Francesco Cipollini - Academia.edu (original) (raw)
Papers by Francesco Cipollini
Gastrointestinal Endoscopy, Aug 1, 1982
International Journal of Clinical Practice, Apr 1, 1987
Microbiologia medica, Sep 30, 2007
Digestive Diseases and Sciences, Feb 1, 1985
This paper reports the results of a multicenter prospective study of 188 consecutive patients aff... more This paper reports the results of a multicenter prospective study of 188 consecutive patients affected by gastric ulcer, verified by endoscopy, in whom the frequency of a mycotic infection of the lesion was evaluated as well as the eventual influence of such pathology on the efficiency of medical treatment, the healing rate, and the healing time. A mycotic infection, defined as penetration of the periulcerous mucosa by the fungi, was found in only 13 patients (6.9%). No significant differences were found in the healing rate and healing time among these patients treated with H2-receptor antagonists and a control group of 43 matched gastric ulcer patients treated in the same period with the same therapy. It would appear from the data that mycotic infections of the gastric ulcer do not modify the efficiency of medical treatment.
PubMed, Jul 1, 1991
The prevalence of cholelithiasis has been investigated in 301 male subjects (age range 35-60 year... more The prevalence of cholelithiasis has been investigated in 301 male subjects (age range 35-60 years) operated on for partial gastrectomy with gastro-jejunostomy (BII), in 277 unoperated peptic ulcer patients (age range 30-60 years) and in a control population of 281 factory's workers (age range 31-58 years). The prevalence of gallstone disease resulted significantly higher in BII operated subjects (23.9%) than in unoperated (9%) and controls (8.5%). No difference was found between unoperated peptic ulcer patients and controls. These results indicate that BII operation is a high risk condition for cholelithiasis while peptic ulcer disease does not constitute a favourable factor for gallstone formation.
BMC Infectious Diseases, Nov 8, 2016
Background: Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patient... more Background: Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patients. The objective of this study was to evaluate the rate, the optimal diagnostic work-up, and outcome of CD infections (CDI) in Internal Medicine (IM) wards in Italy. Methods: PRACTICE is an observational prospective study, involving 40 IM Units and evaluating all consecutive patients hospitalized during a 4-month period. CDI were defined in case of diarrhoea when both enzyme immunoassay for GDH, and test for A/B toxin were positive. Patients with CDI were followed-up for recurrences for 4 weeks after the end of therapy. Results: Among the 10,780 patients observed, 103 (0.96 %) showed CDI, at admission or during hospitalization. A positive history for CD, antibiotics in the previous 4 weeks, recent hospitalization, female gender and age were significantly associated with CDI (multivariable analysis). In-hospital mortality was 16.5 % in CD group vs 6.7 % in No-CD group (p < 0.001), whereas median length of hospital stay was 16 (IQR = 13) vs 8 (IQR = 8) days (p < 0.001) among patients with or without CDI, respectively. Rate of CD recurrences was 14.6 %. As a post-hoc evaluation, 23 out of 34 GDH+/Tox-samples were toxin positive, when analysed by molecular method (a real-time PCR assay). The overall CD incidence rate was 5.3/10,000 patient-days. Conclusions: Our results confirm the severity of CDI in medical wards, showing high in-hospital mortality, prolonged hospitalization and frequent short-term recurrences. Further, our survey supports a 2-3 step algorithm for CD diagnosis: EIA for detecting GDH, A and B toxin, followed by a molecular method in case of toxin-negative samples.
Italian Journal of Medicine
Sonography – similar to what happened almost two centuries ago with the introduction of stethosco... more Sonography – similar to what happened almost two centuries ago with the introduction of stethoscopes – has completely changed patients’ clinical management in Internal Medicine. The availability of performant, sometimes even small-sized and cost-effective machines, has allowed doctors in Internal-Medicine units to perform bedside-ultrasound examinations alongside regular clinical ones. [...]
Clinical Management Issues, 2012
Diagnostic Microbiology and Infectious Disease, 2002
Clostridium difficile causes diarrhea in HIV infected patients but reports of prevalence, risk fa... more Clostridium difficile causes diarrhea in HIV infected patients but reports of prevalence, risk factors, and outcome vary. We studied the impact of C. difficile in 161 HIV infected inpatients admitted to Cook County Hospital. Patients with C. difficile had more hospital admissions in the previous 6 months (p ϭ .04), spent more days in the hospital in the previous 3 months (p ϭ .02), more often had previously received H2 blockers or treatment for Pneumocystis carinii (p Ͻ .05), and had a more frequent history of herpesvirus (p ϭ .03) or opportunistic infections (p ϭ .04). C. difficile associated diarrhea (CDAD) was the etiology in 32% of all study patients with diarrhea. Patients with CDAD were hospitalized for longer periods (p ϭ .02) and received more antibiotics (p ϭ .002). C. difficile was frequently present in our HIV infected patients, especially those with advanced HIV disease, but appeared to have little impact on morbidity or mortality.
Clinical Management Issues, 2007
Chronic cough is a stressful condition and can lead to extensive investigations. We report a case... more Chronic cough is a stressful condition and can lead to extensive investigations. We report a case of a 48-year-old woman who had suffered from persistent chronic cough for more than 3 months. She had been treated with cough suppressant. However, her cough was not alleviated by these treatments, and the patient was referred to our hospital. She did not exhibit typical gastroesophageal reflux disease (GERD) symptoms heartburn and regurgitation. Esophagoscopy did not disclose reflux esophagitis. The patient was treated with a proton-pump inhibitor, which markedly alleviated her cough. Chronic cough due to GERD was diagnosed. Although the diagnosis of chronic cough due to GERD is not easy when traditionally symptoms are not present, our case report underscores the importance of this association to the differential diagnosis of chronic cough. In these cases a relatively simple test as high dose proton pump-inhibitors trial may be useful to confirm GERD related cough.
Italian Journal of Medicine, 2015
Italian Journal of Medicine, 2011
BPCO e malattie gastrointestinali Se si tiene conto della comune embriogenesi e della contiguità ... more BPCO e malattie gastrointestinali Se si tiene conto della comune embriogenesi e della contiguità anatomica, si comprende come la malattia da reflusso gastroesofageo (MRGE) possa coinvolgere diversi segmenti delle vie respiratorie. Anzi, in uno studio di el-Serag et al. [1], è stato osservato che i pazienti con reflusso gastroesofageo, documentato dalla presenza di erosioni all'esame endoscopico, presentavano un rischio significativamente superiore (p < 0,0001) rispetto ai controlli di ammalarsi di malattie polmonari quali asma, bronchite cronica, bronchiectasie, polmoniti, fibrosi polmonare e broncopneumopatia cronica ostruttiva (BPCO). Malattia da reflusso gastroesofageo La MRGE è una patologia molto frequente: in un'indagine eseguita nella contea di Olmsted (Minnesota) [2], la Italian Journal of Medicine (2011) 5S, S109-S118 Messaggi chiave Malattia da reflusso gastroesofageo La broncopneumopatia cronica ostruttiva (BPCO) è fattore di rischio per la malattia da reflusso gastroesofageo (MRGE), ma non viceversa. Gli episodi di reflusso gastroesofageo possono avere un ruolo causale nelle riacutizzazioni della BPCO. Gli inibitori di pompa protonica (PPI) possono avere un ruolo nei pazienti con BPCO e MRGE nel prevenire le riesacerbazioni reflusso-indotte. Nei pazienti con BPCO e MRGE i beta 2-agonisti per via inalatoria e le metilxantine non sono controindicati.
The Lancet, 1981
SlR,—Dr Triger and his colleagues (Oct. 17, p. 837) describe three cases of systemic candid... more SlR,—Dr Triger and his colleagues (Oct. 17, p. 837) describe three cases of systemic candidiasis in patients with acute hepatic failure. They suggest that the Candida infection was related to cimetidine treatment. In 1978 Nicholls and Henryl proposed that the lower
Italian Journal of Medicine, 2013
Introduction: Several studies show that physical activity can reduce the risk of cardiovascular d... more Introduction: Several studies show that physical activity can reduce the risk of cardiovascular disease, but the vast majority of these focus on the short- to intermediate-term benefits or refer to very specific populations. This observational study was conducted to determine whether physical activity performed during the third or fourth decade of life influences the occurrence of cardiovascular events in patients aged 65-75 years. Materials and methods: We studied a cohort of 2191 unselected patients admitted to Internal Medicine Departments. Data were collected on the patients’ medical history and their physical activity level when they were 20 to 40 years old. For the latter purpose, we used a specific questionnaire to assess the levels of physical activity related to the patients’ job, daily life, leisure time, and sports. Results: Almost half (44.2%) of the patients we evaluated reported moderate-intense physical activity when they were 20-40 years old. Around one third (35.8%)...
List of local Ethics Committees which approved the study. (DOC 25Â kb)
Gastrointestinal Endoscopy, Aug 1, 1982
International Journal of Clinical Practice, Apr 1, 1987
Microbiologia medica, Sep 30, 2007
Digestive Diseases and Sciences, Feb 1, 1985
This paper reports the results of a multicenter prospective study of 188 consecutive patients aff... more This paper reports the results of a multicenter prospective study of 188 consecutive patients affected by gastric ulcer, verified by endoscopy, in whom the frequency of a mycotic infection of the lesion was evaluated as well as the eventual influence of such pathology on the efficiency of medical treatment, the healing rate, and the healing time. A mycotic infection, defined as penetration of the periulcerous mucosa by the fungi, was found in only 13 patients (6.9%). No significant differences were found in the healing rate and healing time among these patients treated with H2-receptor antagonists and a control group of 43 matched gastric ulcer patients treated in the same period with the same therapy. It would appear from the data that mycotic infections of the gastric ulcer do not modify the efficiency of medical treatment.
PubMed, Jul 1, 1991
The prevalence of cholelithiasis has been investigated in 301 male subjects (age range 35-60 year... more The prevalence of cholelithiasis has been investigated in 301 male subjects (age range 35-60 years) operated on for partial gastrectomy with gastro-jejunostomy (BII), in 277 unoperated peptic ulcer patients (age range 30-60 years) and in a control population of 281 factory's workers (age range 31-58 years). The prevalence of gallstone disease resulted significantly higher in BII operated subjects (23.9%) than in unoperated (9%) and controls (8.5%). No difference was found between unoperated peptic ulcer patients and controls. These results indicate that BII operation is a high risk condition for cholelithiasis while peptic ulcer disease does not constitute a favourable factor for gallstone formation.
BMC Infectious Diseases, Nov 8, 2016
Background: Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patient... more Background: Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patients. The objective of this study was to evaluate the rate, the optimal diagnostic work-up, and outcome of CD infections (CDI) in Internal Medicine (IM) wards in Italy. Methods: PRACTICE is an observational prospective study, involving 40 IM Units and evaluating all consecutive patients hospitalized during a 4-month period. CDI were defined in case of diarrhoea when both enzyme immunoassay for GDH, and test for A/B toxin were positive. Patients with CDI were followed-up for recurrences for 4 weeks after the end of therapy. Results: Among the 10,780 patients observed, 103 (0.96 %) showed CDI, at admission or during hospitalization. A positive history for CD, antibiotics in the previous 4 weeks, recent hospitalization, female gender and age were significantly associated with CDI (multivariable analysis). In-hospital mortality was 16.5 % in CD group vs 6.7 % in No-CD group (p < 0.001), whereas median length of hospital stay was 16 (IQR = 13) vs 8 (IQR = 8) days (p < 0.001) among patients with or without CDI, respectively. Rate of CD recurrences was 14.6 %. As a post-hoc evaluation, 23 out of 34 GDH+/Tox-samples were toxin positive, when analysed by molecular method (a real-time PCR assay). The overall CD incidence rate was 5.3/10,000 patient-days. Conclusions: Our results confirm the severity of CDI in medical wards, showing high in-hospital mortality, prolonged hospitalization and frequent short-term recurrences. Further, our survey supports a 2-3 step algorithm for CD diagnosis: EIA for detecting GDH, A and B toxin, followed by a molecular method in case of toxin-negative samples.
Italian Journal of Medicine
Sonography – similar to what happened almost two centuries ago with the introduction of stethosco... more Sonography – similar to what happened almost two centuries ago with the introduction of stethoscopes – has completely changed patients’ clinical management in Internal Medicine. The availability of performant, sometimes even small-sized and cost-effective machines, has allowed doctors in Internal-Medicine units to perform bedside-ultrasound examinations alongside regular clinical ones. [...]
Clinical Management Issues, 2012
Diagnostic Microbiology and Infectious Disease, 2002
Clostridium difficile causes diarrhea in HIV infected patients but reports of prevalence, risk fa... more Clostridium difficile causes diarrhea in HIV infected patients but reports of prevalence, risk factors, and outcome vary. We studied the impact of C. difficile in 161 HIV infected inpatients admitted to Cook County Hospital. Patients with C. difficile had more hospital admissions in the previous 6 months (p ϭ .04), spent more days in the hospital in the previous 3 months (p ϭ .02), more often had previously received H2 blockers or treatment for Pneumocystis carinii (p Ͻ .05), and had a more frequent history of herpesvirus (p ϭ .03) or opportunistic infections (p ϭ .04). C. difficile associated diarrhea (CDAD) was the etiology in 32% of all study patients with diarrhea. Patients with CDAD were hospitalized for longer periods (p ϭ .02) and received more antibiotics (p ϭ .002). C. difficile was frequently present in our HIV infected patients, especially those with advanced HIV disease, but appeared to have little impact on morbidity or mortality.
Clinical Management Issues, 2007
Chronic cough is a stressful condition and can lead to extensive investigations. We report a case... more Chronic cough is a stressful condition and can lead to extensive investigations. We report a case of a 48-year-old woman who had suffered from persistent chronic cough for more than 3 months. She had been treated with cough suppressant. However, her cough was not alleviated by these treatments, and the patient was referred to our hospital. She did not exhibit typical gastroesophageal reflux disease (GERD) symptoms heartburn and regurgitation. Esophagoscopy did not disclose reflux esophagitis. The patient was treated with a proton-pump inhibitor, which markedly alleviated her cough. Chronic cough due to GERD was diagnosed. Although the diagnosis of chronic cough due to GERD is not easy when traditionally symptoms are not present, our case report underscores the importance of this association to the differential diagnosis of chronic cough. In these cases a relatively simple test as high dose proton pump-inhibitors trial may be useful to confirm GERD related cough.
Italian Journal of Medicine, 2015
Italian Journal of Medicine, 2011
BPCO e malattie gastrointestinali Se si tiene conto della comune embriogenesi e della contiguità ... more BPCO e malattie gastrointestinali Se si tiene conto della comune embriogenesi e della contiguità anatomica, si comprende come la malattia da reflusso gastroesofageo (MRGE) possa coinvolgere diversi segmenti delle vie respiratorie. Anzi, in uno studio di el-Serag et al. [1], è stato osservato che i pazienti con reflusso gastroesofageo, documentato dalla presenza di erosioni all'esame endoscopico, presentavano un rischio significativamente superiore (p < 0,0001) rispetto ai controlli di ammalarsi di malattie polmonari quali asma, bronchite cronica, bronchiectasie, polmoniti, fibrosi polmonare e broncopneumopatia cronica ostruttiva (BPCO). Malattia da reflusso gastroesofageo La MRGE è una patologia molto frequente: in un'indagine eseguita nella contea di Olmsted (Minnesota) [2], la Italian Journal of Medicine (2011) 5S, S109-S118 Messaggi chiave Malattia da reflusso gastroesofageo La broncopneumopatia cronica ostruttiva (BPCO) è fattore di rischio per la malattia da reflusso gastroesofageo (MRGE), ma non viceversa. Gli episodi di reflusso gastroesofageo possono avere un ruolo causale nelle riacutizzazioni della BPCO. Gli inibitori di pompa protonica (PPI) possono avere un ruolo nei pazienti con BPCO e MRGE nel prevenire le riesacerbazioni reflusso-indotte. Nei pazienti con BPCO e MRGE i beta 2-agonisti per via inalatoria e le metilxantine non sono controindicati.
The Lancet, 1981
SlR,—Dr Triger and his colleagues (Oct. 17, p. 837) describe three cases of systemic candid... more SlR,—Dr Triger and his colleagues (Oct. 17, p. 837) describe three cases of systemic candidiasis in patients with acute hepatic failure. They suggest that the Candida infection was related to cimetidine treatment. In 1978 Nicholls and Henryl proposed that the lower
Italian Journal of Medicine, 2013
Introduction: Several studies show that physical activity can reduce the risk of cardiovascular d... more Introduction: Several studies show that physical activity can reduce the risk of cardiovascular disease, but the vast majority of these focus on the short- to intermediate-term benefits or refer to very specific populations. This observational study was conducted to determine whether physical activity performed during the third or fourth decade of life influences the occurrence of cardiovascular events in patients aged 65-75 years. Materials and methods: We studied a cohort of 2191 unselected patients admitted to Internal Medicine Departments. Data were collected on the patients’ medical history and their physical activity level when they were 20 to 40 years old. For the latter purpose, we used a specific questionnaire to assess the levels of physical activity related to the patients’ job, daily life, leisure time, and sports. Results: Almost half (44.2%) of the patients we evaluated reported moderate-intense physical activity when they were 20-40 years old. Around one third (35.8%)...
List of local Ethics Committees which approved the study. (DOC 25Â kb)