Franco Monache - Academia.edu (original) (raw)

Papers by Franco Monache

Research paper thumbnail of Alkaloids From Discaria serratifolia

Journal of Natural Products, 1979

Research paper thumbnail of A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri

Natural product research, Jan 10, 2015

A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the b... more A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using (1)H and (13)C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.

Research paper thumbnail of ChemInform Abstract: Novel Hypotensive Agents from Verbesina caracasana. Part 3. Caracasandiamide, a Truxinic Hypotensive Agent from Verbesina caracasana

Research paper thumbnail of Three new xanthones and macluraxanthone from Rheedia benthamiana Pl. Triana (guttiferae)

Journal of the Chemical Society, Perkin Transactions 1, 1981

... Three New Xanthones and Macluraxanthone from Rheedia benfharniana PI. Triana (Guttiferae) By ... more ... Three New Xanthones and Macluraxanthone from Rheedia benfharniana PI. Triana (Guttiferae) By Franco Delle Monache and Bruno Botta, Centro Chimica dei Recettori, CNR, presso lstituto di ... 00185 Roma, Italy buco, Departmento de Antiobioticos, 50.000 Recife, Brazil ...

Research paper thumbnail of Antimicrobial activity of methyl australate from Ganoderma australe

Revista Brasileira de Farmacognosia, 2007

... Elza de Fatima Albino Smania I ; Franco Delle Monache II ; Rosendo Augusto Yunes III ; Robert... more ... Elza de Fatima Albino Smania I ; Franco Delle Monache II ; Rosendo Augusto Yunes III ; Roberta Paulert I ; Artur Smania Junior I, *. ... Dictonary of the fungi. Surrey: Cabi International. [ Links ]. León F, Valencia M, Rivera A, Nieto I, Quintana J, Estévez F, Bermejo J 2003. ...

Research paper thumbnail of Avaliação do potencial antimicrobiano de Plinia glomerata (Myrtaceae)

Revista Brasileira de Farmacognosia, 2007

Research paper thumbnail of Filifolinol, a rearranged geranyl aromatic derivative from the resinous exudate of Heliotropium filifolium

Research paper thumbnail of Flavonoids, benzophenones and a new euphane derivative from Clusia columnaris Engl

Revista Brasileira de Farmacognosia, 2008

Research paper thumbnail of Composição química e atividades biológicas das folhas de Cynara scolymus L. (alcachofra) cultivada no Brasil

Research paper thumbnail of Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Journal of Ethnopharmacology, 2003

Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as “palomatias” or “torco”... more Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as “palomatias” or “torco” was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200mg/kg p.o.) and sodium diclofenac (5.64mg/kg

Research paper thumbnail of 1-Acetyl-3-Carboxy-β-Carboline, a New Acid and Other Constituents of Vestia lycioides

Research paper thumbnail of Antibacterial New Clerodane Diterpenes from the Surface of Haplopappus foliosus

Planta Medica, 2003

A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC... more A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC. is reported. Purification of the two active fractions yielded 2-alpha-hydroxy- cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (1) and 2-alpha-acetoxy- cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (2), two new clerodane diterpenes.

Research paper thumbnail of Three new Glutarimide Alkaloids from Croton Cuneatus

Natural Product Research, 2004

Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolati... more Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.

Research paper thumbnail of New cytotoxic isoflavone from the root bark of Brosimum utile

Natural Product Research, 2005

A new isoflavone 5,7,4&am... more A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.

Research paper thumbnail of Antioxidant capacity of flavonoids and a new arylphenol of the resinous exudate from Heliotropium sinuatum

Natural Product Research, 2003

From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3&am... more From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3',5'-dihydroxynonadecyl)phenol 1, together with eight previously described flavonoids, were isolated and their antioxidant activities were assessed by quenching measurements with ABTS and DPPH cation radicals.

Research paper thumbnail of Eudesmane Derivatives from Flourensia thurifera : Structure and Biological Activity

Natural Product Letters, 1997

3β-hydroxycostic acid and a mixture of two acyl (angelate and 3-methylbutyrate) derivatives were ... more 3β-hydroxycostic acid and a mixture of two acyl (angelate and 3-methylbutyrate) derivatives were isolated from the aerial part of Flourensia thurifera. The structures were assigned on the basis of NMR spectra and hydrolysis. The toxicity towards Artemia salina and feeding deterrency against Spodoptera littoralis of some derivatives are also briefly discussed.

Research paper thumbnail of Antioxidant Properties of Lignans and Ferulic Acid From the Resinous Exudate of Larrea Nitida

Journal of the Chilean Chemical Society, 2003

ABSTRACT From the resinous exudate of twigs end leaves of Larrea nitida, two lignans nor isoguaia... more ABSTRACT From the resinous exudate of twigs end leaves of Larrea nitida, two lignans nor isoguaiacine 1 and meso-nor-dihydroguaiaretic acid 2 and ferulic acid 3 were isolated. The antioxidant activities of resin and pure compounds were assesed by bleaching of the ...

Research paper thumbnail of Benzodihydrofurans in the Resinous Exudate From Diplostephium Cinereum

Boletín de la Sociedad Chilena de Química, 2001

... ALEJANDRO URZÚA1,* , RENÉ TORRES1,, LUZ ANDRADE1,, GIULIANO DELLE MONACHE2, ,FRANCO DELLE MON... more ... ALEJANDRO URZÚA1,* , RENÉ TORRES1,, LUZ ANDRADE1,, GIULIANO DELLE MONACHE2, ,FRANCO DELLE MONACHE2, JOSÉ LUIS BRIANSÓ3,, FRANCISCO SANCHEZ ... J=14.1 Hz, HA-13), 4.71 (1H, d, J=14.1 Hz, HB-13), 5.25 (2H, s, H-13), 2.90 (1H, dd, J gem =6.9 ...

Research paper thumbnail of Propiedades Antivirales De Compuestos Naturales y Semi-Sinteticos De La Resina De Heliotropium Filifolium

Boletín de la Sociedad Chilena de Química, 2002

... Extracción, aislamiento y caracterización de filifolinol 1.- Heliotropium filifolium (Miers) ... more ... Extracción, aislamiento y caracterización de filifolinol 1.- Heliotropium filifolium (Miers) Reiche (fam. ... 4) - Se incubaron cultivos de células Vero y Hep-2 en presencia de distintas concentraciones de los tres compuestos y luego de 48 horas a 37° se contó el número de células ...

Research paper thumbnail of Cytotoxic and Antitumor Activity of Vismiones Isolated from Vismieae

Journal of Natural Products, 1986

Research paper thumbnail of Alkaloids From Discaria serratifolia

Journal of Natural Products, 1979

Research paper thumbnail of A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri

Natural product research, Jan 10, 2015

A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the b... more A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using (1)H and (13)C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.

Research paper thumbnail of ChemInform Abstract: Novel Hypotensive Agents from Verbesina caracasana. Part 3. Caracasandiamide, a Truxinic Hypotensive Agent from Verbesina caracasana

Research paper thumbnail of Three new xanthones and macluraxanthone from Rheedia benthamiana Pl. Triana (guttiferae)

Journal of the Chemical Society, Perkin Transactions 1, 1981

... Three New Xanthones and Macluraxanthone from Rheedia benfharniana PI. Triana (Guttiferae) By ... more ... Three New Xanthones and Macluraxanthone from Rheedia benfharniana PI. Triana (Guttiferae) By Franco Delle Monache and Bruno Botta, Centro Chimica dei Recettori, CNR, presso lstituto di ... 00185 Roma, Italy buco, Departmento de Antiobioticos, 50.000 Recife, Brazil ...

Research paper thumbnail of Antimicrobial activity of methyl australate from Ganoderma australe

Revista Brasileira de Farmacognosia, 2007

... Elza de Fatima Albino Smania I ; Franco Delle Monache II ; Rosendo Augusto Yunes III ; Robert... more ... Elza de Fatima Albino Smania I ; Franco Delle Monache II ; Rosendo Augusto Yunes III ; Roberta Paulert I ; Artur Smania Junior I, *. ... Dictonary of the fungi. Surrey: Cabi International. [ Links ]. León F, Valencia M, Rivera A, Nieto I, Quintana J, Estévez F, Bermejo J 2003. ...

Research paper thumbnail of Avaliação do potencial antimicrobiano de Plinia glomerata (Myrtaceae)

Revista Brasileira de Farmacognosia, 2007

Research paper thumbnail of Filifolinol, a rearranged geranyl aromatic derivative from the resinous exudate of Heliotropium filifolium

Research paper thumbnail of Flavonoids, benzophenones and a new euphane derivative from Clusia columnaris Engl

Revista Brasileira de Farmacognosia, 2008

Research paper thumbnail of Composição química e atividades biológicas das folhas de Cynara scolymus L. (alcachofra) cultivada no Brasil

Research paper thumbnail of Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Journal of Ethnopharmacology, 2003

Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as “palomatias” or “torco”... more Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as “palomatias” or “torco” was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200mg/kg p.o.) and sodium diclofenac (5.64mg/kg

Research paper thumbnail of 1-Acetyl-3-Carboxy-β-Carboline, a New Acid and Other Constituents of Vestia lycioides

Research paper thumbnail of Antibacterial New Clerodane Diterpenes from the Surface of Haplopappus foliosus

Planta Medica, 2003

A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC... more A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC. is reported. Purification of the two active fractions yielded 2-alpha-hydroxy- cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (1) and 2-alpha-acetoxy- cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (2), two new clerodane diterpenes.

Research paper thumbnail of Three new Glutarimide Alkaloids from Croton Cuneatus

Natural Product Research, 2004

Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolati... more Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.

Research paper thumbnail of New cytotoxic isoflavone from the root bark of Brosimum utile

Natural Product Research, 2005

A new isoflavone 5,7,4&am... more A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.

Research paper thumbnail of Antioxidant capacity of flavonoids and a new arylphenol of the resinous exudate from Heliotropium sinuatum

Natural Product Research, 2003

From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3&am... more From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3',5'-dihydroxynonadecyl)phenol 1, together with eight previously described flavonoids, were isolated and their antioxidant activities were assessed by quenching measurements with ABTS and DPPH cation radicals.

Research paper thumbnail of Eudesmane Derivatives from Flourensia thurifera : Structure and Biological Activity

Natural Product Letters, 1997

3β-hydroxycostic acid and a mixture of two acyl (angelate and 3-methylbutyrate) derivatives were ... more 3β-hydroxycostic acid and a mixture of two acyl (angelate and 3-methylbutyrate) derivatives were isolated from the aerial part of Flourensia thurifera. The structures were assigned on the basis of NMR spectra and hydrolysis. The toxicity towards Artemia salina and feeding deterrency against Spodoptera littoralis of some derivatives are also briefly discussed.

Research paper thumbnail of Antioxidant Properties of Lignans and Ferulic Acid From the Resinous Exudate of Larrea Nitida

Journal of the Chilean Chemical Society, 2003

ABSTRACT From the resinous exudate of twigs end leaves of Larrea nitida, two lignans nor isoguaia... more ABSTRACT From the resinous exudate of twigs end leaves of Larrea nitida, two lignans nor isoguaiacine 1 and meso-nor-dihydroguaiaretic acid 2 and ferulic acid 3 were isolated. The antioxidant activities of resin and pure compounds were assesed by bleaching of the ...

Research paper thumbnail of Benzodihydrofurans in the Resinous Exudate From Diplostephium Cinereum

Boletín de la Sociedad Chilena de Química, 2001

... ALEJANDRO URZÚA1,* , RENÉ TORRES1,, LUZ ANDRADE1,, GIULIANO DELLE MONACHE2, ,FRANCO DELLE MON... more ... ALEJANDRO URZÚA1,* , RENÉ TORRES1,, LUZ ANDRADE1,, GIULIANO DELLE MONACHE2, ,FRANCO DELLE MONACHE2, JOSÉ LUIS BRIANSÓ3,, FRANCISCO SANCHEZ ... J=14.1 Hz, HA-13), 4.71 (1H, d, J=14.1 Hz, HB-13), 5.25 (2H, s, H-13), 2.90 (1H, dd, J gem =6.9 ...

Research paper thumbnail of Propiedades Antivirales De Compuestos Naturales y Semi-Sinteticos De La Resina De Heliotropium Filifolium

Boletín de la Sociedad Chilena de Química, 2002

... Extracción, aislamiento y caracterización de filifolinol 1.- Heliotropium filifolium (Miers) ... more ... Extracción, aislamiento y caracterización de filifolinol 1.- Heliotropium filifolium (Miers) Reiche (fam. ... 4) - Se incubaron cultivos de células Vero y Hep-2 en presencia de distintas concentraciones de los tres compuestos y luego de 48 horas a 37° se contó el número de células ...

Research paper thumbnail of Cytotoxic and Antitumor Activity of Vismiones Isolated from Vismieae

Journal of Natural Products, 1986