Figen Özgür - Academia.edu (original) (raw)

Papers by Figen Özgür

Research paper thumbnail of Penil Protez Cerrahisine Bağlı Penis Nekrozu ve Rekonstrüksiyonu

Organik empotans nedeniyle penil protez yerlestirilen hastalarda penil nekroz olusmasi cok ender ... more Organik empotans nedeniyle penil protez yerlestirilen hastalarda penil nekroz olusmasi cok ender karsilasilan bir komplikasyondur. Bunun nedeni penisin zengin damarsal yapisidir. Ancak, olumsuz bir cok faktorun bir arada etki etmesi sonucu protez cerrahisi nekrozla sonuclanabilir. Bu major komplikasyonun rekonstruksiyonu da oldukca zordur. Primer olarak nekroza neden olan faktorler rekonstruksiyon esnasinda da problemler yaratabilir. Bu makalede penil protez cerrahisine bagli nekroz gorulen 2 olgu ve rekonstruksiyonlari tartisildi.

Research paper thumbnail of Ameliyathane Oda Teknikerliği Genel Görev Tanımı

Sağlık konusunda birinci sırada tercih edilen Hacettepe Üniversitesi Hastaneleri cerrahi hizmetle... more Sağlık konusunda birinci sırada tercih edilen Hacettepe Üniversitesi Hastaneleri cerrahi hizmetlerde de çağdaş ameliyathaneleri, alt yapı donanımı, güncel teknolojisi ve kadrosu ile birçok başarılı yaklaşımı ve ilkleri gerçekleştirmektedir. Ameliyathanede görev yapan teknikerler bu hizmetlerin büyük bir kısmında önemli görevler üstlenmektedir. Teknik hizmetleri en iyi şekilde vermek misyonu ile çalışan tekniker arkadaşlarımız hizmet içi eğitimler ve yaşam boyu öğrenme süreçleri ile bilgi ve becerilerini sürekli güncelleme gereksinimi duymaktadırlar. Üniversitemiz Sağlık Hizmetleri Meslek Yüksek Okulu'nda 2014-2015 ders yılından itibaren öğrenci alımına başlayacak olan Ameliyathane hizmetleri programı öğrencileri ve ameliyathane ekiplerinde görev yapan teknik elemanlarımız ile stajyer öğrenciler de güncel bilgiye gereksinim duyacaklardır

Research paper thumbnail of Medical and cosmeceutical applications for enhancement of partial-thickness skin graft donor-site healing

Turkish Journal of Plastic Surgery, 2020

Introduction: After partial-thickness skin graft (PTSG) harvesting, a dermal surface is exposed a... more Introduction: After partial-thickness skin graft (PTSG) harvesting, a dermal surface is exposed and an iatrogenic wound is created. Application of various agents has been studied for enhancement of healing process in PTSG donor area. The ideal agent should accelerate healing, provide comfort to the patient, not allow infection, and be easily applicable and cheap. Materials and Methods: The Cochrane Central Register of Controlled Trials, PubMed, Scopus. and EMBASE databases were screened for words (“skin graft” + “donor”), by using time limits between 1989 and 2018. This study involved a total of 5 systematic reviews and 43 original articles which met the inclusion criteria. Articles were reviewed and parameters such as healing time, pain, infection rate, cosmetic result, and cost were extracted. Results: Systematic reviews favor moist dressing materials over dry ones considering healing time and patient comfort. Hydrocolloids provide rapid wound healing, and dressing changes do not ...

Research paper thumbnail of Influence of nasoalveolar molding on skeletal development in patients with unilateral cleft lip and palate at 5 years of age

American Journal of Orthodontics and Dentofacial Orthopedics, 2018

Research paper thumbnail of Liposakşın ve Anestezi

Balkan Medical Journal, 1988

Research paper thumbnail of The advantages of simultaneous abdominoplasty, laparoscopic cholecystectomy, and incisional hernia repair

European Journal of Plastic Surgery, 2002

A 44-year-old woman undergoing abdominoplasty, laparoscopic cholecystectomy, and incisional herni... more A 44-year-old woman undergoing abdominoplasty, laparoscopic cholecystectomy, and incisional hernia repair is presented. Abdominal wall lipodystrophy and incisional hernia, both pathologies leading to esthetic deformity, and cholelithiasis causing biliary symptoms were treated at the same operation without any complications. Combining two or multiple abdominal procedures may reduce the potential risks of multiple anesthesia for each procedure, shorten total hospital stay and operating room time, and, perhaps most importantly for the patient, reduce costs and time off work.

Research paper thumbnail of Geri̇atri̇k Hastalarda Gerçekleşti̇ri̇len Plasti̇k Ve Rekonstrükti̇f Cerrahi̇ İşlemleri̇ni̇n İncelenmesi̇

geriatri.dergisi.org

... Gökhan TUNÇBİLEK, Figen ÖZGÜR. ... Bu gelişmelere ışık tutabilmek amacıyla bölümümüzde son 5 ... more ... Gökhan TUNÇBİLEK, Figen ÖZGÜR. ... Bu gelişmelere ışık tutabilmek amacıyla bölümümüzde son 5 sene içinde opere edilen 65 yaş ve üzeri hastaların yaşları, tanıları, yapılan işlemler, ek dahili problemler, anestezi türleri incelenmiştir. ...

Research paper thumbnail of Yarık Damak Onarımı Yapılan Hastalarda Konuşmanın Değerlendirilmesi

Yarik damak anarimi sonrasi ulasilmasi hedeflenen sonuclar arasinda normal konusmanin saglanmasi ... more Yarik damak anarimi sonrasi ulasilmasi hedeflenen sonuclar arasinda normal konusmanin saglanmasi onemli bir yer tutmaktadir. Bu calismanin amaci opere edilen yarik damak hastalarinin konusma sonuclarini degerlendirmektir. Konusma degerlendirmesinde nazal rezonans, nazal hava kacagi ve artikulasyon hatalari arastirilmistir. Hastalarin % 62.5'inde normal veya kabul edilebilir sinirlarda hipernazalite saptanmistir. Hastalarin % 62.5‘inde nazal kacaga rastlanmamis, % 60'inda da artikulasyon hatasi saptanmamistir. Elde edilen sonuclar birbirleri ile ortaklasa degerlendirildiklerinde 6 hastanin (%I5) tamamen normal bulgulara sahip oldugu, bu gruba ek olarak 14 hastanin (% 35) nazal hava kacagi ve artikulasyon hatasi olmadan hafif derecede hipernazaliteye sahip olduklari saptanmistir. Geriye kalan 20 hastanin (% 50) ise degisen derecelerde hipernazalite, nazal hava kacagi ve artikulasyon hatalari oldugu gorulmustur. Ameliyat anindaki yas ile konusma sonuclari arasinda belirgin bir ...

Research paper thumbnail of Dudak Onarimi İle Eş Zamanli Gerçekleşti̇ri̇len Dudak Yariği Burnu Düzelti̇lmesi̇nde İnterdomal Di̇ki̇ş İle Kresenteri̇k Ci̇lt Eksi̇zyonunun Erken Ve Geç Dönem Etki̇leri̇ni̇n Karşilaştirilmasi

Amac: Bu calismada dudak onarimi ile es seansli olarak CLN deformitesinin giderilmesi amaciyla in... more Amac: Bu calismada dudak onarimi ile es seansli olarak CLN deformitesinin giderilmesi amaciyla interdomal dikis yerlestirilen hastalar ile yarik tarafina kresenterik cilt eksizyonu gerceklestirilen hastalarin takiplerinde elde edilen postoperatif duzeltme oranlarinin karsilastirilmasi amaclanmistir. Gerec ve Yontemler: Modifiye Millard rotasyon ilerletme teknigi ile dudak onarimi gerceklestirilen ve es zamanli olarak ya burun sekillendirici interdomal dikis, ya da kresenterik cilt eksizyonu gerceklestirilen 83 tek tarafli yarik dudak hastasi calismaya dahil edildi. Hastalarin degerlendirilmesi standart olarak cekilen preoperatif, postoperatif erken ve gec donemde rutin olarak cekilen kaudal nazal fotograflar ile gerceklestirilmistir. Burun tabani ile nostril en projekte noktalari arasinda yukseklikler olculmus ve yarik olan tarafta elde edilen yukseklik, yarik olmayan taraftaki yukseklige oranlanmistir. Bulgular: Erken postoperatif donemde en yuksek oran kresenterik cilt eksizyonu g...

Research paper thumbnail of Photobiomodulation combined with adipose-derived stem cells encapsulated in methacrylated gelatin hydrogels enhances in vivo bone regeneration

Lasers in Medical Science, 2021

Reconstruction of bone defects is still a significant challenge. The aim of this study was to eva... more Reconstruction of bone defects is still a significant challenge. The aim of this study was to evaluate the effect of application of photobiomodulation (PBM) to enhance in vivo bone regeneration and osteogenic differentiation potential of adipose-derived stem cells (ADSCs) encapsulated in methacrylated gelatin (GEL-MA) hydrogels. Thirty-six Sprague-Dawley rats were randomly separated into 3 experimental groups ( n = 12 each). The groups were control/blank defect (I), GEL-MA hydrogel (II), and ADSC-loaded GEL-MA (GEL-MA+ADSC) hydrogel (III). Biparietal critical sized bone defects (6 mm in size) are created in each animal. Half of the animals from each group ( n = 6 each) were randomly selected for PBM application using polychromatic light in the near infrared region, 600–1200 nm. PBM was administered from 10 cm distance cranially in 48 h interval. The calvaria were harvested at the 20th week, and macroscopic, microtomographic, and histologic evaluation were performed for further analysis. Microtomographic evaluation demonstrated the highest result for mineralized matrix formation (MMF) in group III. PBM receiving samples of group III showed mean MMF of 79.93±3.41%, whereas the non-PBM receiving samples revealed mean MMF of 60.62±6.34 % ( p =0.002). In terms of histologic evaluation of bone defect repair, the higher scores were obtained in the groups II and III when compared to the control group (2.0 for both PBM receiving and non-receiving specimens; p <0.001). ADSC-loaded microwave-induced GEL-MA hydrogels and periodic application of photobiomodulation with polychromatic light appear to have beneficial effect on bone regeneration and can stimulate ADSCs for osteogenic differentiation.

Research paper thumbnail of Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap

Lasers in Surgery and Medicine, 2019

The aim of this study was to evaluate the effect of relatively novel approach of application of p... more The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap. Methods: Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n ¼ 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention. In group 2 (delay group), photobiomodulation (PBM) was applied for 7 days as a delay procedure, before elevation of the flap. In group 3 (PBM group), the TRAM flap was elevated, and PBM was administered immediately after the flap was sutured back to its bed for therapeutic purpose. PBM was applied in 48 hours interval from 10 cm. distance to the whole abdominal wall both in groups 2 and 3 for one week. After 7 days of postoperative follow-up, as the demarcation of necrosis of the skin paddle was obvious, skin flap survival was further evaluated by macroscopic, histological and microangiographic analysis. Results: The mean percentage of skin flap necrosis was 56.17 AE 23.68 for group 1, 30.92 AE 17.46 for group 2 and 22.73 AE 12.98 for group 3 PBM receiving groups 2 and 3 revealed less necrosis when compared to control group and this difference was statistically significant. Vascularization in zone 4 of PBM applied groups 2 and 3 was higher compared to group 1 (P ¼ 0.001). Acute inflammation in zone 4 of group 1 was significantly higher compared to groups 2 and 3 (P ¼ 0.025). Similarly, evaluation of zone 1 of the flaps reveled more inflammation and less vascularization among the samples of the control group (P ¼ 0.006 and P ¼ 0.007, respectively). Comparison of PBM receiving two groups did not demonstrate further difference in means of vascularization and inflammation density (P ¼ 0.259). Conclusion: Application of PBM in polychromatic fashion enhances skin flap survival in experimental TRAM flap model both on preoperative basis as a delay procedure or as a therapeutic approach. Lasers Surg. Med.

Research paper thumbnail of Cleft Palate Repair Using Single Flap Palatoplasty in Patient With Associated Palatal Hemangioma

The Journal of craniofacial surgery, Jan 30, 2018

Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusu... more Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Magnetic resonance imaging revealed intensive contrasting solid nodule with a lobulated contour that was covering the right half of the hard palate, measuring 2.2×1.3 cm. To reduce the size of the vascular lesion 7 mg/d oral propranolol treatment was initiated. Following reduction in the size of hemangioma, the cleft palate was repaired at 11 months of age. Single mucoperiosteal flap from the left side of the palate preserving the major palatine artery was elevated whereas right mucoperisteal flap was minimally dissected not to interfere with the hemangioma. No intraoperative and postoperative...

Research paper thumbnail of Velofarengeal Yetmezlik Tedavisi

Turkiye Klinikleri Plastik Cerrahi Ozel Dergisi, 2011

Research paper thumbnail of Poly(L-Lactide)/Poly(∊-Caprolactone) and Collagen/β-Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Rat Alveolar Defects: A Microtomographic, Molecular-Biological, and Histological Study

The Cleft Palate-Craniofacial Journal, 2016

Objective To determine the efficacy of a newly developed scaffold (col/β-TCP) in a preclinical ra... more Objective To determine the efficacy of a newly developed scaffold (col/β-TCP) in a preclinical rat model as compared with the gold standard treatment (autograft) and control scaffolds (PLLA/PCL). Design Fifty-six Sprague-Dawley rats were randomized into four experimental groups, and critical-sized alveolar defects (7 × 4 × 3 mm) were created in each animal. Group A was the blank defect group, group B received autograft, group C received col/β-TCP scaffolds, and group D received PLLA/PCL blend scaffolds to fill the bone defects. New bone formation was assessed radiomorphometrically, histomorphometrically, and molecular-biologically at 1 and 4 months following surgery. Results Radiomorphometrically, the best new bone volume rate at 1 month (43.7%) and 4 months (45.4%) was observed in the autograft group, and the difference was significantly higher than in the other three groups ( P ≤ .005, P ≤ .001, P ≤ .001 for 1 month and P = .004, P ≤ .001, P ≤ .001 for 4 months). Even though the n...

Research paper thumbnail of Tissue expansion in median facial cleft reconstruction: A case report

International Journal of Oral and Maxillofacial Surgery, 1994

Median cleft of the face is a rare congenital anomaly. Patients with mild deformities require onl... more Median cleft of the face is a rare congenital anomaly. Patients with mild deformities require only limited nasal reconstruction; however, the nasal dorsal soft tissue envelope is usually tight and insufficient, making bone grafting difficult. The tissue-expansion method was used for nasal reconstruction in a patient with a median facial cleft, an expander being improvised from an intubation tube balloon.

Research paper thumbnail of The Effect of Onlay Alloplastic Implants on Mandibular Growth in Young Rabbits

Plastic and Reconstructive Surgery, 1995

Research paper thumbnail of Repeated Tissue Expansions on Split-Thickness Skin Graft in a Patient With Neurocutaneous Syndrome

Journal of Craniofacial Surgery, 2007

Research paper thumbnail of The Effect of Onlay Medpor Implants on Mandibular Growth in Young Rabbits: An Experimental Study

Annals of Plastic Surgery, 1999

Research paper thumbnail of Giant Rhabdomyosarcoma with Necrosis Visualized with TI-201 Chloride

Clinical Nuclear Medicine, 1991

Research paper thumbnail of A Case of Popliteal Pterygium Treated along with Nerve Expansion

Plastic &amp Reconstructive Surgery, 1997

Research paper thumbnail of Penil Protez Cerrahisine Bağlı Penis Nekrozu ve Rekonstrüksiyonu

Organik empotans nedeniyle penil protez yerlestirilen hastalarda penil nekroz olusmasi cok ender ... more Organik empotans nedeniyle penil protez yerlestirilen hastalarda penil nekroz olusmasi cok ender karsilasilan bir komplikasyondur. Bunun nedeni penisin zengin damarsal yapisidir. Ancak, olumsuz bir cok faktorun bir arada etki etmesi sonucu protez cerrahisi nekrozla sonuclanabilir. Bu major komplikasyonun rekonstruksiyonu da oldukca zordur. Primer olarak nekroza neden olan faktorler rekonstruksiyon esnasinda da problemler yaratabilir. Bu makalede penil protez cerrahisine bagli nekroz gorulen 2 olgu ve rekonstruksiyonlari tartisildi.

Research paper thumbnail of Ameliyathane Oda Teknikerliği Genel Görev Tanımı

Sağlık konusunda birinci sırada tercih edilen Hacettepe Üniversitesi Hastaneleri cerrahi hizmetle... more Sağlık konusunda birinci sırada tercih edilen Hacettepe Üniversitesi Hastaneleri cerrahi hizmetlerde de çağdaş ameliyathaneleri, alt yapı donanımı, güncel teknolojisi ve kadrosu ile birçok başarılı yaklaşımı ve ilkleri gerçekleştirmektedir. Ameliyathanede görev yapan teknikerler bu hizmetlerin büyük bir kısmında önemli görevler üstlenmektedir. Teknik hizmetleri en iyi şekilde vermek misyonu ile çalışan tekniker arkadaşlarımız hizmet içi eğitimler ve yaşam boyu öğrenme süreçleri ile bilgi ve becerilerini sürekli güncelleme gereksinimi duymaktadırlar. Üniversitemiz Sağlık Hizmetleri Meslek Yüksek Okulu'nda 2014-2015 ders yılından itibaren öğrenci alımına başlayacak olan Ameliyathane hizmetleri programı öğrencileri ve ameliyathane ekiplerinde görev yapan teknik elemanlarımız ile stajyer öğrenciler de güncel bilgiye gereksinim duyacaklardır

Research paper thumbnail of Medical and cosmeceutical applications for enhancement of partial-thickness skin graft donor-site healing

Turkish Journal of Plastic Surgery, 2020

Introduction: After partial-thickness skin graft (PTSG) harvesting, a dermal surface is exposed a... more Introduction: After partial-thickness skin graft (PTSG) harvesting, a dermal surface is exposed and an iatrogenic wound is created. Application of various agents has been studied for enhancement of healing process in PTSG donor area. The ideal agent should accelerate healing, provide comfort to the patient, not allow infection, and be easily applicable and cheap. Materials and Methods: The Cochrane Central Register of Controlled Trials, PubMed, Scopus. and EMBASE databases were screened for words (“skin graft” + “donor”), by using time limits between 1989 and 2018. This study involved a total of 5 systematic reviews and 43 original articles which met the inclusion criteria. Articles were reviewed and parameters such as healing time, pain, infection rate, cosmetic result, and cost were extracted. Results: Systematic reviews favor moist dressing materials over dry ones considering healing time and patient comfort. Hydrocolloids provide rapid wound healing, and dressing changes do not ...

Research paper thumbnail of Influence of nasoalveolar molding on skeletal development in patients with unilateral cleft lip and palate at 5 years of age

American Journal of Orthodontics and Dentofacial Orthopedics, 2018

Research paper thumbnail of Liposakşın ve Anestezi

Balkan Medical Journal, 1988

Research paper thumbnail of The advantages of simultaneous abdominoplasty, laparoscopic cholecystectomy, and incisional hernia repair

European Journal of Plastic Surgery, 2002

A 44-year-old woman undergoing abdominoplasty, laparoscopic cholecystectomy, and incisional herni... more A 44-year-old woman undergoing abdominoplasty, laparoscopic cholecystectomy, and incisional hernia repair is presented. Abdominal wall lipodystrophy and incisional hernia, both pathologies leading to esthetic deformity, and cholelithiasis causing biliary symptoms were treated at the same operation without any complications. Combining two or multiple abdominal procedures may reduce the potential risks of multiple anesthesia for each procedure, shorten total hospital stay and operating room time, and, perhaps most importantly for the patient, reduce costs and time off work.

Research paper thumbnail of Geri̇atri̇k Hastalarda Gerçekleşti̇ri̇len Plasti̇k Ve Rekonstrükti̇f Cerrahi̇ İşlemleri̇ni̇n İncelenmesi̇

geriatri.dergisi.org

... Gökhan TUNÇBİLEK, Figen ÖZGÜR. ... Bu gelişmelere ışık tutabilmek amacıyla bölümümüzde son 5 ... more ... Gökhan TUNÇBİLEK, Figen ÖZGÜR. ... Bu gelişmelere ışık tutabilmek amacıyla bölümümüzde son 5 sene içinde opere edilen 65 yaş ve üzeri hastaların yaşları, tanıları, yapılan işlemler, ek dahili problemler, anestezi türleri incelenmiştir. ...

Research paper thumbnail of Yarık Damak Onarımı Yapılan Hastalarda Konuşmanın Değerlendirilmesi

Yarik damak anarimi sonrasi ulasilmasi hedeflenen sonuclar arasinda normal konusmanin saglanmasi ... more Yarik damak anarimi sonrasi ulasilmasi hedeflenen sonuclar arasinda normal konusmanin saglanmasi onemli bir yer tutmaktadir. Bu calismanin amaci opere edilen yarik damak hastalarinin konusma sonuclarini degerlendirmektir. Konusma degerlendirmesinde nazal rezonans, nazal hava kacagi ve artikulasyon hatalari arastirilmistir. Hastalarin % 62.5'inde normal veya kabul edilebilir sinirlarda hipernazalite saptanmistir. Hastalarin % 62.5‘inde nazal kacaga rastlanmamis, % 60'inda da artikulasyon hatasi saptanmamistir. Elde edilen sonuclar birbirleri ile ortaklasa degerlendirildiklerinde 6 hastanin (%I5) tamamen normal bulgulara sahip oldugu, bu gruba ek olarak 14 hastanin (% 35) nazal hava kacagi ve artikulasyon hatasi olmadan hafif derecede hipernazaliteye sahip olduklari saptanmistir. Geriye kalan 20 hastanin (% 50) ise degisen derecelerde hipernazalite, nazal hava kacagi ve artikulasyon hatalari oldugu gorulmustur. Ameliyat anindaki yas ile konusma sonuclari arasinda belirgin bir ...

Research paper thumbnail of Dudak Onarimi İle Eş Zamanli Gerçekleşti̇ri̇len Dudak Yariği Burnu Düzelti̇lmesi̇nde İnterdomal Di̇ki̇ş İle Kresenteri̇k Ci̇lt Eksi̇zyonunun Erken Ve Geç Dönem Etki̇leri̇ni̇n Karşilaştirilmasi

Amac: Bu calismada dudak onarimi ile es seansli olarak CLN deformitesinin giderilmesi amaciyla in... more Amac: Bu calismada dudak onarimi ile es seansli olarak CLN deformitesinin giderilmesi amaciyla interdomal dikis yerlestirilen hastalar ile yarik tarafina kresenterik cilt eksizyonu gerceklestirilen hastalarin takiplerinde elde edilen postoperatif duzeltme oranlarinin karsilastirilmasi amaclanmistir. Gerec ve Yontemler: Modifiye Millard rotasyon ilerletme teknigi ile dudak onarimi gerceklestirilen ve es zamanli olarak ya burun sekillendirici interdomal dikis, ya da kresenterik cilt eksizyonu gerceklestirilen 83 tek tarafli yarik dudak hastasi calismaya dahil edildi. Hastalarin degerlendirilmesi standart olarak cekilen preoperatif, postoperatif erken ve gec donemde rutin olarak cekilen kaudal nazal fotograflar ile gerceklestirilmistir. Burun tabani ile nostril en projekte noktalari arasinda yukseklikler olculmus ve yarik olan tarafta elde edilen yukseklik, yarik olmayan taraftaki yukseklige oranlanmistir. Bulgular: Erken postoperatif donemde en yuksek oran kresenterik cilt eksizyonu g...

Research paper thumbnail of Photobiomodulation combined with adipose-derived stem cells encapsulated in methacrylated gelatin hydrogels enhances in vivo bone regeneration

Lasers in Medical Science, 2021

Reconstruction of bone defects is still a significant challenge. The aim of this study was to eva... more Reconstruction of bone defects is still a significant challenge. The aim of this study was to evaluate the effect of application of photobiomodulation (PBM) to enhance in vivo bone regeneration and osteogenic differentiation potential of adipose-derived stem cells (ADSCs) encapsulated in methacrylated gelatin (GEL-MA) hydrogels. Thirty-six Sprague-Dawley rats were randomly separated into 3 experimental groups ( n = 12 each). The groups were control/blank defect (I), GEL-MA hydrogel (II), and ADSC-loaded GEL-MA (GEL-MA+ADSC) hydrogel (III). Biparietal critical sized bone defects (6 mm in size) are created in each animal. Half of the animals from each group ( n = 6 each) were randomly selected for PBM application using polychromatic light in the near infrared region, 600–1200 nm. PBM was administered from 10 cm distance cranially in 48 h interval. The calvaria were harvested at the 20th week, and macroscopic, microtomographic, and histologic evaluation were performed for further analysis. Microtomographic evaluation demonstrated the highest result for mineralized matrix formation (MMF) in group III. PBM receiving samples of group III showed mean MMF of 79.93±3.41%, whereas the non-PBM receiving samples revealed mean MMF of 60.62±6.34 % ( p =0.002). In terms of histologic evaluation of bone defect repair, the higher scores were obtained in the groups II and III when compared to the control group (2.0 for both PBM receiving and non-receiving specimens; p <0.001). ADSC-loaded microwave-induced GEL-MA hydrogels and periodic application of photobiomodulation with polychromatic light appear to have beneficial effect on bone regeneration and can stimulate ADSCs for osteogenic differentiation.

Research paper thumbnail of Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap

Lasers in Surgery and Medicine, 2019

The aim of this study was to evaluate the effect of relatively novel approach of application of p... more The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap. Methods: Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n ¼ 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention. In group 2 (delay group), photobiomodulation (PBM) was applied for 7 days as a delay procedure, before elevation of the flap. In group 3 (PBM group), the TRAM flap was elevated, and PBM was administered immediately after the flap was sutured back to its bed for therapeutic purpose. PBM was applied in 48 hours interval from 10 cm. distance to the whole abdominal wall both in groups 2 and 3 for one week. After 7 days of postoperative follow-up, as the demarcation of necrosis of the skin paddle was obvious, skin flap survival was further evaluated by macroscopic, histological and microangiographic analysis. Results: The mean percentage of skin flap necrosis was 56.17 AE 23.68 for group 1, 30.92 AE 17.46 for group 2 and 22.73 AE 12.98 for group 3 PBM receiving groups 2 and 3 revealed less necrosis when compared to control group and this difference was statistically significant. Vascularization in zone 4 of PBM applied groups 2 and 3 was higher compared to group 1 (P ¼ 0.001). Acute inflammation in zone 4 of group 1 was significantly higher compared to groups 2 and 3 (P ¼ 0.025). Similarly, evaluation of zone 1 of the flaps reveled more inflammation and less vascularization among the samples of the control group (P ¼ 0.006 and P ¼ 0.007, respectively). Comparison of PBM receiving two groups did not demonstrate further difference in means of vascularization and inflammation density (P ¼ 0.259). Conclusion: Application of PBM in polychromatic fashion enhances skin flap survival in experimental TRAM flap model both on preoperative basis as a delay procedure or as a therapeutic approach. Lasers Surg. Med.

Research paper thumbnail of Cleft Palate Repair Using Single Flap Palatoplasty in Patient With Associated Palatal Hemangioma

The Journal of craniofacial surgery, Jan 30, 2018

Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusu... more Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Magnetic resonance imaging revealed intensive contrasting solid nodule with a lobulated contour that was covering the right half of the hard palate, measuring 2.2×1.3 cm. To reduce the size of the vascular lesion 7 mg/d oral propranolol treatment was initiated. Following reduction in the size of hemangioma, the cleft palate was repaired at 11 months of age. Single mucoperiosteal flap from the left side of the palate preserving the major palatine artery was elevated whereas right mucoperisteal flap was minimally dissected not to interfere with the hemangioma. No intraoperative and postoperative...

Research paper thumbnail of Velofarengeal Yetmezlik Tedavisi

Turkiye Klinikleri Plastik Cerrahi Ozel Dergisi, 2011

Research paper thumbnail of Poly(L-Lactide)/Poly(∊-Caprolactone) and Collagen/β-Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Rat Alveolar Defects: A Microtomographic, Molecular-Biological, and Histological Study

The Cleft Palate-Craniofacial Journal, 2016

Objective To determine the efficacy of a newly developed scaffold (col/β-TCP) in a preclinical ra... more Objective To determine the efficacy of a newly developed scaffold (col/β-TCP) in a preclinical rat model as compared with the gold standard treatment (autograft) and control scaffolds (PLLA/PCL). Design Fifty-six Sprague-Dawley rats were randomized into four experimental groups, and critical-sized alveolar defects (7 × 4 × 3 mm) were created in each animal. Group A was the blank defect group, group B received autograft, group C received col/β-TCP scaffolds, and group D received PLLA/PCL blend scaffolds to fill the bone defects. New bone formation was assessed radiomorphometrically, histomorphometrically, and molecular-biologically at 1 and 4 months following surgery. Results Radiomorphometrically, the best new bone volume rate at 1 month (43.7%) and 4 months (45.4%) was observed in the autograft group, and the difference was significantly higher than in the other three groups ( P ≤ .005, P ≤ .001, P ≤ .001 for 1 month and P = .004, P ≤ .001, P ≤ .001 for 4 months). Even though the n...

Research paper thumbnail of Tissue expansion in median facial cleft reconstruction: A case report

International Journal of Oral and Maxillofacial Surgery, 1994

Median cleft of the face is a rare congenital anomaly. Patients with mild deformities require onl... more Median cleft of the face is a rare congenital anomaly. Patients with mild deformities require only limited nasal reconstruction; however, the nasal dorsal soft tissue envelope is usually tight and insufficient, making bone grafting difficult. The tissue-expansion method was used for nasal reconstruction in a patient with a median facial cleft, an expander being improvised from an intubation tube balloon.

Research paper thumbnail of The Effect of Onlay Alloplastic Implants on Mandibular Growth in Young Rabbits

Plastic and Reconstructive Surgery, 1995

Research paper thumbnail of Repeated Tissue Expansions on Split-Thickness Skin Graft in a Patient With Neurocutaneous Syndrome

Journal of Craniofacial Surgery, 2007

Research paper thumbnail of The Effect of Onlay Medpor Implants on Mandibular Growth in Young Rabbits: An Experimental Study

Annals of Plastic Surgery, 1999

Research paper thumbnail of Giant Rhabdomyosarcoma with Necrosis Visualized with TI-201 Chloride

Clinical Nuclear Medicine, 1991

Research paper thumbnail of A Case of Popliteal Pterygium Treated along with Nerve Expansion

Plastic &amp Reconstructive Surgery, 1997