Flavia Nunes - Academia.edu (original) (raw)

Papers by Flavia Nunes

Research paper thumbnail of Predictors Of Daytime Sleepiness In Patients SubmItted To Coronary Artery Bypass Grafting

C75. OTHER SLEEP ISSUES, 2011

... NJ Danzi , RP Pedrosa , LF Drager , LAC Machado , PR Genta , G. Lorenzi-Filho FS Nunes1 2 2 3... more ... NJ Danzi , RP Pedrosa , LF Drager , LAC Machado , PR Genta , G. Lorenzi-Filho FS Nunes1 2 2 3 1 4 2 ... We studied 73 consecutive candidates to CABG (75% men); age = 57 (52-62) yr, body mass index (BMI), 28±4 kg/m , and ESS score was 7 (5-10). We 2 ...

Research paper thumbnail of Study of Harmful Algal Bloom’s impacts of two strains of Alexandrium minutum on behavior and growth of scallops Pecten maximus

The king scallop Pecten maximus, is an economically important bivalve in Europe, especially in Fr... more The king scallop Pecten maximus, is an economically important bivalve in Europe, especially in France. Due to their repartition, they can be impacted by harmful algal blooms (HAB). Massive blooms of Alexandrium minutum have appeared for the first time recently in the Bay of Brest, causing contamination of many commercial bivalve species, including scallops, rendering them toxic for consumption and causing public health issues. It is thus important to understand their impacts on the biology and physiology of the king scallop. This study aimed to evaluate under controlled conditions the effects of two strains of A. minutum on king scallops P. maximus. The first strain produced paralytic shellfish toxins (PST), while the other strain was not producing PST but secreted other extracellular compounds that may have hemolytic, cytotoxic or allelopathic effects. Juvenile king scallops were experimentally exposed to three different conditions (food algae, food algae and the PSP-producing A. m...

Research paper thumbnail of Case report A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lungq

A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and i... more A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and its evaluation with computed tomography are reported. A 48-year-old man presented with one episode of hemoptysis. Chest radiographs revealed a round nodule in the lower left lung lobe, and fiberoptic bronchoscopy was normal. On the computed tomography scans, the nodule showed intense post-contrast enhancement (74.7 Hounsfield units). The patient underwent a left thoracotomy, and a segmentectomy was performed. Pathologic examination showed a benign sugar cell tumor of the lung. The patient is alive and has remained free of disease for the last 2 years. To the best of our knowledge, this is the first case report of sugar cell tumor located in lung parenchyma that presented with hemoptysis and the second report of the contrast-enhanced computed tomography findings in this neoplasm. q 2004 Elsevier B.V. All rights reserved.

Research paper thumbnail of Critical evaluation of screening questionnaires for obstructive sleep apnea in patients undergoing coronary artery bypass grafting and abdominal surgery

Sleep and Breathing, 2014

Obstructive sleep apnea (OSA) is an independent risk factor for complications after surgery. Howe... more Obstructive sleep apnea (OSA) is an independent risk factor for complications after surgery. However, OSA remains largely under recognized, and questionnaires designed to detect OSA have shown inconsistent results. Patients with cardiovascular diseases may not present with the typical symptoms of OSA. We therefore sought to compare the performance of screening questionnaires of patients referred for coronary artery bypass grafting (CABG) versus abdominal surgery (Abd surgery). We studied 40 consecutive patients referred for CABG [29 men; age 56 ± 7 years; body mass index (BMI) 30 ± 4 kg/m(2)], and 41 referred to Abd Surgery matched for age, gender, and BMI (28 men; age 56 ± 8 years; BMI 29 ± 5 kg/m(2)). All patients were evaluated with validated questionnaires to predict OSA (STOP-Bang and Berlin), Epworth sleepiness scale (ESS) and full overnight polysomnography. The prevalence of OSA (apnea-hypopnea index ≥15 events/hour) in the CABG and Abd surgery groups was similar (52 and 41 %, respectively, p = 0.32). The Berlin questionnaire showed similar sensitivity (67 vs. 82 %, p = 0.17) but lower specificity in the CABG group (26 vs. 62 %, p = 0.02). The STOP-BANG questionnaire had a high sensitivity (90 vs. 94 %, p = 0.42) but low specificity (5 vs. 13 %, p = 0.25) in the CABG and Abd surgery groups, respectively. Patients referred for CABG slept less (323 [285-376] vs. 378 [308-415] minutes, p = 0.04) but had lower levels of daytime sleepiness than Abd surgery patients had (ESS, 6 ± 4 vs. 9 ± 5; p = 0.01, respectively). Presenting clinical characteristics of OSA are modulated by the population evaluated and may affect the performance of screening questionnaires.

Research paper thumbnail of A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung

European Journal of Cardio-Thoracic Surgery, 2004

A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and i... more A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and its evaluation with computed tomography are reported. A 48-year-old man presented with one episode of hemoptysis. Chest radiographs revealed a round nodule in the lower left lung lobe, and fiberoptic bronchoscopy was normal. On the computed tomography scans, the nodule showed intense post-contrast enhancement (74.7 Hounsfield units). The patient underwent a left thoracotomy, and a segmentectomy was performed. Pathologic examination showed a benign sugar cell tumor of the lung. The patient is alive and has remained free of disease for the last 2 years. To the best of our knowledge, this is the first case report of sugar cell tumor located in lung parenchyma that presented with hemoptysis and the second report of the contrast-enhanced computed tomography findings in this neoplasm. q

Research paper thumbnail of Potential Drug-Drug Interactions in Patients with Coronary Artery Disease

Research paper thumbnail of Obstructive sleep apnea is common among patients referred for coronary artery bypass grafting and can be diagnosed by portable monitoring

Coronary Artery Disease, 2012

Receiver operating characteristic (ROC) curve of apnea-hypopnea index (AHI) cut-offs ( Z 5 and Z ... more Receiver operating characteristic (ROC) curve of apnea-hypopnea index (AHI) cut-offs ( Z 5 and Z 15 events/h) for polysomnography and portable monitoring (AUC = 0.90 and 0.79, respectively). AUC, area under the ROC curve.

Research paper thumbnail of Impact of Obstructive Sleep Apnea on Cardiovascular Events after Coronary Artery Bypass Surgery

CHEST Journal, 2015

BACKGROUND: Th e impact of OSA on new cardiovascular events in patients undergoing coronary arter... more BACKGROUND: Th e impact of OSA on new cardiovascular events in patients undergoing coronary artery bypass graft (CABG) surgery is poorly explored. METHODS: Consecutive patients referred for CABG underwent clinical evaluation and standard polysomnography in the preoperative period. CABG surgery data, including percentage of off -pump and on-pump CABG, number of graft s, and intraoperative complications, were collected. Th e primary end point was major adverse cardiac or cerebrovascular events (MACCEs) (combined events of all-cause death, myocardial infarction, repeated revascularization, and cerebrovascular events). Secondary end points included individual MACCEs, typical angina, and arrhythmias. Patients were evaluated at 30 days (short-term) and up to 6.1 years (long term) aft er CABG.

Research paper thumbnail of Predictors Of Daytime Sleepiness In Patients SubmItted To Coronary Artery Bypass Grafting

C75. OTHER SLEEP ISSUES, 2011

... NJ Danzi , RP Pedrosa , LF Drager , LAC Machado , PR Genta , G. Lorenzi-Filho FS Nunes1 2 2 3... more ... NJ Danzi , RP Pedrosa , LF Drager , LAC Machado , PR Genta , G. Lorenzi-Filho FS Nunes1 2 2 3 1 4 2 ... We studied 73 consecutive candidates to CABG (75% men); age = 57 (52-62) yr, body mass index (BMI), 28±4 kg/m , and ESS score was 7 (5-10). We 2 ...

Research paper thumbnail of Study of Harmful Algal Bloom’s impacts of two strains of Alexandrium minutum on behavior and growth of scallops Pecten maximus

The king scallop Pecten maximus, is an economically important bivalve in Europe, especially in Fr... more The king scallop Pecten maximus, is an economically important bivalve in Europe, especially in France. Due to their repartition, they can be impacted by harmful algal blooms (HAB). Massive blooms of Alexandrium minutum have appeared for the first time recently in the Bay of Brest, causing contamination of many commercial bivalve species, including scallops, rendering them toxic for consumption and causing public health issues. It is thus important to understand their impacts on the biology and physiology of the king scallop. This study aimed to evaluate under controlled conditions the effects of two strains of A. minutum on king scallops P. maximus. The first strain produced paralytic shellfish toxins (PST), while the other strain was not producing PST but secreted other extracellular compounds that may have hemolytic, cytotoxic or allelopathic effects. Juvenile king scallops were experimentally exposed to three different conditions (food algae, food algae and the PSP-producing A. m...

Research paper thumbnail of Case report A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lungq

A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and i... more A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and its evaluation with computed tomography are reported. A 48-year-old man presented with one episode of hemoptysis. Chest radiographs revealed a round nodule in the lower left lung lobe, and fiberoptic bronchoscopy was normal. On the computed tomography scans, the nodule showed intense post-contrast enhancement (74.7 Hounsfield units). The patient underwent a left thoracotomy, and a segmentectomy was performed. Pathologic examination showed a benign sugar cell tumor of the lung. The patient is alive and has remained free of disease for the last 2 years. To the best of our knowledge, this is the first case report of sugar cell tumor located in lung parenchyma that presented with hemoptysis and the second report of the contrast-enhanced computed tomography findings in this neoplasm. q 2004 Elsevier B.V. All rights reserved.

Research paper thumbnail of Critical evaluation of screening questionnaires for obstructive sleep apnea in patients undergoing coronary artery bypass grafting and abdominal surgery

Sleep and Breathing, 2014

Obstructive sleep apnea (OSA) is an independent risk factor for complications after surgery. Howe... more Obstructive sleep apnea (OSA) is an independent risk factor for complications after surgery. However, OSA remains largely under recognized, and questionnaires designed to detect OSA have shown inconsistent results. Patients with cardiovascular diseases may not present with the typical symptoms of OSA. We therefore sought to compare the performance of screening questionnaires of patients referred for coronary artery bypass grafting (CABG) versus abdominal surgery (Abd surgery). We studied 40 consecutive patients referred for CABG [29 men; age 56 ± 7 years; body mass index (BMI) 30 ± 4 kg/m(2)], and 41 referred to Abd Surgery matched for age, gender, and BMI (28 men; age 56 ± 8 years; BMI 29 ± 5 kg/m(2)). All patients were evaluated with validated questionnaires to predict OSA (STOP-Bang and Berlin), Epworth sleepiness scale (ESS) and full overnight polysomnography. The prevalence of OSA (apnea-hypopnea index ≥15 events/hour) in the CABG and Abd surgery groups was similar (52 and 41 %, respectively, p = 0.32). The Berlin questionnaire showed similar sensitivity (67 vs. 82 %, p = 0.17) but lower specificity in the CABG group (26 vs. 62 %, p = 0.02). The STOP-BANG questionnaire had a high sensitivity (90 vs. 94 %, p = 0.42) but low specificity (5 vs. 13 %, p = 0.25) in the CABG and Abd surgery groups, respectively. Patients referred for CABG slept less (323 [285-376] vs. 378 [308-415] minutes, p = 0.04) but had lower levels of daytime sleepiness than Abd surgery patients had (ESS, 6 ± 4 vs. 9 ± 5; p = 0.01, respectively). Presenting clinical characteristics of OSA are modulated by the population evaluated and may affect the performance of screening questionnaires.

Research paper thumbnail of A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung

European Journal of Cardio-Thoracic Surgery, 2004

A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and i... more A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and its evaluation with computed tomography are reported. A 48-year-old man presented with one episode of hemoptysis. Chest radiographs revealed a round nodule in the lower left lung lobe, and fiberoptic bronchoscopy was normal. On the computed tomography scans, the nodule showed intense post-contrast enhancement (74.7 Hounsfield units). The patient underwent a left thoracotomy, and a segmentectomy was performed. Pathologic examination showed a benign sugar cell tumor of the lung. The patient is alive and has remained free of disease for the last 2 years. To the best of our knowledge, this is the first case report of sugar cell tumor located in lung parenchyma that presented with hemoptysis and the second report of the contrast-enhanced computed tomography findings in this neoplasm. q

Research paper thumbnail of Potential Drug-Drug Interactions in Patients with Coronary Artery Disease

Research paper thumbnail of Obstructive sleep apnea is common among patients referred for coronary artery bypass grafting and can be diagnosed by portable monitoring

Coronary Artery Disease, 2012

Receiver operating characteristic (ROC) curve of apnea-hypopnea index (AHI) cut-offs ( Z 5 and Z ... more Receiver operating characteristic (ROC) curve of apnea-hypopnea index (AHI) cut-offs ( Z 5 and Z 15 events/h) for polysomnography and portable monitoring (AUC = 0.90 and 0.79, respectively). AUC, area under the ROC curve.

Research paper thumbnail of Impact of Obstructive Sleep Apnea on Cardiovascular Events after Coronary Artery Bypass Surgery

CHEST Journal, 2015

BACKGROUND: Th e impact of OSA on new cardiovascular events in patients undergoing coronary arter... more BACKGROUND: Th e impact of OSA on new cardiovascular events in patients undergoing coronary artery bypass graft (CABG) surgery is poorly explored. METHODS: Consecutive patients referred for CABG underwent clinical evaluation and standard polysomnography in the preoperative period. CABG surgery data, including percentage of off -pump and on-pump CABG, number of graft s, and intraoperative complications, were collected. Th e primary end point was major adverse cardiac or cerebrovascular events (MACCEs) (combined events of all-cause death, myocardial infarction, repeated revascularization, and cerebrovascular events). Secondary end points included individual MACCEs, typical angina, and arrhythmias. Patients were evaluated at 30 days (short-term) and up to 6.1 years (long term) aft er CABG.