Foroogh Mirzania - Academia.edu (original) (raw)

Papers by Foroogh Mirzania

Journal of Agricultural Science and Technology, 2019

Froriepia is one of the Apiaceae genera. Only one species of this genus (Froriepia subpinnata L.)... more Froriepia is one of the Apiaceae genera. Only one species of this genus (Froriepia subpinnata L.) has been reported in Iran. In most parts of the North of Iran, young and pristine leaves are applied as stuffing in the preparation of various local foods. Despite wide applications of this medicinal plant, previously little research has been done on it. In this investigation, chemical compositions and antimicrobial activity of wild and cultivated Froriepia subpinnata essential oils were evaluated and compared. Applying GC and GCMS, 53 components were registered in cultivated plant essential oil with major componentsmyrcenone (27.40%), limonene (18.60%), terpinolene (14.70%), and totarolone (7.35%), while 72 constituents were identified for wild plant essential oil with myrcenone (36.95%), limonene (13.62%), terpinolene (11.04%), and β-pinene (7.69%) as the major constituents. The antibacterial and the antimycotic activities of these oils were tested against six bacterial and fungal str...

Journal of Essential Oil Bearing Plants, 2005

Dracocephalum kotschyi is one of the medicinal and fragrant herbs that can be found in natural lo... more Dracocephalum kotschyi is one of the medicinal and fragrant herbs that can be found in natural locations of mountainous areas. In this investigation the hydrodistilled essential oils obtained from aerial parts of two populations of D. kotschyi collected from Siahbisheh and Baladeh were analysed by capillary GC-FID and GC-MS. Essential oil analysis led to the identification of 48 compounds that represented 85.9 and 90.0% of the total oil compositions, respectively. As the major group of compounds, oxygenated monoterpens comprised 45.5 and 57.4% in the essential oils of compounds as the main group in the essential oils of Siahbisheh and Baladeh samples, respectively. Disagreement in the major contents of the essential oils of these two samples may be ascribed to differences in the ecological, climatic and genetically factors.

Five new manoyloxide-type sesterterpenes were isolated from aerial parts of Salvia mirza... more Five new manoyloxide-type sesterterpenes were isolated from aerial parts of Salvia mirzayanii, a species endemic to Iran. The planar structures were established by means of 1D and 2D NMR and HRESIMS. Compounds 1–3 differed only in their configurations at C-13 and C-14. Assignment of relative and absolute configurations was achieved by NOESY experiments and by comparison of experimental and simulated ECD spectra of possible stereoisomers. The absolute configurations of 4 and 5 were established in a similar manner

Frontiers in Chemistry, 2021

Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. aﬀor... more Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. aﬀorded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+ NMR chemical shift probability calculation technique. Moreover, the absolute conﬁguration of compounds was determined by using electronic circular dichroism spectroscopy. Evaluation of antiproliferative properties of compounds isolated against four human melanoma cancer cells displayed no cytotoxic activity at the concentration range used.

After identification the samples were dried in the shadow at room temperature. Extraction Air dri... more After identification the samples were dried in the shadow at room temperature. Extraction Air dried material (250 g) was hydrodistilled for 3.5 hours using a Clevenger-type apparatus. The essential oils were dried over anhydrous Na 2 SO 4 and then were kept in vials at 5°C until analysis.

Dracocephalum kotschyi essential oils obtained by hydrodistillation (HD), microwave-assisted hydr... more Dracocephalum kotschyi essential oils obtained by hydrodistillation (HD), microwave-assisted hydrodistillation (MAHD), and solvent-free microwave extraction (SFME) were investigated by GC-FID (Gas Chromatography-Flame Ionization Detector) and GC-MS (Gas Chromatography-Mass Spectrometry). The percentage of oxygenated compounds was significantly increased from 62.52% in HD to 76.47% in MAHD, and 84.52% in SFME. Conversely, the monoterpene hydrocarbons were decreased from 30.84% in HD to 13.71% in MAHD, and 5.85% in SFME. The main compound in the essential oil obtained by HD is limonene, which accounted for more than 30% of the oil, while the percentage of this compound was reduced to 9.52% in MAHD, and 5.60% in SFME. The percents of other oxygenated compounds such as neral, geranial, geraniol, geranyl acetate, α-terpineol, trans-verbenol, carvon, and transcarveol were noticeably higher in microwave methods than those present in HD method. In aqueous medium, linear oxygenated monoterpenes may be converted to a monocyclic terpinyl cation, which it could lose a proton to give limonene. The main biosynthetic pathway of these compounds, as well as a possible route of their conversion into limonene, due to prolonged heating in the HD method, was proposed. The antimicrobial activity of D. kotschyi essential oils against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria was evaluated by broth microdilution susceptibility manner. The most sensitive bacteria to these oils was found to be S. aureus with the lowest minimum inhibitory concentration value of 2 mg mL −1 for MAHD and SFME specimens. The results indicated that oils obtained by microwave methods were more active against S. aureus.

Dracocephalum Kotschyi Boiss, is one of Dracocephalum species which has been used in traditional ... more Dracocephalum Kotschyi Boiss, is one of Dracocephalum species which has been used in traditional Iranian medicine with pharmacological and biological activities. The antioxidant properties and total flavonoid and phenolic contents of three different extracts of Dracocephalum Kotschyi Boiss were investigated. The antioxidant activity of the extracts was calculated using three different assay including DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing ability of plasma) and ABTS (2,2ʹ-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)). Among these extracts, the methanol extracts showed the highest radical scavenging activity 6.87±0.01 μmoL Trolox/g ferric reducing activity and the best activity in ABTS test (7.47±0.03 μmoL Trolox/g). The methanol extract of Dracocephalum Kotschyi showed also the highest total phenolic content 188.08±0.01 mg GAE/g, followed by ethyl acetate extract 95.58±0.01 mg GAE/g and also greatest total flavonoid content with 1037.00±0.01 mg quercetine e...

Records of Natural Products, 2018

Salvia macilenta Boiss. is a fragrant subshrub which grows wild in some regions of Iran. In this ... more Salvia macilenta Boiss. is a fragrant subshrub which grows wild in some regions of Iran. In this work, we contrasted essential oil contents and components of two wild populations under two different ecological situations (Kerman and Baluchistan Provinces, Center and South East of Iran, respectively). For the first time the antibacterial and the antimycotic properties of these essential oils were also evaluated against seven bacterial and fungal strains. The essential oils were isolated by hydrodistillation method and the chemical compositions of the samples were examined by GC and GC-MS. Kerman (K) specimen was found to be rich in α-pinene (29.0%), p-cymene (10.7%), veridiflorol (9.1%), α-eudesmol (8.7%), bornyl acetate (7.3%) with lesser concentrations of borneol (4.9%). Principal components were identified as α-eudesmol (35.6%), α-pinene (7.7%), bornyl acetate (7.6%), (E)-nerolidol (6.5%) and veridiflorol (5.9%) from Baluchistan (B) sample. Oxygenated sesquiterpenes were found to be the principal class of components in the oil of Baluchistan sample (53.0%) whereas monoterpene hydrocarbons were the main class in Kerman specimen (46.6%). The results demonstrated that the variety in the volatile compounds could be considered as chemotaxonomic importance and it may be ascribed to their different ecological and geographical source.

Current Bioactive Compounds, 2019

Background: It has been decades since natural biomaterials, including mushrooms, are examined for... more Background: It has been decades since natural biomaterials, including mushrooms, are examined for antioxidant capacity to put them in the place of the synthetic antioxidants causing cancer. Ganoderma lucidum Karst is an annual fungus reputed for possessing medicinal properties. The fungus has a high potential to be used as a dietary supplement or a source of nutrients and antioxidant agents. It has not been more than a decade since the scientists are working on the different medicinal properties of the endemic Ganoderma lucidum in Iran. This study was conducted, in order to complete a part of this goal and comparing the antioxidant potential of the endemic specimen from Iran with findings from other countries. The aim of this investigation was to test the antioxidant properties, total flavonoid and phenolic contents of various extracts of Ganoderma lucidum in the form of fruit bodies. Methods: Mushroom samples were extracted with chloroform, methanol and water by maceration method. ...

Journal of Natural Products, 2014

Five new manoyloxide-type sesterterpenes were isolated from aerial parts of Salvia mirzayanii, a ... more Five new manoyloxide-type sesterterpenes were isolated from aerial parts of Salvia mirzayanii, a species endemic to Iran. The planar structures were established by means of 1D and 2D NMR and HRESIMS. Compounds 1-3 differed only in their configurations at C-13 and C-14. Assignment of relative and absolute configurations was achieved by NOESY experiments and by comparison of experimental and simulated ECD spectra of possible stereoisomers. The absolute configurations of 4 and 5 were established in a similar manner.

Chemistry & Biodiversity, 2013

The hydrodistilled essential oils obtained from aerial flowering parts of Teucrium stocksianum ss... more The hydrodistilled essential oils obtained from aerial flowering parts of Teucrium stocksianum ssp. stocksianum (TSS) and T. stocksianum ssp. gabrielae (TSG) from Iran were analyzed by capillary GC and GC/MS. The oil analysis of two subspecies led to the identification of 65 compounds that accounted for 93.3 and 95.1% of the total oil compositions, respectively. Sesquiterpenoids (52.9%) constituted the main compounds in the essential oil of TSS represented mainly by cis-sesquisabinene hydrate (12.0%), followed by epi-b-bisabolol (6.6%), guaiol (5.4%), and b-eudesmol (4.4%), whilst monoterpenoids (61.2%) were found to be the major components of the oil of TSG, represented by a-pinene (23.0%), bpinene (13.0%), myrcene (6.3%), and sabinene (6.3%). The principal component in both subspecies, TSS and TSG, was a-pinene (22.0 and 23.0%, resp.) and b-pinene (6.5 and 13.0%, resp.). epi-a-Cadinol, myrcene, and sabinene, which were detected as principal compounds of TSG, were characterized in lower amounts (< 1.5%) in the oil of TSS. Seven components were identified in the oil of TSS corresponding to 25.9% of total oil, which were totally absent in the oil of TSG, of which cis-sesquisabinene hydrate (12.0%), guaiol (5.4%), and b-eudesmol (4.4%) were in considerable amounts. Taxonomic position of the subspecies is discussed on the basis of phytochemical data.

Current Bioactive Compounds

Background: Astragalus gossypinus Fisch. is one of Astragalus (Leguminosae) species which has bee... more Background: Astragalus gossypinus Fisch. is one of Astragalus (Leguminosae) species which has been used in traditional medicine with phenomenal pharmacological and biological activities. Objective: In this research, the mutagenicity, anti-mutagenicity, and antioxidant potential of two different extracts of root (chloroform and ethyl acetate) and chloroform extract of aerial parts of Astragalus gossypinus were investigated. Methods: Antioxidant property was expressed as the ability of each extract to scavenge the free radicals DPPH (2, 2-diphenyl-1-picrylhydrazyl) and mutagenicity and anti-mutagenicity were evaluated with the Ames test using Salmonella typhimurium strain TA100. Results: All extracts exhibited antioxidant capacity, but the ethyl acetate extract of the root (IC50 = 289.29 µg/mL) and after that the chloroform extract of the root (IC50 = 327.2 µg/mL) were the best. Probably a higher percentage of phenolic and flavonoid compounds in these extracts have caused these result...