Lais Ferraz - Academia.edu (original) (raw)

Papers by Lais Ferraz

Brazilian Oral Research, 2021

Ingrid Fernandes MATHIAS-SANTAMARIA (a) Laís Fernanda Ferreira FERRAZ (a) Renato Corrêa Viana CAS... more Ingrid Fernandes MATHIAS-SANTAMARIA (a) Laís Fernanda Ferreira FERRAZ (a) Renato Corrêa Viana CASARIN (b) Giuseppe Alexandre ROMITO (c) Enilson Antônio SALLUM (b) Giovan Paolo PINI-PRATO (d) Márcio Zaffalon CASATI (b)

Journal of Periodontology, Feb 7, 2023

Journal of Periodontal Research, Sep 19, 2021

BACKGROUND This study was conducted to evaluate the clinical, immunologic, and patient-centered o... more BACKGROUND This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. MATERIALS Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. RESULTS No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p < .001), without inter-group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter-group differences (p > .05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. CONCLUSION Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.

Journal of Periodontology, Nov 15, 2021

BackgroundXenogeneic matrices (XMs) have been increasingly used for root coverage procedures. Thi... more BackgroundXenogeneic matrices (XMs) have been increasingly used for root coverage procedures. This study compared the use of two types of XM (collagen matrix [CM] and xenogeneic acellular dermal matrix [XDM]) associated with the coronally advanced flap technique (CAF) to treat single gingival recessions.MethodsSeventy‐five patients presenting single RT1 gingival recession were treated by CAF (control group, n = 25), CAF+CM (test group 1, n = 25), or CAF+XDM (test group 2, n = 25) and completed 6‐month follow‐up. Clinical, patient‐centered, and esthetic assessments were performed and intra‐ and intergroup differences were analyzed.ResultsAt 6 months, the mean recession reduction for CAF, CAF+CM, and CAF+XDM was 2.4 ± 0.8 mm, 2.4 ± 0.9 mm and 2.1 ± 0.8 mm, respectively (P > 0.05). The corresponding mean percentage of root coverage was 78.9% ± 26.2% for CAF, 78.0% ± 28.5% for CAF+CM, and 65.6% ± 26.9% for CAF+XDM (P > 0.05). Dentin hypersensitivity and esthetic conditions showed significantly improvements in all groups. Test groups presented significant gains in gingival thickness (GT; CAF+CM: 0.4 ± 0.3 mm; CAF+XDM: 0.4 ± 0.2 mm) compared to the control group (CAF: 0.0 ± 0.1 mm; P < 0.05).ConclusionThe CAF, CAF+CM, and CAF+XDM treatments each provided similar results in the treatment of single gingival recessions. The addition of either CM or XDM to CAF increases the GT.

Clinical advances in periodontics, Aug 30, 2022

The International Journal of Periodontics & Restorative Dentistry

This study evaluated the use of a xenogeneic acellular dermal matrix (XADM) combined with a modif... more This study evaluated the use of a xenogeneic acellular dermal matrix (XADM) combined with a modified coronally advanced flap (MCAF) and partial resin composite filling (anatomic crown plus 1 mm of the root surface) to treat multiple Type 1 gingival recessions associated with B+ noncarious cervical lesions (NCCLs). The study included 24 recessions in 10 patients. Bleeding on probing, probing depth, combined defect height, relative gingival recession, clinical attachment level, esthetics, and dentin hypersensitivity were recorded. After 6 months, the treatment provided statistically significant outcomes: It reduced the combined defect height by 2.02 ± 0.65 mm, increased clinical attachment level by 1.96 ± 0.83 mm, and increased keratinized tissue thickness by 0.46 ± 0.47 mm, and shallow probing depths were seen. Significant dentin hypersensitivity reduction and esthetic improvements were observed. Therefore, XADM associated with MCAF and partial restoration might be a promising alternative to autogenous grafts used to treat multiple gingival recessions associated with B+ NCCLs. Int

Clinical Advances in Periodontics

INTRODUCTION Gingival recession (GR) is a prevalent problem that is related to aesthetic demands ... more INTRODUCTION Gingival recession (GR) is a prevalent problem that is related to aesthetic demands and dentin hypersensitivity. Frequently, GR is associated with non-carious cervical lesion (NCCLs) forming a combined defect (CD), which requires restorative and surgical treatment. Connective tissue graft (CTG) procedures allow predictable root coverage but can result in patient discomfort and bleeding. CASE PRESENTATION This first case report describes multiple GRs associated with B+ NCCL at teeth #4 and 6 of a 27-year-old patient with a thin periodontal phenotype. The aim of this report was to evaluate the 6-month outcome of a new volume-stable collagen matrix (VCMX) combined with modified coronally advanced flap (MCAF) and partial restoration to treat CDs. After 6 months, significant improvement was observed regarding CD coverage (69.05%), recession reduction (RecRed) (2.25 mm), gingival thickness (GT) gain (0.74 mm) and keratinized tissue width (KTW) gain (0.75 mm). In addition, excellent aesthetic evaluation and patient comfort were achieved by using the biomaterial. CONCLUSION VCMX associated with MCAF and partial restoration may be an option to treat multiple recession defects plus B+ NCCLs. This article is protected by copyright. All rights reserved.

Journal of Esthetic and Restorative Dentistry

Clinical Advances in Periodontics, 2021

IntroductionThe use of platelet‐rich fibrin (PRF) membranes has been evaluated for different purp... more IntroductionThe use of platelet‐rich fibrin (PRF) membranes has been evaluated for different purposes. However, few studies aimed to assess the effect of PRF membranes on peri‐implant mucosal thickness augmentation. Thus, the aim was to evaluate whether the use of PRF membranes placed using the same surgical procedure of single implant installation in the anterior area of the maxilla can result in peri‐implant mucosal thickness increase.Case seriesEight patients received single maxillary implants (anterior area), covered by three PRF membranes (2,500 rpm/12 minutes, RCFmax = 719.71 g). Clinical parameters (baseline and 3 months postoperative) and patient‐centered parameters were evaluated. The buccal peri‐implant mucosal thickness (BMT) and ridge defect (RD) parameters showed a statistically significant difference, with a gain of 0.7 ± 0.3 mm in BMT and reduction of 0.8 ± 0.3 mm in RD. Supracrestal tissue height (STH) was >3 mm after 3 months. Postoperative pain and number of ana...

Journal of Periodontology, 2020

BackgroundThis study was conducted to assess the clinical, immunological, and patient‐centered ou... more BackgroundThis study was conducted to assess the clinical, immunological, and patient‐centered outcomes of microcurrent electrotherapy on palatal wound healing.MethodsThis was a parallel, double‐masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly assigned to one of two groups. In the control (sham) group (n = 27), palatal wounds, after free gingival grafts (FGG) harvest, received sham application of electrotherapy. In the test (electrotherapy treatment [EE]) group (n = 26), palatal wounds, after FGG harvest, received application of microcurrent electrotherapy protocol. Clinical parameters, patient‐centered outcomes, and inflammatory markers were evaluated, up to 90 days postoperatively.ResultsThe EE group achieved earlier wound closure (P <0.001) and epithelialization (P <0.05; P = 0.03) at 7 and 14 days after harvest when compared with the sham group. Painful symptomatology was reported less frequently in the E...

Journal of Periodontology, 2019

BackgroundThe literature lacks long‐term evidence regarding outcomes of the coronally advanced tu... more BackgroundThe literature lacks long‐term evidence regarding outcomes of the coronally advanced tunnel flap (TUN) combined with connective tissue graft (CTG) when compared to the trapezoidal coronally advanced flap (CAF) and CTG combination. This study presents 2‐year results of a randomized clinical trial comparing CTG combined with either CAF or TUN in the treatment of single maxillary gingival recession (GR) defects.MethodsThirty‐nine patients, each contributing a single Miller Class I or II GR defect, were treated by CAF+CTG (control; n = 19) or TUN+CTG (test; n = 20) and completed the 2‐year follow up. Clinical, patient centered, and esthetic evaluations were performed and differences among groups were analyzed.ResultsAt 2 years, mean root coverage for control and test group was 89.5% ± 14.6% and 87.7% ± 18.4%, respectively (P = 0.5). The corresponding complete root coverage prevalence was 68.4% and 50% (P = 0.4). Dentin hypersensitivity significantly decreased for both groups. ...

Research, Society and Development, 2021

Stryphnodendron adstringens (Mart.) Coville is a medicinal plant known for its anti-inflammatory ... more Stryphnodendron adstringens (Mart.) Coville is a medicinal plant known for its anti-inflammatory and antimicrobial properties. This study evaluated some biological activities of extract from S. adstringens. Antimicrobial activity was checked in planktonic cultures and monomicrobial biofilms on aerobic, and anaerobic dental microorganisms. Analyzes of cytotoxicity using MTT assay, and genotoxicity by micronucleus test were performed in human keratinocytes (HACAT), murine macrophages (RAW 264.7), and murine fibroblasts (L929). The anti-inflammatory effect was checked in RAW 264.7 stimulated by lipopolysaccharide (LPS) from Escherichia coli, and treated with the plant extract. The levels of cytokines, and nitric oxide (NO) were measured by ELISA, and Griess method, respectively. Data were analyzed by ANOVA, followed by Tukey's, or Kruskal-Wallis, and Dunns tests (P ≤ 0.05). Biofilms of anaerobic bacteria were very susceptible to the plant extract. Effective concentrations showed ce...