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Papers by Franklin Nwagbara
Introduction Some readers may be sceptical about the arguments set out over the previous chapters... more Introduction Some readers may be sceptical about the arguments set out over the previous chapters not so much because of the evidence there presented relating to fields and farms, but rather because of the character of certain other aspects of England's medieval landscapes. In particular, we are accustomed to hearing how ‘woodland’ areas must have been colonised later than champion ones, and must always have lagged behind them in terms of agrarian development, because they were characterised by extensive tracts of common grazing and woodland. Indeed, these are still sometimes treated by historians as little more than environments awaiting transformation into cultivated land, in spite of the light that has been thrown in recent decades on such matters as the sophisticated nature of medieval woodland management. As we have seen, there is little evidence that champion landscapes were actually characterised by a paucity of common grazing. On the contrary: in many heathland and downl...
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) x 10 2 (cfu/ml) were obtained in the river sample while the least values of 0.03 (0.00) x 10 2 (cfu/ml) were obtained in the sachet water. Three bacterial isolates of Escherichia coli, Pseudomonas spp and Aeromonas spp were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of significant opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Journal of public health and epidemiology, Mar 31, 2018
Hepatitis B viral infection is a silent deadly disease. According to the Society for Gastroentero... more Hepatitis B viral infection is a silent deadly disease. According to the Society for Gastroenterology and Hepatology in Nigeria (SOGHIN), over 20 million persons are infected with hepatitis and death from it is on a large scale. This study was carried out in order to estimate the prevalence of Hepatitis B Virus (HBV) among students and non-teaching staff of Nile University of Nigeria, Abuja. The study was crosssectional; involving 200 participants (150 students and 50 non-teaching staff) recruited over a period of three months, from the first week of February 2017 to the end of May 2017 and screened for Hepatitis B surface antigen (HBsAg) using One Step Rapid Diagnostic Test. Structured questionnaires were also issued out to the study population. The study revealed that 13 out of the 200 people tested were positive giving an overall prevalence rate of 6.5% (95% CI: 3.0, 10.0%). 3 out of the 150 students were positive and 10 out of the 50 non-teaching staff tested were positive. The prevalence of HBsAg was higher among the non-teaching staff (20.0%) than among students (2.0%). Disaggregated by gender, the prevalence was higher among males (8.9%) than among females (4.0%). The reasons for the difference in prevalence and health implications of these findings are discussed.
Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup know... more Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup known as 'miyan kuka' in Northern Nigeria. The leaves are believed to have nutritional and medicinal benefits and have been used for those purposes in Africa and Asia. However there has been limited research on the detailed constituents of the dry leaves. In this study, phytochemical, elemental and proximate analyses of stored, sun and shade-dried baobab leaves were conducted. The results revealed a great variation in the nutritional contents of the leaves. The study reveals that the leaves are rich in phytochemicals such as glycosides, saponins, steroids and flavonoids while alkaloids, tannins and resins are absent. Also, they are important source of minerals such as zinc, copper, iron and manganese. In addition, they are rich in fibre, crude protein, nitrogen and ash. Contrasting responses were obtained in the samples studied. The implications of these responses are discussed in relation to crop yield.
Global Journal of Pure and Applied Sciences, Jun 24, 2018
Diseases caused by contaminated water consumption and poor hygiene are among the leading causes o... more Diseases caused by contaminated water consumption and poor hygiene are among the leading causes of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Excluding dissolved oxygen in river sample, the physicochemical parameters of the water sources were generally within the World Health Organization (WHO) standards. The bacteriological analyses revealed that the highest total coliform counts of 1.03 (0.08) x 10 2 cfu/ml were in the river sample while the least counts of 0.03 (0.00) x 10 2 cfu/ml were in the sachet water. All the bacteriological values did not meet international standard as they were higher than WHO standard of zero per 100ml. Three bacterial isolates Escherichia coli, Pseudomonas spp and Aeromonas spp, were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Lecture Notes in Computer Science, 2022
![Research paper thumbnail of Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide](https://attachments.academia-assets.com/106276801/thumbnails/1.jpg)
](International Journal of Environmental Research and Public Health, Mar 31, 2007
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In... more Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration-dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.
Lecture Notes in Computer Science, 2022
Cancer Research, May 1, 2007
Journal of Research in Medical and Dental Science, 2020
Introduction: Enterobacteriaceae can be plants and animals’ disease-causing pathogens, which prom... more Introduction: Enterobacteriaceae can be plants and animals’ disease-causing pathogens, which promote in human, the most common bacterial infections such as gastroenteritis, urinary tract infection, meningitis, septicaemia, and pneumonia. This research work was done to evaluate the prevalence of Enterobacteriaceae amongst children of 5-15 years old in Abuja. Methods: This was a retrospective study using the microbiological datasheet results of patients between January 2018 and April 2019 from selected hospitals and primary health care centres in Abuja, Nigeria. Eight hundred and twenty (820) datasheet results were collected and only two hundred and twenty-eight (228) were positive results. Results: Out of the 228, 130 (57.02%) revealed the presence of enterobacterial species and the remains were results of other microorganisms such as protozoa and other bacteria types. E. coli (47.69%) was the most dominant species, followed by Salmonella (24.62%), Klebsiella (15.38%) while Citrobact...
Journal of Public Health and Epidemiology, 2018
Knowledge Management Research Practice, Jun 4, 2014
Using strategic partnership framework, the purpose of this paper is to explore how to build susta... more Using strategic partnership framework, the purpose of this paper is to explore how to build sustainable future in post-conflict Niger delta of Nigeria given previous attempts by past administrations that failed to bring lasting peace and sustainability in the region. Partnership working amongst governments, businesses and voluntary groups or civil society premised on sharing the burdens of governance for sustainability as well as to defuse conflict or oil complex is the approach taken in the paper. Despite extant scholarship on the Niger delta, none has used the framework of partnership to articulate sustainable future in the amnesty era, which is gradually slipping into a fresh wave of conflict in the wake of distrust by stakeholders. As shall be argued there is a positive correlation between strategic partnership and sustainable future in the region. Thus, in transcending the drawn-out conflict in the Niger delta, strategic partnership is required particularly since stakeholder engagement is necessary for credibility and trust in the structure of the post-conflict peace initiative (Amnesty Deal). This approach will engender trust, credibility and legitimacy as key stakeholders in the region will be involved via partnership working.
![Research paper thumbnail of Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide](https://attachments.academia-assets.com/85658429/thumbnails/1.jpg)
](International Journal of Environmental Research and Public Health, 2007
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In... more Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration-dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.
Global Journal of Pure and Applied Sciences, 2018
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) x 10 2 (cfu/ml) were obtained in the river sample while the least values of 0.03 (0.00) x 10 2 (cfu/ml) were obtained in the sachet water. Three bacterial isolates of Escherichia coli, Pseudomonas spp and Aeromonas spp were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of significant opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup know... more Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup known as ‘miyan kuka’ in Northern Nigeria. The leaves are believed to have nutritional and medicinal benefits and have been used for those purposes in Africa and Asia. However there has been limited research on the detailed constituents of the dry leaves. In this study, phytochemical, elemental and proximate analyses of stored, sun and shade-dried baobab leaves were conducted. The results revealed a great variation in the nutritional contents of the leaves. The study reveals that the leaves are rich in phytochemicals such as glycosides, saponins, steroids and flavonoids while alkaloids, tannins and resins are absent. Also, they are important source of minerals such as zinc, copper, iron and manganese. In addition, they are rich in fibre, crude protein, nitrogen and ash. Contrasting responses were obtained in the samples studied. The implications of these responses are discussed i...
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources—river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) × 102 (cfu/mL) were obtained in the river sample while the least values of 0.03 (0.00) &...
![Research paper thumbnail of Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide](https://attachments.academia-assets.com/49189332/thumbnails/1.jpg)
](International Journal of Environmental Research and Public Health, 2007
pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this st... more pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration -dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.
Introduction Some readers may be sceptical about the arguments set out over the previous chapters... more Introduction Some readers may be sceptical about the arguments set out over the previous chapters not so much because of the evidence there presented relating to fields and farms, but rather because of the character of certain other aspects of England's medieval landscapes. In particular, we are accustomed to hearing how ‘woodland’ areas must have been colonised later than champion ones, and must always have lagged behind them in terms of agrarian development, because they were characterised by extensive tracts of common grazing and woodland. Indeed, these are still sometimes treated by historians as little more than environments awaiting transformation into cultivated land, in spite of the light that has been thrown in recent decades on such matters as the sophisticated nature of medieval woodland management. As we have seen, there is little evidence that champion landscapes were actually characterised by a paucity of common grazing. On the contrary: in many heathland and downl...
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) x 10 2 (cfu/ml) were obtained in the river sample while the least values of 0.03 (0.00) x 10 2 (cfu/ml) were obtained in the sachet water. Three bacterial isolates of Escherichia coli, Pseudomonas spp and Aeromonas spp were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of significant opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Journal of public health and epidemiology, Mar 31, 2018
Hepatitis B viral infection is a silent deadly disease. According to the Society for Gastroentero... more Hepatitis B viral infection is a silent deadly disease. According to the Society for Gastroenterology and Hepatology in Nigeria (SOGHIN), over 20 million persons are infected with hepatitis and death from it is on a large scale. This study was carried out in order to estimate the prevalence of Hepatitis B Virus (HBV) among students and non-teaching staff of Nile University of Nigeria, Abuja. The study was crosssectional; involving 200 participants (150 students and 50 non-teaching staff) recruited over a period of three months, from the first week of February 2017 to the end of May 2017 and screened for Hepatitis B surface antigen (HBsAg) using One Step Rapid Diagnostic Test. Structured questionnaires were also issued out to the study population. The study revealed that 13 out of the 200 people tested were positive giving an overall prevalence rate of 6.5% (95% CI: 3.0, 10.0%). 3 out of the 150 students were positive and 10 out of the 50 non-teaching staff tested were positive. The prevalence of HBsAg was higher among the non-teaching staff (20.0%) than among students (2.0%). Disaggregated by gender, the prevalence was higher among males (8.9%) than among females (4.0%). The reasons for the difference in prevalence and health implications of these findings are discussed.
Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup know... more Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup known as 'miyan kuka' in Northern Nigeria. The leaves are believed to have nutritional and medicinal benefits and have been used for those purposes in Africa and Asia. However there has been limited research on the detailed constituents of the dry leaves. In this study, phytochemical, elemental and proximate analyses of stored, sun and shade-dried baobab leaves were conducted. The results revealed a great variation in the nutritional contents of the leaves. The study reveals that the leaves are rich in phytochemicals such as glycosides, saponins, steroids and flavonoids while alkaloids, tannins and resins are absent. Also, they are important source of minerals such as zinc, copper, iron and manganese. In addition, they are rich in fibre, crude protein, nitrogen and ash. Contrasting responses were obtained in the samples studied. The implications of these responses are discussed in relation to crop yield.
Global Journal of Pure and Applied Sciences, Jun 24, 2018
Diseases caused by contaminated water consumption and poor hygiene are among the leading causes o... more Diseases caused by contaminated water consumption and poor hygiene are among the leading causes of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Excluding dissolved oxygen in river sample, the physicochemical parameters of the water sources were generally within the World Health Organization (WHO) standards. The bacteriological analyses revealed that the highest total coliform counts of 1.03 (0.08) x 10 2 cfu/ml were in the river sample while the least counts of 0.03 (0.00) x 10 2 cfu/ml were in the sachet water. All the bacteriological values did not meet international standard as they were higher than WHO standard of zero per 100ml. Three bacterial isolates Escherichia coli, Pseudomonas spp and Aeromonas spp, were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Lecture Notes in Computer Science, 2022
International Journal of Environmental Research and Public Health, Mar 31, 2007
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In... more Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration-dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.
Lecture Notes in Computer Science, 2022
Cancer Research, May 1, 2007
Journal of Research in Medical and Dental Science, 2020
Introduction: Enterobacteriaceae can be plants and animals’ disease-causing pathogens, which prom... more Introduction: Enterobacteriaceae can be plants and animals’ disease-causing pathogens, which promote in human, the most common bacterial infections such as gastroenteritis, urinary tract infection, meningitis, septicaemia, and pneumonia. This research work was done to evaluate the prevalence of Enterobacteriaceae amongst children of 5-15 years old in Abuja. Methods: This was a retrospective study using the microbiological datasheet results of patients between January 2018 and April 2019 from selected hospitals and primary health care centres in Abuja, Nigeria. Eight hundred and twenty (820) datasheet results were collected and only two hundred and twenty-eight (228) were positive results. Results: Out of the 228, 130 (57.02%) revealed the presence of enterobacterial species and the remains were results of other microorganisms such as protozoa and other bacteria types. E. coli (47.69%) was the most dominant species, followed by Salmonella (24.62%), Klebsiella (15.38%) while Citrobact...
Journal of Public Health and Epidemiology, 2018
Knowledge Management Research Practice, Jun 4, 2014
Using strategic partnership framework, the purpose of this paper is to explore how to build susta... more Using strategic partnership framework, the purpose of this paper is to explore how to build sustainable future in post-conflict Niger delta of Nigeria given previous attempts by past administrations that failed to bring lasting peace and sustainability in the region. Partnership working amongst governments, businesses and voluntary groups or civil society premised on sharing the burdens of governance for sustainability as well as to defuse conflict or oil complex is the approach taken in the paper. Despite extant scholarship on the Niger delta, none has used the framework of partnership to articulate sustainable future in the amnesty era, which is gradually slipping into a fresh wave of conflict in the wake of distrust by stakeholders. As shall be argued there is a positive correlation between strategic partnership and sustainable future in the region. Thus, in transcending the drawn-out conflict in the Niger delta, strategic partnership is required particularly since stakeholder engagement is necessary for credibility and trust in the structure of the post-conflict peace initiative (Amnesty Deal). This approach will engender trust, credibility and legitimacy as key stakeholders in the region will be involved via partnership working.
International Journal of Environmental Research and Public Health, 2007
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In... more Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration-dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.
Global Journal of Pure and Applied Sciences, 2018
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources-river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) x 10 2 (cfu/ml) were obtained in the river sample while the least values of 0.03 (0.00) x 10 2 (cfu/ml) were obtained in the sachet water. Three bacterial isolates of Escherichia coli, Pseudomonas spp and Aeromonas spp were isolated from well water while Pseudomonas spp and Proteus spp were isolated from borehole water. All other bacteria were isolated from the river. The study demonstrates that the safest drinking water source in Idu district, Jabi, Abuja is the sachet/packaged water while the least safe is the river water due to the presence of significant opportunistic pathogens. The results of this study are beneficial for water quality management and could be used for low-cost effective water quality assessment in Jabi.
Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup know... more Baobab (Adansonia digitata) leaves are usually used in dry form in the preparation of a soup known as ‘miyan kuka’ in Northern Nigeria. The leaves are believed to have nutritional and medicinal benefits and have been used for those purposes in Africa and Asia. However there has been limited research on the detailed constituents of the dry leaves. In this study, phytochemical, elemental and proximate analyses of stored, sun and shade-dried baobab leaves were conducted. The results revealed a great variation in the nutritional contents of the leaves. The study reveals that the leaves are rich in phytochemicals such as glycosides, saponins, steroids and flavonoids while alkaloids, tannins and resins are absent. Also, they are important source of minerals such as zinc, copper, iron and manganese. In addition, they are rich in fibre, crude protein, nitrogen and ash. Contrasting responses were obtained in the samples studied. The implications of these responses are discussed i...
Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of... more Diseases caused by contaminated water consumption and poor hygiene are among the leading cause of death in children, the elderly and people with compromised immune system. The present study aims to assess the drinking water quality of some selected drinking water sources in the chosen study area using water quality index (WQI). Samples of drinking waters were collected from four different sources—river, sachet (packaged), borehole and well in Jabi, Abuja, Nigeria for physicochemical and bacteriological analyses using standard methods. With the exception of pH, river water had the highest content of all the physicochemical parameters examined. Some of the physicochemical parameters such as temperature and pH determined in this study were mostly within the World Health Organization (WHO) standard. The bacteriological analyses revealed that the highest total viable counts of 1.54 (0.12) × 102 (cfu/mL) were obtained in the river sample while the least values of 0.03 (0.00) &...
International Journal of Environmental Research and Public Health, 2007
pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this st... more pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration -dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G 1 phase, while about 76% were arrested at G 1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells.