Flora Zárate-Mondragón - Academia.edu (original) (raw)
Papers by Flora Zárate-Mondragón
Andes pediatrica, Feb 20, 2021
Alergia, Asma e Inmunología Pediátricas, 2000
Artículo de investigación Determinación de PH intraesofágico por 24 horas en niños con reflujo ga... more Artículo de investigación Determinación de PH intraesofágico por 24 horas en niños con reflujo gastroesofágico y asma de reciente diagnóstico tratados con ranitidina
Revista de gastroenterología de México, Apr 1, 2019
Acta Pediátrica de México, 2012
PubMed, Aug 28, 2003
Iron-deficiency anemia is still a health problem worldwide. Iron supplementation of some foods su... more Iron-deficiency anemia is still a health problem worldwide. Iron supplementation of some foods such as milk formulas and cereals apparently has not been the solution due to bioavailability of iron. In Mexico, there is high prevalence of anemia in children to date, mainly those under 2 years of age and predominantly in the Southern part of the country. Probably the main causes are iron-deficiency anemia in pregnant women, recurrent infections, such as gastroenteritis and parasites, and the most important one undoubtedly, deficient iron intake.
Journal of Proteomics, Feb 1, 2023
![Research paper thumbnail of [Cholesterol ester storage disease]](https://attachments.academia-assets.com/108974976/thumbnails/1.jpg)
](PubMed, Mar 12, 2005
The goal of this paper is to present a clinical case of a 4 year old boy, with hepatomegaly, sple... more The goal of this paper is to present a clinical case of a 4 year old boy, with hepatomegaly, splenomegaly and intestinal lipid infiltration due to a inborn error of lipid metabolism known as cholesterol ester storage disease. The main clinical manifestations were hepatomegaly, splenomegaly, hypertriglyceridemia, hypercholesterolemia. Duodenal endoscopy showed a yellow appearance of the mucous, and the histological study revealed the presence of macrophages with granular material. Liver biopsy showed steatosis infiltration at the hepatocytes, and macrophages with lipids. This disease is due to a lisosomal acid lipase partial deficiency, that is a glicoprotein that metabolize the hydrolysis of ester of cholesterol and triglycerides. The name of this pathology is cholesterol ester storage disease, but when the deficiency is total the name is Wolman's disease. We conclude that in all the children whit a clinical picture of hepatomegaly, splenomegaly, hypertriglyceridemia and hypercholesterolemia it is obligatory to rule out an inborn error of lipid metabolism like Wolman's disease or cholesterol ester storage disease.
PubMed, Mar 26, 2003
Background: Juvenile polyposis (JP) is a frequent cause of lower gastrointestinal bleeding. It is... more Background: Juvenile polyposis (JP) is a frequent cause of lower gastrointestinal bleeding. It is present in 3-4% of the population < 21 years of age and represents 90% of all polyps in childhood. The most common complaints are hematoquezia, abdominal pain, and polyp prolapse. Methods: A descriptive, observational, transversal study of 225 children with histopatologic diagnosis of JP seen at the Department of Gastroenterology and Nutrition of the Instituto Nacional de Pediatría, between January 1985 and December 2000. Variables studied included age of presentation, gender, frequency, clinical manifestations, type, location, and diagnostic and therapeutic methods. Results: Frequency was one polyp per 162 patient seen during the same period (0.61%) and age 2 to 8 years (82%), a total of 235 patients, 120 females and 273 total polyps were found rectum the most common site 82% (224 polyps) followed by sigmoid. Mean distance from anal margin was 6.5 cm. Of all polyps, 82.9% were in the first 10 cm of anal margin. Of all patients, 92.3% had a single polyp and 7.7% had multiple polyps. A baritated study was made in 39 patients (16.6%) with diagnostic efficacy of 74%. No additional baritated studies were needed because of high diagnostic and therapeutic efficacy of the rectosigmoidoscopy. Conclusions: Rectosigmoidoscopy and colonoscopy remain as the diagnosis and therapeutic method in children with JP.
Acta Pediátrica de México, Jan 9, 2017
Gastrointestinal diseases are an important cause of morbidity and mortality worldwide. These incl... more Gastrointestinal diseases are an important cause of morbidity and mortality worldwide. These include infectious pathologies, allergic and chronic inflammatory conditions such as Crohn´s disease ulcerative colitis and also functional disorders such as irritable bowel syndrome, for which treatment sometimes is difficult due to multiple hypotheses for these pathologies where many factors such as psychological,
Journal of Proteomics, Mar 1, 2023
Cureus, Sep 6, 2022
Introduction Constipation is one of the most frequent chronic disorders in children and is almost... more Introduction Constipation is one of the most frequent chronic disorders in children and is almost always of functional etiology. Manometric alterations in anorectal sensitivity in children with chronic constipation are described in the literature; nevertheless, the impact of the duration of constipation on the parameters of anorectal manometry sensitivity is unknown. Objective To compare the parameters of sensitivity of high-resolution anorectal manometry (first sensation, threshold volume for urgency, and maximal tolerability) in children with chronic constipation, related to the time of evolution from the beginning of the symptoms. Methods This was a retrospective observational analytic study. The data of 39 children with functional constipation who were subjected to high-resolution anorectal manometry were included to evaluate constipation. The patients were divided into three groups according to the duration of constipation: <1 year; from 1 to 2 years; and >2 years. The parameters of sensitivity of the anorectal manometry were compared between the three groups and correlation tests were performed with the duration in months from the beginning of the symptoms of constipation. Results There was no difference between the sensitivity parameters of high-resolution anorectal manometry of the three groups; no correlation of these parameters with the time of evolution of the symptoms was found. Conclusions Alterations in the anorectal distensibility could develop early in the course of the disease, even from the first year of the beginning of the symptoms.
Revista de gastroenterología de México, Apr 1, 2019
Agastria congénita como una malformación aislada Congenital agastria as an isolated malformation
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004
... Mata-Rivera, N.1; Ramirez-Mayans, JA2; Cervantes-Bustamante, R.1; Zarate-Mondragon, F.1; Gala... more ... Mata-Rivera, N.1; Ramirez-Mayans, JA2; Cervantes-Bustamante, R.1; Zarate-Mondragon, F.1; Galaz-Pantoja, M.1; Montijo-Barrios, E ... The manometry was done with solid state catheter microtransducer using Smart lab motility, system Sandhill Co.The catheter was French 7 with ...
Acta Pediátrica de México, Jun 30, 2017
Infant hypertensive emergency secondary to autosomic recessive polycystic kidney disease. Case re... more Infant hypertensive emergency secondary to autosomic recessive polycystic kidney disease. Case report.
Revista de gastroenterología de México, Jul 1, 2021
Dietary fiber intake is one of the most influential and efficacious strategies for modulating the... more Dietary fiber intake is one of the most influential and efficacious strategies for modulating the gut microbiota. Said fiber can be digested by the microbiota itself, producing numerous metabolites, which include the short-chain fatty acids (SCFAs). SCFAs have local and systemic functions that impact the composition and function of the gut microbiota, and consequently, human health. The aim of the present narrative review was to provide a document that serves as a frame of reference for a clear understanding of dietary fiber and its direct and indirect effects on health. The direct benefits of dietary fiber intake can be dependent on or independent of the gut microbiota. The use of dietary fiber by the gut microbiota involves several factors, including the fiber's physiochemical characteristics. Dietary fiber type influences the gut microbiota because not all bacterial species have the same capacity to produce the enzymes needed for its degradation. A low-fiber diet can affect the balance of the SCFAs produced. Dietary fiber indirectly benefits cardiometabolic health, digestive health, certain functional gastrointestinal disorders, and different diseases.
Revista chilena de pediatría, 2020
Revista colombiana de Gastroenterología, Mar 8, 2021
Introducción: la hiperplasia nodular linfoide del colon se define como > 10 nódulos linfoides vis... more Introducción: la hiperplasia nodular linfoide del colon se define como > 10 nódulos linfoides visibles en colonoscopia. No existen estudios de su validez al compararlo con la histopatología. Objetivos: determinar la validez del hallazgo de nódulos en colonoscopia para el diagnóstico de hiperplasia nodular linfoide. Material y métodos: estudio prospectivo de prueba diagnóstica. Se incluyeron colonoscopias realizadas consecutivamente de 2014 al 2018 con equipos Olympus PCFQ150AI y GIFXP150N con obtención de biopsias. El criterio endoscópico fue la presencia de > 10 nódulos de 2 a 10 mm y el criterio histológico fue hiperplasia de folículos linfoides y mantos de linfocitos en lámina propia o submucosa. Los datos se analizaron en Epidat3.1. Se obtuvo la sensibilidad (S), especificidad (E), valor predictivo positivo (VPP) y negativo (VPN), y coeficientes de probabilidad positivo (LR+) y negativo (LR-) con sus intervalos de confianza. Resultados: se incluyeron 327 colonoscopias, la mediana de edad fue de 84 meses. La principal indicación para la colonoscopia fue sangrado digestivo bajo (38,8 %). El hallazgo de nódulos se encontró en el 21 % y el sitio de mayor frecuencia fue el colon total (46 %), mientras que por histopatología se encontró hiperplasia nodular linfoide en el 38 %. El hallazgo de nódulos obtuvo una S de 32 % (intervalo de confianza [IC] del 95 %: 24-140), E de 84 % (IC 95 %: 79-89), VPP de 56 % (IC 95 %: 44-68), VPN de 67 % (IC 95 %: 61-72), LR+ de 2,04 (IC 95 %: 1,4-3) y LR-de 0,8 (IC 95 %: 0,8-0,9). Conclusiones: la validez diagnóstica del hallazgo de nódulos en colonoscopia para hiperplasia nodular linfoide es pobre, por lo que la toma de biopsia debe recomendarse siempre.
Revista de gastroenterología de México, 2014
Background: Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in p... more Background: Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in pediatric consultations. It shares symptoms with gastroesophageal reflux (GER), which can complicate the differential diagnosis. Aims: To attempt to corroborate the presence of acid GER in children with CMPA, as well as to find a characteristic profile through the 24-hour pH monitoring study in children with GER and CMPA Methods: The intraesophageal pH monitoring studies performed on 47 children with CMPA were reviewed. The measurements in all the studies were carried out within a 24-hour period using Digitrapper® equipment with a multi-use GeroFlex® catheter, after calibration with pH 7 and pH 1 buffer solutions. Results: Of the 47 children, 23 were boys (32.4%) and 24 were girls (33.8%) and the mean age was 5 ± 3.7 years. Fourteen of the 47 children (29%) presented with GER, according to the result of the 24-hour intraesophageal measurement. Only 2 of the 47 patients studied fit the phasic profile. Conclusions: The findings show the existing relation between the two pathologies. Nevertheless, it is important to determine the presence of non-acid or weak acid reflux, because their existence can increase this association.
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004
Andes pediatrica, Feb 20, 2021
Alergia, Asma e Inmunología Pediátricas, 2000
Artículo de investigación Determinación de PH intraesofágico por 24 horas en niños con reflujo ga... more Artículo de investigación Determinación de PH intraesofágico por 24 horas en niños con reflujo gastroesofágico y asma de reciente diagnóstico tratados con ranitidina
Revista de gastroenterología de México, Apr 1, 2019
Acta Pediátrica de México, 2012
PubMed, Aug 28, 2003
Iron-deficiency anemia is still a health problem worldwide. Iron supplementation of some foods su... more Iron-deficiency anemia is still a health problem worldwide. Iron supplementation of some foods such as milk formulas and cereals apparently has not been the solution due to bioavailability of iron. In Mexico, there is high prevalence of anemia in children to date, mainly those under 2 years of age and predominantly in the Southern part of the country. Probably the main causes are iron-deficiency anemia in pregnant women, recurrent infections, such as gastroenteritis and parasites, and the most important one undoubtedly, deficient iron intake.
Journal of Proteomics, Feb 1, 2023
PubMed, Mar 12, 2005
The goal of this paper is to present a clinical case of a 4 year old boy, with hepatomegaly, sple... more The goal of this paper is to present a clinical case of a 4 year old boy, with hepatomegaly, splenomegaly and intestinal lipid infiltration due to a inborn error of lipid metabolism known as cholesterol ester storage disease. The main clinical manifestations were hepatomegaly, splenomegaly, hypertriglyceridemia, hypercholesterolemia. Duodenal endoscopy showed a yellow appearance of the mucous, and the histological study revealed the presence of macrophages with granular material. Liver biopsy showed steatosis infiltration at the hepatocytes, and macrophages with lipids. This disease is due to a lisosomal acid lipase partial deficiency, that is a glicoprotein that metabolize the hydrolysis of ester of cholesterol and triglycerides. The name of this pathology is cholesterol ester storage disease, but when the deficiency is total the name is Wolman's disease. We conclude that in all the children whit a clinical picture of hepatomegaly, splenomegaly, hypertriglyceridemia and hypercholesterolemia it is obligatory to rule out an inborn error of lipid metabolism like Wolman's disease or cholesterol ester storage disease.
PubMed, Mar 26, 2003
Background: Juvenile polyposis (JP) is a frequent cause of lower gastrointestinal bleeding. It is... more Background: Juvenile polyposis (JP) is a frequent cause of lower gastrointestinal bleeding. It is present in 3-4% of the population < 21 years of age and represents 90% of all polyps in childhood. The most common complaints are hematoquezia, abdominal pain, and polyp prolapse. Methods: A descriptive, observational, transversal study of 225 children with histopatologic diagnosis of JP seen at the Department of Gastroenterology and Nutrition of the Instituto Nacional de Pediatría, between January 1985 and December 2000. Variables studied included age of presentation, gender, frequency, clinical manifestations, type, location, and diagnostic and therapeutic methods. Results: Frequency was one polyp per 162 patient seen during the same period (0.61%) and age 2 to 8 years (82%), a total of 235 patients, 120 females and 273 total polyps were found rectum the most common site 82% (224 polyps) followed by sigmoid. Mean distance from anal margin was 6.5 cm. Of all polyps, 82.9% were in the first 10 cm of anal margin. Of all patients, 92.3% had a single polyp and 7.7% had multiple polyps. A baritated study was made in 39 patients (16.6%) with diagnostic efficacy of 74%. No additional baritated studies were needed because of high diagnostic and therapeutic efficacy of the rectosigmoidoscopy. Conclusions: Rectosigmoidoscopy and colonoscopy remain as the diagnosis and therapeutic method in children with JP.
Acta Pediátrica de México, Jan 9, 2017
Gastrointestinal diseases are an important cause of morbidity and mortality worldwide. These incl... more Gastrointestinal diseases are an important cause of morbidity and mortality worldwide. These include infectious pathologies, allergic and chronic inflammatory conditions such as Crohn´s disease ulcerative colitis and also functional disorders such as irritable bowel syndrome, for which treatment sometimes is difficult due to multiple hypotheses for these pathologies where many factors such as psychological,
Journal of Proteomics, Mar 1, 2023
Cureus, Sep 6, 2022
Introduction Constipation is one of the most frequent chronic disorders in children and is almost... more Introduction Constipation is one of the most frequent chronic disorders in children and is almost always of functional etiology. Manometric alterations in anorectal sensitivity in children with chronic constipation are described in the literature; nevertheless, the impact of the duration of constipation on the parameters of anorectal manometry sensitivity is unknown. Objective To compare the parameters of sensitivity of high-resolution anorectal manometry (first sensation, threshold volume for urgency, and maximal tolerability) in children with chronic constipation, related to the time of evolution from the beginning of the symptoms. Methods This was a retrospective observational analytic study. The data of 39 children with functional constipation who were subjected to high-resolution anorectal manometry were included to evaluate constipation. The patients were divided into three groups according to the duration of constipation: <1 year; from 1 to 2 years; and >2 years. The parameters of sensitivity of the anorectal manometry were compared between the three groups and correlation tests were performed with the duration in months from the beginning of the symptoms of constipation. Results There was no difference between the sensitivity parameters of high-resolution anorectal manometry of the three groups; no correlation of these parameters with the time of evolution of the symptoms was found. Conclusions Alterations in the anorectal distensibility could develop early in the course of the disease, even from the first year of the beginning of the symptoms.
Revista de gastroenterología de México, Apr 1, 2019
Agastria congénita como una malformación aislada Congenital agastria as an isolated malformation
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004
... Mata-Rivera, N.1; Ramirez-Mayans, JA2; Cervantes-Bustamante, R.1; Zarate-Mondragon, F.1; Gala... more ... Mata-Rivera, N.1; Ramirez-Mayans, JA2; Cervantes-Bustamante, R.1; Zarate-Mondragon, F.1; Galaz-Pantoja, M.1; Montijo-Barrios, E ... The manometry was done with solid state catheter microtransducer using Smart lab motility, system Sandhill Co.The catheter was French 7 with ...
Acta Pediátrica de México, Jun 30, 2017
Infant hypertensive emergency secondary to autosomic recessive polycystic kidney disease. Case re... more Infant hypertensive emergency secondary to autosomic recessive polycystic kidney disease. Case report.
Revista de gastroenterología de México, Jul 1, 2021
Dietary fiber intake is one of the most influential and efficacious strategies for modulating the... more Dietary fiber intake is one of the most influential and efficacious strategies for modulating the gut microbiota. Said fiber can be digested by the microbiota itself, producing numerous metabolites, which include the short-chain fatty acids (SCFAs). SCFAs have local and systemic functions that impact the composition and function of the gut microbiota, and consequently, human health. The aim of the present narrative review was to provide a document that serves as a frame of reference for a clear understanding of dietary fiber and its direct and indirect effects on health. The direct benefits of dietary fiber intake can be dependent on or independent of the gut microbiota. The use of dietary fiber by the gut microbiota involves several factors, including the fiber's physiochemical characteristics. Dietary fiber type influences the gut microbiota because not all bacterial species have the same capacity to produce the enzymes needed for its degradation. A low-fiber diet can affect the balance of the SCFAs produced. Dietary fiber indirectly benefits cardiometabolic health, digestive health, certain functional gastrointestinal disorders, and different diseases.
Revista chilena de pediatría, 2020
Revista colombiana de Gastroenterología, Mar 8, 2021
Introducción: la hiperplasia nodular linfoide del colon se define como > 10 nódulos linfoides vis... more Introducción: la hiperplasia nodular linfoide del colon se define como > 10 nódulos linfoides visibles en colonoscopia. No existen estudios de su validez al compararlo con la histopatología. Objetivos: determinar la validez del hallazgo de nódulos en colonoscopia para el diagnóstico de hiperplasia nodular linfoide. Material y métodos: estudio prospectivo de prueba diagnóstica. Se incluyeron colonoscopias realizadas consecutivamente de 2014 al 2018 con equipos Olympus PCFQ150AI y GIFXP150N con obtención de biopsias. El criterio endoscópico fue la presencia de > 10 nódulos de 2 a 10 mm y el criterio histológico fue hiperplasia de folículos linfoides y mantos de linfocitos en lámina propia o submucosa. Los datos se analizaron en Epidat3.1. Se obtuvo la sensibilidad (S), especificidad (E), valor predictivo positivo (VPP) y negativo (VPN), y coeficientes de probabilidad positivo (LR+) y negativo (LR-) con sus intervalos de confianza. Resultados: se incluyeron 327 colonoscopias, la mediana de edad fue de 84 meses. La principal indicación para la colonoscopia fue sangrado digestivo bajo (38,8 %). El hallazgo de nódulos se encontró en el 21 % y el sitio de mayor frecuencia fue el colon total (46 %), mientras que por histopatología se encontró hiperplasia nodular linfoide en el 38 %. El hallazgo de nódulos obtuvo una S de 32 % (intervalo de confianza [IC] del 95 %: 24-140), E de 84 % (IC 95 %: 79-89), VPP de 56 % (IC 95 %: 44-68), VPN de 67 % (IC 95 %: 61-72), LR+ de 2,04 (IC 95 %: 1,4-3) y LR-de 0,8 (IC 95 %: 0,8-0,9). Conclusiones: la validez diagnóstica del hallazgo de nódulos en colonoscopia para hiperplasia nodular linfoide es pobre, por lo que la toma de biopsia debe recomendarse siempre.
Revista de gastroenterología de México, 2014
Background: Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in p... more Background: Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in pediatric consultations. It shares symptoms with gastroesophageal reflux (GER), which can complicate the differential diagnosis. Aims: To attempt to corroborate the presence of acid GER in children with CMPA, as well as to find a characteristic profile through the 24-hour pH monitoring study in children with GER and CMPA Methods: The intraesophageal pH monitoring studies performed on 47 children with CMPA were reviewed. The measurements in all the studies were carried out within a 24-hour period using Digitrapper® equipment with a multi-use GeroFlex® catheter, after calibration with pH 7 and pH 1 buffer solutions. Results: Of the 47 children, 23 were boys (32.4%) and 24 were girls (33.8%) and the mean age was 5 ± 3.7 years. Fourteen of the 47 children (29%) presented with GER, according to the result of the 24-hour intraesophageal measurement. Only 2 of the 47 patients studied fit the phasic profile. Conclusions: The findings show the existing relation between the two pathologies. Nevertheless, it is important to determine the presence of non-acid or weak acid reflux, because their existence can increase this association.
Journal of Pediatric Gastroenterology and Nutrition, Jun 1, 2004