Fira Sinuraya - Academia.edu (original) (raw)

Papers by Fira Sinuraya

Research paper thumbnail of Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021

BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecu... more BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with de...

Research paper thumbnail of Uric acid and glucose level in high fructose high cholesterol induced Sprague-Dawley rats after therapy with Acalypha indica Linn. ethanol extract

THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019, 2019

Diet with high fructose and cholesterol (HFHC) plays a role in the increasing incidence of diabet... more Diet with high fructose and cholesterol (HFHC) plays a role in the increasing incidence of diabetes mellitus and metabolic syndrome. Ethanol extract from Acalypha indica has been known to alleviate hyperglycemia and hyperuricemic conditions in rats induced by substances that destroy beta cells. This research aimed to evaluate its effect in rats induced by diet. Male Sprague-Dawley rats were divided into seven groups, six of which are given HFHC diet for 1,5 months. In the following month, rats were given therapy while diet continued. Therapy consisted of 250 mg/kg BW/day of Acalypha indica Linn. root's ethanol extract, 100 mg/kgBW/day of metformin, 30mg/kg BW/day of allopurinol, or combination. Lowest blood glucose value was found in group receiving both AI and metformin. No significant difference was found between pre-and post-therapy blood glucose in groups treated with AI (p=0,831), metformin (p=0,056), or both (p=0,908). Uric acid level was increased in all groups, with highest rate found in group receiving both allopurinol and AI. The difference in uric acid level between treatment group was 0.331. Whilst insignificant, ethanolic extract of Acalypha indica Linn. was observed to lower blood glucose in rats. Group treated with AI showed similar rise in uric acid level, with combination therapy showed highest rise. Further research with longer duration of induction and therapy will be required to better understand the hypoglycemic and antihyperuricemic effects exerted by AI.

Research paper thumbnail of Distal renal tubular acidosis presenting with an acute hypokalemic paralysis in an older child with severe vesicoureteral reflux and syringomyelia: a case report

BMC Nephrology

Background Distal renal tubular acidosis (dRTA) is the most common type of renal tubular acidosis... more Background Distal renal tubular acidosis (dRTA) is the most common type of renal tubular acidosis (RTA) in children. Pediatric dRTA is usually genetic and rarely occurs due to acquired issues such as obstructive uropathies, recurrent urinary tract infections (UTIs), and chronic kidney disease (CKD). Although persistent hypokalemia frequently occurs with dRTA, acute hypokalemic paralysis is not frequently reported, especially in older children. Case presentation An eight-year-old girl presented with an acute first episode of paralysis. A physical examination revealed normal vital signs, short stature consistent with her genetic potential, and decreased muscle strength of her upper and lower extremities. Preexisting conditions included stage 4 CKD due to recurrent UTIs, severe vesicoureteral reflux and bilateral hydronephrosis, neurogenic bladder, and multisegment thoracic syringomyelia. Her laboratory work-up revealed hypokalemic, hyperchloremic metabolic acidosis with a normal anion...

Research paper thumbnail of Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021

BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecu... more BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with de...

Research paper thumbnail of Uric acid and glucose level in high fructose high cholesterol induced Sprague-Dawley rats after therapy with Acalypha indica Linn. ethanol extract

THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019, 2019

Diet with high fructose and cholesterol (HFHC) plays a role in the increasing incidence of diabet... more Diet with high fructose and cholesterol (HFHC) plays a role in the increasing incidence of diabetes mellitus and metabolic syndrome. Ethanol extract from Acalypha indica has been known to alleviate hyperglycemia and hyperuricemic conditions in rats induced by substances that destroy beta cells. This research aimed to evaluate its effect in rats induced by diet. Male Sprague-Dawley rats were divided into seven groups, six of which are given HFHC diet for 1,5 months. In the following month, rats were given therapy while diet continued. Therapy consisted of 250 mg/kg BW/day of Acalypha indica Linn. root's ethanol extract, 100 mg/kgBW/day of metformin, 30mg/kg BW/day of allopurinol, or combination. Lowest blood glucose value was found in group receiving both AI and metformin. No significant difference was found between pre-and post-therapy blood glucose in groups treated with AI (p=0,831), metformin (p=0,056), or both (p=0,908). Uric acid level was increased in all groups, with highest rate found in group receiving both allopurinol and AI. The difference in uric acid level between treatment group was 0.331. Whilst insignificant, ethanolic extract of Acalypha indica Linn. was observed to lower blood glucose in rats. Group treated with AI showed similar rise in uric acid level, with combination therapy showed highest rise. Further research with longer duration of induction and therapy will be required to better understand the hypoglycemic and antihyperuricemic effects exerted by AI.

Research paper thumbnail of Distal renal tubular acidosis presenting with an acute hypokalemic paralysis in an older child with severe vesicoureteral reflux and syringomyelia: a case report

BMC Nephrology

Background Distal renal tubular acidosis (dRTA) is the most common type of renal tubular acidosis... more Background Distal renal tubular acidosis (dRTA) is the most common type of renal tubular acidosis (RTA) in children. Pediatric dRTA is usually genetic and rarely occurs due to acquired issues such as obstructive uropathies, recurrent urinary tract infections (UTIs), and chronic kidney disease (CKD). Although persistent hypokalemia frequently occurs with dRTA, acute hypokalemic paralysis is not frequently reported, especially in older children. Case presentation An eight-year-old girl presented with an acute first episode of paralysis. A physical examination revealed normal vital signs, short stature consistent with her genetic potential, and decreased muscle strength of her upper and lower extremities. Preexisting conditions included stage 4 CKD due to recurrent UTIs, severe vesicoureteral reflux and bilateral hydronephrosis, neurogenic bladder, and multisegment thoracic syringomyelia. Her laboratory work-up revealed hypokalemic, hyperchloremic metabolic acidosis with a normal anion...