Fredi Francis Cheruvathoor - Academia.edu (original) (raw)
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Papers by Fredi Francis Cheruvathoor
Gels Horizons: From Science to Smart Materials, 2021
Designing polymeric nanoparticle responding to various stimuli is a promising field in medical ap... more Designing polymeric nanoparticle responding to various stimuli is a promising field in medical applications. A combination of various triggers and polymeric nanoparticles creates unique and smart therapeutic materials. Surface modification of polymeric nanoparticles sensing various chemical and physical signals of the human body is one key aspect towards building up site-specific drug delivery vehicles. Although, several reports of targeted drug delivery systems are existing it is quite unfortunate that only a few particles are able to reach the affected tissues. Most of the preclinical trials exploit the enhanced permeation and retention effect, but then again this strategy is questionable in the case of clinical applications. So far most of the drug delivery systems reported has extremely intricate designs which may perhaps be possible to hinder the cost-effective and scaled-up production. Likewise, the other factors that can affect the success ratio towards medical applications may include toxicity of the nanomaterials, weak stability, high drug loading ability, poor degradability, and inadequate biocompatibility. In the future, creating designs by considering and rectifying the aforementioned factors will certainly elevate the stimuli-responsive nanoparticles towards clinical acceptance.
Gels Horizons: From Science to Smart Materials, 2021
Hydrogels are extremely swollen, hydrophilic, three-dimensional polymer networks that are capable... more Hydrogels are extremely swollen, hydrophilic, three-dimensional polymer networks that are capable of absorbing vast amounts of body fluids or water. Hydrogels possess the ability to swell within their structure and hold a large fraction of water, but they may not dissolve in water. They have attracted tremendous attention as candidates for biomedical applications because of their ability to swell, under physiological conditions and their consequent biocompatibility. The ability of hydrogels to absorb large quantities of water is due to the presence of functional hydrophilic groups attached to their back bones or as lateral chains, whereas crosslinks between network chains result in their resistance to dissolution. Due to their specific physical properties, which make them promising materials for drug delivery, tissue engineering, and even in food and cosmetic manufacturing, they have attracted considerable attention in recent years. The interplay between their chemical-structure-property relationships and their interaction with the biological system, taking careful account of their physical, chemical, and biological properties, makes it possible to effectively design a hydrogel for biomedical applications. In this chapter, the structural parameters of polymer hydrogels and various drug release mechanisms of hydrogel drug delivery systems are discussed.
Gels Horizons: From Science to Smart Materials, 2021
Designing polymeric nanoparticle responding to various stimuli is a promising field in medical ap... more Designing polymeric nanoparticle responding to various stimuli is a promising field in medical applications. A combination of various triggers and polymeric nanoparticles creates unique and smart therapeutic materials. Surface modification of polymeric nanoparticles sensing various chemical and physical signals of the human body is one key aspect towards building up site-specific drug delivery vehicles. Although, several reports of targeted drug delivery systems are existing it is quite unfortunate that only a few particles are able to reach the affected tissues. Most of the preclinical trials exploit the enhanced permeation and retention effect, but then again this strategy is questionable in the case of clinical applications. So far most of the drug delivery systems reported has extremely intricate designs which may perhaps be possible to hinder the cost-effective and scaled-up production. Likewise, the other factors that can affect the success ratio towards medical applications may include toxicity of the nanomaterials, weak stability, high drug loading ability, poor degradability, and inadequate biocompatibility. In the future, creating designs by considering and rectifying the aforementioned factors will certainly elevate the stimuli-responsive nanoparticles towards clinical acceptance.
Gels Horizons: From Science to Smart Materials, 2021
Hydrogels are extremely swollen, hydrophilic, three-dimensional polymer networks that are capable... more Hydrogels are extremely swollen, hydrophilic, three-dimensional polymer networks that are capable of absorbing vast amounts of body fluids or water. Hydrogels possess the ability to swell within their structure and hold a large fraction of water, but they may not dissolve in water. They have attracted tremendous attention as candidates for biomedical applications because of their ability to swell, under physiological conditions and their consequent biocompatibility. The ability of hydrogels to absorb large quantities of water is due to the presence of functional hydrophilic groups attached to their back bones or as lateral chains, whereas crosslinks between network chains result in their resistance to dissolution. Due to their specific physical properties, which make them promising materials for drug delivery, tissue engineering, and even in food and cosmetic manufacturing, they have attracted considerable attention in recent years. The interplay between their chemical-structure-property relationships and their interaction with the biological system, taking careful account of their physical, chemical, and biological properties, makes it possible to effectively design a hydrogel for biomedical applications. In this chapter, the structural parameters of polymer hydrogels and various drug release mechanisms of hydrogel drug delivery systems are discussed.