Forhadul Mollah - Academia.edu (original) (raw)

Papers by Forhadul Mollah

Research paper thumbnail of Association of HbA1c Level with Lipid Profiles among Type 2 Diabetic Patients attended at Medical University of Bangladesh

Journal of National Institute of Neurosciences Bangladesh

Background: Type 2 diabetic patients are presented with dyslipidemia. Objective: The objective of... more Background: Type 2 diabetic patients are presented with dyslipidemia. Objective: The objective of this study was to see the association between the HbA1c and lipid profiles among the diabetic subjects. Methodology: The cross-sectional study was carried in the Department of Biochemistry at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on type 2 diabetic individual attending the endocrine OPD of BSMMU. In this study estimation of HbA1c level and lipid profiles in diabetic subjects were performed and was compared the lipid profiles between the controlled (HbA1c <7%) and uncontrolled (HbA1c >7%) groups. Result: A total number of 95 patients were recruited for this study. The mean age of the respondents was 42.63 ±5.56 years. Female (8.21± 1.88) had lower HbA1c than male (8.42±2.21) in the study. TC: HDL (6.07±1.02:1) and LDL: HDL (3.88±1.58:1) were also higher. Among the study population 30 had good (HbA1c<7 mg%) glycemic control and 14 of them were mal...

Research paper thumbnail of Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal, Mar 9, 2018

Research paper thumbnail of Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal

Vitamin D has an important role and supposed to be a risk factor in the development of pathogenes... more Vitamin D has an important role and supposed to be a risk factor in the development of pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity or β-cell function, or both. The present study was conducted to evaluate the relation of serum vitamin D3 and type 2 diabetes mellitus. Total 80 individuals were enrolled in this study. Forty newly diagnosed type 2 diabetic individual were enrolled as cases and 40 healthy glucose tolerant subjects were enrolled as controls. Serum vitamin D3 was measured by chemiluminescence microparticle immunoassay. Fasting and 2 hours plasma glucose level were measured by hexokinase method using the Dimension clinical chemistry system. The mean serum vitamin D3 level was significantly low in type 2 diabetes mellitus than in controls (p= 0,007). The individual with vitamin D3 deficiency showed 3.4 times higher chances to develop type 2 diabetes mellitus compare to the individual with normal vitamin D status. Correlation test showed ...

Research paper thumbnail of Correlation of serum aspartate aminotransferase level to platelet count ratio index with non-alcoholic fatty liver disease activity score

Bangabandhu Sheikh Mujib Medical University Journal

In case of non-alcoholic fatty liver disease, the ratio of serum aspartate aminotransferase (AST... more In case of non-alcoholic fatty liver disease, the ratio of serum aspartate aminotransferase (AST) level to platelet count index has been proposed as a non-invasive and readily available tool for the assessment of non-alcoholic steatohepatitis. The study was conducted on 50 non-alcoholic fatty liver disease patient (25 non-alcoholic steatohepatitis and 25 simple steatosis). The mean (± SD) serum AST level in the non-alcoholic steatohepatitis group was 55.2 ± 30.1 IU/L whereas in simple steatosis group it was 33.6 ± 20.0 IU/L. The mean platelet count in the non-alcoholic steatohepatitis group was 303.1 ± 68.7 x 109 /L whereas in the simple steatosis group it was 327.8 ± 66.8 x 109/L. The mean AST platelet ratio index (APRI) score in non-alcoholic steatohepatitis group was 0.5 ± 0.3 and in the simple steatosis group it was 0.3 ± 0.2. In conclusion, the APRI was significantly higher in the non-alcoholic steatohepatitis group than the simple steatosis group.

Research paper thumbnail of Serum Homocysteine and its Association with Lipid Profile in Type 2 Diabetic Patients

Journal of Shaheed Suhrawardy Medical College, Nov 22, 2018

Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassoci... more Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassociated deaths being attributed to cardiovascular disease (CVD). Prevalence of type 2 diabetes in rural Bangladeshi and in urban Bangladeshi is found to be 7.2% and 10.5% respectively. People of developing countries suffer from the disease at earlier age than that of developed countries. Among the diabetic patients, vascular complications represent a major cause of morbidity and mortality. Diabetes is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and increased prothrombotic factors. Total plasma homocysteine (tHcy) is an emerging CVD risk factor. Insulin resistance and hyperinsulinemia in diabetes mellitus along with increased homocysteine is thought to cause endothelial dysfunction. Endothelial dysfunction together with other factors such as dyslipidemia, microalbuminemia etc. causes cardiovascular disease. Objectives: Objective of the study was to evaluate serum total homocysteine level and to correlate it with fasting lipid profile in type 2 diabetic patients. Methodology: This cross sectional study was conducted during the period of July 2011-June 2013 on 95 patients of type 2 diabetes mellitus, attending the Endocrine OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out in the

Research paper thumbnail of Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

Journal of Enam Medical College, 2015

Research paper thumbnail of Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

Bangladesh Journal of Physiology and Pharmacology, 2010

... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry... more ... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh ... Page 3. 8. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. ...

Research paper thumbnail of Study of phases of insulin secretion in pre-diabetes and newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal, 2016

Research paper thumbnail of Assessment of Thyroid Peroxidase Antibody And Thyroid Stimulating Hormone In First Trimester Of Pregnancy

Bangladesh Journal of Medical Science, 2013

Research paper thumbnail of Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

Journal of Enam Medical College, 2015

Research paper thumbnail of Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

Bangladesh Journal of Physiology and Pharmacology, 2010

... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry... more ... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh ... Page 3. 8. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. ...

Research paper thumbnail of Leptin and Other Factors as Determinants of Insulin Secretion and Sensitivity in Bangladeshi Type 2 Diabetic Subjects

Journal of Bangladesh Society of Physiologist, 2009

The relative contribution of insulin secretion and sensitivity in the development of Type 2 diabe... more The relative contribution of insulin secretion and sensitivity in the development of Type 2 diabetes mellitus (T2DM) vary from population to population due to the heterogeneous nature of the disease. The study was undertaken to evaluate insulin secretory capacity and sensitivity in a Bangladeshi Type 2 diabetic population and to explore the association of some of the anthropometric and biochemical factors known to modulate B-cell function and insulin action. Methods: Ninety one T2DM subjects and 32 age-matched controls were studied for their fasting plasma glucose (FPG), lipids, HbA 1c (by HPLC), leptin and C-peptide (ELISA). Insulin secretion (HOMA B) and insulin sensitivity (HOMA S) were calculated by homeostasis model assessment (HOMA). Results: Both insulin secretion and sensitivity were significantly reduced in diabetic as compared to control (HOMA B%, geometric mean±SD, 35.65±1.75 vs. 96.29±1.50, p<0.001; HOMA S%, 68.66±1.71 vs. 104.951.63, p<0.001). However, B-cell dysfunction was predominant than insulin resistance in predicting T2DM as the discriminate function coefficient for HOMA B (1.098) was greater than that for HOMA S (0.821). In T2DM, HOMA B had positive correlation with BMI (r=0.368, p<0.001) and HOMA S was inversely correlated to BMI (r=-0.261, p<0.01), WHR (r=-0.258, p<0.01) and plasma TG (r=-0.233, p<0.001). On multiple regression analysis HOMA B and HOMA S were found to be inversely associated to FPG (p<0.001) and leptin (p<0.05) in T2DM.

Research paper thumbnail of Association of C-reactive Protein with Fasting Blood Glucose in Newly Diagnosed Type 2 Diabetes Mellitus Patients

Bangladesh Journal of Pathology, 2010

Page 1. Or/g/na/ Artide Bangladesh J Pathol 24 {2) : Association of C-reactive Protein with Fasti... more Page 1. Or/g/na/ Artide Bangladesh J Pathol 24 {2) : Association of C-reactive Protein with Fasting blood glucose in Newly Diagnosed Type 2 Diabetes Mellitus Patients Md. Matiur Rahman1, Abu Hena Mostafa Kamal2, Forhadul Hoque Mollah3, Md. ...

Research paper thumbnail of Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

Journal of Enam Medical College, 2013

Research paper thumbnail of Urinary Iodine Excretion of Lactating Mothers Predicts the Iodine Content of Their Breast Milk

Journal of Enam Medical College, 2012

Research paper thumbnail of Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Chattagram Maa-O-Shishu Hospital Medical College Journal, 2014

Research paper thumbnail of Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects

Diabetes and Vascular Disease Research, 2013

This study was designed to explore the relationship between serum levels of soluble receptor for ... more This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and medical history including detail history of cigarette smoking was collected. The serum sRAGE levels were found significantly higher (p=0.002) in cigarette smokers (1475±422 pg/ml, n=45) compared with non-smokers (1165±350 pg/ml, n=53). Moreover, among the cigarette smokers, serum sRAGE levels were found significantly correlated with number of cigarettes smoked per day (r=0.60, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). In bivariate analysis in the total population, sRAGE positively correlated with smoking habit (r=0.37, p=0.002) and negatively correlated with systolic (r=-0.32, p=0.01) and diastolic blood pressure (r=-0.36, p=0.003). However, in stepwise multivariate linear regression model, sRAGE showed a significant independent association with smoking habit (b=0.32, p=0.007, R2=0.23). In conclusion, this study for the first time shows a significant elevation of serum sRAGE in cigarette smokers compared with non-smokers, a strong correlation between sRAGE and number of cigarettes smoked per day and an independent association of sRAGE with smoking habit in non-diabetic healthy subjects.

Research paper thumbnail of Serum Lipids and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Subjects

Journal of Enam Medical College, 2012

Research paper thumbnail of Association of HbA1c Level with Lipid Profiles among Type 2 Diabetic Patients attended at Medical University of Bangladesh

Journal of National Institute of Neurosciences Bangladesh

Background: Type 2 diabetic patients are presented with dyslipidemia. Objective: The objective of... more Background: Type 2 diabetic patients are presented with dyslipidemia. Objective: The objective of this study was to see the association between the HbA1c and lipid profiles among the diabetic subjects. Methodology: The cross-sectional study was carried in the Department of Biochemistry at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on type 2 diabetic individual attending the endocrine OPD of BSMMU. In this study estimation of HbA1c level and lipid profiles in diabetic subjects were performed and was compared the lipid profiles between the controlled (HbA1c <7%) and uncontrolled (HbA1c >7%) groups. Result: A total number of 95 patients were recruited for this study. The mean age of the respondents was 42.63 ±5.56 years. Female (8.21± 1.88) had lower HbA1c than male (8.42±2.21) in the study. TC: HDL (6.07±1.02:1) and LDL: HDL (3.88±1.58:1) were also higher. Among the study population 30 had good (HbA1c<7 mg%) glycemic control and 14 of them were mal...

Research paper thumbnail of Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal, Mar 9, 2018

Research paper thumbnail of Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal

Vitamin D has an important role and supposed to be a risk factor in the development of pathogenes... more Vitamin D has an important role and supposed to be a risk factor in the development of pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity or β-cell function, or both. The present study was conducted to evaluate the relation of serum vitamin D3 and type 2 diabetes mellitus. Total 80 individuals were enrolled in this study. Forty newly diagnosed type 2 diabetic individual were enrolled as cases and 40 healthy glucose tolerant subjects were enrolled as controls. Serum vitamin D3 was measured by chemiluminescence microparticle immunoassay. Fasting and 2 hours plasma glucose level were measured by hexokinase method using the Dimension clinical chemistry system. The mean serum vitamin D3 level was significantly low in type 2 diabetes mellitus than in controls (p= 0,007). The individual with vitamin D3 deficiency showed 3.4 times higher chances to develop type 2 diabetes mellitus compare to the individual with normal vitamin D status. Correlation test showed ...

Research paper thumbnail of Correlation of serum aspartate aminotransferase level to platelet count ratio index with non-alcoholic fatty liver disease activity score

Bangabandhu Sheikh Mujib Medical University Journal

In case of non-alcoholic fatty liver disease, the ratio of serum aspartate aminotransferase (AST... more In case of non-alcoholic fatty liver disease, the ratio of serum aspartate aminotransferase (AST) level to platelet count index has been proposed as a non-invasive and readily available tool for the assessment of non-alcoholic steatohepatitis. The study was conducted on 50 non-alcoholic fatty liver disease patient (25 non-alcoholic steatohepatitis and 25 simple steatosis). The mean (± SD) serum AST level in the non-alcoholic steatohepatitis group was 55.2 ± 30.1 IU/L whereas in simple steatosis group it was 33.6 ± 20.0 IU/L. The mean platelet count in the non-alcoholic steatohepatitis group was 303.1 ± 68.7 x 109 /L whereas in the simple steatosis group it was 327.8 ± 66.8 x 109/L. The mean AST platelet ratio index (APRI) score in non-alcoholic steatohepatitis group was 0.5 ± 0.3 and in the simple steatosis group it was 0.3 ± 0.2. In conclusion, the APRI was significantly higher in the non-alcoholic steatohepatitis group than the simple steatosis group.

Research paper thumbnail of Serum Homocysteine and its Association with Lipid Profile in Type 2 Diabetic Patients

Journal of Shaheed Suhrawardy Medical College, Nov 22, 2018

Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassoci... more Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassociated deaths being attributed to cardiovascular disease (CVD). Prevalence of type 2 diabetes in rural Bangladeshi and in urban Bangladeshi is found to be 7.2% and 10.5% respectively. People of developing countries suffer from the disease at earlier age than that of developed countries. Among the diabetic patients, vascular complications represent a major cause of morbidity and mortality. Diabetes is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and increased prothrombotic factors. Total plasma homocysteine (tHcy) is an emerging CVD risk factor. Insulin resistance and hyperinsulinemia in diabetes mellitus along with increased homocysteine is thought to cause endothelial dysfunction. Endothelial dysfunction together with other factors such as dyslipidemia, microalbuminemia etc. causes cardiovascular disease. Objectives: Objective of the study was to evaluate serum total homocysteine level and to correlate it with fasting lipid profile in type 2 diabetic patients. Methodology: This cross sectional study was conducted during the period of July 2011-June 2013 on 95 patients of type 2 diabetes mellitus, attending the Endocrine OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out in the

Research paper thumbnail of Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

Journal of Enam Medical College, 2015

Research paper thumbnail of Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

Bangladesh Journal of Physiology and Pharmacology, 2010

... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry... more ... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh ... Page 3. 8. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. ...

Research paper thumbnail of Study of phases of insulin secretion in pre-diabetes and newly diagnosed type 2 diabetes mellitus

Bangabandhu Sheikh Mujib Medical University Journal, 2016

Research paper thumbnail of Assessment of Thyroid Peroxidase Antibody And Thyroid Stimulating Hormone In First Trimester Of Pregnancy

Bangladesh Journal of Medical Science, 2013

Research paper thumbnail of Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

Journal of Enam Medical College, 2015

Research paper thumbnail of Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

Bangladesh Journal of Physiology and Pharmacology, 2010

... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry... more ... SIFAT JUBAIRA, FORHADUL HAQUE MOLLAH, TAHRIM MEHDI, M IQBAL ARSLAN Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh ... Page 3. 8. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. ...

Research paper thumbnail of Leptin and Other Factors as Determinants of Insulin Secretion and Sensitivity in Bangladeshi Type 2 Diabetic Subjects

Journal of Bangladesh Society of Physiologist, 2009

The relative contribution of insulin secretion and sensitivity in the development of Type 2 diabe... more The relative contribution of insulin secretion and sensitivity in the development of Type 2 diabetes mellitus (T2DM) vary from population to population due to the heterogeneous nature of the disease. The study was undertaken to evaluate insulin secretory capacity and sensitivity in a Bangladeshi Type 2 diabetic population and to explore the association of some of the anthropometric and biochemical factors known to modulate B-cell function and insulin action. Methods: Ninety one T2DM subjects and 32 age-matched controls were studied for their fasting plasma glucose (FPG), lipids, HbA 1c (by HPLC), leptin and C-peptide (ELISA). Insulin secretion (HOMA B) and insulin sensitivity (HOMA S) were calculated by homeostasis model assessment (HOMA). Results: Both insulin secretion and sensitivity were significantly reduced in diabetic as compared to control (HOMA B%, geometric mean±SD, 35.65±1.75 vs. 96.29±1.50, p<0.001; HOMA S%, 68.66±1.71 vs. 104.951.63, p<0.001). However, B-cell dysfunction was predominant than insulin resistance in predicting T2DM as the discriminate function coefficient for HOMA B (1.098) was greater than that for HOMA S (0.821). In T2DM, HOMA B had positive correlation with BMI (r=0.368, p<0.001) and HOMA S was inversely correlated to BMI (r=-0.261, p<0.01), WHR (r=-0.258, p<0.01) and plasma TG (r=-0.233, p<0.001). On multiple regression analysis HOMA B and HOMA S were found to be inversely associated to FPG (p<0.001) and leptin (p<0.05) in T2DM.

Research paper thumbnail of Association of C-reactive Protein with Fasting Blood Glucose in Newly Diagnosed Type 2 Diabetes Mellitus Patients

Bangladesh Journal of Pathology, 2010

Page 1. Or/g/na/ Artide Bangladesh J Pathol 24 {2) : Association of C-reactive Protein with Fasti... more Page 1. Or/g/na/ Artide Bangladesh J Pathol 24 {2) : Association of C-reactive Protein with Fasting blood glucose in Newly Diagnosed Type 2 Diabetes Mellitus Patients Md. Matiur Rahman1, Abu Hena Mostafa Kamal2, Forhadul Hoque Mollah3, Md. ...

Research paper thumbnail of Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

Journal of Enam Medical College, 2013

Research paper thumbnail of Urinary Iodine Excretion of Lactating Mothers Predicts the Iodine Content of Their Breast Milk

Journal of Enam Medical College, 2012

Research paper thumbnail of Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Chattagram Maa-O-Shishu Hospital Medical College Journal, 2014

Research paper thumbnail of Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects

Diabetes and Vascular Disease Research, 2013

This study was designed to explore the relationship between serum levels of soluble receptor for ... more This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and medical history including detail history of cigarette smoking was collected. The serum sRAGE levels were found significantly higher (p=0.002) in cigarette smokers (1475±422 pg/ml, n=45) compared with non-smokers (1165±350 pg/ml, n=53). Moreover, among the cigarette smokers, serum sRAGE levels were found significantly correlated with number of cigarettes smoked per day (r=0.60, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). In bivariate analysis in the total population, sRAGE positively correlated with smoking habit (r=0.37, p=0.002) and negatively correlated with systolic (r=-0.32, p=0.01) and diastolic blood pressure (r=-0.36, p=0.003). However, in stepwise multivariate linear regression model, sRAGE showed a significant independent association with smoking habit (b=0.32, p=0.007, R2=0.23). In conclusion, this study for the first time shows a significant elevation of serum sRAGE in cigarette smokers compared with non-smokers, a strong correlation between sRAGE and number of cigarettes smoked per day and an independent association of sRAGE with smoking habit in non-diabetic healthy subjects.

Research paper thumbnail of Serum Lipids and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Subjects

Journal of Enam Medical College, 2012