una muestra de 50 MYPES escogida de manera dirigida de una población de 187, a quienes se les aplicó un cuestionario de 27 preguntas cerradas utilizando la técnica de la encuesta; obteniéndose los siguientes resultados: El 78 % de las MYPES encuestadas vienen funcionando entre 6 o más años en el sector industrial; el 92 % tienen entre 3 a 15 años como empresa y el 42 % se dedican a actividades relacionadas con la pesca. Por otro lado, el 70 % de las MYPES encuestadas han pagado el impuesto a la renta en el año 2014 y el 30 % no. Asimismo, para el 74 %, el pago del impuesto a la renta ha reducido la liquidez de sus empresas y el 76 % tienen prob...
In Crescendo Ciencias Contables & Administrativas, May 10, 2016
Rem: Revista Escola de Minas, 2013
Two simple methods of aquifer vulnerability assessment were used in this study: the GOD and AVI m... more Two simple methods of aquifer vulnerability assessment were used in this study: the GOD and AVI methods. The main purpose was to appraise their faithfulness as exploratory techniques, and their applicability to the scale of a small watershed. The study area was the Sordo River Basin (area: 50 km2), located in the Northeast of Portugal. To measure accuracy, model results were compared with vulnerability maps previously obtained for the basin, but using the standard DRASTIC model. Results of the GOD method were a map dominated by class "low vulnerability" where parameter O (overlying strata) imprinted its signature, very similar to the DRASTIC map but with smaller resolution. The method was considered valuable for exploration of primary factors of aquifer vulnerability (e.g. discrimination between water table and confined aquifers) but not for description of secondary factors (e.g. nuances in the degree of confinement). The application of the AVI method was proven inefficien...
Science of The Total Environment, 2015
• Compare techniques of factor weighting in DRASTIC modeling • Evaluate the impact of changing th... more • Compare techniques of factor weighting in DRASTIC modeling • Evaluate the impact of changing the weighting technique on the vulnerability index • Model the vulnerability of a large group of aquifer systems in continental Portugal
Brazilian Journal of Physics, 2006
In this work, the influence of the substrate bias on the crystalline structure and surface compos... more In this work, the influence of the substrate bias on the crystalline structure and surface composition of Ti6Al4V thin films prepared by rf magnetron sputtering were studied. Samples were grown onto two different types of substrates: AISI 420 steel and common glass using a Ti6Al4V (99.9 %) target. Substrate bias was varied from-100V to-200 V. Samples were characterized by X-ray diffraction (XRD), Energy Dispersive X-ray Analysis (EDX), Scanning Electron Microscopy (SEM), and X-Ray Photoelectron Spectroscopy (XPS). It was observed that the increase of the substrate voltage improved the crystallinity of the deposited films. The stoichiometry of the deposited thin films was studied by EDX and found to be slightly different from that of the target material. Finally, the passive film spontaneously formed on the deposited films upon exposure to the laboratory atmosphere was studied by XPS. The composition of the passive film is rather complex since it contains several forms of oxidized titanium and vanadium as well as Al 2 O 3 .
In Crescendo Ciencias Contables & Administrativas, May 10, 2016
Applied Geochemistry, 2006
To quantify and explain the contributions by pollution and chemical weathering to their compositi... more To quantify and explain the contributions by pollution and chemical weathering to their composition, we studied the chemistries of springs and surface waters in the mountainous part of the Vouga River basin. Water samples were collected during a number of consecutive summer campaigns. Recharge rates were derived from monitored discharge rates within the basin. Very large contributions by meteoric, agricultural and domestic sources to the water chemistries were found, identified by the chloride, sulfate and nitrate concentrations: on average only 1/4 to 1/3 of the solutes could be attributed to chemical weathering. Two petrologic units characterize the river basin: granites and metasediments. The waters collected within metasediment units are distinct from those in granite terrain by a higher magnesium (Mg) concentration. On that basis, it could be estimated that the Rio Vouga, when leaving the mountainous part of the basin, has for some 2/5 a signature determined by chemical weathering in the metasediments. The dominant primary minerals subject to chemical weathering are plagioclase (Pl) and biotite (in granite) or plagioclase and chlorite (in metasediment). Kaolinite, gibbsite and vermiculite are the major weathering products where annual precipitation (P) > 1000 mm⋅y-1 , and kaolinite, vermiculite and smectite where P was lower. Using an algorithm based on the ratio of dissolved silica to bicarbonate, the contributions of chemical weathering of primary minerals could be unraveled. The results show that in granite the export rate (as mol⋅ha-1 ⋅y-1 ⋅wt.%mineral-1) of oligoclase (Pl with An 10−30) was 5.0 ± 2.6 and of biotite 3.2 ± 2.6, while in metasediment these rates for albite (Pl with An 0-10) are 16.5 ± 8.9 and for chlorite are 0.5 ± 0.5. The observed decrease of dissolved silica in surface waters relative to springs was ascribed to (summer) uptake by aquatic biota.
Computers & Geosciences, 1998
Cluster Analysis has numerous scientific and practical applications. This paper presents a comput... more Cluster Analysis has numerous scientific and practical applications. This paper presents a computer program to find an adequate (natural) number of clusters and to isolate anomalous samples in a data set. The program stands on an algorithm that is based on the mathematical concept of equivalence class and uses the framework of the graph theory to identify equivalence classes in multivariate data bases. This type of clustering algorithm is particularly useful when one is dealing with groundwater data sets, because anomalies are frequent in these sets, and because the number of groups that is present is often impossible to estimate; it will depend on the combined effect of many factors, including geology, morphology, climate and pollution. As an example of the utility of this program, a set of groundwater samples is clustered, and the average chemistry of nine identified equivalence classes is related to weathering reactions of plagioclase in a Portuguese granitoid area.
Medicina Clínica, 2016
España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex... more España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (basel
Medicina Clínica, 2016
España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex... more España, S.L.U. Background and objective Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (basel
Applied Geochemistry, 2006
In the Szigetvár area, SW Hungary, shallow groundwaters draining upper Pleistocene loess and Holo... more In the Szigetvár area, SW Hungary, shallow groundwaters draining upper Pleistocene loess and Holocene sediments are considerably contaminated by domestic effluents and leachates of farmland fertilizers. The loess contains calcite and dolomite, but gypsum was not recognized in these sediments. The anthropogenic inputs contain significant amounts of calcium and sulfate. The calcium from these anthropogenic inputs is promoting calcite growth, with concomitant consumption of carbonate alkalinity, undersaturation of the system with respect to dolomite, and dolomite dissolution; in brief, is driving "dedolomitization reactions". Geochemical arguments supporting the occurrence of "dedolomitization reactions" in the area are provided by the results of mass balance and thermodynamic analyses. The mass balances predicted the weather sequence dolomite > calcite > plagioclase > K-feldspar, at odds with widely accepted sequences of weatherability where calcite is the first mineral in the row. The exchange between calcite and dolomite can be a side effect of "dedolomitization reactions" because they cause precipitation of calcite. The thermodynamic prerequisites for "dedolomitization reactions" are satisfied by most local groundwaters (70%) since they are supersaturated (or in equilibrium) with respect to calcite, undersaturated (or in equilibrium) with respect to dolomite, and undersaturated with respect to gypsum. The calcium vs. sulfate and magnesium vs. sulfate trends are also compatible with homologous trends resulting from "dedolomitization reactions".
Journal of Hydrology, 2012
Journal of Hydrology, 2006
A weathering study of a fractured environment composed of granites and metasediments was conducte... more A weathering study of a fractured environment composed of granites and metasediments was conducted in Trás-os-Montes and Alto Douro (north of Portugal) and covered the hydrographic basin of Sordo river. Within the basin, a number of perennial springs were monitored for discharge rate, which allowed for the estimation of annual recharges. A small area of the basin was characterized for parameters such as hydraulic conductivity and effective porosity, which, in combination with the previously calculated recharges, allowed for the calculation of a fracture surface area. The monitored springs were also sampled and analyzed for major inorganic compounds, and using a mole balance model the chemistry of the water samples was explained by weathering to kaolinite of albiteoligoclase plus biotite (granites) or of albite plus chlorite (metasediments). The number of moles of dissolved primary minerals (e.g. albite) could be calculated using this method. These mass transfers were then multiplied by the spring's median discharge rate and divided by the fracture surface area to obtain a weathering rate. Another weathering rate was determined, but using a BET surface area as normalizing factor. Comparing both rates with a representative record of laboratory as well as of field-based weathering rates, it has been noted that rates normalized by the BET were, as expected, similar to commonly reported field-based rates, whereas rates normalized by the fracture surface area were unexpectedly relatively close to laboratory rates (one order of magnitude smaller). The monitored springs are of the fracture artesian type, which means that water emerging at the spring site flowed preferentially through joints and fractures and that weathering took place predominantly at their walls. Consequently, it was concluded that the most realistic weathering rates are those normalized by the fracture surface area, and as a corollary that the gap between laboratory and field weathering rates might not be as wide as usually is reported to be.
Inf. psiquiatr, 1992
Base de dados : LILACS. Pesquisa : 113653 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 113653 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 113653. ...