Frank Artinger - Academia.edu (original) (raw)

Papers by Frank Artinger

Research paper thumbnail of Contrasting spatial hearing deficits in hemianopia and spatial neglect

Neuroreport, Nov 1, 1999

SPATIAL hearing de®cits have been described in widely differing pathologies, including bilateral ... more SPATIAL hearing de®cits have been described in widely differing pathologies, including bilateral temporal or unilateral parietal lesions, hemispherectomy, spatial neglect and right-sided cortical lesions without neglect. However, the topography of spatial hearing de®cits after cortical lesions is only poorly understood, unlike that of vision and touch. We investigated the auditory subjective straight ahead (SSA) with a new technique of binaural sound source simulation using broad-band single pulses which were ®ltered with head-related transfer functions and delivered with a 58 resolution over headphones in front space. Normal subjects showed quite accurate judgments of the SSA, with a small but signi®cant shift to the left of centre (À1.78) in the horizontal plane. Hemineglect without a scotoma, produced a large ipsilesional deviation of the auditory SSA (228), while two hemianopic subjects, both without neglect, showed the opposite deviation of their perceived auditory SSA towards their contralesional, blind hemi®eld (10 vs À288). Two control patients with unilateral lesions, both without neglect and without hemianopia, produced normal judgments of their auditory SSA (À3.08, 3.88). These results suggest at least two contrasting in¯uences on directional spatial hearing after unilateral cortical lesions: hemianopia vs hemispatial neglect. The results are interpreted in favour of multisensory convergence of visual and auditory information in directional spatial hearing.

Research paper thumbnail of Spatial Processing of Spoken Words in Aphasia and in Neglect

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Neuropsychologia, 2012

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive leftward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Smooth pursuit eye movement training accelerates recovery from auditory/visual neglect and reduces disability and unawareness: 2 randomized controlled trials

Journal of the Neurological Sciences, 2013

WCN 2013 No: 990 Topic: 10 — Neurorehabilitation Profile of patients followed by physiotherapy at... more WCN 2013 No: 990 Topic: 10 — Neurorehabilitation Profile of patients followed by physiotherapy at a neurological step-down unit P.D. Gaiolla, T. Falsoni, P.R.P. Hidalgo, E.M. Araujo, R. Lobato, N.M. Barros, R.A.C. Eid, C. Talerman. Hospital Israelita Albert Einstein,

Research paper thumbnail of Zeitenwandel: Die HochschulAllianz für Angewandte Wissenschaften (HAWtech) als Wegbegleiter und Impulsgeber der großen gesellschaftlichen Transformationsprozesse

Nomos Verlagsgesellschaft mbH & Co. KG eBooks, 2022

Weltweit stehen unsere Gesellschaften an einem Wendepunkt: Klimakri se, Ressourcenverbrauch und d... more Weltweit stehen unsere Gesellschaften an einem Wendepunkt: Klimakri se, Ressourcenverbrauch und die damit verbundenen gesellschaftlichen, wirtschaftlichen und politischen Prozesse bedingen eine neue Priorisie rung unserer Werte und Ziele, um das Leben auf unserem Planeten für uns und unsere Nachfahren lebenswert und positiv zu gestalten. Die sechs Hochschulen der HochschulAllianz für Angewandte Wissenschaften (HAWtech) begleiten und gestalten diese Transformationsprozesse durch zukunftsweisende Projekte und Ideen.

Research paper thumbnail of Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect

Neurorehabilitation and Neural Repair, 2013

Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patien... more Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patients with hemiparesis after stroke. Patients with neglect, in particular, show a significantly impaired contralesional APS. Currently, there is no treatment available for this disorder. Galvanic vestibular stimulation (GVS) may ameliorate neglect and extinction by activating the thalamocortical network. Objective. The present study aimed to investigate the immediate effects and aftereffects (AEs; 20 minutes) of subsensory, bipolar GVS ( M = 0.6 mA current intensity) on APS in stroke patients with versus without spatial neglect and matched healthy controls. Methods. A novel optoelectronic arm position device was developed, enabling the precise measurement of the horizontal APS of both arms. In all, 10 healthy controls, 7 patients with left-sided hemiparesis and left-spatial neglect, and 15 patients with left hemiparesis but without neglect were tested. Horizontal APS was measured separately...

Research paper thumbnail of Sham-Stimulation-Controlled Study Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect : A

Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patien... more Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patients with hemiparesis after stroke. Patients with neglect, in particular, show a significantly impaired contralesional APS. Currently, there is no treatment available for this disorder. Galvanic vestibular stimulation (GVS) may ameliorate neglect and extinction by activating the thalamocortical network. Objective. The present study aimed to investigate the immediate effects and aftereffects (AEs; 20 minutes) of subsensory, bipolar GVS (M = 0.6 mA current intensity) on APS in stroke patients with versus without spatial neglect and matched healthy controls. Methods. A novel optoelectronic arm position device was developed, enabling the precise measurement of the horizontal APS of both arms. In all, 10 healthy controls, 7 patients with left-sided hemiparesis and left-spatial neglect, and 15 patients with left hemiparesis but without neglect were tested. Horizontal APS was measured separately ...

Research paper thumbnail of Entwurf und Erprobung eines PC-basierten Systems zur Diagnose und Therapie von Störungen der lexikalischen Sprachverarbeitung und des räumlichen Hörens

Im Mittelpunkt dieser Arbeit steht der Entwurf, die Realisierung und die Erprobung des PC-basiert... more Im Mittelpunkt dieser Arbeit steht der Entwurf, die Realisierung und die Erprobung des PC-basierten Systems CompX, mit dem neue Untersuchungs-und Behandlungsverfahren f r hirngesch digte Patienten mit Sprachst rungen und St rungen in der Verarbeitung r umlicher Informationen entwickelt wurden. Die klinische Behandlung beider St rungsformen konzentriert sich bislang auf die Verarbeitung visueller Information. So wird in der Therapie von Sprachst rungen fast ausschlie lich s c hriftsprachliches oder bildhaftes Reizmaterial verwendet, das mit konventionellen Hilfsmitteln herstellbar ist. Gleiches gilt f r die Diagnostik r umlicher Verarbeitungsst rungen, die sich auf den visuellen bzw. taktilen Sinneskanal beschr nkt. Dies war der Ausl ser f r die Entwicklung von CompX, ein interdisziplin res Projekt, das die bestehende L cke in der experimentellen Untersuchung akustischer Verarbeitungsleistungen schlie t. Das System ist das Ergebnis einer langj hrigen erfolgreichen Zusammenarbeit mit der Entwicklungsgruppe Klinische Neuropsychologie (EKN) des St dtischen Krankenhauses M nchen-Bogenhausen, in der Synergiee ekte zwischen ingenieurwissenschaftlichen und medizinisch/psychologischen Disziplinen gewinnbringend genutzt werden konnten (s. Abb. 1.1).

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24 h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24 h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive left- ward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Rotation or translation of auditory space in neglect?

Neuropsychologia, 2006

Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by a... more Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by an ipsilesional shift of a subjective reference frame. However, they differ in the direction of shift (rotation around the midsagittal plane vs. translation in front/back space). We tested this hypothesis in a patient (AJ) with persistent right-sided neglect following a left temporo-parieto-occipital and hypoxic lesion and in six age-matched healthy subjects. AJ showed visual neglect in line bisection, size matching, reading and visual search. Auditory localization was tested by using two different psychophysical techniques based on binaurally simulated stimuli for the horizontal plane in front and back space. Eye position was continuously monitored during stimulus presentation in all subjects. AJ revealed a significant ipsilesional, leftward shift of his auditory subjective median plane (ASMP) in front space (mean: -22.6°), and a rightward shift of the ASMP in back space (+14.5°). This pattern of results was replicated with a different psychophysical technique in a retest 10 months later. The rotational shift of AJ´s ASMP contrasted with normal performance in the healthy subjects. Monaural hearing deficits

Research paper thumbnail of Smooth Pursuit Eye Movement Training Promotes Recovery From Auditory and Visual Neglect: A Randomized Controlled Study

Neurorehabilitation and Neural Repair, 2013

Background. No treatment for auditory neglect and no randomized controlled trial evaluating smoot... more Background. No treatment for auditory neglect and no randomized controlled trial evaluating smooth pursuit eye movement therapy (SPT) for multimodal neglect are available. Objective. To compare the effects of SPT and visual scanning therapy (VST) on auditory and visual neglect in chronic stroke patients with neglect. Methods. A randomized, prospective trial was conducted. Fifty patients with left auditory and visual neglect were randomly assigned. Twenty-four patients completed SPT therapy and 21 patients VST. Five patients (4 VST, 1 SPT) were lost. Each group received 1-hour sessions of neglect therapy for 5 consecutive days totaling 5 hours. Outcome measures in visual neglect (digit cancellation, visuoperceptual-and motor line bisection, paragraph reading) and auditory neglect (auditory midline) were assessed twice before therapy, thereafter, and at 2-week follow-up. The SPT group practiced smooth pursuit eye movements while tracking stimuli moving leftward. The VST group systematically scanned the same but static stimuli. Both groups were divided into subgroups, and effects were separately investigated for mild and severe neglect. Results. Both groups did not differ before therapy in clinical/ demographic variables or neglect severity (auditory/visual). After treatment, the SPT group showed significant and lasting improvements in all visual measures and normal performance in the auditory midline. Neither visual nor auditory neglect impairments changed significantly after VST. Moreover, the treatment effect sizes (Cohen's d) were considerably higher for visual and auditory neglect after SPT versus VST, both for mild and severe neglect. Conclusions. Repetitive contralesional, smooth pursuit training induces superior, multimodal therapeutic effects in mild and severe neglect.

Research paper thumbnail of Smooth pursuit eye movement training accelerates recovery from auditory/visual neglect and reduces disability and unawareness: 2 randomized controlled trials

Journal of the Neurological Sciences, 2013

Research paper thumbnail of Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect: A Sham-Stimulation-Controlled Study

Neurorehabilitation and Neural Repair, 2013

Research paper thumbnail of COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGY NEUROREPORT

... NEUROREPORT (2001). Download: http://www.sfu.ca/\~jeffpell/Ling480.08/ SteinhauerM CACHED: Dow... more ... NEUROREPORT (2001). Download: http://www.sfu.ca/~jeffpell/Ling480.08/ SteinhauerM CACHED: Download as a PDF. by Karsten Steinhauer , Ca RoumyanaPancheva , Aaron J. Newman , Silvia Gennari , Michael T. Ullman. ...

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Neuropsychologia, 2012

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive leftward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Multimodal and multispatial deficits of verticality perception in hemispatial neglect

Neuroscience, 2011

sual and haptic perception of verticality in the frontal and sagittal plane. However, little is k... more sual and haptic perception of verticality in the frontal and sagittal plane. However, little is known about the multimodality of these impairments and the relationship between deviations in the frontal and the sagittal plane. Moreover, no previous study has combined investigations of verticality judgments in both modalities and both spatial planes within the same sample of subjects using the same apparatus. Thus, the aim of the present study was to investigate both subjective visual vertical (SVV) and subjective haptic vertical (SHV) judgments in the frontal and the sagittal plane in rightbrain-damaged patients with visuospatial neglect (n‫,)61؍‬ right-brain-damaged patients without neglect (n‫)81؍‬ and age-matched healthy individuals (n‫)61؍‬ using the same testing device for all tasks. This allowed for direct comparisons of visual vs. haptic and frontal vs. sagittal verticality judgments. Neglect patients showed significant counterclockwise tilts in their SVV and SHV judgments in the frontal plane as well as marked backward (upper end of the rod towards the observer) tilts in the sagittal plane. In contrast, right-braindamaged patients without neglect and healthy individuals showed no marked deviations in the frontal plane, but small forward (upper end of the rod away from the observer) tilts in the sagittal plane. Moreover, neglect patients showed significantly higher unsigned errors in all tasks. These results demonstrate multimodal and multispatial deficits in the judgment of verticality in patients with visuospatial neglect which are most likely due to an altered representation of verticality caused by lesions of brain areas related to multisensory integration and space representation in the right temporoparietal cortex.

Research paper thumbnail of Contrasting spatial hearing deficits in hemianopia and spatial neglect

Research paper thumbnail of Smooth Pursuit Eye Movement Training Promotes Recovery From Auditory and Visual Neglect: A Randomized Controlled Study

Neurorehabilitation and Neural Repair, 2013

Background. No treatment for auditory neglect and no randomized controlled trial evaluating smoot... more Background. No treatment for auditory neglect and no randomized controlled trial evaluating smooth pursuit eye movement therapy (SPT) for multimodal neglect are available. Objective. To compare the effects of SPT and visual scanning therapy (VST) on auditory and visual neglect in chronic stroke patients with neglect. Methods. A randomized, prospective trial was conducted. Fifty patients with left auditory and visual neglect were randomly assigned. Twenty-four patients completed SPT therapy and 21 patients VST. Five patients (4 VST, 1 SPT) were lost. Each group received 1-hour sessions of neglect therapy for 5 consecutive days totaling 5 hours. Outcome measures in visual neglect (digit cancellation, visuoperceptual-and motor line bisection, paragraph reading) and auditory neglect (auditory midline) were assessed twice before therapy, thereafter, and at 2-week follow-up. The SPT group practiced smooth pursuit eye movements while tracking stimuli moving leftward. The VST group systematically scanned the same but static stimuli. Both groups were divided into subgroups, and effects were separately investigated for mild and severe neglect. Results. Both groups did not differ before therapy in clinical/ demographic variables or neglect severity (auditory/visual). After treatment, the SPT group showed significant and lasting improvements in all visual measures and normal performance in the auditory midline. Neither visual nor auditory neglect impairments changed significantly after VST. Moreover, the treatment effect sizes (Cohen's d) were considerably higher for visual and auditory neglect after SPT versus VST, both for mild and severe neglect. Conclusions. Repetitive contralesional, smooth pursuit training induces superior, multimodal therapeutic effects in mild and severe neglect.

Research paper thumbnail of Rotation or translation of auditory space in neglect?

Neuropsychologia, 2006

Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by a... more Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by an ipsilesional shift of a subjective reference frame. However, they differ in the direction of shift (rotation around the midsagittal plane vs. translation in front/back space). We tested this hypothesis in a patient (AJ) with persistent right-sided neglect following a left temporo-parieto-occipital and hypoxic lesion and in six age-matched healthy subjects. AJ showed visual neglect in line bisection, size matching, reading and visual search. Auditory localization was tested by using two different psychophysical techniques based on binaurally simulated stimuli for the horizontal plane in front and back space. Eye position was continuously monitored during stimulus presentation in all subjects. AJ revealed a significant ipsilesional, leftward shift of his auditory subjective median plane (ASMP) in front space (mean: -22.6°), and a rightward shift of the ASMP in back space (+14.5°). This pattern of results was replicated with a different psychophysical technique in a retest 10 months later. The rotational shift of AJ´s ASMP contrasted with normal performance in the healthy subjects. Monaural hearing deficits

Research paper thumbnail of Differential effects of galvanic vestibular stimulation on arm position sense in right- vs. left-handers

Neuropsychologia, 2013

The human brain is organized asymmetrically in two hemispheres with different functional speciali... more The human brain is organized asymmetrically in two hemispheres with different functional specializations. Left-and right-handers differ in many functional capacities and their anatomical representations. Right-handers often show a stronger functional lateralization than left-handers, the latter showing a more bilateral, symmetrical brain organization. Recent functional imaging evidence shows a different lateralization of the cortical vestibular system towards the side of the preferred hand in left-vs. righthanders as well. Since the vestibular system is involved in somatosensory processing and the coding of body position, vestibular stimulation should affect such capacities differentially in left-vs. righthanders. In the present, sham-stimulation-controlled study we explored this hypothesis by studying the effects of galvanic vestibular stimulation (GVS) on proprioception in both forearms in left-and right-handers. Horizontal arm position sense (APS) was measured with an opto-electronic device. Second, the polarity-specific online-and after-effects of subsensory, bipolar GVS on APS were investigated in different sessions separately for both forearms. At baseline, both groups did not differ in their unsigned errors for both arms. However, right-handers showed significant directional errors in APS of both arms towards their own body. Right-cathodal/left-anodal GVS, resulting in right vestibular cortex activation, significantly deteriorated left APS in right-handers, but had no detectable effect on APS in left-handers in either arm. These findings are compatible with a right-hemisphere dominance for vestibular functions in right-handers and a differential vestibular organization in left-handers that compensates for the disturbing effects of GVS on APS. Moreover, our results show superior arm proprioception in left-handers in both forearms.

Research paper thumbnail of Contrasting spatial hearing deficits in hemianopia and spatial neglect

Neuroreport, Nov 1, 1999

SPATIAL hearing de®cits have been described in widely differing pathologies, including bilateral ... more SPATIAL hearing de®cits have been described in widely differing pathologies, including bilateral temporal or unilateral parietal lesions, hemispherectomy, spatial neglect and right-sided cortical lesions without neglect. However, the topography of spatial hearing de®cits after cortical lesions is only poorly understood, unlike that of vision and touch. We investigated the auditory subjective straight ahead (SSA) with a new technique of binaural sound source simulation using broad-band single pulses which were ®ltered with head-related transfer functions and delivered with a 58 resolution over headphones in front space. Normal subjects showed quite accurate judgments of the SSA, with a small but signi®cant shift to the left of centre (À1.78) in the horizontal plane. Hemineglect without a scotoma, produced a large ipsilesional deviation of the auditory SSA (228), while two hemianopic subjects, both without neglect, showed the opposite deviation of their perceived auditory SSA towards their contralesional, blind hemi®eld (10 vs À288). Two control patients with unilateral lesions, both without neglect and without hemianopia, produced normal judgments of their auditory SSA (À3.08, 3.88). These results suggest at least two contrasting in¯uences on directional spatial hearing after unilateral cortical lesions: hemianopia vs hemispatial neglect. The results are interpreted in favour of multisensory convergence of visual and auditory information in directional spatial hearing.

Research paper thumbnail of Spatial Processing of Spoken Words in Aphasia and in Neglect

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Neuropsychologia, 2012

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive leftward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Smooth pursuit eye movement training accelerates recovery from auditory/visual neglect and reduces disability and unawareness: 2 randomized controlled trials

Journal of the Neurological Sciences, 2013

WCN 2013 No: 990 Topic: 10 — Neurorehabilitation Profile of patients followed by physiotherapy at... more WCN 2013 No: 990 Topic: 10 — Neurorehabilitation Profile of patients followed by physiotherapy at a neurological step-down unit P.D. Gaiolla, T. Falsoni, P.R.P. Hidalgo, E.M. Araujo, R. Lobato, N.M. Barros, R.A.C. Eid, C. Talerman. Hospital Israelita Albert Einstein,

Research paper thumbnail of Zeitenwandel: Die HochschulAllianz für Angewandte Wissenschaften (HAWtech) als Wegbegleiter und Impulsgeber der großen gesellschaftlichen Transformationsprozesse

Nomos Verlagsgesellschaft mbH & Co. KG eBooks, 2022

Weltweit stehen unsere Gesellschaften an einem Wendepunkt: Klimakri se, Ressourcenverbrauch und d... more Weltweit stehen unsere Gesellschaften an einem Wendepunkt: Klimakri se, Ressourcenverbrauch und die damit verbundenen gesellschaftlichen, wirtschaftlichen und politischen Prozesse bedingen eine neue Priorisie rung unserer Werte und Ziele, um das Leben auf unserem Planeten für uns und unsere Nachfahren lebenswert und positiv zu gestalten. Die sechs Hochschulen der HochschulAllianz für Angewandte Wissenschaften (HAWtech) begleiten und gestalten diese Transformationsprozesse durch zukunftsweisende Projekte und Ideen.

Research paper thumbnail of Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect

Neurorehabilitation and Neural Repair, 2013

Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patien... more Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patients with hemiparesis after stroke. Patients with neglect, in particular, show a significantly impaired contralesional APS. Currently, there is no treatment available for this disorder. Galvanic vestibular stimulation (GVS) may ameliorate neglect and extinction by activating the thalamocortical network. Objective. The present study aimed to investigate the immediate effects and aftereffects (AEs; 20 minutes) of subsensory, bipolar GVS ( M = 0.6 mA current intensity) on APS in stroke patients with versus without spatial neglect and matched healthy controls. Methods. A novel optoelectronic arm position device was developed, enabling the precise measurement of the horizontal APS of both arms. In all, 10 healthy controls, 7 patients with left-sided hemiparesis and left-spatial neglect, and 15 patients with left hemiparesis but without neglect were tested. Horizontal APS was measured separately...

Research paper thumbnail of Sham-Stimulation-Controlled Study Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect : A

Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patien... more Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patients with hemiparesis after stroke. Patients with neglect, in particular, show a significantly impaired contralesional APS. Currently, there is no treatment available for this disorder. Galvanic vestibular stimulation (GVS) may ameliorate neglect and extinction by activating the thalamocortical network. Objective. The present study aimed to investigate the immediate effects and aftereffects (AEs; 20 minutes) of subsensory, bipolar GVS (M = 0.6 mA current intensity) on APS in stroke patients with versus without spatial neglect and matched healthy controls. Methods. A novel optoelectronic arm position device was developed, enabling the precise measurement of the horizontal APS of both arms. In all, 10 healthy controls, 7 patients with left-sided hemiparesis and left-spatial neglect, and 15 patients with left hemiparesis but without neglect were tested. Horizontal APS was measured separately ...

Research paper thumbnail of Entwurf und Erprobung eines PC-basierten Systems zur Diagnose und Therapie von Störungen der lexikalischen Sprachverarbeitung und des räumlichen Hörens

Im Mittelpunkt dieser Arbeit steht der Entwurf, die Realisierung und die Erprobung des PC-basiert... more Im Mittelpunkt dieser Arbeit steht der Entwurf, die Realisierung und die Erprobung des PC-basierten Systems CompX, mit dem neue Untersuchungs-und Behandlungsverfahren f r hirngesch digte Patienten mit Sprachst rungen und St rungen in der Verarbeitung r umlicher Informationen entwickelt wurden. Die klinische Behandlung beider St rungsformen konzentriert sich bislang auf die Verarbeitung visueller Information. So wird in der Therapie von Sprachst rungen fast ausschlie lich s c hriftsprachliches oder bildhaftes Reizmaterial verwendet, das mit konventionellen Hilfsmitteln herstellbar ist. Gleiches gilt f r die Diagnostik r umlicher Verarbeitungsst rungen, die sich auf den visuellen bzw. taktilen Sinneskanal beschr nkt. Dies war der Ausl ser f r die Entwicklung von CompX, ein interdisziplin res Projekt, das die bestehende L cke in der experimentellen Untersuchung akustischer Verarbeitungsleistungen schlie t. Das System ist das Ergebnis einer langj hrigen erfolgreichen Zusammenarbeit mit der Entwicklungsgruppe Klinische Neuropsychologie (EKN) des St dtischen Krankenhauses M nchen-Bogenhausen, in der Synergiee ekte zwischen ingenieurwissenschaftlichen und medizinisch/psychologischen Disziplinen gewinnbringend genutzt werden konnten (s. Abb. 1.1).

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24 h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24 h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive left- ward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Rotation or translation of auditory space in neglect?

Neuropsychologia, 2006

Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by a... more Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by an ipsilesional shift of a subjective reference frame. However, they differ in the direction of shift (rotation around the midsagittal plane vs. translation in front/back space). We tested this hypothesis in a patient (AJ) with persistent right-sided neglect following a left temporo-parieto-occipital and hypoxic lesion and in six age-matched healthy subjects. AJ showed visual neglect in line bisection, size matching, reading and visual search. Auditory localization was tested by using two different psychophysical techniques based on binaurally simulated stimuli for the horizontal plane in front and back space. Eye position was continuously monitored during stimulus presentation in all subjects. AJ revealed a significant ipsilesional, leftward shift of his auditory subjective median plane (ASMP) in front space (mean: -22.6°), and a rightward shift of the ASMP in back space (+14.5°). This pattern of results was replicated with a different psychophysical technique in a retest 10 months later. The rotational shift of AJ´s ASMP contrasted with normal performance in the healthy subjects. Monaural hearing deficits

Research paper thumbnail of Smooth Pursuit Eye Movement Training Promotes Recovery From Auditory and Visual Neglect: A Randomized Controlled Study

Neurorehabilitation and Neural Repair, 2013

Background. No treatment for auditory neglect and no randomized controlled trial evaluating smoot... more Background. No treatment for auditory neglect and no randomized controlled trial evaluating smooth pursuit eye movement therapy (SPT) for multimodal neglect are available. Objective. To compare the effects of SPT and visual scanning therapy (VST) on auditory and visual neglect in chronic stroke patients with neglect. Methods. A randomized, prospective trial was conducted. Fifty patients with left auditory and visual neglect were randomly assigned. Twenty-four patients completed SPT therapy and 21 patients VST. Five patients (4 VST, 1 SPT) were lost. Each group received 1-hour sessions of neglect therapy for 5 consecutive days totaling 5 hours. Outcome measures in visual neglect (digit cancellation, visuoperceptual-and motor line bisection, paragraph reading) and auditory neglect (auditory midline) were assessed twice before therapy, thereafter, and at 2-week follow-up. The SPT group practiced smooth pursuit eye movements while tracking stimuli moving leftward. The VST group systematically scanned the same but static stimuli. Both groups were divided into subgroups, and effects were separately investigated for mild and severe neglect. Results. Both groups did not differ before therapy in clinical/ demographic variables or neglect severity (auditory/visual). After treatment, the SPT group showed significant and lasting improvements in all visual measures and normal performance in the auditory midline. Neither visual nor auditory neglect impairments changed significantly after VST. Moreover, the treatment effect sizes (Cohen's d) were considerably higher for visual and auditory neglect after SPT versus VST, both for mild and severe neglect. Conclusions. Repetitive contralesional, smooth pursuit training induces superior, multimodal therapeutic effects in mild and severe neglect.

Research paper thumbnail of Smooth pursuit eye movement training accelerates recovery from auditory/visual neglect and reduces disability and unawareness: 2 randomized controlled trials

Journal of the Neurological Sciences, 2013

Research paper thumbnail of Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect: A Sham-Stimulation-Controlled Study

Neurorehabilitation and Neural Repair, 2013

Research paper thumbnail of COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGY NEUROREPORT

... NEUROREPORT (2001). Download: http://www.sfu.ca/\~jeffpell/Ling480.08/ SteinhauerM CACHED: Dow... more ... NEUROREPORT (2001). Download: http://www.sfu.ca/~jeffpell/Ling480.08/ SteinhauerM CACHED: Download as a PDF. by Karsten Steinhauer , Ca RoumyanaPancheva , Aaron J. Newman , Silvia Gennari , Michael T. Ullman. ...

Research paper thumbnail of Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements – Transient modulation and enduring treatment effects

Neuropsychologia, 2012

Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimula... more Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive leftward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect.

Research paper thumbnail of Multimodal and multispatial deficits of verticality perception in hemispatial neglect

Neuroscience, 2011

sual and haptic perception of verticality in the frontal and sagittal plane. However, little is k... more sual and haptic perception of verticality in the frontal and sagittal plane. However, little is known about the multimodality of these impairments and the relationship between deviations in the frontal and the sagittal plane. Moreover, no previous study has combined investigations of verticality judgments in both modalities and both spatial planes within the same sample of subjects using the same apparatus. Thus, the aim of the present study was to investigate both subjective visual vertical (SVV) and subjective haptic vertical (SHV) judgments in the frontal and the sagittal plane in rightbrain-damaged patients with visuospatial neglect (n‫,)61؍‬ right-brain-damaged patients without neglect (n‫)81؍‬ and age-matched healthy individuals (n‫)61؍‬ using the same testing device for all tasks. This allowed for direct comparisons of visual vs. haptic and frontal vs. sagittal verticality judgments. Neglect patients showed significant counterclockwise tilts in their SVV and SHV judgments in the frontal plane as well as marked backward (upper end of the rod towards the observer) tilts in the sagittal plane. In contrast, right-braindamaged patients without neglect and healthy individuals showed no marked deviations in the frontal plane, but small forward (upper end of the rod away from the observer) tilts in the sagittal plane. Moreover, neglect patients showed significantly higher unsigned errors in all tasks. These results demonstrate multimodal and multispatial deficits in the judgment of verticality in patients with visuospatial neglect which are most likely due to an altered representation of verticality caused by lesions of brain areas related to multisensory integration and space representation in the right temporoparietal cortex.

Research paper thumbnail of Contrasting spatial hearing deficits in hemianopia and spatial neglect

Research paper thumbnail of Smooth Pursuit Eye Movement Training Promotes Recovery From Auditory and Visual Neglect: A Randomized Controlled Study

Neurorehabilitation and Neural Repair, 2013

Background. No treatment for auditory neglect and no randomized controlled trial evaluating smoot... more Background. No treatment for auditory neglect and no randomized controlled trial evaluating smooth pursuit eye movement therapy (SPT) for multimodal neglect are available. Objective. To compare the effects of SPT and visual scanning therapy (VST) on auditory and visual neglect in chronic stroke patients with neglect. Methods. A randomized, prospective trial was conducted. Fifty patients with left auditory and visual neglect were randomly assigned. Twenty-four patients completed SPT therapy and 21 patients VST. Five patients (4 VST, 1 SPT) were lost. Each group received 1-hour sessions of neglect therapy for 5 consecutive days totaling 5 hours. Outcome measures in visual neglect (digit cancellation, visuoperceptual-and motor line bisection, paragraph reading) and auditory neglect (auditory midline) were assessed twice before therapy, thereafter, and at 2-week follow-up. The SPT group practiced smooth pursuit eye movements while tracking stimuli moving leftward. The VST group systematically scanned the same but static stimuli. Both groups were divided into subgroups, and effects were separately investigated for mild and severe neglect. Results. Both groups did not differ before therapy in clinical/ demographic variables or neglect severity (auditory/visual). After treatment, the SPT group showed significant and lasting improvements in all visual measures and normal performance in the auditory midline. Neither visual nor auditory neglect impairments changed significantly after VST. Moreover, the treatment effect sizes (Cohen's d) were considerably higher for visual and auditory neglect after SPT versus VST, both for mild and severe neglect. Conclusions. Repetitive contralesional, smooth pursuit training induces superior, multimodal therapeutic effects in mild and severe neglect.

Research paper thumbnail of Rotation or translation of auditory space in neglect?

Neuropsychologia, 2006

Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by a... more Egocentric models of neglect explain the lateralised omission of stimuli in neglect patients by an ipsilesional shift of a subjective reference frame. However, they differ in the direction of shift (rotation around the midsagittal plane vs. translation in front/back space). We tested this hypothesis in a patient (AJ) with persistent right-sided neglect following a left temporo-parieto-occipital and hypoxic lesion and in six age-matched healthy subjects. AJ showed visual neglect in line bisection, size matching, reading and visual search. Auditory localization was tested by using two different psychophysical techniques based on binaurally simulated stimuli for the horizontal plane in front and back space. Eye position was continuously monitored during stimulus presentation in all subjects. AJ revealed a significant ipsilesional, leftward shift of his auditory subjective median plane (ASMP) in front space (mean: -22.6°), and a rightward shift of the ASMP in back space (+14.5°). This pattern of results was replicated with a different psychophysical technique in a retest 10 months later. The rotational shift of AJ´s ASMP contrasted with normal performance in the healthy subjects. Monaural hearing deficits

Research paper thumbnail of Differential effects of galvanic vestibular stimulation on arm position sense in right- vs. left-handers

Neuropsychologia, 2013

The human brain is organized asymmetrically in two hemispheres with different functional speciali... more The human brain is organized asymmetrically in two hemispheres with different functional specializations. Left-and right-handers differ in many functional capacities and their anatomical representations. Right-handers often show a stronger functional lateralization than left-handers, the latter showing a more bilateral, symmetrical brain organization. Recent functional imaging evidence shows a different lateralization of the cortical vestibular system towards the side of the preferred hand in left-vs. righthanders as well. Since the vestibular system is involved in somatosensory processing and the coding of body position, vestibular stimulation should affect such capacities differentially in left-vs. righthanders. In the present, sham-stimulation-controlled study we explored this hypothesis by studying the effects of galvanic vestibular stimulation (GVS) on proprioception in both forearms in left-and right-handers. Horizontal arm position sense (APS) was measured with an opto-electronic device. Second, the polarity-specific online-and after-effects of subsensory, bipolar GVS on APS were investigated in different sessions separately for both forearms. At baseline, both groups did not differ in their unsigned errors for both arms. However, right-handers showed significant directional errors in APS of both arms towards their own body. Right-cathodal/left-anodal GVS, resulting in right vestibular cortex activation, significantly deteriorated left APS in right-handers, but had no detectable effect on APS in left-handers in either arm. These findings are compatible with a right-hemisphere dominance for vestibular functions in right-handers and a differential vestibular organization in left-handers that compensates for the disturbing effects of GVS on APS. Moreover, our results show superior arm proprioception in left-handers in both forearms.