Francesco Amadei - Academia.edu (original) (raw)
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Papers by Francesco Amadei
2020 AEIT International Annual Conference (AEIT), 2020
The purpose of this article is to outline Enel Global Infrastructure and Networks strategy of the... more The purpose of this article is to outline Enel Global Infrastructure and Networks strategy of the Innovative Resilience that integrates the concept of increasing the resistance of power distribution installations to weather events with that of resilience extended to all phases of business management. The strategy is geared towards defining all the system levers to mitigate the impact of extreme weather event on the distribution grid and to restore service for almost all customers in the shortest possible time.
Journal of medicinal chemistry, Jan 28, 2017
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of infl... more Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein, we describe a drug discovery program aiming at the identification of novel classes of potent PDE4 inhibitors suitable for pulmonary administration. Starting from a previous series of benzoic acid esters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding pocket. Extensive structural modifications led to the discovery of a number of heterocycloalkyl esters as potent in vitro PDE4 inhibitors. (S*,S**)-18e and (S*,S**)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-dependently counteracted acute lung eosinophilia in an experimental animal model. The optimal biological profile as well as the excellent solid-state properties suggest that both compounds h...
18th International Conference and Exhibition on Electricity Distribution (CIRED 2005), 2005
In most Countries all over the world the quality of service delivered by Distribution Companies t... more In most Countries all over the world the quality of service delivered by Distribution Companies to final customers is measured through SAIDI (System Average Duration of Interruption Index). Enel Global Infrastructures and Networks currently operates 11 Distribution Companies (DisCos) in 8 Countries, in Europe and South America, serving around 72 million customers. The diversity of structure, technology, organization, history of each network rises the issue of setting a global and unique strategy for undertaking specific actions at local level to improve the continuity of supply to final customers. The document, addressed to DisCos and Regulators, intents to show an effective and robust method of disaggregation of the SAIDI indicator in a spectrum of control dimensions covering all the aspects of network management, from Capital Allocation to Operations.
2020 AEIT International Annual Conference (AEIT), 2020
The purpose of this article is to outline Enel Global Infrastructure and Networks strategy of the... more The purpose of this article is to outline Enel Global Infrastructure and Networks strategy of the Innovative Resilience that integrates the concept of increasing the resistance of power distribution installations to weather events with that of resilience extended to all phases of business management. The strategy is geared towards defining all the system levers to mitigate the impact of extreme weather event on the distribution grid and to restore service for almost all customers in the shortest possible time.
Journal of medicinal chemistry, Jan 28, 2017
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of infl... more Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein, we describe a drug discovery program aiming at the identification of novel classes of potent PDE4 inhibitors suitable for pulmonary administration. Starting from a previous series of benzoic acid esters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding pocket. Extensive structural modifications led to the discovery of a number of heterocycloalkyl esters as potent in vitro PDE4 inhibitors. (S*,S**)-18e and (S*,S**)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-dependently counteracted acute lung eosinophilia in an experimental animal model. The optimal biological profile as well as the excellent solid-state properties suggest that both compounds h...
18th International Conference and Exhibition on Electricity Distribution (CIRED 2005), 2005
In most Countries all over the world the quality of service delivered by Distribution Companies t... more In most Countries all over the world the quality of service delivered by Distribution Companies to final customers is measured through SAIDI (System Average Duration of Interruption Index). Enel Global Infrastructures and Networks currently operates 11 Distribution Companies (DisCos) in 8 Countries, in Europe and South America, serving around 72 million customers. The diversity of structure, technology, organization, history of each network rises the issue of setting a global and unique strategy for undertaking specific actions at local level to improve the continuity of supply to final customers. The document, addressed to DisCos and Regulators, intents to show an effective and robust method of disaggregation of the SAIDI indicator in a spectrum of control dimensions covering all the aspects of network management, from Capital Allocation to Operations.