Filiz Mine Cizmecioglu - Academia.edu (original) (raw)

Papers by Filiz Mine Cizmecioglu

Purpose Pediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be... more Purpose Pediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be challenging to manage. Most studies evaluating PPA are based on surgical series. We aimed to present the clinical features, hormonal status and treatment outcomes of children with PPA managed in a joint neuroendocrine setting. Methods In this single-center study, demographic, clinical and endocrinological data of patients under 19 years old who were followed up with the diagnosis of PPA between 2002–2022 were retrospectively reviewed. A total of 21 studies published in the past 20 years were also systematically reviewed. Results There were 79 patients (52 girls, 27 boys) with a median age of 15.8 years. Median follow-up time was 30 months. The most common adenoma subtype was non-functioning adenoma (NFA) (35.5%), followed by prolactinoma (29.1%), corticotropinoma (21.5%), and somatotropinoma (13.9%), respectively. The frequency of micro and macroadenomas was almost equal while 38% of al...

Medical and Pediatric Oncology, Jan 21, 2002

... Brief Report. Methotrexate-induced systemic vasculitis. Asim Yoruk MD,; Filiz Cizmecioglu MD,... more ... Brief Report. Methotrexate-induced systemic vasculitis. Asim Yoruk MD,; Filiz Cizmecioglu MD,; Handan Yukselgungor MD,; Cetin Timur MD,; Hikmet Baydilli MD,; Sevil Ozcay MD. Article first published online: 21 JAN 2002. DOI: 10.1002/mpo.1293. Copyright © 2002 Wiley-Liss, Inc ...

Turk Pediatri Arsivi-turkish Archives of Pediatrics, Jul 20, 2015

McCune-Albright Syndrome is a rare syndrome characterized with excessive function of peripheral e... more McCune-Albright Syndrome is a rare syndrome characterized with excessive function of peripheral endocrine organs and activating mutations of the stimulatory G protein alpha subunit are involved in the pathogenesis. The three main findings of the disease include hyperpigmented café au lait spots, fibrous dysplasia and increased endocrine functions and excessive secretion of growth hormone is observed in 21% of the patients. Clinical signs may be missed in these patients because of precocious puberty and craniofacial fibrous dysplasia. Since radiotherapy causes to sarcomatous changes and transsphenoidal surgery may cause to severe thickening in the cranial bones, they are not appropriate treatment options and medical treatment is recommended. Bromocriptine, cabergoline and octreotide or different combinations of these drugs are used in treatment and pegvisomant has also been used in recent years. Here, we present a male patient aged 12 years and 7 months to show gigantism as a rare clinical reflection of McCune-Albright Syndrome with an excessive height (197 cm), café au lait spots, growht hormone levels which could not be supressed with oral glucose tolerance test and increased prolactin levels.

PubMed, Aug 2, 2005

Although much is known about diabetic ketoacidosis (DKA) and its treatment, the pathology of cere... more Although much is known about diabetic ketoacidosis (DKA) and its treatment, the pathology of cerebral complications in patients who develop ketoacidosis is not yet well understood. In this article, we discuss the cerebral complications due to DKA by presenting two cases who were admitted with severe DKA and who both developed early and severe neurological complications.

PubMed, Oct 11, 2011

Skeletal dysplasias (osteochondrodysplasias) are a group of diseases that must be included in the... more Skeletal dysplasias (osteochondrodysplasias) are a group of diseases that must be included in the differential diagnosis of disproportionate short stature. History, clinical and radiologic findings and consanguinity are important features to be considered when a specific diagnosis is investigated. Spondyloenchondrodysplasia is a very rare skeletal dysplasia characterized with enchondromas in the long bones and platyspondyly. Manifestation of the disorder may include neurological involvement (spasticity, intracranial calcifications and mental retardation) and immune dysfunction. Herein, we report a 12-year-old boy who admitted to our clinic with short stature, who was born to consanguineous parents. He presented clinical (significant widening of wrists, ankles and knees) and radiologic (enchondromatous lesions in the metaphysis of long bones) features of spondyloenchondrodysplasia but did not yet have neurologic or immunologic involvement.

PubMed, Dec 21, 2005

Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisph... more Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisphosphonates, inhibitors of osteoclast-mediated bone resorption, however, have been proposed as a safe and effective alternative in the treatment of vitamin D intoxication. We present here two infants with vitamin D intoxication who were successfully treated with alendronate. We propose that oral alendronate is an alternative to intravenous bisphosphonates in the treatment of vitamin D intoxication in infancy.

Journal of Clinical Research in Pediatric Endocrinology, Dec 3, 2015

The findings in this study show that in Turkey, there is a need to establish school-based reprodu... more The findings in this study show that in Turkey, there is a need to establish school-based reproductive health education programs to enable schoolgirls to learn how to cope with these critical issues. Concerns about the normality of pubertal development and of menstrual patterns are among the most common problems of young girls. Girls frequently have difficulty assessing what represents normal pubertal development and menstrual cycle, or patterns of bleeding.

Journal of Pediatric Urology, Oct 1, 2014

Objective: Partial/total urogenital sinus mobilization (UGSM) is one of the recommended technique... more Objective: Partial/total urogenital sinus mobilization (UGSM) is one of the recommended techniques for treatment of female congenital adrenal hyperplasia (CAH). In this study we compared the length of common channel (CC) and type of operation performed in CAH patients. Patients and methods: We retrospectively analyzed data of patients receiving surgery for female CAH. Patients were separated into three groups: group 1 had partial UGSM, group 2 had total UGSM, and group 3 had total UGSM plus the vaginal anterior wall was made from CC. Age at surgery, length of CC, surgical time, follow-up time, and complications were compared. Results: There were a total of 29 patients. For groups 1, 2, and 3, the average age at surgery was 47.2 months, 14.4 months, and 21.3 months, respectively, and the average CC length was 1.25 cm, 3.1 cm, 4.3 cm, respectively. The average time of surgery was 165 min, 193.1 min, 282.5 min, respectively. The average follow-up time was 34.7 months, 36.3 months, 28.3 months, respectively. There were two complications (UGS flap necrosis and opening of sutures) in the third group.

Journal of Pediatric Endocrinology and Metabolism, 2013

Ovotesticular disorder of sexual development (DSD) is characterized by the presence of both ovari... more Ovotesticular disorder of sexual development (DSD) is characterized by the presence of both ovarian and testicular tissues in the same individual. The most common karyotype is 46,XX. Here, we report the case of a boy with a 46,XX/47,XXY karyotype diagnosed as ovotesticular DSD by gonadal biopsy. A 5-month-old boy presented with hypospadias, unilateral cryptorchidism, and a micropenis. Pelvic magnetic resonance imaging revealed a suspicious gonad tissue that is solid in structure in the right scrotum and a suspicious gonad that is cystic in structure in the left inguinal canal. He underwent a diagnostic laparoscopy. Cytogenetic analysis of peripheral blood revealed a 46,XX/47,XXY karyotype. Histopathologic examination of the left gonad showed ovarian tissue containing primordial follicles with ipsilateral undifferentiated tuba uterina. The right gonad showed immature testis tissue. He underwent left gonadectomy and hypospadias repair, and was raised as a male. Through this rare case, we highlight the importance of histological and cytogenetic investigation in DSD.

Medical and Pediatric Oncology, Feb 1, 2002

Journal of Clinical Research in Pediatric Endocrinology, Jan 10, 2011

Objective: To investigate prevalence, persistence and clinical correlates of increased microalbum... more Objective: To investigate prevalence, persistence and clinical correlates of increased microalbumin excretion in random urine samples collected in a paediatric diabetes clinic. Method: Random urine samples were collected annually in patients >10 years attending the diabetes clinic in the Royal Hospital for Sick Children, Edinburgh. Albumin excretion is expressed as albumin:creatinine ratio (ACR) and classified as normal (<3.5 mg/mmol), equivocal (3.5-10 mg/mmol), microalbuminuria (>10mg/mmol), or macroalbuminuria (>47 mg/mmol in females, >35 mg/mmol in males). We analyzed retrospectively results on 421 urine samples collected from 217 patients (109 males), of a median age of 12.3 years (94% 10-16 years) over 3 years. For each sample, the corresponding mean HbA 1c over the previous year was calculated. Results: Prevalence of micro-and macro-albuminuria in individual samples was 1% and 0.5% respectively. ACR was equivocal in 10.1% and 4.7% in samples from females and males respectively (p=0.03). HbA 1c showed borderline significant differences across ACR groups (p=0.06). Equivocal ACR excretion was associated with slightly higher mean HbA 1c (9.5±1.3%) compared to normal albuminuria (9.0±1.1%, p<0.05). Multiple regression modelling indicated that increasing age (p=0.02), female sex (p=0.05) but not HbA 1c (p=0.79) were associated with a greater likelihood of ACR >3.5 mg/mmol. The 14-16 years age group patients were most likely to have ACR >3.5 mg/mmol (p=0.05). Conclusions: Female sex and increasing age, but not HbA 1c , were independently associated with increased ACR. A robust mechanism for collection of repeat early morning urine samples from patients with increased ACR in random urine samples, and follow-up of those patients who have persistently high microalbumin excretion are important. It is also important to confirm the usefulness of ACR measurements in random urine samples as a marker of incipent nephropathy.

54th Annual ESPE, Aug 26, 2015

PubMed, May 23, 2013

It was aimed to evaluate the national congenital hypothyroidism program in terms of thyroid-stimu... more It was aimed to evaluate the national congenital hypothyroidism program in terms of thyroid-stimulating hormone (TSH) cut-off level, frequency of cases that required treatment and the stages before treatment in the Kocaeli district area. This research was performed with the contribution of Kocaeli University Medical Faculty, Pediatric Endocrinology Department, and the Kocaeli Local Health District. 25,188 babies born in 2009 were evaluated. The previous laboratory data including heel prick samples and venous thyroid function tests (TSH, free/total T4 levels) of babies requiring investigation were evaluated retrospectively. 49,785 heel prick blood samples were collected from 25,188 babies born in our region. TSH levels of 3,355 babies in the first sampling were greater than the cut-off level (15 mIU/L) (recall rate was 13.3%). Venous sampling was required for 107 babies, and 39 of them needed to be treated (treatment rate was 1/645). Eleven of the babies who were treated were diagnosed with thyroid dysgenesis. Families of the babies who needed further venous sampling were given final results in an average of 28.5 days after the first heel sampling. We concluded that the recall rate is high, but raising the cut-off level for TSH may lead to overlooking the diagnosis of thyroid dysgenesis. The duration for providing final results to the families is quite long. It is necessary to take venous blood samples in the pediatric endocrinology units to reduce this duration.

DergiPark (Istanbul University), Aug 1, 2008

Diabetologia, 2021

Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infanc... more Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic diabetes that are likely to be more common in populations with high rates of consanguinity. We aimed to determine the contribution of recessive causes of monogenic diabetes in paediatric diabetes clinics and to identify clinical criteria by which to select individuals for recessive monogenic diabetes testing. Methods We conducted a cross-sectional study of 1093 children from seven paediatric diabetes clinics across Turkey (a population with high rates of consanguinity). We undertook genetic testing of 50 known dominant and recessive causes of monogenic diabetes for 236 children at low risk of type 1 diabetes. As a comparison, we used monogenic diabetes cases from UK paediatric diabetes clinics (a population wi...

$Research paper thumbnail of An endoscopic endonasal approach to craniopharyngioma via the infrachiasmatic corridor: a single center experience of 84 patients$

Acta Neurochirurgica, 2021

The infrachiasmatic corridor is the most important surgical access route for craniopharyngiomas a... more The infrachiasmatic corridor is the most important surgical access route for craniopharyngiomas and was identified and used in clinical series. The aims of this study were to describe the characteristics that assist dissection and resection rates in endoscopic surgery of solid, cystic, and recurrent cases and their importance in the infrachiasmatic corridor in endoscopic surgery. One hundred operations on 84 patients with pathologically identified craniopharyngioma were included in the study. The MRI findings were evaluated, and the location of the lesions was classified as (1) infrasellar; (2) sellar; or (3) suprasellar. In the sagittal plane, we measured the longest diameter of cystic and solid components and the height of chiasm-sella. Images were assessed for the extent of resection and were classified as gross total resection. This was deemed as the absence of residual tumor and subtotal resection, which had residual tumor. The infrasellar location was reported in 7/84 (8.3%) patients, the sellar location in 8/84 (9.5%), and the suprasellar location in 69/84 (82.1%) patients. The narrow and high chiasm-sella were observed in 28/69 (40.5%) and 41/69 patients (59.4%), respectively. The mean distance of the chiasm-sella was 9.46± 3.76. Gross total tumor resection was achieved in 60/84 (71.4%) and subtotal tumor resection was performed in 24/84 (28.6%) patients. The results revealed that suprasellar location (OR: 0.068; p = 0.017) and recurrent cases (OR: 0.011; p<0.001) were negative predictive factors on GTR. Increasing the experience (OR: 42,504; p = 0.001) was a positive predictor factor for GTR. An EETS approach that uses the infrachiasmatic corridor is required for skull base lesions extending into the suprasellar area. The infrachiasmatic corridor can determine the limitations of endoscopic craniopharyngioma surgery. This corridor is a surgical safety zone for inferior approaches.

Turkiye Cocuk Hastalıkları Dergisi, Mar 1, 2008

Early retinal change and evaluate its progression in children and adolescents diagnosed with insu... more Early retinal change and evaluate its progression in children and adolescents diagnosed with insulin dependent diabetes mellitus we examined in 20 Turkish children (8 female, 12 male ). Thein mean age was 13.1 ± 3.9 years with mean diabetes duration of 4.9 ± 3.1 years. Direct ophtal-moscopy and fluorescein fundus angiography (FFA) were performed at the beginning and at and the end of two years follow-up period. The stage of diabetic retinopathy (DR) was evaluated in six stages according to ''Madison modification of Airlie House Classification of Diabetic Retinopathy”. We also considered age, pubertal stage, disease duration, arterial blood pressure, micro- albuminuria and HbA1c levels. Retinopathy of varying stage was detected with direct ophtalmoscopy in 2 cases (15 %) and FFA in 6 cases (30 %) respectively. A significant statistical relationship was present between the stage of the DR and patient age. DR was present in 60 % of the patients with a disease duration exceeding 5 years. In the two years follow-up of these patients, regression was noted in 3, new retinal changes consistent with stage 2 and 3 appeared in two patients. A significant positive correlation was present between HbA1c and retinal changes; microalbuminuria and retinal changes. No DR was noted in prepubertal cases. Conclusion: Because DR may give no symptom early in disease course, routine eye examination must be done regularly in diabetic patients. In early stages; FFA is more sensitive than direct ophtalmoscopy. Regression changes are possible with close follow-up of these cases and the maintenance of good metabolic control of the retinal.

The Journal of nutrition, 2005

Vitamin D deficiency continues to be a worldwide problem, especially in developing countries. The... more Vitamin D deficiency continues to be a worldwide problem, especially in developing countries. The aim of this study was to investigate potential risk factors for vitamin D deficiency. Girls (n = 89) aged 13 to 17 y were enrolled in the study. Study subjects were stratified into 3 groups: Group I included girls living in a suburban area; Group II girls lived in an urban area, and Group III girls lived in an urban area and wore concealing clothes for religious reasons. At the end of winter (in April) serum 25-hydroxyvitamin D [25(OH)D] levels were measured and dietary data were collected using questionnaires. Vitamin D deficiency was defined as a serum 25(OH)D concentration < 25 nmol/L, and insufficiency as a 25(OH)D concentration between 25 and 50 nmol/L. The lumbar and femur neck bone mineral densities (BMD) were measured using dual X-ray absorptiometry (DEXA). Overall, 39 girls (43.8%) had vitamin D insufficiency and 19 (21.3%) had vitamin D deficiency. In group III (wearing cov...