Frédéric Rodesch - Academia.edu (original) (raw)
Papers by Frédéric Rodesch
Acta Chirurgica Belgica, 2001
A 36 year old woman who ruptured a basilar artery aneurysm at 38 weeks gestation in her second pr... more A 36 year old woman who ruptured a basilar artery aneurysm at 38 weeks gestation in her second pregnancy was managed successfully by endovascular embolisation 36 hours after an emergency Caesarean section. The timing of treatment along with the obstetric, neurosurgical and anaesthetic aspects of this complex problem are discussed along with a review of the current literature on the subject.
Feuillets De Radiologie, 1998
The evaluation of fetal growth and well being requires a detailed and complex analysis of the fet... more The evaluation of fetal growth and well being requires a detailed and complex analysis of the fetus. It should be more or less extensive as requested by clinical data. The report must include measurements, morphological data, analysis of fetal behaviour and if necessary conclusions drawn of the analysis of the foeto maternal circulation. The interest of doppler in obstetric is its ability to study the maternal, the fetal and the feto-placenta circulation. US brings morphological data, doppler functional ones.
We have measured the levels of alpha-feto protein in 127 samples of amniotic fluid, obtained in t... more We have measured the levels of alpha-feto protein in 127 samples of amniotic fluid, obtained in the course of antenata diagnosis, using the immunoelectrophoretic method of Laurell. The mean, the upper limit of normal and the extreme levels of alpha-feto protein in liquor have been calculated for each gestational age. The difficulties which have been met with in interpreting the results (false positives and false negatives) have been discussed.
Journal of Ultrasound in Medicine, 1984
Molecular and Cellular Endocrinology, 1976
The présent work suggests that in dog thyroid tissue Ca^^is distributed af least in two com partm... more The présent work suggests that in dog thyroid tissue Ca^^is distributed af least in two com partments (A) and (B). Compartment (A) could be the extracellular space, and extracellular binding sites for Ca^*. The uptake of Ca^* in this compartment is increased and the release is decreased at 0°C. The release is not influenced by the ionophore A23187 or by metabolic in hibitors (NaF, iodoacetate, dinitrophenol) or by thyrotropin (TSH). Compartment (B) is de fined functionally as a slowly exchangeable store of Ca^*. Uptake and release from this com partment are température dépendent. The release is accelerated by A23187 and by antimycin A, this suggests an intracellular, presumably mitochondrial, location. TSH stimulâtes the efflux of Ca^* originating from the cellular compartment (B). Our data are compatible with the hypothesis that, as in other tissues, the translocations of stored intracellular calcium may be a crucial step in the activation of the thyroid cell. Kcywords : thyroid; calcium; movement. The rôle of calcium is clearly demonstrated in a variety of biological phenomena (Rasmussen, 1970). Calcium is involved in the excitation-contraction coupling mechanism of muscle (Hasselbach, 1964; Ebashi and Endo, 1969), in the stimulussecretion coupling of exocrine (Heisler et al., 1972; Case and Clausen, 1973) and endocrine glands (Douglas, 1968; Malaisse et al., 1971) and in many membrane phenoinena such as cellular adhesiveness (Coman, 1953; Rappaport, 1956). The concentration of Ca^* is around 1 X 10"^ M in the extracellular space and around 1 X 10"* M in the cytoplasm. To maintain such a gradient, cells extrude Ca^* actively (Wallach et al., 1966; Borle, 1968), the influx being passive. In muscle and other cells Ca^'^ is accumulated by an active process and sequestered in cell organelles (Borle, 1967) such as endoplasmic reticulum (Hasselbach, 1964; Martonosi and Feretos, 1964) and mitochondria (Borle, 1972).
Comptes rendus des séances de la Société de biologie et de ses filiales, 1964
The Journal of reproductive medicine, 1997
Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relati... more Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation-induction agents. We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.
The Journal of reproductive medicine, 1997
The early development of complications in twin-twin transfusion syndrome is a poor prognostic sig... more The early development of complications in twin-twin transfusion syndrome is a poor prognostic sign. For this reason, new techniques for intrauterine therapy are being developed: invasive options, such as selective feticide of one of the twins, have been reported. Two cases of twin-twin transfusion syndrome in the late second trimester were treated by selective feticide using vascular embolization to the more severely damaged fetus. In one case the embolized fetus was a hydropic recipient with a normal cotwin; in the other, the donor fetus was affected by bilateral hydrocephalus. These fetuses underwent ultrasound-guided embolization using a bolus of histoacryl injected into the umbilical vein and fetal heart. Both patients went on to deliver healthy singletons in the third trimester. In twin-twin transfusion syndrome of early onset, embolization may help one of the twins survive. This technique is neither time-consuming nor expensive and does not require a general anesthetic.
Acta paediatrica Belgica
Journal Articleinfo:eu-repo/semantics/publishe
Revue médicale de Bruxelles, 1984
Since the very start of using ultrasound to monitor pregnancy the information that the obstetrici... more Since the very start of using ultrasound to monitor pregnancy the information that the obstetrician has obtained from it has been great. Measuring the fetus (biparietal diameters, rump-crown length etc.) makes it possible to check development of the fetus in the uterus, as well as seeing the various organs and their placing and internal structure. Real time pictures make it possible to visualise the organs precisely from the point of view of their positioning and their internal structures. We report 12 cases of malformations of the central nervous system which were diagnosed in utero and we point out the value of early diagnosis in pregnancy. The 12 cases we found included four of hydrocephaly, one cyst of the choroid plexus, one hydrencephaly , two cases of holoprocencephaly and four cases of anencephaly. Since these malformations may be part of generalised malformations it is important to search for these others by ultrasound as well as by caryotyping and estimation of alpha-fetoprotein levels.
Progress in clinical and biological research, 1982
Case ReportsJournal Articleinfo:eu-repo/semantics/publishe
Archives internationales de physiologie et de biochimie, 1969
Revue médicale de Bruxelles, 1985
Revue médicale de Bruxelles, 1987
Reflexion sur la detection directe de lesions genetiques, le diagnostic d'une maladie genetiq... more Reflexion sur la detection directe de lesions genetiques, le diagnostic d'une maladie genetique dont le gene est inconnu et sur l'utilisation des polymorphismes de taille des fragments de restriction
Obstetrics and gynecology, 1988
The pathologic findings in placentas from ten multiple gestations complicated by the so-called va... more The pathologic findings in placentas from ten multiple gestations complicated by the so-called vanishing twin phenomenon were studied to confirm the ultrasonographic evidence. Five pregnancies resulted from in vitro fertilization and embryo transfer, and five conceptions were spontaneous. The pregnancies were studied by repeat ultrasound examinations between five and 12 weeks' gestation. First-trimester bleeding was the only clinical sign of this phenomenon. Postpartum evidence of the vanishing twin phenomenon was found in five cases. Morphologically, the lesions were characterized by well-delineated plaques of perivillous fibrin deposition, associated in one case with embryonic remnants. This focal degenerative change of the placental mass, which also exists in about 25% of placentas from uncomplicated term pregnancies, may be the only clue to the disappearance of one conceptus.
Obstetrics and gynecology, 1989
Percutaneous umbilical blood sampling (cordocentesis) appears to be a valuable new procedure for ... more Percutaneous umbilical blood sampling (cordocentesis) appears to be a valuable new procedure for prenatal diagnosis. In order to evaluate whether focal injury of the umbilical vessels caused by the needle puncture is potentially harmful, we completely examined 50 umbilical cords collected between 1 hour and 20 weeks after cordocentesis. Macroscopic evidence of the needle entry was found in 37 cases, including one giant hematoma of the cord. Within 48 hours after the procedure, microscopic examination of transverse sections taken at the puncture site revealed distinct perforation of the vessel wall, associated in four cases with a small hematoma encircling the vessel. One week after cordocentesis, the vessel wall was partially reformed. There were no histologic differences between needle entry in a vein or in an artery. No thromboses of the umbilical vessels were found.
Pédiatrie, 1990
Ultrasonography of the neck in a 28 week-old fetus suggested the presence of a goiter. Since sono... more Ultrasonography of the neck in a 28 week-old fetus suggested the presence of a goiter. Since sonographic evaluation of epiphyseal ossification centers showed no delayed bone maturation, the fetus was considered to have an euthyroid goiter, that allowed amniocentesis to be performed. The fetus was sonographically followed from 32 to 36 weeks: the development was normal. At birth, hormonal tests confirmed an euthyroid goiter. The authors consider that bone maturation should be monitored in utero especially when a thyroid dysfunction is suspected, in order to detect severe disease and to prompt treatment.
Revue médicale de Bruxelles, 1992
Our institution admitted 39 ELBW (less than 1 kg) between November 1978 and December 1990. In our... more Our institution admitted 39 ELBW (less than 1 kg) between November 1978 and December 1990. In our center, mortality has decreased from 61% to 33% within a decade. Improvements in neonatal intensive care have lowered the limit for these possible survival to 26 weeks of gestational age and 700g of birthweight. Morbidity is still very high. The mean hospital stay is 96 days. Perinatal asphyxia is frequent (3/4) as well as infections, nutritional problems and renal failure. Sixty-six % of this population suffer from respiratory distress syndrome which is the main cause of death. Morbidity and mortality are explained and compared to the recent literature.
Prenatal Diagnosis, 1985
Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;... more Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;p12), inv(18)(p11q11). The pregnancy was complicated by severe oligohydramnios. The fetal karyotype was unbalanced: 46XX, der(4), t(4;20)(p16;p12), inv(18) (p11q11)pat., thus resulting in partial trisomy 2Op and monosomy 4p. In addition, the amniotic fluid alpha‐fetoprotein (AFP) became increasingly elevated with gestational age. The pregnancy was terminated at 25 weeks. The fetus presented with typical facial dysmorphic features, unilateral cleft lip and palate, severe renal hypoplasia, consistent with the 4p‐ (Wolf‐Hirschhorn) syndrome.
Acta Chirurgica Belgica, 2001
A 36 year old woman who ruptured a basilar artery aneurysm at 38 weeks gestation in her second pr... more A 36 year old woman who ruptured a basilar artery aneurysm at 38 weeks gestation in her second pregnancy was managed successfully by endovascular embolisation 36 hours after an emergency Caesarean section. The timing of treatment along with the obstetric, neurosurgical and anaesthetic aspects of this complex problem are discussed along with a review of the current literature on the subject.
Feuillets De Radiologie, 1998
The evaluation of fetal growth and well being requires a detailed and complex analysis of the fet... more The evaluation of fetal growth and well being requires a detailed and complex analysis of the fetus. It should be more or less extensive as requested by clinical data. The report must include measurements, morphological data, analysis of fetal behaviour and if necessary conclusions drawn of the analysis of the foeto maternal circulation. The interest of doppler in obstetric is its ability to study the maternal, the fetal and the feto-placenta circulation. US brings morphological data, doppler functional ones.
We have measured the levels of alpha-feto protein in 127 samples of amniotic fluid, obtained in t... more We have measured the levels of alpha-feto protein in 127 samples of amniotic fluid, obtained in the course of antenata diagnosis, using the immunoelectrophoretic method of Laurell. The mean, the upper limit of normal and the extreme levels of alpha-feto protein in liquor have been calculated for each gestational age. The difficulties which have been met with in interpreting the results (false positives and false negatives) have been discussed.
Journal of Ultrasound in Medicine, 1984
Molecular and Cellular Endocrinology, 1976
The présent work suggests that in dog thyroid tissue Ca^^is distributed af least in two com partm... more The présent work suggests that in dog thyroid tissue Ca^^is distributed af least in two com partments (A) and (B). Compartment (A) could be the extracellular space, and extracellular binding sites for Ca^*. The uptake of Ca^* in this compartment is increased and the release is decreased at 0°C. The release is not influenced by the ionophore A23187 or by metabolic in hibitors (NaF, iodoacetate, dinitrophenol) or by thyrotropin (TSH). Compartment (B) is de fined functionally as a slowly exchangeable store of Ca^*. Uptake and release from this com partment are température dépendent. The release is accelerated by A23187 and by antimycin A, this suggests an intracellular, presumably mitochondrial, location. TSH stimulâtes the efflux of Ca^* originating from the cellular compartment (B). Our data are compatible with the hypothesis that, as in other tissues, the translocations of stored intracellular calcium may be a crucial step in the activation of the thyroid cell. Kcywords : thyroid; calcium; movement. The rôle of calcium is clearly demonstrated in a variety of biological phenomena (Rasmussen, 1970). Calcium is involved in the excitation-contraction coupling mechanism of muscle (Hasselbach, 1964; Ebashi and Endo, 1969), in the stimulussecretion coupling of exocrine (Heisler et al., 1972; Case and Clausen, 1973) and endocrine glands (Douglas, 1968; Malaisse et al., 1971) and in many membrane phenoinena such as cellular adhesiveness (Coman, 1953; Rappaport, 1956). The concentration of Ca^* is around 1 X 10"^ M in the extracellular space and around 1 X 10"* M in the cytoplasm. To maintain such a gradient, cells extrude Ca^* actively (Wallach et al., 1966; Borle, 1968), the influx being passive. In muscle and other cells Ca^'^ is accumulated by an active process and sequestered in cell organelles (Borle, 1967) such as endoplasmic reticulum (Hasselbach, 1964; Martonosi and Feretos, 1964) and mitochondria (Borle, 1972).
Comptes rendus des séances de la Société de biologie et de ses filiales, 1964
The Journal of reproductive medicine, 1997
Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relati... more Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation-induction agents. We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.
The Journal of reproductive medicine, 1997
The early development of complications in twin-twin transfusion syndrome is a poor prognostic sig... more The early development of complications in twin-twin transfusion syndrome is a poor prognostic sign. For this reason, new techniques for intrauterine therapy are being developed: invasive options, such as selective feticide of one of the twins, have been reported. Two cases of twin-twin transfusion syndrome in the late second trimester were treated by selective feticide using vascular embolization to the more severely damaged fetus. In one case the embolized fetus was a hydropic recipient with a normal cotwin; in the other, the donor fetus was affected by bilateral hydrocephalus. These fetuses underwent ultrasound-guided embolization using a bolus of histoacryl injected into the umbilical vein and fetal heart. Both patients went on to deliver healthy singletons in the third trimester. In twin-twin transfusion syndrome of early onset, embolization may help one of the twins survive. This technique is neither time-consuming nor expensive and does not require a general anesthetic.
Acta paediatrica Belgica
Journal Articleinfo:eu-repo/semantics/publishe
Revue médicale de Bruxelles, 1984
Since the very start of using ultrasound to monitor pregnancy the information that the obstetrici... more Since the very start of using ultrasound to monitor pregnancy the information that the obstetrician has obtained from it has been great. Measuring the fetus (biparietal diameters, rump-crown length etc.) makes it possible to check development of the fetus in the uterus, as well as seeing the various organs and their placing and internal structure. Real time pictures make it possible to visualise the organs precisely from the point of view of their positioning and their internal structures. We report 12 cases of malformations of the central nervous system which were diagnosed in utero and we point out the value of early diagnosis in pregnancy. The 12 cases we found included four of hydrocephaly, one cyst of the choroid plexus, one hydrencephaly , two cases of holoprocencephaly and four cases of anencephaly. Since these malformations may be part of generalised malformations it is important to search for these others by ultrasound as well as by caryotyping and estimation of alpha-fetoprotein levels.
Progress in clinical and biological research, 1982
Case ReportsJournal Articleinfo:eu-repo/semantics/publishe
Archives internationales de physiologie et de biochimie, 1969
Revue médicale de Bruxelles, 1985
Revue médicale de Bruxelles, 1987
Reflexion sur la detection directe de lesions genetiques, le diagnostic d'une maladie genetiq... more Reflexion sur la detection directe de lesions genetiques, le diagnostic d'une maladie genetique dont le gene est inconnu et sur l'utilisation des polymorphismes de taille des fragments de restriction
Obstetrics and gynecology, 1988
The pathologic findings in placentas from ten multiple gestations complicated by the so-called va... more The pathologic findings in placentas from ten multiple gestations complicated by the so-called vanishing twin phenomenon were studied to confirm the ultrasonographic evidence. Five pregnancies resulted from in vitro fertilization and embryo transfer, and five conceptions were spontaneous. The pregnancies were studied by repeat ultrasound examinations between five and 12 weeks' gestation. First-trimester bleeding was the only clinical sign of this phenomenon. Postpartum evidence of the vanishing twin phenomenon was found in five cases. Morphologically, the lesions were characterized by well-delineated plaques of perivillous fibrin deposition, associated in one case with embryonic remnants. This focal degenerative change of the placental mass, which also exists in about 25% of placentas from uncomplicated term pregnancies, may be the only clue to the disappearance of one conceptus.
Obstetrics and gynecology, 1989
Percutaneous umbilical blood sampling (cordocentesis) appears to be a valuable new procedure for ... more Percutaneous umbilical blood sampling (cordocentesis) appears to be a valuable new procedure for prenatal diagnosis. In order to evaluate whether focal injury of the umbilical vessels caused by the needle puncture is potentially harmful, we completely examined 50 umbilical cords collected between 1 hour and 20 weeks after cordocentesis. Macroscopic evidence of the needle entry was found in 37 cases, including one giant hematoma of the cord. Within 48 hours after the procedure, microscopic examination of transverse sections taken at the puncture site revealed distinct perforation of the vessel wall, associated in four cases with a small hematoma encircling the vessel. One week after cordocentesis, the vessel wall was partially reformed. There were no histologic differences between needle entry in a vein or in an artery. No thromboses of the umbilical vessels were found.
Pédiatrie, 1990
Ultrasonography of the neck in a 28 week-old fetus suggested the presence of a goiter. Since sono... more Ultrasonography of the neck in a 28 week-old fetus suggested the presence of a goiter. Since sonographic evaluation of epiphyseal ossification centers showed no delayed bone maturation, the fetus was considered to have an euthyroid goiter, that allowed amniocentesis to be performed. The fetus was sonographically followed from 32 to 36 weeks: the development was normal. At birth, hormonal tests confirmed an euthyroid goiter. The authors consider that bone maturation should be monitored in utero especially when a thyroid dysfunction is suspected, in order to detect severe disease and to prompt treatment.
Revue médicale de Bruxelles, 1992
Our institution admitted 39 ELBW (less than 1 kg) between November 1978 and December 1990. In our... more Our institution admitted 39 ELBW (less than 1 kg) between November 1978 and December 1990. In our center, mortality has decreased from 61% to 33% within a decade. Improvements in neonatal intensive care have lowered the limit for these possible survival to 26 weeks of gestational age and 700g of birthweight. Morbidity is still very high. The mean hospital stay is 96 days. Perinatal asphyxia is frequent (3/4) as well as infections, nutritional problems and renal failure. Sixty-six % of this population suffer from respiratory distress syndrome which is the main cause of death. Morbidity and mortality are explained and compared to the recent literature.
Prenatal Diagnosis, 1985
Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;... more Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;p12), inv(18)(p11q11). The pregnancy was complicated by severe oligohydramnios. The fetal karyotype was unbalanced: 46XX, der(4), t(4;20)(p16;p12), inv(18) (p11q11)pat., thus resulting in partial trisomy 2Op and monosomy 4p. In addition, the amniotic fluid alpha‐fetoprotein (AFP) became increasingly elevated with gestational age. The pregnancy was terminated at 25 weeks. The fetus presented with typical facial dysmorphic features, unilateral cleft lip and palate, severe renal hypoplasia, consistent with the 4p‐ (Wolf‐Hirschhorn) syndrome.