Frank Hu - Academia.edu (original) (raw)
Papers by Frank Hu
Journal of Allergy and Clinical Immunology, 2002
Journal of Allergy and Clinical Immunology, 2002
p = 0.0345, respectively); 5) 38.3% and 53.8% homes in group A and group B, respectively, had pet... more p = 0.0345, respectively); 5) 38.3% and 53.8% homes in group A and group B, respectively, had pets in the home (p < 0.02). This study confirms that the number of live mites recovered from carpets by vacuum cleaning is low. However, most central Florida homes have total mite numbers above the proposed thresholds to cause sensitization and/or symptoms. Mite numbers are positively associated with home and carpet age and negatively with the presence of pets in homes.
Journal of Allergy and Clinical Immunology, 2002
Aerobiologia, 2001
Major weather parameters have long been known to alter airborne pollen and spore concentrations. ... more Major weather parameters have long been known to alter airborne pollen and spore concentrations. The following study was conducted to study the effect of three of these parameters on airborne ragweed pollen concentrations.During the ragweed (RW) season for the years 1997 and 1998, 10 minute pollen collections were taken at least every 4 hours using an Allergenco MK-3 spore trap.
Annals of Allergy, Asthma & Immunology, 2001
Introduction: Ragweed pollen is one of the major causes of allergic rhinitis in the midwest Unite... more Introduction: Ragweed pollen is one of the major causes of allergic rhinitis in the midwest United States. Previous studies have demonstrated that ragweed pollen production begins after sunrise and airborne pollen levels peak several hours later. Variations in this pattern that may be of clinical importance within a small region and the effect of weather on these variations have not been investigated. Methods:Volumetric pollen collectors were stationed at four sites around the metropolitan area. Ten-minute grab samples were taken at each location every 2 hours for continuous 24-hour periods during the 1997 ragweed season. The downtown location had a weather station that logged meteorological conditions at hourly intervals during this time. Ragweed pollen grains were counted microscopically at 400 ϫ. Uninterrupted data covering at least 20 days during the season were evaluated for each collection site. Results:The lowest ragweed pollen counts occur at 6:00 AM and the highest occur at noon for both suburban and urban sites. Rainfall was seen to be the most influential weather-related factor. Significant rainfall events effectively removed pollen grains from the air. Conclusions:Though ragweed pollen emission begins at 6:00 AM, peak pollen exposure occurs at midday. This observation is in agreement with many other studies. The myth that highest ragweed exposure occurs in the early morning hours is not supported by this or previous studies.
Annals of Allergy, Asthma & Immunology, 2001
Introduction: Environmental agents including animal, fungal, tree, and weed antigens are known to... more Introduction: Environmental agents including animal, fungal, tree, and weed antigens are known to cause allergic rhinitis and asthma. The following study was performed to measure the antigen concentration of several of these in house dust of children seen in an allergy clinic. Comparisons are made between household allergen levels of children seen for asthma and children seen for other reasons. Methods: Dust samples were solicited from patients in a pediatric allergy specialty clinic and other individuals associated with the clinic. Persons submitting dust were asked to complete a questionnaire describing their house. Samples were extracted, centrifuged, and filtered for sterility. Samples were stored in 50% glycerol at Ϫ20°C. Specific antigens for Alternaria, Cladosporium, Aspergillus, Candida, Dermatophagoides farinae, cat, dog, oak, fescue, ragweed, plantain, and cockroach were measured using inhibition assays developed with whole antigen extract. Allergens Der p1, Der f 1, Alt a 1, and Alt a 70 kD were measured using double monoclonal antibody assays. Results: Significant concentrations of whole antigen from cat, dog, oak, Alternaria, and Cladosporium were detected. Between 0.1 and 18 g of Der f1 and Der p1 per gram of dust were also measured. Alt a 1 and Alt a 70 kD levels varied between 3.0 and 1000 U/g of dust. Significant positive correlations were observed in levels of dust mite and Alternaria allergen for patients with an evaluation of asthma. Conclusions: We found measurable levels of fungal antigens (Alternaria, Cladosporium), mite antigens, and animal antigens (dog and cat) in the majority of dust samples in this self-selected set of allergy clinic patients. Specific allergens Alt a 1, Alt a 70kD, and Der p 1 were significantly higher in the homes of asthmatic patients when compared with patients seen for reasons other than asthma. These studies support the hypothesis that fungal allergen exposure is an important component in the pathogenesis of the clinical condition known as asthma.
Allergy and Asthma Proceedings, 2008
Treatment with common household bleach containing hypochlorite destroys dust mites and denatures ... more Treatment with common household bleach containing hypochlorite destroys dust mites and denatures protein allergens. The purpose of this study was to determine if home use of hypochlorite products results in lowered exposure to bacteria, fungi, and protein allergens and improved quality of life (QOL) for asthmatic persons in the home. Asthmatic and nonasthmatic households containing at least three persons (between 2 and 17 years of age) were recruited. Households were supplied one of three sets of cleaning products (regular products, some containing hypochlorite; regular products plus three additional products with dilute hypochlorite; control, no products). Participants were supplied with cleaning instructions and asthma education. The control group was instructed to clean as usual. Participants completed general health and QOL questionnaires. Asthmatic participants completed an additional asthma QOL questionnaire. Families participated in the study for 8 weeks and completed the full set of questions every 2 weeks. Homes were visited at the beginning of the study and twice thereafter at monthly intervals. Samples evaluated were surface bacteria, viable and nonviable airborne spores, and dust antigen content. Reductions in surface bacteria, airborne fungal spores, and dust antigen levels were achieved. Significant improvement in general health parameters was seen for the asthmatic product groups over the control group. Significant improvement in general QOL and asthma-specific QOL was seen in the asthmatic group. Emphasis on cleaning and cleaning education combined with hypochlorite-based cleaning supplies resulted in significantly improved QOL for families with asthmatic children.
Journal of Allergy and Clinical Immunology, 2002
Journal of Allergy and Clinical Immunology, 2002
Journal of Allergy and Clinical Immunology, 2002
p = 0.0345, respectively); 5) 38.3% and 53.8% homes in group A and group B, respectively, had pet... more p = 0.0345, respectively); 5) 38.3% and 53.8% homes in group A and group B, respectively, had pets in the home (p < 0.02). This study confirms that the number of live mites recovered from carpets by vacuum cleaning is low. However, most central Florida homes have total mite numbers above the proposed thresholds to cause sensitization and/or symptoms. Mite numbers are positively associated with home and carpet age and negatively with the presence of pets in homes.
Journal of Allergy and Clinical Immunology, 2002
Aerobiologia, 2001
Major weather parameters have long been known to alter airborne pollen and spore concentrations. ... more Major weather parameters have long been known to alter airborne pollen and spore concentrations. The following study was conducted to study the effect of three of these parameters on airborne ragweed pollen concentrations.During the ragweed (RW) season for the years 1997 and 1998, 10 minute pollen collections were taken at least every 4 hours using an Allergenco MK-3 spore trap.
Annals of Allergy, Asthma & Immunology, 2001
Introduction: Ragweed pollen is one of the major causes of allergic rhinitis in the midwest Unite... more Introduction: Ragweed pollen is one of the major causes of allergic rhinitis in the midwest United States. Previous studies have demonstrated that ragweed pollen production begins after sunrise and airborne pollen levels peak several hours later. Variations in this pattern that may be of clinical importance within a small region and the effect of weather on these variations have not been investigated. Methods:Volumetric pollen collectors were stationed at four sites around the metropolitan area. Ten-minute grab samples were taken at each location every 2 hours for continuous 24-hour periods during the 1997 ragweed season. The downtown location had a weather station that logged meteorological conditions at hourly intervals during this time. Ragweed pollen grains were counted microscopically at 400 ϫ. Uninterrupted data covering at least 20 days during the season were evaluated for each collection site. Results:The lowest ragweed pollen counts occur at 6:00 AM and the highest occur at noon for both suburban and urban sites. Rainfall was seen to be the most influential weather-related factor. Significant rainfall events effectively removed pollen grains from the air. Conclusions:Though ragweed pollen emission begins at 6:00 AM, peak pollen exposure occurs at midday. This observation is in agreement with many other studies. The myth that highest ragweed exposure occurs in the early morning hours is not supported by this or previous studies.
Annals of Allergy, Asthma & Immunology, 2001
Introduction: Environmental agents including animal, fungal, tree, and weed antigens are known to... more Introduction: Environmental agents including animal, fungal, tree, and weed antigens are known to cause allergic rhinitis and asthma. The following study was performed to measure the antigen concentration of several of these in house dust of children seen in an allergy clinic. Comparisons are made between household allergen levels of children seen for asthma and children seen for other reasons. Methods: Dust samples were solicited from patients in a pediatric allergy specialty clinic and other individuals associated with the clinic. Persons submitting dust were asked to complete a questionnaire describing their house. Samples were extracted, centrifuged, and filtered for sterility. Samples were stored in 50% glycerol at Ϫ20°C. Specific antigens for Alternaria, Cladosporium, Aspergillus, Candida, Dermatophagoides farinae, cat, dog, oak, fescue, ragweed, plantain, and cockroach were measured using inhibition assays developed with whole antigen extract. Allergens Der p1, Der f 1, Alt a 1, and Alt a 70 kD were measured using double monoclonal antibody assays. Results: Significant concentrations of whole antigen from cat, dog, oak, Alternaria, and Cladosporium were detected. Between 0.1 and 18 g of Der f1 and Der p1 per gram of dust were also measured. Alt a 1 and Alt a 70 kD levels varied between 3.0 and 1000 U/g of dust. Significant positive correlations were observed in levels of dust mite and Alternaria allergen for patients with an evaluation of asthma. Conclusions: We found measurable levels of fungal antigens (Alternaria, Cladosporium), mite antigens, and animal antigens (dog and cat) in the majority of dust samples in this self-selected set of allergy clinic patients. Specific allergens Alt a 1, Alt a 70kD, and Der p 1 were significantly higher in the homes of asthmatic patients when compared with patients seen for reasons other than asthma. These studies support the hypothesis that fungal allergen exposure is an important component in the pathogenesis of the clinical condition known as asthma.
Allergy and Asthma Proceedings, 2008
Treatment with common household bleach containing hypochlorite destroys dust mites and denatures ... more Treatment with common household bleach containing hypochlorite destroys dust mites and denatures protein allergens. The purpose of this study was to determine if home use of hypochlorite products results in lowered exposure to bacteria, fungi, and protein allergens and improved quality of life (QOL) for asthmatic persons in the home. Asthmatic and nonasthmatic households containing at least three persons (between 2 and 17 years of age) were recruited. Households were supplied one of three sets of cleaning products (regular products, some containing hypochlorite; regular products plus three additional products with dilute hypochlorite; control, no products). Participants were supplied with cleaning instructions and asthma education. The control group was instructed to clean as usual. Participants completed general health and QOL questionnaires. Asthmatic participants completed an additional asthma QOL questionnaire. Families participated in the study for 8 weeks and completed the full set of questions every 2 weeks. Homes were visited at the beginning of the study and twice thereafter at monthly intervals. Samples evaluated were surface bacteria, viable and nonviable airborne spores, and dust antigen content. Reductions in surface bacteria, airborne fungal spores, and dust antigen levels were achieved. Significant improvement in general health parameters was seen for the asthmatic product groups over the control group. Significant improvement in general QOL and asthma-specific QOL was seen in the asthmatic group. Emphasis on cleaning and cleaning education combined with hypochlorite-based cleaning supplies resulted in significantly improved QOL for families with asthmatic children.
Journal of Allergy and Clinical Immunology, 2002