Francisco Ayala Mata - Academia.edu (original) (raw)

Papers by Francisco Ayala Mata

Revista Alergia México, Apr 10, 2018

Asthma is a condition of unknown etiology characterized by chronic airway infl ammation. Cells th... more Asthma is a condition of unknown etiology characterized by chronic airway infl ammation. Cells that mediate the infl ammatory response generate reactive oxygen species that, together with other respiratory tract naturally-occurring oxidant species, produce a rupture of the redox balance, generating oxidative stress. It has been proposed that oxidative stress can be reverted by supplemental or dietary intake of antioxidant vitamins such as vitamin A, C, D and E, and this way relieve, improve or protect people with asthma. In this research, observational and placebocontrolled trials with regard to the role of antioxidant vitamins in the course of asthma, published between 1979 and 2016, were reviewed. The search engines were Google and Google Scholar, whereas consulted databases were PubMed and The Cochrane Library. There were 75 articles relevant to the subject that were found and reviewed, and it was concluded that it is not clear if the intake of supplements of these vitamins has any benefi cial clinical eff ect on asthma control. Further controlled, longer trials are needed to elucidate the role of these nutrients in the course of asthma.

Molecules, 2012

The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of repres... more The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

New (1R)-(–)-myrtenal-derived macrocycles 5a and 5b were efficiently used as chiral auxiliaries i... more New (1R)-(–)-myrtenal-derived macrocycles 5a and 5b were efficiently used as chiral auxiliaries in the
diastereoselective nucleophilic addition of several nucleophiles (RMgX, RLi, LiAlH4, and NaBH4). We
observed that the diastereoselectivity depended on the nucleophile, with the stereoselectivity order
being RMgX (>99:1 dr) > RLi (7:3 dr) > AlLiH4PNaBH4 (6:4 dr). The absolute configuration of the resulting
carbinols was established by X-ray diffraction of adducts 9a and 9b, and through chemical correlation
of carbinols 9b and 9c with diols of known absolute configuration.

Revista Alergia México, Apr 10, 2018

Asthma is a condition of unknown etiology characterized by chronic airway infl ammation. Cells th... more Asthma is a condition of unknown etiology characterized by chronic airway infl ammation. Cells that mediate the infl ammatory response generate reactive oxygen species that, together with other respiratory tract naturally-occurring oxidant species, produce a rupture of the redox balance, generating oxidative stress. It has been proposed that oxidative stress can be reverted by supplemental or dietary intake of antioxidant vitamins such as vitamin A, C, D and E, and this way relieve, improve or protect people with asthma. In this research, observational and placebocontrolled trials with regard to the role of antioxidant vitamins in the course of asthma, published between 1979 and 2016, were reviewed. The search engines were Google and Google Scholar, whereas consulted databases were PubMed and The Cochrane Library. There were 75 articles relevant to the subject that were found and reviewed, and it was concluded that it is not clear if the intake of supplements of these vitamins has any benefi cial clinical eff ect on asthma control. Further controlled, longer trials are needed to elucidate the role of these nutrients in the course of asthma.

Molecules, 2012

The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of repres... more The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

New (1R)-(–)-myrtenal-derived macrocycles 5a and 5b were efficiently used as chiral auxiliaries i... more New (1R)-(–)-myrtenal-derived macrocycles 5a and 5b were efficiently used as chiral auxiliaries in the
diastereoselective nucleophilic addition of several nucleophiles (RMgX, RLi, LiAlH4, and NaBH4). We
observed that the diastereoselectivity depended on the nucleophile, with the stereoselectivity order
being RMgX (>99:1 dr) > RLi (7:3 dr) > AlLiH4PNaBH4 (6:4 dr). The absolute configuration of the resulting
carbinols was established by X-ray diffraction of adducts 9a and 9b, and through chemical correlation
of carbinols 9b and 9c with diols of known absolute configuration.