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Papers by Frida Sosa Amay

Research paper thumbnail of Efektivitas Petani Dalam Mengadopsi Sapta Usaha Pada Ternak Sapi Potong Dan Tingkat Pendapatan Petani DI Kecamatan Popayato Kabupaten Pohuwato

Research paper thumbnail of Evaluación de metales pesados en recursos terapéuticos vegetales de la ciudad de Iquitos

The concentration of cadmium, lead, mercury and arsenic in the bark of twelve botanical species o... more The concentration of cadmium, lead, mercury and arsenic in the bark of twelve botanical species of the Peruvian Amazon, considered as therapeutic resources, was evaluated by atomic bsorption. Cadmium and lead were determined by flame (SpectrAA, Varian AA 240); Mercury with cold vapor (AAnalyst 300, Perkin Elmer) and arsenic by hydridegeneration (AAnalyst 300, Perkin Elmer). Thelevelsfound in the case of the species: Tynanthus panurensis (clavo huasca), Campsiandra angustifolia (Huacapurana) Abutarufescens (abuta), Anomospermunsp. (achunisanango) and Hymnaea oblongfolia (azucar huayro) exceed the maximum limit sall owed for cadmium. None of the species studied exceeded the limit sall owed for lead. On the otherhand, Brosiun potabile (tamamuri) was the only one of the studied species that exceeds the limit sall owed for mercury. In case of arsenic,allspeciesrecordedconcentrationsabovethemaximumallowedlimits, in a rangebetween 1,7 – 8,19 μg/g. It is concluded that all the vegetal barks...

Research paper thumbnail of Targeting Receptor Binding Domain and Cryptic Pocket of Spike glycoprotein from SARS-CoV-2 by biomolecular modeling

arXiv: Biomolecules, 2020

SARS-CoV-2, the causative agent of the disease known as Covid-19, has so far reported around 3,43... more SARS-CoV-2, the causative agent of the disease known as Covid-19, has so far reported around 3,435,000 cases of human infections, including more than 239,000 deaths in 187 countries, with no effective treatment currently available. For this reason, it is necessary to explore new approaches for the development of a drug capable of inhibiting the entry of the virus into the host cell. Therefore, this work includes the exploration of potential inhibitory compounds for the Spike protein of SARS-CoV-2 (PDB ID: 6VSB), which were obtained from The Patogen Box. Later, they were filtered through virtual screening and molecular docking techniques, thus obtaining a top of 1000 compounds, which were used against a binding site located in the Receptor Binding Domain (RBD) and a cryptic site located in the N-Terminal Domain (NTD), resulting in good pharmaceutical targets for the blocking the infection. From the top 1000, the best compound (TCMDC-124223) was selected for the binding site. It inter...

Research paper thumbnail of Mutaciones en el exón 9 del Gen CYP2D6 en población homogénea y heterogénea de Loreto y su implicancia en el metabolismo de fármacos

Research paper thumbnail of Estudio fitoquímico de la corteza de la raíz de Aspidosperma desmanthum Benth. ex Müll. Arg. con actividad antiplasmodial

Research paper thumbnail of Ocupación anterior y caracterización de la situación económica de las internas del penal San Jacinto de Iquitos, año 2011

Research paper thumbnail of Estudio fitoquímico de la corteza de la raíz de Aspidosperma desmanthum Benth. ex Müll. Arg. con actividad antiplasmodial

Research paper thumbnail of Antiparasitic indole alkaloids from Aspidosperma desmanthum and A. spruceanum from the Peruvian Amazonia

Natural product communications, 2014

Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkal... more Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkaloids 1-4 were isolated from the leaves, 5-8 from the stem bark and 9-15 from the root bark of A. desmanthum. Alkaloids 5, 11, 16, 17 and 19 were isolated from the stem bark, 18 and 20-22 from the root bark and 23 from the flowers of A. spruceanum. Compounds 4, 14, and 15 have not been previously reported as natural products while 16 and 20 have been isolated for the first time from the genus Aspidosperma. Their structures were determined by spectroscopic techniques including 1D and 2D NMR experiments (COSY, NOESY, HSQC, HMBC). The antiparasitic activity of these compounds was tested against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity on mammalian cells. The most active compounds were 10, 12, 13, and 14 from A. desmanthum, and 19, 21 and 22 from A. spruceanum. Aspidolimine (10) aspidocarpine (12) and tubotaiwine (21) showed selective activity against L. i...

Research paper thumbnail of Efektivitas Petani Dalam Mengadopsi Sapta Usaha Pada Ternak Sapi Potong Dan Tingkat Pendapatan Petani DI Kecamatan Popayato Kabupaten Pohuwato

Research paper thumbnail of Evaluación de metales pesados en recursos terapéuticos vegetales de la ciudad de Iquitos

The concentration of cadmium, lead, mercury and arsenic in the bark of twelve botanical species o... more The concentration of cadmium, lead, mercury and arsenic in the bark of twelve botanical species of the Peruvian Amazon, considered as therapeutic resources, was evaluated by atomic bsorption. Cadmium and lead were determined by flame (SpectrAA, Varian AA 240); Mercury with cold vapor (AAnalyst 300, Perkin Elmer) and arsenic by hydridegeneration (AAnalyst 300, Perkin Elmer). Thelevelsfound in the case of the species: Tynanthus panurensis (clavo huasca), Campsiandra angustifolia (Huacapurana) Abutarufescens (abuta), Anomospermunsp. (achunisanango) and Hymnaea oblongfolia (azucar huayro) exceed the maximum limit sall owed for cadmium. None of the species studied exceeded the limit sall owed for lead. On the otherhand, Brosiun potabile (tamamuri) was the only one of the studied species that exceeds the limit sall owed for mercury. In case of arsenic,allspeciesrecordedconcentrationsabovethemaximumallowedlimits, in a rangebetween 1,7 – 8,19 μg/g. It is concluded that all the vegetal barks...

Research paper thumbnail of Targeting Receptor Binding Domain and Cryptic Pocket of Spike glycoprotein from SARS-CoV-2 by biomolecular modeling

arXiv: Biomolecules, 2020

SARS-CoV-2, the causative agent of the disease known as Covid-19, has so far reported around 3,43... more SARS-CoV-2, the causative agent of the disease known as Covid-19, has so far reported around 3,435,000 cases of human infections, including more than 239,000 deaths in 187 countries, with no effective treatment currently available. For this reason, it is necessary to explore new approaches for the development of a drug capable of inhibiting the entry of the virus into the host cell. Therefore, this work includes the exploration of potential inhibitory compounds for the Spike protein of SARS-CoV-2 (PDB ID: 6VSB), which were obtained from The Patogen Box. Later, they were filtered through virtual screening and molecular docking techniques, thus obtaining a top of 1000 compounds, which were used against a binding site located in the Receptor Binding Domain (RBD) and a cryptic site located in the N-Terminal Domain (NTD), resulting in good pharmaceutical targets for the blocking the infection. From the top 1000, the best compound (TCMDC-124223) was selected for the binding site. It inter...

Research paper thumbnail of Mutaciones en el exón 9 del Gen CYP2D6 en población homogénea y heterogénea de Loreto y su implicancia en el metabolismo de fármacos

Research paper thumbnail of Estudio fitoquímico de la corteza de la raíz de Aspidosperma desmanthum Benth. ex Müll. Arg. con actividad antiplasmodial

Research paper thumbnail of Ocupación anterior y caracterización de la situación económica de las internas del penal San Jacinto de Iquitos, año 2011

Research paper thumbnail of Estudio fitoquímico de la corteza de la raíz de Aspidosperma desmanthum Benth. ex Müll. Arg. con actividad antiplasmodial

Research paper thumbnail of Antiparasitic indole alkaloids from Aspidosperma desmanthum and A. spruceanum from the Peruvian Amazonia

Natural product communications, 2014

Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkal... more Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkaloids 1-4 were isolated from the leaves, 5-8 from the stem bark and 9-15 from the root bark of A. desmanthum. Alkaloids 5, 11, 16, 17 and 19 were isolated from the stem bark, 18 and 20-22 from the root bark and 23 from the flowers of A. spruceanum. Compounds 4, 14, and 15 have not been previously reported as natural products while 16 and 20 have been isolated for the first time from the genus Aspidosperma. Their structures were determined by spectroscopic techniques including 1D and 2D NMR experiments (COSY, NOESY, HSQC, HMBC). The antiparasitic activity of these compounds was tested against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity on mammalian cells. The most active compounds were 10, 12, 13, and 14 from A. desmanthum, and 19, 21 and 22 from A. spruceanum. Aspidolimine (10) aspidocarpine (12) and tubotaiwine (21) showed selective activity against L. i...