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Papers by Frederiek D'Hondt
Journal of endourology / Endourological Society, Jan 24, 2015
The aim of our study was to assess the oncologic outcomes of robot-assisted radical cystectomy (R... more The aim of our study was to assess the oncologic outcomes of robot-assisted radical cystectomy (RARC) in patients with bladder cancer (BCa) treated in a high-volume robotic center. We retrospectively collected data of 155 consecutive patients who received RARC for urothelial BCa from January 2004 to May 2014. Kaplan-Meier analyses were used to assess time to recurrence, cancer-specific mortality (CSM) rate, and overall mortality rate. Uni- and multivariable Cox regression models addressed the predictors of recurrence and CSM. Median follow-up for survivors was 42 months. Overall, 43%, 34%, 55%, and 18% of the patients had pT ≤1, pT2, pT3/4, and pN1-3 disease, respectively. Overall, 76% of the patients had high-grade disease at final pathology. The positive surgical margin rate was 9%. The 5-year recurrence-free, CSM-free, and overall survival estimates were 53.7%, 73.5%, and 65.2%, respectively. Among patients who experienced recurrence, 12.0%, 4.0%, and 84.0% had local, peritoneal,...
Clinical Genitourinary Cancer, 2014
For prostate cancer diagnoses we simultaneously incorporated the 2005 modified Gleason score (GS)... more For prostate cancer diagnoses we simultaneously incorporated the 2005 modified Gleason score (GS) and increased the standard number of biopsy cylinders to 8 to 12. This provided better Gleason score concordance between biopsy and radical prostatectomy (RP) specimens (n [ 193) than before this change of practice (n [ 135), although concordance rate (54%) remained rather poor. More tumors are labeled intermediate-/ high-grade using the modified Gleason score. Introduction: The objectives of this study were to assess the agreement of GS on biopsy compared with RP specimens and to assess whether an increased number of biopsy cylinders and the 2005 International Society of Urological Pathology (ISUP) GS modification improved this agreement. Materials and Methods: Pathological data of biopsy and RP specimens were analyzed in 328 consecutive patients, before (group 1; n ¼ 135) and after (group 2; n ¼ 193) implementation of the 2005 ISUP modification. Additionally, patients had more biopsy cylinders taken in group 2 (mean 10 vs. 6.9). The agreement of GS between biopsy and RP specimens was evaluated using the kappa coefficient. GS was pooled into 3 grades: low-(GS 6), intermediate- , and high-grade (GS ! 8) prostate cancer. Results: Kappa coefficient for GS in group 1 and 2 was 0.261 and 0.341, respectively. For tumor grade, this was 0.308 and 0.359 for group 1 and 2, respectively. For RP specimens, there was more agreement between biopsy and RP GS in group 2 compared with group 1 (53.9% vs. 37.8%). Upgrading was almost exclusively (89.5%) seen in patients with biopsy GS 6 and was lower in group 2 (25.4% vs. 48.1%) because of classification of more intermediate-and high-grade tumors using the 2005 ISUP modification. Taking > 6 biopsy cylinders was associated with better GS and tumor grade agreement. Conclusion: Extended biopsy template and the 2005 ISUP modification resulted in an improved agreement between biopsy GS and RP GS and a shift toward more aggressive tumors.
The journal of sexual medicine, Jan 9, 2015
Idiopathic partial thrombosis (IPT) of the corpus cavernosum is a rare condition. The etiology is... more Idiopathic partial thrombosis (IPT) of the corpus cavernosum is a rare condition. The etiology is not fully understood; however, the presence of an either or not congenital web in these patients may contribute to the development of IPT. The aim of this study was to describe 18 new IPT cases and compare these with 38 cases found in the literature. A multicenter retrospective analysis was performed. Descriptive statistics are given. The main outcome measures used were clinical presentation, clinical and radiographical diagnostics, treatment and resolution of symptoms. Patients most frequently presented with perineal swelling (10/18; 56%) and pain (13/18; 72%), unilateral (12/18; 67%) or bilateral (4/18; 22%), and pain during erection (10/18; 72%). Penile curvature, dysuria or fever (each 1/18; 6%) were uncommon presenting symptoms. In our series, magnetic resonance imaging demonstrated a fibrous web in the corpus cavernosum in 100% of cases and was more bilaterally (11/18; 61%) than u...
Journal of endourology / Endourological Society, Jan 24, 2015
The aim of our study was to assess the oncologic outcomes of robot-assisted radical cystectomy (R... more The aim of our study was to assess the oncologic outcomes of robot-assisted radical cystectomy (RARC) in patients with bladder cancer (BCa) treated in a high-volume robotic center. We retrospectively collected data of 155 consecutive patients who received RARC for urothelial BCa from January 2004 to May 2014. Kaplan-Meier analyses were used to assess time to recurrence, cancer-specific mortality (CSM) rate, and overall mortality rate. Uni- and multivariable Cox regression models addressed the predictors of recurrence and CSM. Median follow-up for survivors was 42 months. Overall, 43%, 34%, 55%, and 18% of the patients had pT ≤1, pT2, pT3/4, and pN1-3 disease, respectively. Overall, 76% of the patients had high-grade disease at final pathology. The positive surgical margin rate was 9%. The 5-year recurrence-free, CSM-free, and overall survival estimates were 53.7%, 73.5%, and 65.2%, respectively. Among patients who experienced recurrence, 12.0%, 4.0%, and 84.0% had local, peritoneal,...
Clinical Genitourinary Cancer, 2014
For prostate cancer diagnoses we simultaneously incorporated the 2005 modified Gleason score (GS)... more For prostate cancer diagnoses we simultaneously incorporated the 2005 modified Gleason score (GS) and increased the standard number of biopsy cylinders to 8 to 12. This provided better Gleason score concordance between biopsy and radical prostatectomy (RP) specimens (n [ 193) than before this change of practice (n [ 135), although concordance rate (54%) remained rather poor. More tumors are labeled intermediate-/ high-grade using the modified Gleason score. Introduction: The objectives of this study were to assess the agreement of GS on biopsy compared with RP specimens and to assess whether an increased number of biopsy cylinders and the 2005 International Society of Urological Pathology (ISUP) GS modification improved this agreement. Materials and Methods: Pathological data of biopsy and RP specimens were analyzed in 328 consecutive patients, before (group 1; n ¼ 135) and after (group 2; n ¼ 193) implementation of the 2005 ISUP modification. Additionally, patients had more biopsy cylinders taken in group 2 (mean 10 vs. 6.9). The agreement of GS between biopsy and RP specimens was evaluated using the kappa coefficient. GS was pooled into 3 grades: low-(GS 6), intermediate- , and high-grade (GS ! 8) prostate cancer. Results: Kappa coefficient for GS in group 1 and 2 was 0.261 and 0.341, respectively. For tumor grade, this was 0.308 and 0.359 for group 1 and 2, respectively. For RP specimens, there was more agreement between biopsy and RP GS in group 2 compared with group 1 (53.9% vs. 37.8%). Upgrading was almost exclusively (89.5%) seen in patients with biopsy GS 6 and was lower in group 2 (25.4% vs. 48.1%) because of classification of more intermediate-and high-grade tumors using the 2005 ISUP modification. Taking > 6 biopsy cylinders was associated with better GS and tumor grade agreement. Conclusion: Extended biopsy template and the 2005 ISUP modification resulted in an improved agreement between biopsy GS and RP GS and a shift toward more aggressive tumors.
The journal of sexual medicine, Jan 9, 2015
Idiopathic partial thrombosis (IPT) of the corpus cavernosum is a rare condition. The etiology is... more Idiopathic partial thrombosis (IPT) of the corpus cavernosum is a rare condition. The etiology is not fully understood; however, the presence of an either or not congenital web in these patients may contribute to the development of IPT. The aim of this study was to describe 18 new IPT cases and compare these with 38 cases found in the literature. A multicenter retrospective analysis was performed. Descriptive statistics are given. The main outcome measures used were clinical presentation, clinical and radiographical diagnostics, treatment and resolution of symptoms. Patients most frequently presented with perineal swelling (10/18; 56%) and pain (13/18; 72%), unilateral (12/18; 67%) or bilateral (4/18; 22%), and pain during erection (10/18; 72%). Penile curvature, dysuria or fever (each 1/18; 6%) were uncommon presenting symptoms. In our series, magnetic resonance imaging demonstrated a fibrous web in the corpus cavernosum in 100% of cases and was more bilaterally (11/18; 61%) than u...