Fred Ovsiew - Academia.edu (original) (raw)
Papers by Fred Ovsiew
American Psychiatric Press eBooks, 1999
Perspectives in Biology and Medicine, 1997
ABSTRACT
Current Opinion in Psychiatry, 1996
Neurology, 1995
We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild diff... more We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild difficulty falling asleep. A diagnosis of fatal familial insomnia (FFI) became evident over the next 6 months when he developed progressive insomnia, myoclonus, sympathetic hyperactivity, and dementia. The amyloid or prion protein (PrP) genotype showed features typically seen in FFI, with a 178Asn mutation and a 129Met polymorphism. There was also a deletion of one octapeptide repeat, suggesting that the association of 178Asn mutation with the 129Met polymorphism is not due to "founder effect." Western immunoblot showed a trace of protease-resistant PrP in the thalamus--which had the most significant neuronal loss and gliosis--a moderate amount of PrP in the fronto-temporal area, and no detectable protein elsewhere in the brain. Endocrine studies showed that a circadian modulation of hormonal levels could be maintained despite a near-total absence of sleep. Administration of gamma-hydroxybutyrate induced a remarkable increase in slow-wave sleep.
Molecular Psychiatry, 2013
Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce de... more Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce delayed inactivation of Cav1.2 voltage-gated calcium channels during cellular action potentials, with greatly increased influx of calcium into the activated cells. The major clinical feature of this syndrome is a long QT interval that results in cardiac arrhythmias. However, TS also includes cognitive impairment, autism and major developmental delays in many of the patients. We observed the appearance of bipolar disorder (BD) in a patient with a previously reported case of TS, who is one of the very few patients to survive childhood. This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. To combine the CACNA1C perturbations in the presence of BD in this patient and in patients with the common CACNA1C SNP risk allele, we would propose that either increase or decrease in calcium influx in excitable cells can be associated with BD. In treatment of BD with calcium channel blocking drugs, we would predict better response in patients without the risk allele, because they have increased CACNA1C expression.
Rage, Power, and Aggression
American Journal of Psychiatry, 1984
While in some cases, as with certain inflammatory brain diseases, the neuropsychiatrist can relie... more While in some cases, as with certain inflammatory brain diseases, the neuropsychiatrist can relieve the underlying pathology of a condition and alter its course through pharmaceutical intervention, this chapter is focused predominantly on the symptomatic treatment side of psychopharmacotherapy. After laying out a series of tenets on the responsible application of pharmaceuticals, pharmaceutical intervention is discussed with regard to a number of conditions such as cognitive impairment, apathy, and psychosis. The potential side effects are also discussed, such as psychotoxicity arising from the application of antipsychotics to patients suffering from Parkinson’s disease and the correlation between antiepileptic drug use and suicidal thoughts in patients.
Neuropsychiatry is thriving, and the articles in this Special Report demonstrate its breadth and ... more Neuropsychiatry is thriving, and the articles in this Special Report demonstrate its breadth and depth while providing the opportunity to characterize and delimit its scope.
European Journal of Neurology, 2003
Current Opinion in Psychiatry, 1993
Current Opinion in Psychiatry, 1994
ABSTRACT
Behavioural Neurology, 1992
A seventeenth-century painter left an account of his seizures, trances and visions; in 1923 Freud... more A seventeenth-century painter left an account of his seizures, trances and visions; in 1923 Freud commented on this “demonological neurosis” without discussing the seizures. Attention is drawn to the concurrence of epilepsy and psychosis in this early autobiographical source.
Annals of Internal Medicine, 1982
Excerpt To the editor: The recent papers by Larson and colleagues (1) on the cost effectiveness o... more Excerpt To the editor: The recent papers by Larson and colleagues (1) on the cost effectiveness of computed tomography (CT) scanning in psychiatric patients is in the good company of many similar s...
Journal of Neurology, Neurosurgery & Psychiatry, 2004
Seminars in Clinical Neuropsychiatry, 2002
Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conc... more Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conceptualizing cognitive function and discuss bedside examination and neuropsychological assessment, as well as the limitations of these tools. We stress the clinical importance of executive cognitive dysfunction, and we provide guidance or its assessment.
Seminars in Clinical Neuropsychiatry, 2002
Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conc... more Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conceptualizing cognitive function and discuss bedside examination and neuropsychological assessment, as well as the limitations of these tools. We stress the clinical importance of executive cognitive dysfunction, and we provide guidance or its assessment.
The American Psychiatric Association Publishing Textbook of Neuropsychiatry and Clinical Neurosciences
Tienda online donde Comprar Principles of Inpatient Psychiatry al precio 80,85 € de Richard L. Mu... more Tienda online donde Comprar Principles of Inpatient Psychiatry al precio 80,85 € de Richard L. Munich MD | Fred Ovsiew MD, tienda de Libros de Medicina, Libros de Psiquiatria - Psiquiatria General
American Psychiatric Press eBooks, 1999
Perspectives in Biology and Medicine, 1997
ABSTRACT
Current Opinion in Psychiatry, 1996
Neurology, 1995
We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild diff... more We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild difficulty falling asleep. A diagnosis of fatal familial insomnia (FFI) became evident over the next 6 months when he developed progressive insomnia, myoclonus, sympathetic hyperactivity, and dementia. The amyloid or prion protein (PrP) genotype showed features typically seen in FFI, with a 178Asn mutation and a 129Met polymorphism. There was also a deletion of one octapeptide repeat, suggesting that the association of 178Asn mutation with the 129Met polymorphism is not due to "founder effect." Western immunoblot showed a trace of protease-resistant PrP in the thalamus--which had the most significant neuronal loss and gliosis--a moderate amount of PrP in the fronto-temporal area, and no detectable protein elsewhere in the brain. Endocrine studies showed that a circadian modulation of hormonal levels could be maintained despite a near-total absence of sleep. Administration of gamma-hydroxybutyrate induced a remarkable increase in slow-wave sleep.
Molecular Psychiatry, 2013
Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce de... more Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce delayed inactivation of Cav1.2 voltage-gated calcium channels during cellular action potentials, with greatly increased influx of calcium into the activated cells. The major clinical feature of this syndrome is a long QT interval that results in cardiac arrhythmias. However, TS also includes cognitive impairment, autism and major developmental delays in many of the patients. We observed the appearance of bipolar disorder (BD) in a patient with a previously reported case of TS, who is one of the very few patients to survive childhood. This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. To combine the CACNA1C perturbations in the presence of BD in this patient and in patients with the common CACNA1C SNP risk allele, we would propose that either increase or decrease in calcium influx in excitable cells can be associated with BD. In treatment of BD with calcium channel blocking drugs, we would predict better response in patients without the risk allele, because they have increased CACNA1C expression.
Rage, Power, and Aggression
American Journal of Psychiatry, 1984
While in some cases, as with certain inflammatory brain diseases, the neuropsychiatrist can relie... more While in some cases, as with certain inflammatory brain diseases, the neuropsychiatrist can relieve the underlying pathology of a condition and alter its course through pharmaceutical intervention, this chapter is focused predominantly on the symptomatic treatment side of psychopharmacotherapy. After laying out a series of tenets on the responsible application of pharmaceuticals, pharmaceutical intervention is discussed with regard to a number of conditions such as cognitive impairment, apathy, and psychosis. The potential side effects are also discussed, such as psychotoxicity arising from the application of antipsychotics to patients suffering from Parkinson’s disease and the correlation between antiepileptic drug use and suicidal thoughts in patients.
Neuropsychiatry is thriving, and the articles in this Special Report demonstrate its breadth and ... more Neuropsychiatry is thriving, and the articles in this Special Report demonstrate its breadth and depth while providing the opportunity to characterize and delimit its scope.
European Journal of Neurology, 2003
Current Opinion in Psychiatry, 1993
Current Opinion in Psychiatry, 1994
ABSTRACT
Behavioural Neurology, 1992
A seventeenth-century painter left an account of his seizures, trances and visions; in 1923 Freud... more A seventeenth-century painter left an account of his seizures, trances and visions; in 1923 Freud commented on this “demonological neurosis” without discussing the seizures. Attention is drawn to the concurrence of epilepsy and psychosis in this early autobiographical source.
Annals of Internal Medicine, 1982
Excerpt To the editor: The recent papers by Larson and colleagues (1) on the cost effectiveness o... more Excerpt To the editor: The recent papers by Larson and colleagues (1) on the cost effectiveness of computed tomography (CT) scanning in psychiatric patients is in the good company of many similar s...
Journal of Neurology, Neurosurgery & Psychiatry, 2004
Seminars in Clinical Neuropsychiatry, 2002
Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conc... more Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conceptualizing cognitive function and discuss bedside examination and neuropsychological assessment, as well as the limitations of these tools. We stress the clinical importance of executive cognitive dysfunction, and we provide guidance or its assessment.
Seminars in Clinical Neuropsychiatry, 2002
Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conc... more Cognitive dysfunction is a core feature of neuropsychiatric illness. We offer a framework or conceptualizing cognitive function and discuss bedside examination and neuropsychological assessment, as well as the limitations of these tools. We stress the clinical importance of executive cognitive dysfunction, and we provide guidance or its assessment.
The American Psychiatric Association Publishing Textbook of Neuropsychiatry and Clinical Neurosciences
Tienda online donde Comprar Principles of Inpatient Psychiatry al precio 80,85 € de Richard L. Mu... more Tienda online donde Comprar Principles of Inpatient Psychiatry al precio 80,85 € de Richard L. Munich MD | Fred Ovsiew MD, tienda de Libros de Medicina, Libros de Psiquiatria - Psiquiatria General