Feruza Ahmed - Academia.edu (original) (raw)

Papers by Feruza Ahmed

Research paper thumbnail of Venous Thromboembolism Risk, Prophylaxis and Outcome in Hospitalized Patients to Medical Wards of University Teaching Hospital

Journal of Clinical and Experimental Cardiology, 2019

Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary emb... more Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary embolism are important causes of disability and death in hospitalized patient. This study aimed at assessing venous VTE risks and prophylaxis and outcome in hospitalized patients to medical wards of Tikur Anbessa Specialized Hospital (TASH). Material and methods: A retrospective cross sectional study involving 200 patients' chart review in those who admitted to medical wards of TASH was conducted using the instrument from TASH guideline on VTE prophylaxis and treatment. Data was entered by EPI Info 7 and then exported to SPSS 21 version software database for analysis. Results: Out of 200 medically admitted patients, 186 (93%) of them had at least two risk factors for VTE development. Only 75 (40%) patients received thromboprophylaxis and VTE was prevented in 61 (32.8%) patients who received prophylaxis. However, 11 (5.5%) of high and highest risk categories study population, developed VTE during their stay at hospital. In 128/200 (64%) study participants, the status of VTE outcome was not known since such information was not documented on patents' charts. Among 14 variables associated with occurrence of VTE, multivariable logistic regression analysis revealed that patients aged ≥ 60 years, AOR=6.55 (95% CI [1.40-30.74]), AMI, AOR=83.22 (95% CI [3.07-225.90]), lung diseases including pneumonia, AOR=9.55 (95% CI [11.62-56.40]) and having stroke within one last month, AOR=1.61 (95% CI [9.16-16.8]) were independent predictors for development of VTE events. Conclusion: In this study, all patients have at least one risk factor for VTE. Only 37.5% of patients received TP. There is a need for implementation of existing evidence based guidelines proposed by TASH.

Research paper thumbnail of Principles and Applications of Ultra-High-Performance Liquid Chromatography

IntechOpen eBooks, May 24, 2023

The science of separation had advanced significantly with the development of ultra-high-performan... more The science of separation had advanced significantly with the development of ultra-high-performance liquid chromatography (UHPLC), a brand-new type of liquid chromatography. The need for the evolution of HPLC into UHPLC has been driven by the continuously evolving of packing material modifications that affect the separation of mixtures. The separation process of analytes is completed in a substantially decreased amount of time due to the lower particle sizes, which increases surface area of interaction allowing reduction of column length to one-third; thus, shorter columns are employed in UHPLC, which consequently causes the flow rate to be three times higher and subsequently reducing analysis time. Although UHPLC shares the same fundamental idea and instrument layout as HPLC, it differs from HPLC in that it produces narrow peaks and has high spectral quality, allowing for simple compound identification in a variety of analytical applications such as impurity profiling, product formulation, and improved analytical technique and method development. However, high back pressure in UHPLC might lead to decreased column life, and the instrument's higher price compared to HPLC are the disadvantages.

Research paper thumbnail of Principles and Applications of Ultra-High-Performance Liquid Chromatography

High Performance Liquid Chromatography - Recent Advances and Applications [Working Title]

The science of separation had advanced significantly with the development of ultra-high-performan... more The science of separation had advanced significantly with the development of ultra-high-performance liquid chromatography (UHPLC), a brand-new type of liquid chromatography. The need for the evolution of HPLC into UHPLC has been driven by the continuously evolving of packing material modifications that affect the separation of mixtures. The separation process of analytes is completed in a substantially decreased amount of time due to the lower particle sizes, which increases surface area of interaction allowing reduction of column length to one-third; thus, shorter columns are employed in UHPLC, which consequently causes the flow rate to be three times higher and subsequently reducing analysis time. Although UHPLC shares the same fundamental idea and instrument layout as HPLC, it differs from HPLC in that it produces narrow peaks and has high spectral quality, allowing for simple compound identification in a variety of analytical applications such as impurity profiling, product form...

Research paper thumbnail of Venous Thromboembolism Risk, Prophylaxis and Outcome in Hospitalized Patients to Medical Wards of University Teaching Hospital

Journal of Clinical & Experimental Cardiology, 2019

Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary emb... more Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary embolism are important causes of disability and death in hospitalized patient. This study aimed at assessing venous VTE risks and prophylaxis and outcome in hospitalized patients to medical wards of Tikur Anbessa Specialized Hospital (TASH). Material and methods: A retrospective cross sectional study involving 200 patients' chart review in those who admitted to medical wards of TASH was conducted using the instrument from TASH guideline on VTE prophylaxis and treatment. Data was entered by EPI Info 7 and then exported to SPSS 21 version software database for analysis. Results: Out of 200 medically admitted patients, 186 (93%) of them had at least two risk factors for VTE development. Only 75 (40%) patients received thromboprophylaxis and VTE was prevented in 61 (32.8%) patients who received prophylaxis. However, 11 (5.5%) of high and highest risk categories study population, developed VTE during their stay at hospital. In 128/200 (64%) study participants, the status of VTE outcome was not known since such information was not documented on patents' charts. Among 14 variables associated with occurrence of VTE, multivariable logistic regression analysis revealed that patients aged ≥ 60 years, AOR=6.55 (95% CI [1.40-30.74]), AMI, AOR=83.22 (95% CI [3.07-225.90]), lung diseases including pneumonia, AOR=9.55 (95% CI [11.62-56.40]) and having stroke within one last month, AOR=1.61 (95% CI [9.16-16.8]) were independent predictors for development of VTE events. Conclusion: In this study, all patients have at least one risk factor for VTE. Only 37.5% of patients received TP. There is a need for implementation of existing evidence based guidelines proposed by TASH.

Research paper thumbnail of Venous Thromboembolism Risk, Prophylaxis and Outcome in Hospitalized Patients to Medical Wards of University Teaching Hospital

Journal of Clinical and Experimental Cardiology, 2019

Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary emb... more Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary embolism are important causes of disability and death in hospitalized patient. This study aimed at assessing venous VTE risks and prophylaxis and outcome in hospitalized patients to medical wards of Tikur Anbessa Specialized Hospital (TASH). Material and methods: A retrospective cross sectional study involving 200 patients' chart review in those who admitted to medical wards of TASH was conducted using the instrument from TASH guideline on VTE prophylaxis and treatment. Data was entered by EPI Info 7 and then exported to SPSS 21 version software database for analysis. Results: Out of 200 medically admitted patients, 186 (93%) of them had at least two risk factors for VTE development. Only 75 (40%) patients received thromboprophylaxis and VTE was prevented in 61 (32.8%) patients who received prophylaxis. However, 11 (5.5%) of high and highest risk categories study population, developed VTE during their stay at hospital. In 128/200 (64%) study participants, the status of VTE outcome was not known since such information was not documented on patents' charts. Among 14 variables associated with occurrence of VTE, multivariable logistic regression analysis revealed that patients aged ≥ 60 years, AOR=6.55 (95% CI [1.40-30.74]), AMI, AOR=83.22 (95% CI [3.07-225.90]), lung diseases including pneumonia, AOR=9.55 (95% CI [11.62-56.40]) and having stroke within one last month, AOR=1.61 (95% CI [9.16-16.8]) were independent predictors for development of VTE events. Conclusion: In this study, all patients have at least one risk factor for VTE. Only 37.5% of patients received TP. There is a need for implementation of existing evidence based guidelines proposed by TASH.

Research paper thumbnail of Principles and Applications of Ultra-High-Performance Liquid Chromatography

IntechOpen eBooks, May 24, 2023

The science of separation had advanced significantly with the development of ultra-high-performan... more The science of separation had advanced significantly with the development of ultra-high-performance liquid chromatography (UHPLC), a brand-new type of liquid chromatography. The need for the evolution of HPLC into UHPLC has been driven by the continuously evolving of packing material modifications that affect the separation of mixtures. The separation process of analytes is completed in a substantially decreased amount of time due to the lower particle sizes, which increases surface area of interaction allowing reduction of column length to one-third; thus, shorter columns are employed in UHPLC, which consequently causes the flow rate to be three times higher and subsequently reducing analysis time. Although UHPLC shares the same fundamental idea and instrument layout as HPLC, it differs from HPLC in that it produces narrow peaks and has high spectral quality, allowing for simple compound identification in a variety of analytical applications such as impurity profiling, product formulation, and improved analytical technique and method development. However, high back pressure in UHPLC might lead to decreased column life, and the instrument's higher price compared to HPLC are the disadvantages.

Research paper thumbnail of Principles and Applications of Ultra-High-Performance Liquid Chromatography

High Performance Liquid Chromatography - Recent Advances and Applications [Working Title]

The science of separation had advanced significantly with the development of ultra-high-performan... more The science of separation had advanced significantly with the development of ultra-high-performance liquid chromatography (UHPLC), a brand-new type of liquid chromatography. The need for the evolution of HPLC into UHPLC has been driven by the continuously evolving of packing material modifications that affect the separation of mixtures. The separation process of analytes is completed in a substantially decreased amount of time due to the lower particle sizes, which increases surface area of interaction allowing reduction of column length to one-third; thus, shorter columns are employed in UHPLC, which consequently causes the flow rate to be three times higher and subsequently reducing analysis time. Although UHPLC shares the same fundamental idea and instrument layout as HPLC, it differs from HPLC in that it produces narrow peaks and has high spectral quality, allowing for simple compound identification in a variety of analytical applications such as impurity profiling, product form...

Research paper thumbnail of Venous Thromboembolism Risk, Prophylaxis and Outcome in Hospitalized Patients to Medical Wards of University Teaching Hospital

Journal of Clinical & Experimental Cardiology, 2019

Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary emb... more Background: In patients with venous thromboembolism (VTE), deep vein thrombosis and pulmonary embolism are important causes of disability and death in hospitalized patient. This study aimed at assessing venous VTE risks and prophylaxis and outcome in hospitalized patients to medical wards of Tikur Anbessa Specialized Hospital (TASH). Material and methods: A retrospective cross sectional study involving 200 patients' chart review in those who admitted to medical wards of TASH was conducted using the instrument from TASH guideline on VTE prophylaxis and treatment. Data was entered by EPI Info 7 and then exported to SPSS 21 version software database for analysis. Results: Out of 200 medically admitted patients, 186 (93%) of them had at least two risk factors for VTE development. Only 75 (40%) patients received thromboprophylaxis and VTE was prevented in 61 (32.8%) patients who received prophylaxis. However, 11 (5.5%) of high and highest risk categories study population, developed VTE during their stay at hospital. In 128/200 (64%) study participants, the status of VTE outcome was not known since such information was not documented on patents' charts. Among 14 variables associated with occurrence of VTE, multivariable logistic regression analysis revealed that patients aged ≥ 60 years, AOR=6.55 (95% CI [1.40-30.74]), AMI, AOR=83.22 (95% CI [3.07-225.90]), lung diseases including pneumonia, AOR=9.55 (95% CI [11.62-56.40]) and having stroke within one last month, AOR=1.61 (95% CI [9.16-16.8]) were independent predictors for development of VTE events. Conclusion: In this study, all patients have at least one risk factor for VTE. Only 37.5% of patients received TP. There is a need for implementation of existing evidence based guidelines proposed by TASH.