Flora Eslam - Academia.edu (original) (raw)

Papers by Flora Eslam

Research paper thumbnail of The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

Indian Journal of Pharmaceutical Education and Research, Dec 26, 2023

This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood g... more This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood glucose and cholesterol concentrations in diabetic rats when administered orally. Materials and Methods: Thirty-eight male Sprague Dawley rats were divided into normal (n=8) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided into five groups, (1) non-diabetic group (n=8) received distilled water (2 mL/ day); (2) diabetic control group (n=8) received distilled water (2 mL/ day); (3) metformin diabetic group (n=7) received 2 mL of metformin drug solution (dose=100 mg/kg/day); (4) honeybee diabetic group (n=8) received honeybee solution (dose=2 g/kg/ day); and (5) wheat germ diabetic group (n=7) received 2 mL of honeybee (95 g) mixed with wheat germ (5 g) solution (dose= 2 g/kg/day). After 28 days, blood was collected, and serum was extracted to determine glucose, HbA 1c , and blood lipids. Results: The results showed that honeybee alone and mixed with wheat germ increased blood glucose significantly above 350 mg/dL and HbA 1c above 8.4%. Conversely, the administration of wheat germ caused a noteworthy decrease in total cholesterol, triglycerides, and LDL concentrations among rats with diabetes. Conclusion: Consuming honeybees alone and combined with wheat germ may lead to hyperglycemia. Conversely, consuming honeybees in combination with wheat germ may result in hypocholesterolemia. These results indicate that honeybee and wheat germ could be functional food for managing hyperlipidemia in diabetic patients.

Research paper thumbnail of Mechanistic Assessment of Anise Seeds and Clove Buds against the Neurotoxicity Caused by Metronidazole in Rats: Possible Role of Antioxidants, Neurotransmitters, and Cytokines

Toxics, Aug 23, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Comparative Study between Synthetic and Natural Antioxidants of Banana, Mango and Orange Peels Extracts and their Effect on the Soybean and Olive Oils

Journal of Food and Dairy Sciences, 2017

This study assayed to evaluate the effect of phenolic and flavonoids compound of banana, mango an... more This study assayed to evaluate the effect of phenolic and flavonoids compound of banana, mango and orange peels extracts on some chemical properties of soybean and olive oils during storage period. Phenolic and Flavonoids compounds were determined by high performance liquid chromatographic method (HPLC) using ultraviolet (UV) detector set at 280 nm and 330nm, respectively. Soybean and olive oils storied (Six months) at room temperature (20 ± 2 ºC) after additional 1200 ppm banana, mango and orange peels extracts and compared with additional 200 ppm of synthetic antioxidants (BHT & BHA) The oils samples analyzed every month for acid, peroxide and iodine values during storage period. The results indicated that in the end of storage period acid and peroxide values of soybean and olive oils which treated with banana, mango and orange peels extracts (1200 ppm) were lower than other treatments , while iodine value were higher. It can be concluded that the additional of banana, mango and orange peels extracts enhanced the acid, peroxide and iodine values of soybean and olive oils in the end of storage period.

Research paper thumbnail of Effect Different Levels of Powder and Aqueous Extract of Artichoke Leaves on Gastric Ulcer

A total of 54 adult female albino rats weighting 130±10g were used in the present study, 6 rats w... more A total of 54 adult female albino rats weighting 130±10g were used in the present study, 6 rats were excluded to use as negative control group (normal control) and others were fasted for 18 hours and given aspirin solution in a dose 200 mg/kg, body weight (oral administration 2 ml three times each 8 hours) to induced gastric ulceration. After 6 hours, 6 rats were sacrificed then stomach was left and opened to insure from gastric ulcer. The reminder 42 inducted rats and control group were divided into 8 groups (6 rats in each group) as follows: First group rats fed basal diet as (negative control) (G1), second group inducted rats fed basal diet as (positive control) (G2) and from third to fifth group were fed on basal diet with substituted artichoke leaves powder at three levels (5, 10 and 20%). Groups 6, 7 and 8 inducted rats fed on basal diet and orally administrated by aqueous leaves extract at three levels (5, 10 and 20%) 2 ml three times/day. Rats were sacrificed at two phases t...

Research paper thumbnail of Biological effect of Parsley and honey on side effects of Cisplatin induced nephrotoxicity in experimental male rats

Bulletin of the National Nutrition Institute, 2017

he research was carried out on 50 adult albino male rats (Sprague-Dawley strain) weighing 160±7 g... more he research was carried out on 50 adult albino male rats (Sprague-Dawley strain) weighing 160±7 g. 10 rats served as control negative group and 40 rats were injected with Cisplatin (7.5 mg/kg bwt, ip) to induce nephrotoxicity. Then, rats reclassified into positive control group and three treated rat groups which administered parsley juice with honey, parsley powder with honey, and parsley extract with honey. The treatment period was designed for eight weeks. The chemical composition revealed that dry parsley contain highest amount of protein, fat, ash, calcium, iron, zinc, potassium, sodium, magnesium, total polyphenols and total flavonoids than dry honey but dry honey contain highest amount of carbohydrate and moisture. The biological results revealed that, there was a significant increases in weight gain , food intake , feed efficiency ratio , protein efficiency ratio ,serum total protein , globulin , albumin , and also kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) antioxidant enzymes. There was a significant decrease in serum creatinine, urea and uric acid and albumin to globulin ratio and kidney tissues malondialdehyde (MDA) in all treated rat groups at p<0.001 compared with positive control group. Rat groups which administered Cisplatin showed a significant increase in creatinine , urea and uric acid and albumin to globulin ratio and kidney tissues malodialdehyde (MDA) and significant decrease in weight gain , food intake , food efficiency ratio , protein efficiency ratio ,serum total protein , globulin, abumin, And kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-Stransferase (GST) at p<0.001 compared with negative control group and all treated rat groups. Histopathological examination revealed that, kidney tissues of rat treated with administered parsley with honey showed apparent normal kidney and nonhistopathological changes. These biochemical changes were accompanied with histopathological. It can be concluded that the administration of Parsley juice, powder and extract with honey can lower the side effects of Cisplatin induced nephrotoxicity in human and reducing the risk factors for nephrotoxicity disease such as hyperemia, leakage of renal markers and healthy condition.

Research paper thumbnail of The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

Indian Journal of Pharmaceutical Education and Research, Dec 26, 2023

This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood g... more This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood glucose and cholesterol concentrations in diabetic rats when administered orally. Materials and Methods: Thirty-eight male Sprague Dawley rats were divided into normal (n=8) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided into five groups, (1) non-diabetic group (n=8) received distilled water (2 mL/ day); (2) diabetic control group (n=8) received distilled water (2 mL/ day); (3) metformin diabetic group (n=7) received 2 mL of metformin drug solution (dose=100 mg/kg/day); (4) honeybee diabetic group (n=8) received honeybee solution (dose=2 g/kg/ day); and (5) wheat germ diabetic group (n=7) received 2 mL of honeybee (95 g) mixed with wheat germ (5 g) solution (dose= 2 g/kg/day). After 28 days, blood was collected, and serum was extracted to determine glucose, HbA 1c , and blood lipids. Results: The results showed that honeybee alone and mixed with wheat germ increased blood glucose significantly above 350 mg/dL and HbA 1c above 8.4%. Conversely, the administration of wheat germ caused a noteworthy decrease in total cholesterol, triglycerides, and LDL concentrations among rats with diabetes. Conclusion: Consuming honeybees alone and combined with wheat germ may lead to hyperglycemia. Conversely, consuming honeybees in combination with wheat germ may result in hypocholesterolemia. These results indicate that honeybee and wheat germ could be functional food for managing hyperlipidemia in diabetic patients.

Research paper thumbnail of Mechanistic Assessment of Anise Seeds and Clove Buds against the Neurotoxicity Caused by Metronidazole in Rats: Possible Role of Antioxidants, Neurotransmitters, and Cytokines

Toxics, Aug 23, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Comparative Study between Synthetic and Natural Antioxidants of Banana, Mango and Orange Peels Extracts and their Effect on the Soybean and Olive Oils

Journal of Food and Dairy Sciences, 2017

This study assayed to evaluate the effect of phenolic and flavonoids compound of banana, mango an... more This study assayed to evaluate the effect of phenolic and flavonoids compound of banana, mango and orange peels extracts on some chemical properties of soybean and olive oils during storage period. Phenolic and Flavonoids compounds were determined by high performance liquid chromatographic method (HPLC) using ultraviolet (UV) detector set at 280 nm and 330nm, respectively. Soybean and olive oils storied (Six months) at room temperature (20 ± 2 ºC) after additional 1200 ppm banana, mango and orange peels extracts and compared with additional 200 ppm of synthetic antioxidants (BHT & BHA) The oils samples analyzed every month for acid, peroxide and iodine values during storage period. The results indicated that in the end of storage period acid and peroxide values of soybean and olive oils which treated with banana, mango and orange peels extracts (1200 ppm) were lower than other treatments , while iodine value were higher. It can be concluded that the additional of banana, mango and orange peels extracts enhanced the acid, peroxide and iodine values of soybean and olive oils in the end of storage period.

Research paper thumbnail of Effect Different Levels of Powder and Aqueous Extract of Artichoke Leaves on Gastric Ulcer

A total of 54 adult female albino rats weighting 130±10g were used in the present study, 6 rats w... more A total of 54 adult female albino rats weighting 130±10g were used in the present study, 6 rats were excluded to use as negative control group (normal control) and others were fasted for 18 hours and given aspirin solution in a dose 200 mg/kg, body weight (oral administration 2 ml three times each 8 hours) to induced gastric ulceration. After 6 hours, 6 rats were sacrificed then stomach was left and opened to insure from gastric ulcer. The reminder 42 inducted rats and control group were divided into 8 groups (6 rats in each group) as follows: First group rats fed basal diet as (negative control) (G1), second group inducted rats fed basal diet as (positive control) (G2) and from third to fifth group were fed on basal diet with substituted artichoke leaves powder at three levels (5, 10 and 20%). Groups 6, 7 and 8 inducted rats fed on basal diet and orally administrated by aqueous leaves extract at three levels (5, 10 and 20%) 2 ml three times/day. Rats were sacrificed at two phases t...

Research paper thumbnail of Biological effect of Parsley and honey on side effects of Cisplatin induced nephrotoxicity in experimental male rats

Bulletin of the National Nutrition Institute, 2017

he research was carried out on 50 adult albino male rats (Sprague-Dawley strain) weighing 160±7 g... more he research was carried out on 50 adult albino male rats (Sprague-Dawley strain) weighing 160±7 g. 10 rats served as control negative group and 40 rats were injected with Cisplatin (7.5 mg/kg bwt, ip) to induce nephrotoxicity. Then, rats reclassified into positive control group and three treated rat groups which administered parsley juice with honey, parsley powder with honey, and parsley extract with honey. The treatment period was designed for eight weeks. The chemical composition revealed that dry parsley contain highest amount of protein, fat, ash, calcium, iron, zinc, potassium, sodium, magnesium, total polyphenols and total flavonoids than dry honey but dry honey contain highest amount of carbohydrate and moisture. The biological results revealed that, there was a significant increases in weight gain , food intake , feed efficiency ratio , protein efficiency ratio ,serum total protein , globulin , albumin , and also kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) antioxidant enzymes. There was a significant decrease in serum creatinine, urea and uric acid and albumin to globulin ratio and kidney tissues malondialdehyde (MDA) in all treated rat groups at p<0.001 compared with positive control group. Rat groups which administered Cisplatin showed a significant increase in creatinine , urea and uric acid and albumin to globulin ratio and kidney tissues malodialdehyde (MDA) and significant decrease in weight gain , food intake , food efficiency ratio , protein efficiency ratio ,serum total protein , globulin, abumin, And kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-Stransferase (GST) at p<0.001 compared with negative control group and all treated rat groups. Histopathological examination revealed that, kidney tissues of rat treated with administered parsley with honey showed apparent normal kidney and nonhistopathological changes. These biochemical changes were accompanied with histopathological. It can be concluded that the administration of Parsley juice, powder and extract with honey can lower the side effects of Cisplatin induced nephrotoxicity in human and reducing the risk factors for nephrotoxicity disease such as hyperemia, leakage of renal markers and healthy condition.