Fouad Kettani - Academia.edu (original) (raw)
Papers by Fouad Kettani
Annales d'Urologie, 2003
Resume Les auteurs rapportent un cas de tumeur fibromyxoide pseudosarcomateuse de la prostate. Il... more Resume Les auteurs rapportent un cas de tumeur fibromyxoide pseudosarcomateuse de la prostate. Il s'agit d'une lesion toujours benigne dont les principaux diagnostics differentiels sont les sarcomes de prostate. Le diagnostic repose sur l'etude anatomopathologique. Le traitement est chirurgical.
Objective: Accurate mutation detection assays for KRAS and BRAF genes in colorectal cancer are st... more Objective: Accurate mutation detection assays for KRAS and BRAF genes in colorectal cancer are strongly needed. We describe a simple and reliable technique for determination of KRAS and BRAF mutational status, and we estimate the KRAS and BRAF mutations frequency in Moroccan patients with colorectal cancer. Methods: Forty-seven samples from patients with metastasic colorectal adenocarcinomas were studied for BRAF exon 15 and KRAS codons 12 and 13 mutations. Tumor tissue was removed by manual macrodissection from formalin-fixed paraffin-embedded tissues specimens. After DNA extraction, conventional PCR was performed and the DNA was analyzed by direct sequencing. Results: KRAS codon 12 or 13 mutations were present in 51% of patients. Gly12Val mutation was present in 21% of all patients, Gly12Asp in 15%, Gly13Asp in 6%, Gly12Arg in 4%, Gly12Cys in 2% and Gly12Ala in 2%. No BRAF mutation was detected. Conclusion: Our data suggest that KRAS mutations are more frequent than BRAF mutations...
Resume Objectifs. – Les tumeurs phyllodes du sein (TPS) sont des tumeurs fibro-epitheliales rares... more Resume Objectifs. – Les tumeurs phyllodes du sein (TPS) sont des tumeurs fibro-epitheliales rares. Elles sont un sujet de controverse, concernant notamment terminologie, classification histologique et traitement. Le but de notre travail est de souligner a travers une etude retrospective et a la lumiere des donnees de la litterature les particularites epidemiologiques, cliniques, histologiques, therapeutiques, pronostiques et evolutives de ces tumeurs. Patients et methodes. – A l'Institut national d'oncologie de Rabat au Maroc entre 1985 et 1998 nous avons revu tous les dossiers de patients porteurs de TPS certifiees histologiquement. Ont ete exclus tous les dossiers de diagnostic histologique douteux de tumeur phyllode. Une fiche d'exploitation a permis de relever les caracteristiques epidemiologiques, cliniques, histologiques, therapeutiques, pronostiques et evolutives de ces tumeurs. Statistiques : les variables quantitatives sont exprimees sous forme de moyenne ± DS, ...
Tumori Journal
Background: Mutations in the epidermal growth factor receptor ( EGFR) gene are commonly observed ... more Background: Mutations in the epidermal growth factor receptor ( EGFR) gene are commonly observed in non-small cell lung cancer (NSCLC), particularly in adenocarcinoma histology. The frequency of EGFR mutations is ethnicity-dependent, with a higher proportion reported in Asian populations than Caucasian populations. There is a lack of data on these mutations in north Africa. Methods: Tumor specimens from Moroccan patients with NSCLC were collected from five pathology laboratories between November 2010 and December 2017 to determine frequency and types of EGFR mutations. Tumors were tested in a reference center for EGFR by polymerase chain reaction and sequencing of exons 18, 19, 20, and 21. Results: A total of 334 patients were enrolled: 242 (72.5%) males and 92 females (27.5%). A total of 56.9% had a history of smoking. EGFR testing of the 334 lung adenocarcinoma samples demonstrated a wild-type EGFR in 261 (78.1%) and mutated EGFR in 73 (21.9%). Mutations were mainly detected in th...
BMC Cancer
Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ... more Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. Methods: A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC). Results: The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients. Conclusions: The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients' numbers are needed to verify these findings.
Pan African Medical Journal, Apr 24, 2013
Journal of Medical Case Reports, 2016
Sebaceous carcinoma is a rare malignancy primarily with aggressive growth affecting the cutaneous... more Sebaceous carcinoma is a rare malignancy primarily with aggressive growth affecting the cutaneous tissues of the periocular region. Sebaceous carcinoma of the parotid gland is exceedingly rare, with only 32 cases reported in the literature. Our case brings this total to 33. We present a case of a 57-year-old Moroccan woman with a firm, painless, slowly enlarging swelling at her left parotid area, with normal overlying skin and no palpable neck nodes. Parotidectomy with facial nerve preservation was performed, and microscopic examination showed sebaceous carcinoma. Then, she underwent adjuvant radiotherapy. With a follow up of 20 months, head and neck computed tomography revealed no recurrence. The optimal treatment is unclear. With more cases reported, clinicopathological characteristics and histogenesis are increasingly understood. Therefore the treatment for this rare tumor continues to evolve.
Mammary sarcomas are uncommon tumors. Of these pure chondrosarcoma without any other area of epit... more Mammary sarcomas are uncommon tumors. Of these pure chondrosarcoma without any other area of epithelial or mesenchymal differentiation feature as even rarer. This excludes tumors like malignant cystosarcoma phyllodes and metaplastic carcinoma where malignant cartilaginous areas may be present. Further primary chondrosarcoma arises from breast stroma and not from underlying bone or cartilage. Only five cases of pure and primary chondrosarcoma have been reported so far. The sixth case is reported here.
The Pan African medical journal, 2015
Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignan... more Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignant ovarian tumor with hepatic differentiation and production of α-fetoprotein (AFP). We describe a 78-year-old Moroccan woman who presented to our hospital with abdominal distension and purplish nodules infiltrating the para umbilical skin with weight loss and impairment of her performance status. Excisional biopsy of the para umbilical nodule revealed a cutaneous localization of moderately differentiated adenocarcinoma and pelvic ultrasonography noted the presence of a tumoral right adnexal mass. The patient underwent an exploratory laparoscopy which found peritoneal carcinomatosis with pelvic adhesions allowing only a peritoneal biopsy. Diagnosis of primary hepatoid carcinoma of the ovary was established on the basis of classic histopathologic findings, immunohistochemical staining and marked elevation in serum of α-fetoprotein more than the carbohydrate antigen 125. The patient receive...
World Journal of Surgical Oncology, 2015
Intussusception in adults is a rare cause of abdominal pain that is often associated with organic... more Intussusception in adults is a rare cause of abdominal pain that is often associated with organic pathology. We describe a case of ileocolic intussusception revealing a cecal adenocarcinoma in a young woman successfully managed by laparoscopic-assisted surgery adhering to oncological principles. A 30-year-old woman with a family history of colon adenocarcinoma in a young brother presented to our emergency department with a 2-month history of intermittent colicky abdominal pain accompanied by nausea and vomiting. Physical examination showed a palpable mass in the right lower quadrant of the abdomen. Computed tomography showed a 3-layered structure giving the characteristic target-shaped appearance in the ascending colon, highly suggestive for an ileocolic intussusception associated with right colic parietal thickening and an adjacent lymphadenopathy. Patient was planned for laparoscopic exploration and eventually definitive surgery. Intra-operatively, we found an ileocolic intussusception with thickening of the colic wall and slight proximal intestinal dilation. Multiple lymphadenopathies along the ileocecal artery were observed. Laparoscopic right hemicolectomy was performed following strict oncologic principles with "en bloc resection" and lymphadenectomy given the risk of an underlying malignancy. Considering this risk, previous reduction of the invaginated segments was not attempted and primary extracorporeal anastomosis was performed using manual sutures. Macroscopic examination of the resected specimen revealed a tumor mass of the caecal wall .The histological analysis identified a moderately differentiated tubular adenocarcinoma invading the serosa (T3) without permeation of the lymphatic or venous capillaries. No lymphatic metastasis of 28 nodes removed was seen. Postoperative course was uneventful and patient was discharged 5 days after surgery. Postoperative chest, abdomen, and pelvis CT scan were normal. Therefore, tumor is classified as stage II A (T3N0 M0).There was loss of MLH2 and MSH6 protein expression on immunohistochemistry findings reflecting a microsatellite instability phenotype, and the patient was followed up without adjuvant chemotherapy. Ileocolic intussusception rarely revealed a cancer in young adults. Laparoscopic surgery has a special interest in the diagnosis and treatment in this pathology. Oncogenetic consultation should be required in malignant lesion.
Clinics and research in hepatology and gastroenterology, 2011
Santé (Montrouge, France)
Gastrointestinal stromal tumours (GIST) are the most frequent mesenchymatous tumours of the diges... more Gastrointestinal stromal tumours (GIST) are the most frequent mesenchymatous tumours of the digestive tract. Options for diagnosis and treatment have developed rapidly in recent years. The authors report five cases of GIST. The study concerns 5 patients: 3 men and 2 women, with a mean age at diagnosis of 39.8 years. We describe the circumstances of discovery and the clinical and morphological characteristics of these tumours. They were located in the oesophagus (1 case), stomach (2 cases), small intestine (1 case) and mesentery (1 case). Tumour size ranged from 4-20 cm. Liver metastasis was identified at initial diagnosis for one patient. Immunohistochemical analysis identified expression of CD34, CD117 and S-100 proteins in all cases and smooth muscle actin in 2 cases. All the patients underwent surgical resection for GIST, and one received chemotherapy. No patient received imatinib treatment. After a mean follow-up of 40 months: one patient presented peritoneal carcinosis at one y...
Revue Française des Laboratoires, 2005
Revue du Rhumatisme, 2006
Veillonella spp. est retardée (quatre à cinq jours), ce qui peut retarder le diagnostic, a fortio... more Veillonella spp. est retardée (quatre à cinq jours), ce qui peut retarder le diagnostic, a fortiori quand la symptomatologie clinique initiale n'est pas parlante. L'isolement de Veillonella spp. en culture pure témoigne de sa pathogénicité.
Pan African Medical Journal, 2014
Les métastases du cuir chevelu et surrénaliennes d'un carcinome urothélial de la vessie sont rare... more Les métastases du cuir chevelu et surrénaliennes d'un carcinome urothélial de la vessie sont rares, peu de cas ont été rapportés dans la littérature, et la chimiothérapie est le traitement de choix. Nous rapportons le cas d'une femme de 60 ans qui présente un carcinome urothélial stade IV avec métastases surrénaliennes, pulmonaire et osseuses (cotes et scapula). Deux lignes de chimiothérapies ont été instaurées et la patiente bénéficia d'une radiothérapie palliative antalgique sur la scapula. Après la première ligne de chimiothérapie, une masse du cuir chevelu augmentant progressivement de volume apparue, une biopsie fut faite et le diagnostic de métastase d'un carcinome urothélial de la vessie fut confirmé par l'histologie.
ISRN Oncology, 2014
Background. In lung adenocarcinoma, the frequency of KRAS mutations is ethnicity dependent with a... more Background. In lung adenocarcinoma, the frequency of KRAS mutations is ethnicity dependent with a higher proportion in African Americans and white Caucasians than in Asians. The prevalence of these mutations among North Africans patients is unknown. The objective of this study was to report the frequency and spectrum of KRAS mutations in a group of Moroccan lung adenocarcinoma patients. Methods. Tumor specimens from 117 Moroccan patients with lung adenocarcinoma were selected to determine frequency and spectrum of KRAS mutations. KRAS mutations in codons 12 and 13 of exon 2 were analyzed using conventional DNA sequencing. Results. The overall frequency of the KRAS mutations was 9% (11/117). In the population with KRAS mutations, there was a trend towards more male ( = 0.06) and more smokers ( = 0.08) compared to patients with wild type KRAS. KRAS mutations were located at codon 12 in 10 out of 11 patients (91%). The G12C mutation was the most frequent KRAS mutation (73%). Conclusion. This is the first study to date examining the frequency and spectrum of KRAS mutations in lung adenocarcinomas in North African and Arab populations. KRAS mutation frequency in Moroccan patients was comparable with the frequency observed in East-Asian population. KRAS mutations are more likely observed in males and smokers and to be transversions. Further studies, in larger numbers of patients, are needed to confirm these findings.
Journal of Translational Internal Medicine, 2014
Pan African Medical Journal, 2013
Le pseudomyxome péritonéal est défini par la présence de mucine extra-cellulaire dans la cavité p... more Le pseudomyxome péritonéal est défini par la présence de mucine extra-cellulaire dans la cavité péritonéale. Il est dû dans la majorité des cas à la rupture intrapéritonéale d'une tumeur mucineuse d'origine appendiculaire avec extension secondaire ovarienne. Nous rapportons le cas d'une patiente opérée pour tumeur ovarienne droite et dont l'étude histologique était en faveur d'un pseudomyxome péritonéal sur tératome ovarien associé à une tumeur mucineuse bordeline.
Urologia Internationalis, 2002
A case of primary renal lymphoma (PRL) in a 78-year-old man is reported. The tumor was found by c... more A case of primary renal lymphoma (PRL) in a 78-year-old man is reported. The tumor was found by computed tomography during a check-up for hematuria and weight loss. Histologic and immunohistochemical analyses of this tumor revealed features typical of low-grade lymphoma with localized amyloid deposition. PRL is a rare disease and only a few cases have been reported previously. To our knowledge, there have been no other reports of PRL with localized amyloid deposition.
Annales d'Urologie, 2003
Resume Les auteurs rapportent un cas de tumeur fibromyxoide pseudosarcomateuse de la prostate. Il... more Resume Les auteurs rapportent un cas de tumeur fibromyxoide pseudosarcomateuse de la prostate. Il s'agit d'une lesion toujours benigne dont les principaux diagnostics differentiels sont les sarcomes de prostate. Le diagnostic repose sur l'etude anatomopathologique. Le traitement est chirurgical.
Objective: Accurate mutation detection assays for KRAS and BRAF genes in colorectal cancer are st... more Objective: Accurate mutation detection assays for KRAS and BRAF genes in colorectal cancer are strongly needed. We describe a simple and reliable technique for determination of KRAS and BRAF mutational status, and we estimate the KRAS and BRAF mutations frequency in Moroccan patients with colorectal cancer. Methods: Forty-seven samples from patients with metastasic colorectal adenocarcinomas were studied for BRAF exon 15 and KRAS codons 12 and 13 mutations. Tumor tissue was removed by manual macrodissection from formalin-fixed paraffin-embedded tissues specimens. After DNA extraction, conventional PCR was performed and the DNA was analyzed by direct sequencing. Results: KRAS codon 12 or 13 mutations were present in 51% of patients. Gly12Val mutation was present in 21% of all patients, Gly12Asp in 15%, Gly13Asp in 6%, Gly12Arg in 4%, Gly12Cys in 2% and Gly12Ala in 2%. No BRAF mutation was detected. Conclusion: Our data suggest that KRAS mutations are more frequent than BRAF mutations...
Resume Objectifs. – Les tumeurs phyllodes du sein (TPS) sont des tumeurs fibro-epitheliales rares... more Resume Objectifs. – Les tumeurs phyllodes du sein (TPS) sont des tumeurs fibro-epitheliales rares. Elles sont un sujet de controverse, concernant notamment terminologie, classification histologique et traitement. Le but de notre travail est de souligner a travers une etude retrospective et a la lumiere des donnees de la litterature les particularites epidemiologiques, cliniques, histologiques, therapeutiques, pronostiques et evolutives de ces tumeurs. Patients et methodes. – A l'Institut national d'oncologie de Rabat au Maroc entre 1985 et 1998 nous avons revu tous les dossiers de patients porteurs de TPS certifiees histologiquement. Ont ete exclus tous les dossiers de diagnostic histologique douteux de tumeur phyllode. Une fiche d'exploitation a permis de relever les caracteristiques epidemiologiques, cliniques, histologiques, therapeutiques, pronostiques et evolutives de ces tumeurs. Statistiques : les variables quantitatives sont exprimees sous forme de moyenne ± DS, ...
Tumori Journal
Background: Mutations in the epidermal growth factor receptor ( EGFR) gene are commonly observed ... more Background: Mutations in the epidermal growth factor receptor ( EGFR) gene are commonly observed in non-small cell lung cancer (NSCLC), particularly in adenocarcinoma histology. The frequency of EGFR mutations is ethnicity-dependent, with a higher proportion reported in Asian populations than Caucasian populations. There is a lack of data on these mutations in north Africa. Methods: Tumor specimens from Moroccan patients with NSCLC were collected from five pathology laboratories between November 2010 and December 2017 to determine frequency and types of EGFR mutations. Tumors were tested in a reference center for EGFR by polymerase chain reaction and sequencing of exons 18, 19, 20, and 21. Results: A total of 334 patients were enrolled: 242 (72.5%) males and 92 females (27.5%). A total of 56.9% had a history of smoking. EGFR testing of the 334 lung adenocarcinoma samples demonstrated a wild-type EGFR in 261 (78.1%) and mutated EGFR in 73 (21.9%). Mutations were mainly detected in th...
BMC Cancer
Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ... more Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. Methods: A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC). Results: The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients. Conclusions: The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients' numbers are needed to verify these findings.
Pan African Medical Journal, Apr 24, 2013
Journal of Medical Case Reports, 2016
Sebaceous carcinoma is a rare malignancy primarily with aggressive growth affecting the cutaneous... more Sebaceous carcinoma is a rare malignancy primarily with aggressive growth affecting the cutaneous tissues of the periocular region. Sebaceous carcinoma of the parotid gland is exceedingly rare, with only 32 cases reported in the literature. Our case brings this total to 33. We present a case of a 57-year-old Moroccan woman with a firm, painless, slowly enlarging swelling at her left parotid area, with normal overlying skin and no palpable neck nodes. Parotidectomy with facial nerve preservation was performed, and microscopic examination showed sebaceous carcinoma. Then, she underwent adjuvant radiotherapy. With a follow up of 20 months, head and neck computed tomography revealed no recurrence. The optimal treatment is unclear. With more cases reported, clinicopathological characteristics and histogenesis are increasingly understood. Therefore the treatment for this rare tumor continues to evolve.
Mammary sarcomas are uncommon tumors. Of these pure chondrosarcoma without any other area of epit... more Mammary sarcomas are uncommon tumors. Of these pure chondrosarcoma without any other area of epithelial or mesenchymal differentiation feature as even rarer. This excludes tumors like malignant cystosarcoma phyllodes and metaplastic carcinoma where malignant cartilaginous areas may be present. Further primary chondrosarcoma arises from breast stroma and not from underlying bone or cartilage. Only five cases of pure and primary chondrosarcoma have been reported so far. The sixth case is reported here.
The Pan African medical journal, 2015
Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignan... more Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignant ovarian tumor with hepatic differentiation and production of α-fetoprotein (AFP). We describe a 78-year-old Moroccan woman who presented to our hospital with abdominal distension and purplish nodules infiltrating the para umbilical skin with weight loss and impairment of her performance status. Excisional biopsy of the para umbilical nodule revealed a cutaneous localization of moderately differentiated adenocarcinoma and pelvic ultrasonography noted the presence of a tumoral right adnexal mass. The patient underwent an exploratory laparoscopy which found peritoneal carcinomatosis with pelvic adhesions allowing only a peritoneal biopsy. Diagnosis of primary hepatoid carcinoma of the ovary was established on the basis of classic histopathologic findings, immunohistochemical staining and marked elevation in serum of α-fetoprotein more than the carbohydrate antigen 125. The patient receive...
World Journal of Surgical Oncology, 2015
Intussusception in adults is a rare cause of abdominal pain that is often associated with organic... more Intussusception in adults is a rare cause of abdominal pain that is often associated with organic pathology. We describe a case of ileocolic intussusception revealing a cecal adenocarcinoma in a young woman successfully managed by laparoscopic-assisted surgery adhering to oncological principles. A 30-year-old woman with a family history of colon adenocarcinoma in a young brother presented to our emergency department with a 2-month history of intermittent colicky abdominal pain accompanied by nausea and vomiting. Physical examination showed a palpable mass in the right lower quadrant of the abdomen. Computed tomography showed a 3-layered structure giving the characteristic target-shaped appearance in the ascending colon, highly suggestive for an ileocolic intussusception associated with right colic parietal thickening and an adjacent lymphadenopathy. Patient was planned for laparoscopic exploration and eventually definitive surgery. Intra-operatively, we found an ileocolic intussusception with thickening of the colic wall and slight proximal intestinal dilation. Multiple lymphadenopathies along the ileocecal artery were observed. Laparoscopic right hemicolectomy was performed following strict oncologic principles with "en bloc resection" and lymphadenectomy given the risk of an underlying malignancy. Considering this risk, previous reduction of the invaginated segments was not attempted and primary extracorporeal anastomosis was performed using manual sutures. Macroscopic examination of the resected specimen revealed a tumor mass of the caecal wall .The histological analysis identified a moderately differentiated tubular adenocarcinoma invading the serosa (T3) without permeation of the lymphatic or venous capillaries. No lymphatic metastasis of 28 nodes removed was seen. Postoperative course was uneventful and patient was discharged 5 days after surgery. Postoperative chest, abdomen, and pelvis CT scan were normal. Therefore, tumor is classified as stage II A (T3N0 M0).There was loss of MLH2 and MSH6 protein expression on immunohistochemistry findings reflecting a microsatellite instability phenotype, and the patient was followed up without adjuvant chemotherapy. Ileocolic intussusception rarely revealed a cancer in young adults. Laparoscopic surgery has a special interest in the diagnosis and treatment in this pathology. Oncogenetic consultation should be required in malignant lesion.
Clinics and research in hepatology and gastroenterology, 2011
Santé (Montrouge, France)
Gastrointestinal stromal tumours (GIST) are the most frequent mesenchymatous tumours of the diges... more Gastrointestinal stromal tumours (GIST) are the most frequent mesenchymatous tumours of the digestive tract. Options for diagnosis and treatment have developed rapidly in recent years. The authors report five cases of GIST. The study concerns 5 patients: 3 men and 2 women, with a mean age at diagnosis of 39.8 years. We describe the circumstances of discovery and the clinical and morphological characteristics of these tumours. They were located in the oesophagus (1 case), stomach (2 cases), small intestine (1 case) and mesentery (1 case). Tumour size ranged from 4-20 cm. Liver metastasis was identified at initial diagnosis for one patient. Immunohistochemical analysis identified expression of CD34, CD117 and S-100 proteins in all cases and smooth muscle actin in 2 cases. All the patients underwent surgical resection for GIST, and one received chemotherapy. No patient received imatinib treatment. After a mean follow-up of 40 months: one patient presented peritoneal carcinosis at one y...
Revue Française des Laboratoires, 2005
Revue du Rhumatisme, 2006
Veillonella spp. est retardée (quatre à cinq jours), ce qui peut retarder le diagnostic, a fortio... more Veillonella spp. est retardée (quatre à cinq jours), ce qui peut retarder le diagnostic, a fortiori quand la symptomatologie clinique initiale n'est pas parlante. L'isolement de Veillonella spp. en culture pure témoigne de sa pathogénicité.
Pan African Medical Journal, 2014
Les métastases du cuir chevelu et surrénaliennes d'un carcinome urothélial de la vessie sont rare... more Les métastases du cuir chevelu et surrénaliennes d'un carcinome urothélial de la vessie sont rares, peu de cas ont été rapportés dans la littérature, et la chimiothérapie est le traitement de choix. Nous rapportons le cas d'une femme de 60 ans qui présente un carcinome urothélial stade IV avec métastases surrénaliennes, pulmonaire et osseuses (cotes et scapula). Deux lignes de chimiothérapies ont été instaurées et la patiente bénéficia d'une radiothérapie palliative antalgique sur la scapula. Après la première ligne de chimiothérapie, une masse du cuir chevelu augmentant progressivement de volume apparue, une biopsie fut faite et le diagnostic de métastase d'un carcinome urothélial de la vessie fut confirmé par l'histologie.
ISRN Oncology, 2014
Background. In lung adenocarcinoma, the frequency of KRAS mutations is ethnicity dependent with a... more Background. In lung adenocarcinoma, the frequency of KRAS mutations is ethnicity dependent with a higher proportion in African Americans and white Caucasians than in Asians. The prevalence of these mutations among North Africans patients is unknown. The objective of this study was to report the frequency and spectrum of KRAS mutations in a group of Moroccan lung adenocarcinoma patients. Methods. Tumor specimens from 117 Moroccan patients with lung adenocarcinoma were selected to determine frequency and spectrum of KRAS mutations. KRAS mutations in codons 12 and 13 of exon 2 were analyzed using conventional DNA sequencing. Results. The overall frequency of the KRAS mutations was 9% (11/117). In the population with KRAS mutations, there was a trend towards more male ( = 0.06) and more smokers ( = 0.08) compared to patients with wild type KRAS. KRAS mutations were located at codon 12 in 10 out of 11 patients (91%). The G12C mutation was the most frequent KRAS mutation (73%). Conclusion. This is the first study to date examining the frequency and spectrum of KRAS mutations in lung adenocarcinomas in North African and Arab populations. KRAS mutation frequency in Moroccan patients was comparable with the frequency observed in East-Asian population. KRAS mutations are more likely observed in males and smokers and to be transversions. Further studies, in larger numbers of patients, are needed to confirm these findings.
Journal of Translational Internal Medicine, 2014
Pan African Medical Journal, 2013
Le pseudomyxome péritonéal est défini par la présence de mucine extra-cellulaire dans la cavité p... more Le pseudomyxome péritonéal est défini par la présence de mucine extra-cellulaire dans la cavité péritonéale. Il est dû dans la majorité des cas à la rupture intrapéritonéale d'une tumeur mucineuse d'origine appendiculaire avec extension secondaire ovarienne. Nous rapportons le cas d'une patiente opérée pour tumeur ovarienne droite et dont l'étude histologique était en faveur d'un pseudomyxome péritonéal sur tératome ovarien associé à une tumeur mucineuse bordeline.
Urologia Internationalis, 2002
A case of primary renal lymphoma (PRL) in a 78-year-old man is reported. The tumor was found by c... more A case of primary renal lymphoma (PRL) in a 78-year-old man is reported. The tumor was found by computed tomography during a check-up for hematuria and weight loss. Histologic and immunohistochemical analyses of this tumor revealed features typical of low-grade lymphoma with localized amyloid deposition. PRL is a rare disease and only a few cases have been reported previously. To our knowledge, there have been no other reports of PRL with localized amyloid deposition.