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Papers by Anne François

Research paper thumbnail of Barriers to interferon-a therapy are higher in intravenous drug users than in other patients with acute hepatitis C

Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C ... more Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C patients, thus preventing chronic hepatitis and avoiding less efficacious combination therapy.

Research paper thumbnail of High-frequency oscillatory ventilation in neonatal RDS: initial volume optimization and respiratory mechanics

Journal of applied physiology (Bethesda, Md. : 1985), 1998

To determine whether initial lung volume optimization influences respiratory mechanics, which cou... more To determine whether initial lung volume optimization influences respiratory mechanics, which could indicate the achievement of optimal volume, we studied 17 premature infants with respiratory distress syndrome (RDS) assisted by high-frequency oscillatory ventilation. The continuous distending pressure (CDP) was increased stepwise from 6-8 cmH2O up to optimal CDP (OCDP), i.e., that allowing good oxygenation with the lowest inspired O2 fraction. Respiratory system compliance (Crs) and resistance were concomitantly measured. Mean OCDP was 16.5 +/- 1.2 cmH2O. Inspired O2 fraction could be reduced from an initial level of 0.73 +/- 0.17 to 0.33 +/- 0.07. However, Crs (0.45 +/- 0.14 ml . cmH2O-1 . kg-1 at starting CDP point) remained unchanged through lung volume optimization but appeared inversely related to OCDP. Similarly, respiratory system resistance was not affected. We conclude that there is a marked dissociation between oxygenation improvement and Crs profile during the initial ph...

Research paper thumbnail of Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients

Transplantation, 1993

Renal transplantation in patients presenting end-stage renal failure can be hampered by the prese... more Renal transplantation in patients presenting end-stage renal failure can be hampered by the presence of alloantibodies against HLA antigens. In 4 out of 5 patients with HLA-specific alloantibodies waiting for a renal allograft, treatment with high-dose i.v. Ig resulted in a prolonged suppression (over 3 months) of most of the panel-reactive anti-HLA antibodies (PRA). Intravenous polyclonal human Ig (IVIg) and F(ab')2 fragments from IVIg inhibited the binding of patients' plasma and IgG fractions to peripheral blood lymphocytes from normal donors as well as their cytotoxicity, suggesting that the in vivo effect of IVIg was mediated by the presence, in the IVIg preparation, of anti-idiotypes directed against idiotypes borne on the anti-HLA antibodies. Thus, treatment with IVIg can be a valuable tool toward the transplantation of immunized patients.

Research paper thumbnail of Fetal treatment for early dyshormonogenetic goiter

Research paper thumbnail of The EPIBEL Study: Outcomes to Discharge From Hospital for Extremely Preterm Infants in Belgium

PEDIATRICS, 2004

Objective. To determine mortality and morbidity at discharge from the hospital of a large populat... more Objective. To determine mortality and morbidity at discharge from the hospital of a large population-based cohort of infants who were born at <26 weeks' gestation.

Research paper thumbnail of High Frequency Oscillatory Ventilation (HFOV) in Neonatal Respiratory Distress Syndrome (RDS): effects of early Lung Volume Optimization(LVO). 1522

Research paper thumbnail of Early Respiratory changes after Surfactant Therapy in Premature Infants assisted by Primary High Frequency Oscillatory Ventilation (HFOV). 1684

Research paper thumbnail of Barriers to interferon-α therapy are higher in intravenous drug users than in other patients with acute hepatitis C

Journal of Hepatology, 2005

Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C ... more Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C patients, thus preventing chronic hepatitis and avoiding less efficacious combination therapy.

Research paper thumbnail of Barriers to interferon-a therapy are higher in intravenous drug users than in other patients with acute hepatitis C

Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C ... more Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C patients, thus preventing chronic hepatitis and avoiding less efficacious combination therapy.

Research paper thumbnail of High-frequency oscillatory ventilation in neonatal RDS: initial volume optimization and respiratory mechanics

Journal of applied physiology (Bethesda, Md. : 1985), 1998

To determine whether initial lung volume optimization influences respiratory mechanics, which cou... more To determine whether initial lung volume optimization influences respiratory mechanics, which could indicate the achievement of optimal volume, we studied 17 premature infants with respiratory distress syndrome (RDS) assisted by high-frequency oscillatory ventilation. The continuous distending pressure (CDP) was increased stepwise from 6-8 cmH2O up to optimal CDP (OCDP), i.e., that allowing good oxygenation with the lowest inspired O2 fraction. Respiratory system compliance (Crs) and resistance were concomitantly measured. Mean OCDP was 16.5 +/- 1.2 cmH2O. Inspired O2 fraction could be reduced from an initial level of 0.73 +/- 0.17 to 0.33 +/- 0.07. However, Crs (0.45 +/- 0.14 ml . cmH2O-1 . kg-1 at starting CDP point) remained unchanged through lung volume optimization but appeared inversely related to OCDP. Similarly, respiratory system resistance was not affected. We conclude that there is a marked dissociation between oxygenation improvement and Crs profile during the initial ph...

Research paper thumbnail of Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients

Transplantation, 1993

Renal transplantation in patients presenting end-stage renal failure can be hampered by the prese... more Renal transplantation in patients presenting end-stage renal failure can be hampered by the presence of alloantibodies against HLA antigens. In 4 out of 5 patients with HLA-specific alloantibodies waiting for a renal allograft, treatment with high-dose i.v. Ig resulted in a prolonged suppression (over 3 months) of most of the panel-reactive anti-HLA antibodies (PRA). Intravenous polyclonal human Ig (IVIg) and F(ab')2 fragments from IVIg inhibited the binding of patients' plasma and IgG fractions to peripheral blood lymphocytes from normal donors as well as their cytotoxicity, suggesting that the in vivo effect of IVIg was mediated by the presence, in the IVIg preparation, of anti-idiotypes directed against idiotypes borne on the anti-HLA antibodies. Thus, treatment with IVIg can be a valuable tool toward the transplantation of immunized patients.

Research paper thumbnail of Fetal treatment for early dyshormonogenetic goiter

Research paper thumbnail of The EPIBEL Study: Outcomes to Discharge From Hospital for Extremely Preterm Infants in Belgium

PEDIATRICS, 2004

Objective. To determine mortality and morbidity at discharge from the hospital of a large populat... more Objective. To determine mortality and morbidity at discharge from the hospital of a large population-based cohort of infants who were born at <26 weeks' gestation.

Research paper thumbnail of High Frequency Oscillatory Ventilation (HFOV) in Neonatal Respiratory Distress Syndrome (RDS): effects of early Lung Volume Optimization(LVO). 1522

Research paper thumbnail of Early Respiratory changes after Surfactant Therapy in Premature Infants assisted by Primary High Frequency Oscillatory Ventilation (HFOV). 1684

Research paper thumbnail of Barriers to interferon-α therapy are higher in intravenous drug users than in other patients with acute hepatitis C

Journal of Hepatology, 2005

Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C ... more Background/Aims: Treatment with interferon-a (IFN-a) may eradicate HCV in most acute hepatitis C patients, thus preventing chronic hepatitis and avoiding less efficacious combination therapy.

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