Fethullah Kayan - Academia.edu (original) (raw)
Papers by Fethullah Kayan
Dicle tıp dergisi, Apr 17, 2024
Interdisciplinary medical journal, Mar 23, 2024
Dicle tıp dergisi, Feb 26, 2024
Objective: The effective administration of lipid-lowering treatment is of utmost importance in mi... more Objective: The effective administration of lipid-lowering treatment is of utmost importance in mitigating cardiovascular (CV) risk in patients who are undergoing secondary prevention. High-dose statins, ezetimibe, and the relatively newer PCSK9 inhibitors (PCSK9i) have shown effectiveness in achieving low density lipoprotein cholesterol(LDL-C) treatment targets for these patients. However, despite substantial evidence supporting their efficacy, these interventions remain significantly underutilized, primarily due to poor levels of patient adherence. Moreover, there is limited data available on the overall effectiveness of cholesterol-lowering treatment and the proportion of secondary prevention patients who have achieved a well-regulated lipid profile. In light of these factors, the principal aim of this investigation was to evaluate the present status of lipid-lowering medication within this specific group of individuals.
Dicle Medical Journal, Sep 14, 2023
Objective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in... more Objective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in daily clinical practice. Post-prandial AF episodes have been reported in GERD patients. Although it was reported in previous studies that it was caused by sympathovagal imbalance, there are no studies on cardiac conduction system involvement. In this study, we aimed to evaluate whether the risk of developing AF increases in untreated GERD patients with non-invasive electrophysiological tests. Methods: The research was prospectively performed. Endoscopy was performed on the individuals due to reflux complaints. ECG was recorded at 25mm/s and 10 mm/mV amplitude, and 24-hour Holter ECG (three-channel; V1, V2, and V5) was performed. ECG parameters were measured and Holter ECG results were analyzed. Results: A total of 120 individuals, 60 patients and 60 controls, were included. No significant statistically differences existed between groups for hypertension, diabetes, smoking, or dyslipidemia (p>0.05). In terms of heart rate, Pmax, Pmin, QTd, and QTcd, there were no significant differences across the two groups (p>0.05). P-wave dispersion (Pd) was substantially higher in the study group (p=0.014). Comparing the heart rate variabilities of 24-hour Holter ECG recordings across the groups, the standard deviation of R-R intervals (SDNN) was substantially higher in the study group (p<0.001). Low Frequency (LF) and LF/HF were significantly higher in the control group (p<0.001 and p=0.003, respectively). AF was detected in nine individuals on Holter ECG. Conclusion: Pd duration and risk of developing AF were higher in GERD patients.
Miyokardiyal kas bandı miyokart içinde seyreden epikardiyal koroner arterlerin sistolde daralması... more Miyokardiyal kas bandı miyokart içinde seyreden epikardiyal koroner arterlerin sistolde daralması ile seyreden konjenital bir anomalidir. İyi huylu olmasına rağmen önceki çalışmalarda proksimal kesimlerin artmış ateroskleroza eğilimli olduğu gösterilmiştir. Nötrofil/lenfosit oranı (NLO) aterosklerotik kalp hastalıklarında kötü prognozu öngören sistemik enflamasyonun duyarlı bir belirtecidir. Biz bu çalışmada NLO ile miyokardiyal kas bandı arasında bir ilişki var olup olmadığını araştırmayı amaçladık. Yöntemler: Anjiyografik olarak tespit edilmiş miyokardiyal kas bandı veya normal koroner arterleri olan 172 hasta (ortalama yaş: 50.8 ± 11.5 yıl, %77.3 erkek) çalışmaya dahil edildi. Otomatik kan sayacı kullanılarak tüm hastaların hematolojik parametreleri ölçüldü. Bulgular: Çalışma 71 miyokardiyal kas bandı (ortalama yaş: 51,4 ± 11,9 yıl, %80,3 erkek) ve 101 normal koroner arterleri (ortalama yaş: 50,5 ± 11,3 yıl, %75.2 erkek) olan hastadan oluşmaktaydı. Hemoglobin, trombosit sayısı, glukoz ve kreatinin açısından gruplar arasında fark saptanmadı. Kontrol grubuna göre miyokardiyal kas bandı grubunda NLO anlamlı olarak daha yüksekti (2,45 ± 1,19 vs. 1,72 ± 0,48; p< 0,001). ROC analizinde, NLO > 1,82 miyokardiyal kas bandı varlığını %70 duyarlılık ve %71 özgüllükle öngörmüştür (ROC eğri altında kalan alan: 0.733, 95% güvenlik aralığı: 0.654-0.811, p < 0.001). Sonuç: Çalışmamız miyokardiyal kas bandının vücutta enflamatuar düzeyi gösteren yüksek NLO seviyeleri ile ilişkili olduğunu göstermiştir.
African Health Sciences, Jan 15, 2013
Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aure... more Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aureus and coagulase-negative Staphilococci are the most common causes of infections of pacemaker and defibrillator systems. In this case an implantable cardioverter defibrillator pocket infection caused by an extremely rare microorganism, Klebsiella pneumonia, is presented.
Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerl... more Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerlendirilen koroner aterosklerozun şiddeti arasındaki ilişkiyi ST yükselmeli miyokard infarktüsü (STEMİ)'ünde değerlendirmeyi amaçladık. Yöntemler: Dışlama kriterleri sonrası primer perkütan koroner girişim uygulanan geriye dönük olarak toplamda 291 STEMI hastası çalışmaya alındı. (216 erkek,75 kadın, ortalama yaş 61,6±14,0 yıl). Toplam ve diferensiyel lökosit sayımı ve diğer biyokimyasal belirteçler hasta kabulünde alındı. Hastalar SS göre üç tertile ayrıldı. Majör istenmeyen kardiyak olaylar (MİKO) için izleme hastanede yatış döneminde yapıldı Bulgular: SSyüksek grup, lökosit (p=0,009), nötrofil (p=0,008), NLO (p=0,048), zirve troponin (p<0,001), zirve CK-MB (p=0,001) laktat dehidrogenaz (p=0,005), aspartat aminotransferaz (p=0,004) değerleri SSdüşük ve SSorta grupları ile karşılaştırıldığında anlamlı derecede yüksek saptandı. SS artığında, Sol ventrikül ejeksiyon fraksiyonunda düşme (p<0,001) ve sol ventrikül sistolik çapında (p=0,007) artış izlendi. Hastane içi ölüm oranı ve MİKO diğer gruplara (p<0,001 her ikisi için) oranla SS yüksek grubunda daha fazlaydı. Sonuçlar: Çalışmamızda NLO artışı ile SS artışı arasında anlamlı bir ilişki bulduk. Buna ek olarak, SS artışı ile hastane içi MİKO ve hastane içi ölüm arsındaki artan önemli bir ilişki saptadık. İleriye dönük çalışmalarda NLO ve SS birlikte STEMİ hastalarının sınıflandırılmasında risk tahmininde değerlendirilebilir.
The anatolian journal of cardiology, May 15, 2015
Dicle Medical Journal, Sep 1, 2014
Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may o... more Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may occur when excessive intake. A sixteen year-old female was admitted to emergency department with nausea, vomiting, and altered mental status. Wide QRS tachycardia and subsequent ventricular fibrillation occurred following gastric lavage in the patient who confesses that she had taken excessive amount (4500mg propafenone) of drug for the purpose of suicide. After cardiopulmonary resuscitation for ten minutes the patient was intubated because of blurred consciousness and shallow breathing. Transtoracic echocardiography didn't show any pathology. First degree AV block and widened QRS complexes determined in her electrocardiograph (ECG) after resuscitation. These pathological changes in the ECG and clinical status of the patient improved completely in the following days and she was discharged from hospital without any sequelae.
Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır †Department of Cardiov... more Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır †Department of Cardiovascular Surgery, Dicle University Faculty of Medicine, Diyarbakır # Clinics of Cardiology, Izmir Atatürk Training and Research Hospital, İzmir * Clinics of Cardiology, Kartal Koşuyolu Higher Specialization Training and Research Hospital, İstanbul; ‡ Department of Cardiology, Süleyman Demirel University, Isparta; § Department of Cardiology Bülent Ecevit University Faculty of Medicine, Zonguldak
Medicine, 2016
Rheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and lead... more Rheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and leads to significant morbidity and mortality. RHD is a chronic inflammatory and autoimmune disease that is associated with cytokine activities. The etiology of RMS is not fully understood yet. Interleukin (IL)-17 and IL-23 have a key role in development of the autoimmunity. The expression of these cytokines in RMS remains unclear. In this study, we investigated the serum levels of IL-17 and IL-23 in RMS patients compared to healthy subjects.A total of 35 patients admitted to cardiology outpatient clinic between December 2014 and May 2015 who were diagnosed with RMS formed the study group. Age- and gender-matched 35 healthy subjects were included as the control group. Statistical analyses were performed using SPSS 18.0 and P value <0.05 was considered as statistically significant.The patients with RMS had higher WBC count, hsCRP, systolic pulmonary artery pressure (PAPs), left atrial diame...
Dicle Medical Journal / Dicle Tip Dergisi, 2014
Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may o... more Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may occur when excessive intake. A sixteen year-old female was admitted to emergency department with nausea, vomiting, and altered mental status. Wide QRS tachycardia and subsequent ventricular fibrillation occurred following gastric lavage in the patient who confesses that she had taken excessive amount (4500mg propafenone) of drug for the purpose of suicide. After cardiopulmonary resuscitation for ten minutes the patient was intubated because of blurred consciousness and shallow breathing. Transtoracic echocardiography didn't show any pathology. First degree AV block and widened QRS complexes determined in her electrocardiograph (ECG) after resuscitation. These pathological changes in the ECG and clinical status of the patient improved completely in the following days and she was discharged from hospital without any sequelae.
![Research paper thumbnail of [Cardiac device related infective endocarditis; analysis of 15 cases]](https://attachments.academia-assets.com/117592521/thumbnails/1.jpg)
](Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2013
We aimed to investigate the demographic and clinical characteristics, echocardiographic and micro... more We aimed to investigate the demographic and clinical characteristics, echocardiographic and microbiologic features, and outcomes of patients with permanent pacemaker (PM) and implantable cardioverter-defibrillator (ICD) endocarditis in this study. The study population consisted of 15 patients with permanent PM and ICD endocarditis. Data on demographics, medications, clinical procedures, microbiology, echocardiography, surgery, and outcome were collected. The mean age of the patients was 57 ± 16. Seven patients (47%) were female. Of the 15 permanent PM and ICD endocarditis patients, 5 died during hospital follow-up (33%). Four patients (27%) experienced a pulmonary embolism. Culture-negative endocarditis was seen in 5 cases (33%). Staphylococci were the most common causative organisms (60%). Three patients had undergone surgical treatment (20%). Cardiac device-related endocarditis remain a rare but potentially fatal complication of device implantation.
Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir
International Journal of Diabetes in Developing Countries, 2013
ABSTRACT Contrast-induced nephropathy (CIN) is a common complication following percutaneous coron... more ABSTRACT Contrast-induced nephropathy (CIN) is a common complication following percutaneous coronary intervention (PCI). Contrast-induced nephropathy after emergency PCI in subjects with insulin resistance (IR) has not been studied before. In this prospective study we determined the relation between IR on CIN, among those undergoing PCI due to acute coronary syndrome. One hundred twenty four consecutive acute coronary syndrome patients with diabetes (N = 44), insulin resistance (N = 38) and normal glycemic metabolism (N = 42) were included in the study. They were all treated with PCI. Pre- and post procedural creatinines were measured and independent predictors of CIN were analyzed. IR was defined as a HOMA level (HOMA-IR = Serum Glucose (mg/dL) X Plasma Insulin (micro unit/mL) / 405 >2.5. Patients with IR or diabetes had significantly higher levels of creatinine after procedure, serum cholesterol, glucose, contrast volume, hospital stay and HOMA. Female gender, frequency of CIN and multivessel disease were also higher in these patients. On the other hand they had significantly lower ejection fraction. Logistic regression analysis showed that HOMA was the single independent risk factor for CIN in patients with acute coronary syndrome treated with PCI. Insulin resistance is an independent risk factor for CIN in patients with acute coronary syndrome treated with PCI. It carries a similar risk with diabetes and proper prophylaxis should be performed.
European Heart Journal - Cardiovascular Imaging, 2013
Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease... more Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease. The physiology of cardiac adaptation to deconditioning has not been fully elucidated. The purpose of the present study was to assess the effects of 21-days of strict headdown (-6 degrees) bed-rest (BR) deconditioning on left ventricular (LV) dimensions and mass measured by MRI. Methods: Ten healthy men (mean age 32+6) were enrolled; the experiment was conducted at DLR (Koln, Germany) as part of the European Space Agency BR studies. Steady-state free precession MRI images (7mm thickness, no gap, no overlap) were obtained (Symphony 1.5T, Siemens) in a stack of short-axis views from LV base to LV apex, before (PRE), at the end of BR (HDT20), and four days after the BR conclusion (POST). Endocardial and epicardial semi-automated contouring was performed using freely available software (Segment). Results: At HDT20, significant reductions in LV mass (16%), end-diastolic (26%) and endsystolic (27%) volumes and stroke volume (27%) were observed, while ejection fraction did not change. These changes were accompanied by a measured decrease (14%) in plasma and blood volume (by gas-rebreathing technique), as well as by a significant reduction (14%) in VO2max aerobic power, measured using a graded cycle ergometer test protocol to volitional fatigue, at one day after the BR conclusion, while expiratory exchange ratio did not change. At POST, LV volumes were restored, while LV mass was still trending towards control values. Conclusions: Cardiac adaptation to deconditioning affected LV mass and dimensions, as a combined result of LV remodeling and fluids loss, accompanied by worsening in aerobic power. This should be taken into account in patients with cardiovascular diseases, when immobilized in bed, to proper adjust the therapy, or to define appropriate physical exercises when possible, in order to avoid further complications.
African Health Sciences, 2013
Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aure... more Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aureus and coagulase-negative Staphilococci are the most common causes of infections of pacemaker and defibrillator systems. In this case an implantable cardioverter defibrillator pocket infection caused by an extremely rare microorganism, Klebsiella pneumonia, is presented.
The Anatolian Journal of Cardiology, 2015
Objective: The coronary slow flow phenomenon (CSFP), which is characterized by delayed distal ves... more Objective: The coronary slow flow phenomenon (CSFP), which is characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, is an angiographic finding. The aim of this study is to investigate the association between platelet-tolymphocyte ratio (PLR) and coronary blood flow rate. Methods: This is a retrospective observational study. It was based on two medical centers. A total of 197 patients undergoing coronary angiography were included in the study, 95 of whom were patients with coronary slow flow without stenosis in coronary angiography and 102 of whom had normal coronary arteries and normal flow. Results: The PLR was higher in the coronary slow flow group compared with the control groups (p=0.001). In the correlation analysis, PLR showed a significant correlation with left anterior descending (LAD) artery thrombolysis in myocardial infarction (TIMI) frame count. After multiple logistic regression, high levels of PLR were independently associated with coronary slow flow, together with hemoglobin. Conclusion: PLR was higher in patients with CSFP, and we also showed that PLR was significantly and independently associated with CSFP.
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2012
The American Journal of Cardiology, 2013
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) a... more The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR ≤ 2.73 [n = 370]) vs. high NLR group (NLR > 2.73 [n = 101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9 ± 149.7 μL vs. 192.5 ± 127.7 μL, P = 0.001, and 32.7 ± 26.8 μL vs. 22.8 ± 19.4 μL, P = 0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P = 0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P = 0.050) and NLR > 2.73 (OR, 1.848; 95% CI, 1.016-3.360, P = 0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P = 0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR.
Dicle tıp dergisi, Apr 17, 2024
Interdisciplinary medical journal, Mar 23, 2024
Dicle tıp dergisi, Feb 26, 2024
Objective: The effective administration of lipid-lowering treatment is of utmost importance in mi... more Objective: The effective administration of lipid-lowering treatment is of utmost importance in mitigating cardiovascular (CV) risk in patients who are undergoing secondary prevention. High-dose statins, ezetimibe, and the relatively newer PCSK9 inhibitors (PCSK9i) have shown effectiveness in achieving low density lipoprotein cholesterol(LDL-C) treatment targets for these patients. However, despite substantial evidence supporting their efficacy, these interventions remain significantly underutilized, primarily due to poor levels of patient adherence. Moreover, there is limited data available on the overall effectiveness of cholesterol-lowering treatment and the proportion of secondary prevention patients who have achieved a well-regulated lipid profile. In light of these factors, the principal aim of this investigation was to evaluate the present status of lipid-lowering medication within this specific group of individuals.
Dicle Medical Journal, Sep 14, 2023
Objective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in... more Objective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in daily clinical practice. Post-prandial AF episodes have been reported in GERD patients. Although it was reported in previous studies that it was caused by sympathovagal imbalance, there are no studies on cardiac conduction system involvement. In this study, we aimed to evaluate whether the risk of developing AF increases in untreated GERD patients with non-invasive electrophysiological tests. Methods: The research was prospectively performed. Endoscopy was performed on the individuals due to reflux complaints. ECG was recorded at 25mm/s and 10 mm/mV amplitude, and 24-hour Holter ECG (three-channel; V1, V2, and V5) was performed. ECG parameters were measured and Holter ECG results were analyzed. Results: A total of 120 individuals, 60 patients and 60 controls, were included. No significant statistically differences existed between groups for hypertension, diabetes, smoking, or dyslipidemia (p>0.05). In terms of heart rate, Pmax, Pmin, QTd, and QTcd, there were no significant differences across the two groups (p>0.05). P-wave dispersion (Pd) was substantially higher in the study group (p=0.014). Comparing the heart rate variabilities of 24-hour Holter ECG recordings across the groups, the standard deviation of R-R intervals (SDNN) was substantially higher in the study group (p<0.001). Low Frequency (LF) and LF/HF were significantly higher in the control group (p<0.001 and p=0.003, respectively). AF was detected in nine individuals on Holter ECG. Conclusion: Pd duration and risk of developing AF were higher in GERD patients.
Miyokardiyal kas bandı miyokart içinde seyreden epikardiyal koroner arterlerin sistolde daralması... more Miyokardiyal kas bandı miyokart içinde seyreden epikardiyal koroner arterlerin sistolde daralması ile seyreden konjenital bir anomalidir. İyi huylu olmasına rağmen önceki çalışmalarda proksimal kesimlerin artmış ateroskleroza eğilimli olduğu gösterilmiştir. Nötrofil/lenfosit oranı (NLO) aterosklerotik kalp hastalıklarında kötü prognozu öngören sistemik enflamasyonun duyarlı bir belirtecidir. Biz bu çalışmada NLO ile miyokardiyal kas bandı arasında bir ilişki var olup olmadığını araştırmayı amaçladık. Yöntemler: Anjiyografik olarak tespit edilmiş miyokardiyal kas bandı veya normal koroner arterleri olan 172 hasta (ortalama yaş: 50.8 ± 11.5 yıl, %77.3 erkek) çalışmaya dahil edildi. Otomatik kan sayacı kullanılarak tüm hastaların hematolojik parametreleri ölçüldü. Bulgular: Çalışma 71 miyokardiyal kas bandı (ortalama yaş: 51,4 ± 11,9 yıl, %80,3 erkek) ve 101 normal koroner arterleri (ortalama yaş: 50,5 ± 11,3 yıl, %75.2 erkek) olan hastadan oluşmaktaydı. Hemoglobin, trombosit sayısı, glukoz ve kreatinin açısından gruplar arasında fark saptanmadı. Kontrol grubuna göre miyokardiyal kas bandı grubunda NLO anlamlı olarak daha yüksekti (2,45 ± 1,19 vs. 1,72 ± 0,48; p< 0,001). ROC analizinde, NLO > 1,82 miyokardiyal kas bandı varlığını %70 duyarlılık ve %71 özgüllükle öngörmüştür (ROC eğri altında kalan alan: 0.733, 95% güvenlik aralığı: 0.654-0.811, p < 0.001). Sonuç: Çalışmamız miyokardiyal kas bandının vücutta enflamatuar düzeyi gösteren yüksek NLO seviyeleri ile ilişkili olduğunu göstermiştir.
African Health Sciences, Jan 15, 2013
Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aure... more Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aureus and coagulase-negative Staphilococci are the most common causes of infections of pacemaker and defibrillator systems. In this case an implantable cardioverter defibrillator pocket infection caused by an extremely rare microorganism, Klebsiella pneumonia, is presented.
Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerl... more Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerlendirilen koroner aterosklerozun şiddeti arasındaki ilişkiyi ST yükselmeli miyokard infarktüsü (STEMİ)'ünde değerlendirmeyi amaçladık. Yöntemler: Dışlama kriterleri sonrası primer perkütan koroner girişim uygulanan geriye dönük olarak toplamda 291 STEMI hastası çalışmaya alındı. (216 erkek,75 kadın, ortalama yaş 61,6±14,0 yıl). Toplam ve diferensiyel lökosit sayımı ve diğer biyokimyasal belirteçler hasta kabulünde alındı. Hastalar SS göre üç tertile ayrıldı. Majör istenmeyen kardiyak olaylar (MİKO) için izleme hastanede yatış döneminde yapıldı Bulgular: SSyüksek grup, lökosit (p=0,009), nötrofil (p=0,008), NLO (p=0,048), zirve troponin (p<0,001), zirve CK-MB (p=0,001) laktat dehidrogenaz (p=0,005), aspartat aminotransferaz (p=0,004) değerleri SSdüşük ve SSorta grupları ile karşılaştırıldığında anlamlı derecede yüksek saptandı. SS artığında, Sol ventrikül ejeksiyon fraksiyonunda düşme (p<0,001) ve sol ventrikül sistolik çapında (p=0,007) artış izlendi. Hastane içi ölüm oranı ve MİKO diğer gruplara (p<0,001 her ikisi için) oranla SS yüksek grubunda daha fazlaydı. Sonuçlar: Çalışmamızda NLO artışı ile SS artışı arasında anlamlı bir ilişki bulduk. Buna ek olarak, SS artışı ile hastane içi MİKO ve hastane içi ölüm arsındaki artan önemli bir ilişki saptadık. İleriye dönük çalışmalarda NLO ve SS birlikte STEMİ hastalarının sınıflandırılmasında risk tahmininde değerlendirilebilir.
The anatolian journal of cardiology, May 15, 2015
Dicle Medical Journal, Sep 1, 2014
Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may o... more Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may occur when excessive intake. A sixteen year-old female was admitted to emergency department with nausea, vomiting, and altered mental status. Wide QRS tachycardia and subsequent ventricular fibrillation occurred following gastric lavage in the patient who confesses that she had taken excessive amount (4500mg propafenone) of drug for the purpose of suicide. After cardiopulmonary resuscitation for ten minutes the patient was intubated because of blurred consciousness and shallow breathing. Transtoracic echocardiography didn't show any pathology. First degree AV block and widened QRS complexes determined in her electrocardiograph (ECG) after resuscitation. These pathological changes in the ECG and clinical status of the patient improved completely in the following days and she was discharged from hospital without any sequelae.
Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır †Department of Cardiov... more Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır †Department of Cardiovascular Surgery, Dicle University Faculty of Medicine, Diyarbakır # Clinics of Cardiology, Izmir Atatürk Training and Research Hospital, İzmir * Clinics of Cardiology, Kartal Koşuyolu Higher Specialization Training and Research Hospital, İstanbul; ‡ Department of Cardiology, Süleyman Demirel University, Isparta; § Department of Cardiology Bülent Ecevit University Faculty of Medicine, Zonguldak
Medicine, 2016
Rheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and lead... more Rheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and leads to significant morbidity and mortality. RHD is a chronic inflammatory and autoimmune disease that is associated with cytokine activities. The etiology of RMS is not fully understood yet. Interleukin (IL)-17 and IL-23 have a key role in development of the autoimmunity. The expression of these cytokines in RMS remains unclear. In this study, we investigated the serum levels of IL-17 and IL-23 in RMS patients compared to healthy subjects.A total of 35 patients admitted to cardiology outpatient clinic between December 2014 and May 2015 who were diagnosed with RMS formed the study group. Age- and gender-matched 35 healthy subjects were included as the control group. Statistical analyses were performed using SPSS 18.0 and P value <0.05 was considered as statistically significant.The patients with RMS had higher WBC count, hsCRP, systolic pulmonary artery pressure (PAPs), left atrial diame...
Dicle Medical Journal / Dicle Tip Dergisi, 2014
Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may o... more Propafenone is a group 1C antiarrhythmic agent. Serious side effects such as cardiac arrest may occur when excessive intake. A sixteen year-old female was admitted to emergency department with nausea, vomiting, and altered mental status. Wide QRS tachycardia and subsequent ventricular fibrillation occurred following gastric lavage in the patient who confesses that she had taken excessive amount (4500mg propafenone) of drug for the purpose of suicide. After cardiopulmonary resuscitation for ten minutes the patient was intubated because of blurred consciousness and shallow breathing. Transtoracic echocardiography didn't show any pathology. First degree AV block and widened QRS complexes determined in her electrocardiograph (ECG) after resuscitation. These pathological changes in the ECG and clinical status of the patient improved completely in the following days and she was discharged from hospital without any sequelae.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2013
We aimed to investigate the demographic and clinical characteristics, echocardiographic and micro... more We aimed to investigate the demographic and clinical characteristics, echocardiographic and microbiologic features, and outcomes of patients with permanent pacemaker (PM) and implantable cardioverter-defibrillator (ICD) endocarditis in this study. The study population consisted of 15 patients with permanent PM and ICD endocarditis. Data on demographics, medications, clinical procedures, microbiology, echocardiography, surgery, and outcome were collected. The mean age of the patients was 57 ± 16. Seven patients (47%) were female. Of the 15 permanent PM and ICD endocarditis patients, 5 died during hospital follow-up (33%). Four patients (27%) experienced a pulmonary embolism. Culture-negative endocarditis was seen in 5 cases (33%). Staphylococci were the most common causative organisms (60%). Three patients had undergone surgical treatment (20%). Cardiac device-related endocarditis remain a rare but potentially fatal complication of device implantation.
Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir
International Journal of Diabetes in Developing Countries, 2013
ABSTRACT Contrast-induced nephropathy (CIN) is a common complication following percutaneous coron... more ABSTRACT Contrast-induced nephropathy (CIN) is a common complication following percutaneous coronary intervention (PCI). Contrast-induced nephropathy after emergency PCI in subjects with insulin resistance (IR) has not been studied before. In this prospective study we determined the relation between IR on CIN, among those undergoing PCI due to acute coronary syndrome. One hundred twenty four consecutive acute coronary syndrome patients with diabetes (N = 44), insulin resistance (N = 38) and normal glycemic metabolism (N = 42) were included in the study. They were all treated with PCI. Pre- and post procedural creatinines were measured and independent predictors of CIN were analyzed. IR was defined as a HOMA level (HOMA-IR = Serum Glucose (mg/dL) X Plasma Insulin (micro unit/mL) / 405 >2.5. Patients with IR or diabetes had significantly higher levels of creatinine after procedure, serum cholesterol, glucose, contrast volume, hospital stay and HOMA. Female gender, frequency of CIN and multivessel disease were also higher in these patients. On the other hand they had significantly lower ejection fraction. Logistic regression analysis showed that HOMA was the single independent risk factor for CIN in patients with acute coronary syndrome treated with PCI. Insulin resistance is an independent risk factor for CIN in patients with acute coronary syndrome treated with PCI. It carries a similar risk with diabetes and proper prophylaxis should be performed.
European Heart Journal - Cardiovascular Imaging, 2013
Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease... more Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease. The physiology of cardiac adaptation to deconditioning has not been fully elucidated. The purpose of the present study was to assess the effects of 21-days of strict headdown (-6 degrees) bed-rest (BR) deconditioning on left ventricular (LV) dimensions and mass measured by MRI. Methods: Ten healthy men (mean age 32+6) were enrolled; the experiment was conducted at DLR (Koln, Germany) as part of the European Space Agency BR studies. Steady-state free precession MRI images (7mm thickness, no gap, no overlap) were obtained (Symphony 1.5T, Siemens) in a stack of short-axis views from LV base to LV apex, before (PRE), at the end of BR (HDT20), and four days after the BR conclusion (POST). Endocardial and epicardial semi-automated contouring was performed using freely available software (Segment). Results: At HDT20, significant reductions in LV mass (16%), end-diastolic (26%) and endsystolic (27%) volumes and stroke volume (27%) were observed, while ejection fraction did not change. These changes were accompanied by a measured decrease (14%) in plasma and blood volume (by gas-rebreathing technique), as well as by a significant reduction (14%) in VO2max aerobic power, measured using a graded cycle ergometer test protocol to volitional fatigue, at one day after the BR conclusion, while expiratory exchange ratio did not change. At POST, LV volumes were restored, while LV mass was still trending towards control values. Conclusions: Cardiac adaptation to deconditioning affected LV mass and dimensions, as a combined result of LV remodeling and fluids loss, accompanied by worsening in aerobic power. This should be taken into account in patients with cardiovascular diseases, when immobilized in bed, to proper adjust the therapy, or to define appropriate physical exercises when possible, in order to avoid further complications.
African Health Sciences, 2013
Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aure... more Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aureus and coagulase-negative Staphilococci are the most common causes of infections of pacemaker and defibrillator systems. In this case an implantable cardioverter defibrillator pocket infection caused by an extremely rare microorganism, Klebsiella pneumonia, is presented.
The Anatolian Journal of Cardiology, 2015
Objective: The coronary slow flow phenomenon (CSFP), which is characterized by delayed distal ves... more Objective: The coronary slow flow phenomenon (CSFP), which is characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, is an angiographic finding. The aim of this study is to investigate the association between platelet-tolymphocyte ratio (PLR) and coronary blood flow rate. Methods: This is a retrospective observational study. It was based on two medical centers. A total of 197 patients undergoing coronary angiography were included in the study, 95 of whom were patients with coronary slow flow without stenosis in coronary angiography and 102 of whom had normal coronary arteries and normal flow. Results: The PLR was higher in the coronary slow flow group compared with the control groups (p=0.001). In the correlation analysis, PLR showed a significant correlation with left anterior descending (LAD) artery thrombolysis in myocardial infarction (TIMI) frame count. After multiple logistic regression, high levels of PLR were independently associated with coronary slow flow, together with hemoglobin. Conclusion: PLR was higher in patients with CSFP, and we also showed that PLR was significantly and independently associated with CSFP.
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2012
The American Journal of Cardiology, 2013
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) a... more The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR ≤ 2.73 [n = 370]) vs. high NLR group (NLR > 2.73 [n = 101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9 ± 149.7 μL vs. 192.5 ± 127.7 μL, P = 0.001, and 32.7 ± 26.8 μL vs. 22.8 ± 19.4 μL, P = 0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P = 0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P = 0.050) and NLR > 2.73 (OR, 1.848; 95% CI, 1.016-3.360, P = 0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P = 0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR.