Francesca Larese Filon - Academia.edu (original) (raw)
Papers by Francesca Larese Filon
Pathogens
The rapid rollout of COVID-19 vaccines in 2021 sparked general optimism toward controlling the se... more The rapid rollout of COVID-19 vaccines in 2021 sparked general optimism toward controlling the severe form of the disease, preventing hospitalizations and COVID-19-associated mortality, and the transmissibility of SARS-CoV-2 infection [...]
Kompass Neumología
La fracción exhalada de óxido nítrico (FeNO) es un biomarcador no-invasivo de la inflamación de l... more La fracción exhalada de óxido nítrico (FeNO) es un biomarcador no-invasivo de la inflamación de las vías respiratorias, concebido originalmente para identificar la inflamación eosinofílica de las vías respiratorias y para predecir la respuesta a los esteroides. El principal campo de aplicación de este biomarcador es el asma, pero la FeNO también se ha utilizado para otros trastornos pulmonares alérgicos y no-alérgicos, como la enfermedad pulmonar obstructiva crónica, la neumonitis por hipersensibilidad y la enfermedad pulmonar intersticial. Una parte importante de las enfermedades respiratorias se relacionan con el trabajo, y la FeNO, una medida segura y fácil de realizar, es un examen potencialmente valioso en el entorno laboral. Esta revisión sistemática evalúa la utilidad de la medición de la FeNO en relación con tres tipos de exposición aérea: alérgenos, irritantes y partículas respiratorias inhaladas durante las actividades laborales. La revisión abarca los resultados de estudi...
Environmental Science and Pollution Research
The Gulf of Trieste (Northern Adriatic Sea, Italy) is the coastal area of the Mediterranean Sea m... more The Gulf of Trieste (Northern Adriatic Sea, Italy) is the coastal area of the Mediterranean Sea most highly contaminated by mercury (Hg) due to fluvial inputs from the Isonzo/Soča River system, draining over 500 years’ worth of cinnabar extraction activity from the Idrija mining district (Western Slovenia). The aim of this research is to investigate the concentration of Hg in hair samples taken from participants from the general population from the coast of the Friuli Venezia Giulia Region (FVG), as a marker of chronic exposure to Hg.Three hundred and one individuals - 119 males and 182 females - were recruited by convenience sampling in Trieste in September 2021. An amount of approximately 100 mg of hair was collected from the occipital scalp of each participant to measure the respective Hg concentrations (expressed as mg/kg). Moreover, participants completed a self-report questionnaire collecting extensive socio-demographic and life-style information. A multiple linear regression ...
La Medicina del Lavoro, 2021
Background: During major epidemic outbreaks, the preparedness of public health systems is challen... more Background: During major epidemic outbreaks, the preparedness of public health systems is challenged and healthcare workers (HCWs) are at the frontline. Italy was among the first- and worst-hit countries by COVID-19. Aim: To analyze the prevalence and incidence of infection among HCWs in Friuli Venezia Giulia region (north-eastern Italy) from March 1 to the end of the Italian lock-down, May 10, 2020. Methods. HCWs exposed to COVID-19 patients were actively surveyed and all HCWs were routinely tested with nasopharyngeal and oropharyngeal swab for RNA virus detection (n. 54,670). Results: Infected HCWs (n. 595) represented the 32.3% of all COVID-19 cases in the region under 65 years of age, and incidence of infection was 11.4 cases/1000 workers. HCWs accounted for a significant proportion of coronavirus infection and experienced high infection incidence after unprotected contact. Conclusions. HCWs’ knowledge of SARS-CoV-2 epidemiology and proper infection control practices are critica...
Giornale italiano di medicina del lavoro ed ergonomia, 2017
OBJECTIVES A literature review was performed to highlight which work-related diseases express sex... more OBJECTIVES A literature review was performed to highlight which work-related diseases express sex/gender differences in health outcomes and focus the main limits of studies in this field. METHODS The research, carried out on PubMed by specific search string, identified 4828 articles (1997-2017 period) of which 381 are eligible for review (4-22%, depending on the disease). RESULTS Among them, 68% reported sex/gender differences in health outcomes, which in most cases appear to be due to different exposure and/or work segregation rather than to biological differences. However, few studies place this assessment among the research goals and results are almost never discussed and hypothesis are seldom formulated about any observed differences. CONCLUSIONS It seems necessary to use research methodologies and study design that can detect and explain the described complexity and useful in defining appropriate preventive strategies.
Giornale italiano di medicina del lavoro ed ergonomia, 2017
OBJECTIVES A thorough and fully application of the principles of gender mainstreaming, in accorda... more OBJECTIVES A thorough and fully application of the principles of gender mainstreaming, in accordance with the European Community guidelines, to the health and safety at work, implies the systematic review of the whole prevention from the gendered point of view. This means that both biology- and gender-based differences between male and female workers should be conceived not only as determinants of health but also as factors affecting either positively or negatively the health and safety risk prevention. In this evolutionary cultural step the role of the occupational physician is particularly important. METHODS In this paper we propose some operative tools that can concretely implement gender perspective in all the various areas of prevention, where the occupational physician has a leading, if not even exclusive, role such as risk assessment, training and health medical surveillance.
Riassunti / absract presentati al XXV Congresso della Divisione di Chimica Analitica della Societ... more Riassunti / absract presentati al XXV Congresso della Divisione di Chimica Analitica della Societ\ue0 Chimica Italian
Policing: A Journal of Policy and Practice, 2021
Exposure to organizational stressors is known to negatively affect police officers’ well-being in... more Exposure to organizational stressors is known to negatively affect police officers’ well-being in terms of mental and physical health and performance. In this study, we adopted the Health and Safety Executive’s Management Standards to identify specific associations between organizational stressors and health outcomes in a sample of local police officers employed in an Italian municipality (N = 111). Compared with benchmark data, participants were exposed to high risks in six out of seven organizational dimensions, and five of those (namely, Demands, Control, Managers’ Support, Relationships, and Role) displayed significant associations with psychological and physical problems, such as perceived stress, hypertension, gastrointestinal disorders, dermatitis, and musculoskeletal pain. While most stress-reduction interventions for police forces are designed at the individual level, the results of the present study also indicate the need for designing and implementing interventions aimed ...
Contact Dermatitis, 2020
BackgroundClinical surveillance of the prevalence of contact allergy in consecutively patch teste... more BackgroundClinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series.ObjectivesTo present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments.MethodsAnonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control.ResultsIn the 4 years (2015‐2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%).ConclusionsWhile the prevalenc...
Regulatory Toxicology and Pharmacology, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Nano Biomedicine and Engineering, 2016
Workers may be exposed to nanoparticles (NPs) by inhalation, cutaneous contact and gastroenteric ... more Workers may be exposed to nanoparticles (NPs) by inhalation, cutaneous contact and gastroenteric pathways, but today there is no standardized method for either assessing or monitoring the occupational exposure. Moreover, there is no all-in-one assessment strategy, so it is preferable to consider different perspectives. Every assessment should be preceded by a preliminary analysis of the workplace in order to gather useful data on the potential exposure sources, which will help in outlining the assessment strategy. The purpose of air monitoring should be to characterize NP emissions and assess, as a minimum, the mass, particle number concentration, granulometric distribution, specific surface and chemical composition. There are several techniques which may assess these characteristics: the most used in real occupational contexts are mobility particle sizers, particle counters (optical, condensation, etc.), surface area monitors, while personal samplers are promising tools which still have been used almost only in research or controlled contexts. Skin and surfaces may be sampled according to the nature of substances and the circumstances of exposure. Sampling methods can be divided in three main categories: interception (e.g. carbon tabs), removal (e.g. adhesive tape stripping, wiping), in situ methods (e.g. UV fluorescence). Chemical analysis methods (e.g. spectroscopy) and electron microscopy techniques may enhance available data. Considering the available information, we suggest a stepwise approach for risk assessment composed of three steps, starting from a quick and relatively cheap screening method to assess exposure, followed by 2 gradually more accurate but costly approaches to perform whether a significant exposure is detected.
Pathogens
The rapid rollout of COVID-19 vaccines in 2021 sparked general optimism toward controlling the se... more The rapid rollout of COVID-19 vaccines in 2021 sparked general optimism toward controlling the severe form of the disease, preventing hospitalizations and COVID-19-associated mortality, and the transmissibility of SARS-CoV-2 infection [...]
Kompass Neumología
La fracción exhalada de óxido nítrico (FeNO) es un biomarcador no-invasivo de la inflamación de l... more La fracción exhalada de óxido nítrico (FeNO) es un biomarcador no-invasivo de la inflamación de las vías respiratorias, concebido originalmente para identificar la inflamación eosinofílica de las vías respiratorias y para predecir la respuesta a los esteroides. El principal campo de aplicación de este biomarcador es el asma, pero la FeNO también se ha utilizado para otros trastornos pulmonares alérgicos y no-alérgicos, como la enfermedad pulmonar obstructiva crónica, la neumonitis por hipersensibilidad y la enfermedad pulmonar intersticial. Una parte importante de las enfermedades respiratorias se relacionan con el trabajo, y la FeNO, una medida segura y fácil de realizar, es un examen potencialmente valioso en el entorno laboral. Esta revisión sistemática evalúa la utilidad de la medición de la FeNO en relación con tres tipos de exposición aérea: alérgenos, irritantes y partículas respiratorias inhaladas durante las actividades laborales. La revisión abarca los resultados de estudi...
Environmental Science and Pollution Research
The Gulf of Trieste (Northern Adriatic Sea, Italy) is the coastal area of the Mediterranean Sea m... more The Gulf of Trieste (Northern Adriatic Sea, Italy) is the coastal area of the Mediterranean Sea most highly contaminated by mercury (Hg) due to fluvial inputs from the Isonzo/Soča River system, draining over 500 years’ worth of cinnabar extraction activity from the Idrija mining district (Western Slovenia). The aim of this research is to investigate the concentration of Hg in hair samples taken from participants from the general population from the coast of the Friuli Venezia Giulia Region (FVG), as a marker of chronic exposure to Hg.Three hundred and one individuals - 119 males and 182 females - were recruited by convenience sampling in Trieste in September 2021. An amount of approximately 100 mg of hair was collected from the occipital scalp of each participant to measure the respective Hg concentrations (expressed as mg/kg). Moreover, participants completed a self-report questionnaire collecting extensive socio-demographic and life-style information. A multiple linear regression ...
La Medicina del Lavoro, 2021
Background: During major epidemic outbreaks, the preparedness of public health systems is challen... more Background: During major epidemic outbreaks, the preparedness of public health systems is challenged and healthcare workers (HCWs) are at the frontline. Italy was among the first- and worst-hit countries by COVID-19. Aim: To analyze the prevalence and incidence of infection among HCWs in Friuli Venezia Giulia region (north-eastern Italy) from March 1 to the end of the Italian lock-down, May 10, 2020. Methods. HCWs exposed to COVID-19 patients were actively surveyed and all HCWs were routinely tested with nasopharyngeal and oropharyngeal swab for RNA virus detection (n. 54,670). Results: Infected HCWs (n. 595) represented the 32.3% of all COVID-19 cases in the region under 65 years of age, and incidence of infection was 11.4 cases/1000 workers. HCWs accounted for a significant proportion of coronavirus infection and experienced high infection incidence after unprotected contact. Conclusions. HCWs’ knowledge of SARS-CoV-2 epidemiology and proper infection control practices are critica...
Giornale italiano di medicina del lavoro ed ergonomia, 2017
OBJECTIVES A literature review was performed to highlight which work-related diseases express sex... more OBJECTIVES A literature review was performed to highlight which work-related diseases express sex/gender differences in health outcomes and focus the main limits of studies in this field. METHODS The research, carried out on PubMed by specific search string, identified 4828 articles (1997-2017 period) of which 381 are eligible for review (4-22%, depending on the disease). RESULTS Among them, 68% reported sex/gender differences in health outcomes, which in most cases appear to be due to different exposure and/or work segregation rather than to biological differences. However, few studies place this assessment among the research goals and results are almost never discussed and hypothesis are seldom formulated about any observed differences. CONCLUSIONS It seems necessary to use research methodologies and study design that can detect and explain the described complexity and useful in defining appropriate preventive strategies.
Giornale italiano di medicina del lavoro ed ergonomia, 2017
OBJECTIVES A thorough and fully application of the principles of gender mainstreaming, in accorda... more OBJECTIVES A thorough and fully application of the principles of gender mainstreaming, in accordance with the European Community guidelines, to the health and safety at work, implies the systematic review of the whole prevention from the gendered point of view. This means that both biology- and gender-based differences between male and female workers should be conceived not only as determinants of health but also as factors affecting either positively or negatively the health and safety risk prevention. In this evolutionary cultural step the role of the occupational physician is particularly important. METHODS In this paper we propose some operative tools that can concretely implement gender perspective in all the various areas of prevention, where the occupational physician has a leading, if not even exclusive, role such as risk assessment, training and health medical surveillance.
Riassunti / absract presentati al XXV Congresso della Divisione di Chimica Analitica della Societ... more Riassunti / absract presentati al XXV Congresso della Divisione di Chimica Analitica della Societ\ue0 Chimica Italian
Policing: A Journal of Policy and Practice, 2021
Exposure to organizational stressors is known to negatively affect police officers’ well-being in... more Exposure to organizational stressors is known to negatively affect police officers’ well-being in terms of mental and physical health and performance. In this study, we adopted the Health and Safety Executive’s Management Standards to identify specific associations between organizational stressors and health outcomes in a sample of local police officers employed in an Italian municipality (N = 111). Compared with benchmark data, participants were exposed to high risks in six out of seven organizational dimensions, and five of those (namely, Demands, Control, Managers’ Support, Relationships, and Role) displayed significant associations with psychological and physical problems, such as perceived stress, hypertension, gastrointestinal disorders, dermatitis, and musculoskeletal pain. While most stress-reduction interventions for police forces are designed at the individual level, the results of the present study also indicate the need for designing and implementing interventions aimed ...
Contact Dermatitis, 2020
BackgroundClinical surveillance of the prevalence of contact allergy in consecutively patch teste... more BackgroundClinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series.ObjectivesTo present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments.MethodsAnonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control.ResultsIn the 4 years (2015‐2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%).ConclusionsWhile the prevalenc...
Regulatory Toxicology and Pharmacology, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Nano Biomedicine and Engineering, 2016
Workers may be exposed to nanoparticles (NPs) by inhalation, cutaneous contact and gastroenteric ... more Workers may be exposed to nanoparticles (NPs) by inhalation, cutaneous contact and gastroenteric pathways, but today there is no standardized method for either assessing or monitoring the occupational exposure. Moreover, there is no all-in-one assessment strategy, so it is preferable to consider different perspectives. Every assessment should be preceded by a preliminary analysis of the workplace in order to gather useful data on the potential exposure sources, which will help in outlining the assessment strategy. The purpose of air monitoring should be to characterize NP emissions and assess, as a minimum, the mass, particle number concentration, granulometric distribution, specific surface and chemical composition. There are several techniques which may assess these characteristics: the most used in real occupational contexts are mobility particle sizers, particle counters (optical, condensation, etc.), surface area monitors, while personal samplers are promising tools which still have been used almost only in research or controlled contexts. Skin and surfaces may be sampled according to the nature of substances and the circumstances of exposure. Sampling methods can be divided in three main categories: interception (e.g. carbon tabs), removal (e.g. adhesive tape stripping, wiping), in situ methods (e.g. UV fluorescence). Chemical analysis methods (e.g. spectroscopy) and electron microscopy techniques may enhance available data. Considering the available information, we suggest a stepwise approach for risk assessment composed of three steps, starting from a quick and relatively cheap screening method to assess exposure, followed by 2 gradually more accurate but costly approaches to perform whether a significant exposure is detected.