Francisco Lopez - Academia.edu (original) (raw)
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Papers by Francisco Lopez
ACM Transactions on Applied Perception, 2009
Viewpoint selection is an emerging area in computer graphics with applications in fields such as ... more Viewpoint selection is an emerging area in computer graphics with applications in fields such as scene under- standing, volume visualization, image-based modeling, and molecular visualization. In this paper, we present a unified framework for viewpoint selection and mesh saliency based on the definition of an information channel between a set of viewpoints and the set of polygons of an object.
Bioorganic & medicinal chemistry
Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer... more Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer's disease, and small molecules that attenuate Aβ aggregation have been identified toward a therapeutic strategy that targets the disease's underlying cause. Compounds containing aromatic structures have been repeatedly reported as effective inhibitors of Aβ aggregation, but the functional groups that influence inhibition by these aromatic centers have been less frequently explored. The current study identifies analogs of naturally occurring coumarin as novel inhibitors of Aβ aggregation. Derivatization of the coumarin structure is shown to affect inhibitory capabilities and to influence the point at which an inhibitor intervenes within the nucleation dependent Aβ aggregation pathway. In particular, functional groups found within amyloid binding dyes, such as benzothiazole and triazole, can improve inhibition efficacy. Furthermore, inhibitor intervention at early or late stages w...
ACM Transactions on Applied Perception, 2009
Viewpoint selection is an emerging area in computer graphics with applications in fields such as ... more Viewpoint selection is an emerging area in computer graphics with applications in fields such as scene under- standing, volume visualization, image-based modeling, and molecular visualization. In this paper, we present a unified framework for viewpoint selection and mesh saliency based on the definition of an information channel between a set of viewpoints and the set of polygons of an object.
Bioorganic & medicinal chemistry
Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer... more Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer's disease, and small molecules that attenuate Aβ aggregation have been identified toward a therapeutic strategy that targets the disease's underlying cause. Compounds containing aromatic structures have been repeatedly reported as effective inhibitors of Aβ aggregation, but the functional groups that influence inhibition by these aromatic centers have been less frequently explored. The current study identifies analogs of naturally occurring coumarin as novel inhibitors of Aβ aggregation. Derivatization of the coumarin structure is shown to affect inhibitory capabilities and to influence the point at which an inhibitor intervenes within the nucleation dependent Aβ aggregation pathway. In particular, functional groups found within amyloid binding dyes, such as benzothiazole and triazole, can improve inhibition efficacy. Furthermore, inhibitor intervention at early or late stages w...