Frank Hildner - Academia.edu (original) (raw)

Papers by Frank Hildner

Pulmonary Thromboembolism—Update

JAMA: The Journal of the American Medical Association, 1980

A Noninvasive Technique for the Study of Cardiac Hemodynamics Utilizing C 15 O 2 Inhalation 1

Radiology, 1976

A new technique for the study of cardiac hemodynamics is described which utilizes single-breath i... more A new technique for the study of cardiac hemodynamics is described which utilizes single-breath inhalation of C15O2 (T 1/2 = 124 sec.) and the recording of activity vs. time curves with scintillation counters placed externally over the left ventricle and right lung. The results from 10 normal volunteers and 28 patients with acquired or congenital heart disease have been compared to the findings at cardiac catheterization. The technique is safe, rapid, and nontraumatic, and yielded no false positives or negatives in this series.

Localization of A-V conduction defects in man by recording of the his bundle electrogram

The American Journal of Cardiology, Feb 28, 1970

... Clinical Study Localization of AV Conduction Defects in Man by Recording of the His Bundle El... more ... Clinical Study Localization of AV Conduction Defects in Man by Recording of the His Bundle Electrogram ONKAR S. NARULA, MD LAWRENCE SANFORD COHEN, MD, FACC PH I LI P SAM ET, MD, FACC JOHN W. LISTER, MD BENJAMIN SCHERLAG, PhD and FRANK J ...

Calcific aortic insufficiency

Amer J Cardiol, 1974

Catheterization and Cardiovascular Diagnosis, 1975

All selective coronary arteriographic examinations (1,833) performed in the authors' laboratory d... more All selective coronary arteriographic examinations (1,833) performed in the authors' laboratory during a fiveyear period (1/1/70 to 12/31/74) were analyzed for mortality and total morbidity according to method used. During the first two years, the control period, the classic brachial artery cutdown (Sones) and percutaneous femoral artery puncture (Judkins) techniques were utilized. Mortality rate for the total 589 patients was 1.01%. This included a mortality of 0.26% (11386) for the brachial arteriotomy method, and 2.5% (51203) for the percutaneous femoral puncture approach.

Catheterization and Cardiovascular Diagnosis, 1975

The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabe... more The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. lnotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular enddiastolic pressure, shift to an augmented function curve in work-pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5-15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject. While the measurable net hemodynamic effect of tolbutamide in the human heart is small, its effect on ischemic and normal areas within the heart of a diabetic patient with atherosclerosis may be different. Thus, its ultimate effect on the diseased heart may be significant.

Catheterization and Cardiovascular Diagnosis, 1990

Recent technology has produced high-flow and large-lumen catheters as well as other angiographic ... more Recent technology has produced high-flow and large-lumen catheters as well as other angiographic accessories to enhance the visualization of the coronary arteries during diagnostic and percutaneous transluminal coronary angioplasty (PTCA) procedures. In spite of these technological advances, there are still many cases in which the quality of the coronary angiography could be significantly improved. This paper reports on a clinical evaluation of a hand-held power syringe. The syringe offers the ability to power inject contrast safely and effectively during routine angiograms as well as through guiding catheters with the balloon catheter present during PTCA. At the same time, control of the injection is equal to that associated with manual syringes.

Catheterization and Cardiovascular Diagnosis, 1986

Left ventriculography has become the single most important procedure in the evaluation of cardiac... more Left ventriculography has become the single most important procedure in the evaluation of cardiac function. This study reevaluated the refinements of catheter and power injector technology to assess recommendations of past years and establish new principles for optimum ventriculography. Ventriculograms from 102 patients undergoing left heart catheterization and coronary arteriography for coronary, valvular, and myocardial heart disease served as the test sample. Three styles of #7F high-flow 110-cm pigtail catheters were utilized. One had 12 sideholes while the other two had six sideholes positioned nearer the base of the curl. Analysis of ventriculographic quality of each angiogram was performed by three of the authors independently and subsequently together. Five variables were analyzed for their effect on the diagnostic quality of the angiogram: 1) 6-hole catheters, 2) 12-hole catheters, 3) volume of contrast, 4) flow rate, and 5) location of injection. Once these analyses were complete, the effect of combinations of these variables was tested to determine their effect on angiographic quality. The first combination included contrast volume and flow rate. The second combination compared contrast volume and flow rate when utilized with 6-or 12-hole catheters. The third combination tested the 6-and 12-hole catheters in the apex or inflow locations. A multivariate contingency analysis was used to define relationships between the variables and the quality of the angiogram obtained.

Echocardiographic assessment of left ventricular function in coronary arterial disease

Heart, 1977

This investigation was designed to determine the role of echocardiography in the assessment of le... more This investigation was designed to determine the role of echocardiography in the assessment of left ventricular function in patients with significant coronary arterial disease. Satisfactory echocardiograms were obtained in 43 patients with coronary arterial disease. The ventriculographic ejection fraction was determined by the area length method. The echocardiographic left ventricular end-diastolic dimension was increased to more than 5-4 cm in

Mitral Stenosis in a Patient with a Congenital Communication between the Systemic and Pulmonary Venous Beds

CHEST Journal, 1970

... Page 2. II. I H IIIIT I4t,Tt RII L LL I. . .:lIllll I I __L..LLJI III 1 I . ;:. I.: I .. __ _... more ... Page 2. II. I H IIIIT I4t,Tt RII L LL I. . .:lIllll I I __L..LLJI III 1 I . ;:. I.: I .. __ _____ I; I I L. .1... m I.! ii I I#{149}IdlI#{149}i JIH-H-- iiI 1 I :11 --- i#{149}I Ti If I. l I It f !1 :i: ii-.Ii. V4 ..:W. if:r II. Ll±l;i : I. I:.I: Li III 337 CHEST, VOL. 57, NO. 4, APRIL 1970 MITRAL STENOSIS I :: II FIGURE 1A. ...

CHEST Journal, 1973

This prospectlve study was performed to determine whether complications that occur immediately be... more This prospectlve study was performed to determine whether complications that occur immediately before or after the time of scheduled catheterization are as much disease-related as procedure-related. During 24 months all complications associated with 1,806 diagnostic cardiac catheterizations were recorded i f they occurred from 24 hours before the time the procedure was scheduled to 72 hours later, longer if compiications were clearly procedure-related. Pseudo complications are spontaneous medical or surgical incidents that occur during the 24-hour period before catheterization is scheduled to be performed. Proceduredated complications are Incidents that occur durlng or after the catheterization procedure. There were 13 (0.619'0) procedurere lated complications but no deaths. There were 13 (a619'0) pseudo wtnplkatlonr In cluding 4 (0.24%) deaths. Ail complications were similar in nature except for 3 instances of vascular injury, which were procedure-related. Pseudo complications occur as commonly as procedure-related complications and at times are more severe. Complications occurring before catheterization are related to the underlying disease process and not medical intervention. It is likely that similar diseasetaused incidents occur after a catheterization and are not necessarily procedure-related.

Catheterization and Cardiovascular Interventions, 1999

The Laboratory Survey Committee of the Society for Cardiac Angiography and Interventions was crea... more The Laboratory Survey Committee of the Society for Cardiac Angiography and Interventions was created as a resource for physicians and administrators to provide comprehensive independent outside review services for cardiac catheterization laboratories. Since 1989, when the committee began its work, surveys of 23 catheterization laboratories have been completed. Our review of this experience identified several recurring problems among the laboratories. The purpose of this paper is to summarize our experience and highlight the lessons we learned in the hope that this information will benefit many other laboratories. Cathet.

The Annals of Thoracic Surgery, 1969

rosthetic valve replacement in patients over 60 years of age, although still uncommon, is becomin... more rosthetic valve replacement in patients over 60 years of age, although still uncommon, is becoming more frequent. Valvular

Preoperative and Postoperative Cardiac Output Determinations Using an Instantaneous Pulmonary Capillary Blood Flow Method

The Annals of Thoracic Surgery, 1971

Isotope Quantitation of Aortic Insufficiency Compared to Cineangiography in Man

The Annals of Thoracic Surgery, 1969

Page 1. DOI: 10.1016/S0003-4975(10)66413-2 1969;8:84-93 Ann Thorac Surg Joseph W. Linhart and Phi... more Page 1. DOI: 10.1016/S0003-4975(10)66413-2 1969;8:84-93 Ann Thorac Surg Joseph W. Linhart and Philip Samet Frank J. Hildner, William R. Pierson, S. Serge Barold, to Cineangiography in Man Isotope Quantitation of Aortic Insufficiency Compared ...

Effect of Chest Wall Stimulation on Cardiac Pacemaker Function

The American Journal of the Medical Sciences, 1970

The American Journal of Medicine, 1972

The American Journal of Cardiology, 1968

The American Journal of Cardiology, 1994

P athology studies have shown that coronary atherosclerosis is much more extensive in those who d... more P athology studies have shown that coronary atherosclerosis is much more extensive in those who die of coronary artery disease than in those who die of other causes.1'2 If a simple, safe, and rapid noninvasive test could indicate the presence and extent of coronary atherosclerosis in its preclinical phase, then a high-risk population could be selected in whom aggressive risk factor modification would be cost-effective.3*4 Ultrafast computed tomography (CT) combines the excellent contrast and spatial resolution of conventional CT with subsecond scan times that freeze cardiac motion. It has been shown to be sensitive for detecting and accurate for quantifying coronary artery calcium.5Jj Accordingly, we studied the correlation between quantitative measures of coronary calcium by ultrafast CT and the extent of atherosclerosis documented by coronary angiography.

The American Journal of Cardiology, 1969

Abstracts wedge pressure is normal in all cases. Although S-T segment and T wave changes are pres... more Abstracts wedge pressure is normal in all cases. Although S-T segment and T wave changes are present after operation, there is no S-T depression after exercise.

Pulmonary Thromboembolism—Update

JAMA: The Journal of the American Medical Association, 1980

A Noninvasive Technique for the Study of Cardiac Hemodynamics Utilizing C 15 O 2 Inhalation 1

Radiology, 1976

A new technique for the study of cardiac hemodynamics is described which utilizes single-breath i... more A new technique for the study of cardiac hemodynamics is described which utilizes single-breath inhalation of C15O2 (T 1/2 = 124 sec.) and the recording of activity vs. time curves with scintillation counters placed externally over the left ventricle and right lung. The results from 10 normal volunteers and 28 patients with acquired or congenital heart disease have been compared to the findings at cardiac catheterization. The technique is safe, rapid, and nontraumatic, and yielded no false positives or negatives in this series.

Localization of A-V conduction defects in man by recording of the his bundle electrogram

The American Journal of Cardiology, Feb 28, 1970

... Clinical Study Localization of AV Conduction Defects in Man by Recording of the His Bundle El... more ... Clinical Study Localization of AV Conduction Defects in Man by Recording of the His Bundle Electrogram ONKAR S. NARULA, MD LAWRENCE SANFORD COHEN, MD, FACC PH I LI P SAM ET, MD, FACC JOHN W. LISTER, MD BENJAMIN SCHERLAG, PhD and FRANK J ...

Calcific aortic insufficiency

Amer J Cardiol, 1974

Catheterization and Cardiovascular Diagnosis, 1975

All selective coronary arteriographic examinations (1,833) performed in the authors' laboratory d... more All selective coronary arteriographic examinations (1,833) performed in the authors' laboratory during a fiveyear period (1/1/70 to 12/31/74) were analyzed for mortality and total morbidity according to method used. During the first two years, the control period, the classic brachial artery cutdown (Sones) and percutaneous femoral artery puncture (Judkins) techniques were utilized. Mortality rate for the total 589 patients was 1.01%. This included a mortality of 0.26% (11386) for the brachial arteriotomy method, and 2.5% (51203) for the percutaneous femoral puncture approach.

Catheterization and Cardiovascular Diagnosis, 1975

The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabe... more The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. lnotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular enddiastolic pressure, shift to an augmented function curve in work-pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5-15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject. While the measurable net hemodynamic effect of tolbutamide in the human heart is small, its effect on ischemic and normal areas within the heart of a diabetic patient with atherosclerosis may be different. Thus, its ultimate effect on the diseased heart may be significant.

Catheterization and Cardiovascular Diagnosis, 1990

Recent technology has produced high-flow and large-lumen catheters as well as other angiographic ... more Recent technology has produced high-flow and large-lumen catheters as well as other angiographic accessories to enhance the visualization of the coronary arteries during diagnostic and percutaneous transluminal coronary angioplasty (PTCA) procedures. In spite of these technological advances, there are still many cases in which the quality of the coronary angiography could be significantly improved. This paper reports on a clinical evaluation of a hand-held power syringe. The syringe offers the ability to power inject contrast safely and effectively during routine angiograms as well as through guiding catheters with the balloon catheter present during PTCA. At the same time, control of the injection is equal to that associated with manual syringes.

Catheterization and Cardiovascular Diagnosis, 1986

Left ventriculography has become the single most important procedure in the evaluation of cardiac... more Left ventriculography has become the single most important procedure in the evaluation of cardiac function. This study reevaluated the refinements of catheter and power injector technology to assess recommendations of past years and establish new principles for optimum ventriculography. Ventriculograms from 102 patients undergoing left heart catheterization and coronary arteriography for coronary, valvular, and myocardial heart disease served as the test sample. Three styles of #7F high-flow 110-cm pigtail catheters were utilized. One had 12 sideholes while the other two had six sideholes positioned nearer the base of the curl. Analysis of ventriculographic quality of each angiogram was performed by three of the authors independently and subsequently together. Five variables were analyzed for their effect on the diagnostic quality of the angiogram: 1) 6-hole catheters, 2) 12-hole catheters, 3) volume of contrast, 4) flow rate, and 5) location of injection. Once these analyses were complete, the effect of combinations of these variables was tested to determine their effect on angiographic quality. The first combination included contrast volume and flow rate. The second combination compared contrast volume and flow rate when utilized with 6-or 12-hole catheters. The third combination tested the 6-and 12-hole catheters in the apex or inflow locations. A multivariate contingency analysis was used to define relationships between the variables and the quality of the angiogram obtained.

Echocardiographic assessment of left ventricular function in coronary arterial disease

Heart, 1977

This investigation was designed to determine the role of echocardiography in the assessment of le... more This investigation was designed to determine the role of echocardiography in the assessment of left ventricular function in patients with significant coronary arterial disease. Satisfactory echocardiograms were obtained in 43 patients with coronary arterial disease. The ventriculographic ejection fraction was determined by the area length method. The echocardiographic left ventricular end-diastolic dimension was increased to more than 5-4 cm in

Mitral Stenosis in a Patient with a Congenital Communication between the Systemic and Pulmonary Venous Beds

CHEST Journal, 1970

... Page 2. II. I H IIIIT I4t,Tt RII L LL I. . .:lIllll I I __L..LLJI III 1 I . ;:. I.: I .. __ _... more ... Page 2. II. I H IIIIT I4t,Tt RII L LL I. . .:lIllll I I __L..LLJI III 1 I . ;:. I.: I .. __ _____ I; I I L. .1... m I.! ii I I#{149}IdlI#{149}i JIH-H-- iiI 1 I :11 --- i#{149}I Ti If I. l I It f !1 :i: ii-.Ii. V4 ..:W. if:r II. Ll±l;i : I. I:.I: Li III 337 CHEST, VOL. 57, NO. 4, APRIL 1970 MITRAL STENOSIS I :: II FIGURE 1A. ...

CHEST Journal, 1973

This prospectlve study was performed to determine whether complications that occur immediately be... more This prospectlve study was performed to determine whether complications that occur immediately before or after the time of scheduled catheterization are as much disease-related as procedure-related. During 24 months all complications associated with 1,806 diagnostic cardiac catheterizations were recorded i f they occurred from 24 hours before the time the procedure was scheduled to 72 hours later, longer if compiications were clearly procedure-related. Pseudo complications are spontaneous medical or surgical incidents that occur during the 24-hour period before catheterization is scheduled to be performed. Proceduredated complications are Incidents that occur durlng or after the catheterization procedure. There were 13 (0.619'0) procedurere lated complications but no deaths. There were 13 (a619'0) pseudo wtnplkatlonr In cluding 4 (0.24%) deaths. Ail complications were similar in nature except for 3 instances of vascular injury, which were procedure-related. Pseudo complications occur as commonly as procedure-related complications and at times are more severe. Complications occurring before catheterization are related to the underlying disease process and not medical intervention. It is likely that similar diseasetaused incidents occur after a catheterization and are not necessarily procedure-related.

Catheterization and Cardiovascular Interventions, 1999

The Laboratory Survey Committee of the Society for Cardiac Angiography and Interventions was crea... more The Laboratory Survey Committee of the Society for Cardiac Angiography and Interventions was created as a resource for physicians and administrators to provide comprehensive independent outside review services for cardiac catheterization laboratories. Since 1989, when the committee began its work, surveys of 23 catheterization laboratories have been completed. Our review of this experience identified several recurring problems among the laboratories. The purpose of this paper is to summarize our experience and highlight the lessons we learned in the hope that this information will benefit many other laboratories. Cathet.

The Annals of Thoracic Surgery, 1969

rosthetic valve replacement in patients over 60 years of age, although still uncommon, is becomin... more rosthetic valve replacement in patients over 60 years of age, although still uncommon, is becoming more frequent. Valvular

Preoperative and Postoperative Cardiac Output Determinations Using an Instantaneous Pulmonary Capillary Blood Flow Method

The Annals of Thoracic Surgery, 1971

Isotope Quantitation of Aortic Insufficiency Compared to Cineangiography in Man

The Annals of Thoracic Surgery, 1969

Page 1. DOI: 10.1016/S0003-4975(10)66413-2 1969;8:84-93 Ann Thorac Surg Joseph W. Linhart and Phi... more Page 1. DOI: 10.1016/S0003-4975(10)66413-2 1969;8:84-93 Ann Thorac Surg Joseph W. Linhart and Philip Samet Frank J. Hildner, William R. Pierson, S. Serge Barold, to Cineangiography in Man Isotope Quantitation of Aortic Insufficiency Compared ...

Effect of Chest Wall Stimulation on Cardiac Pacemaker Function

The American Journal of the Medical Sciences, 1970

The American Journal of Medicine, 1972

The American Journal of Cardiology, 1968

The American Journal of Cardiology, 1994

P athology studies have shown that coronary atherosclerosis is much more extensive in those who d... more P athology studies have shown that coronary atherosclerosis is much more extensive in those who die of coronary artery disease than in those who die of other causes.1'2 If a simple, safe, and rapid noninvasive test could indicate the presence and extent of coronary atherosclerosis in its preclinical phase, then a high-risk population could be selected in whom aggressive risk factor modification would be cost-effective.3*4 Ultrafast computed tomography (CT) combines the excellent contrast and spatial resolution of conventional CT with subsecond scan times that freeze cardiac motion. It has been shown to be sensitive for detecting and accurate for quantifying coronary artery calcium.5Jj Accordingly, we studied the correlation between quantitative measures of coronary calcium by ultrafast CT and the extent of atherosclerosis documented by coronary angiography.

The American Journal of Cardiology, 1969

Abstracts wedge pressure is normal in all cases. Although S-T segment and T wave changes are pres... more Abstracts wedge pressure is normal in all cases. Although S-T segment and T wave changes are present after operation, there is no S-T depression after exercise.