Fridolin Bannwart - Academia.edu (original) (raw)
Papers by Fridolin Bannwart
BJU International, 2000
Objective To assess the reliability of the histological diagnosis of bladder cancer by assessing ... more Objective To assess the reliability of the histological diagnosis of bladder cancer by assessing the interobserver variability of staging and grading in pTa/pT1 tumours and evaluating the clinical signi®cance of discrepancies. Materials and methods All sections from 301 super®cial bladder carcinomas were reviewed by one pathologist. The prognostic relevance of grade and stage from both the initial and review diagnosis were determined in 128 patients for whom there was long-term follow-up information. Results There were signi®cant interobserver differences in both the grading and staging of tumours. From a total of 235 tumours that were initially considered pT1, the reviewer classi®ed 35% as pTa, 56% as pT1, 6% as pT1-(at least pT1), and 3% as pT2±4. In 39% of all biopsies there were interobserver differences in tumour grade. The prognostic signi®cance of grade and stage differed between the initial pathology report and the reviewer's diagnosis. The reviewer's staging allowed a better estimate of the risk of subsequent tumour progression than the initial staging. Progression was signi®cantly more common in 49 tumours in which the reviewer agreed with stage pT1 than in 29 tumours that were down-staged from pT1 to pTa (P = 0.0116). However, the initial tumour grade (P = 0.0386) but not the reviewer's grade (P = 0.2645) was signi®cantly linked to progression. Conclusions These results show that grading and staging by different pathologists have varying prognostic implications. If possible, biopsies from bladder tumours should be independently evaluated by two different pathologists before radical therapy is administered.
Praxis, Apr 1, 2008
Vorgestellt wird eine 32-jährige III-Para, bei welcher sich anlässlich der zweiten und der dritte... more Vorgestellt wird eine 32-jährige III-Para, bei welcher sich anlässlich der zweiten und der dritten Sectio caesarea eine stille Uterusruptur fand. Nach der dritten Sectio caesarea bestand in der Stillphase während fünf Monaten eine geringgradige uterine Blutung, dann stellte sich unter oraler Kontrazeption eine Amenorrhoe ein. Regelmässige klinische und sonographische Kontrollen zeigten negative Serum-β- HCG-Werte und eine retrovesikale Resistenz, die nach 18 Monaten an Grösse zunahm und symptomatisch wurde. Bei abgeschlossener Familienplanung erfolgte die abdominale Hysterektomie ohne Adnexektomie. Histologisch zeigte sich ein Placental site trophoblastic tumor (PSTT), ein seltener trophoblastärer Tumor mit malignem Potential, dessen Prognose abhängig ist vom primären Tumorstadium, dem Zeitintervall zwischen letzter Schwangerschaft und Erkrankung, dem Alter der Patientin sowie der Mitoserate, und dessen Verlauf mit dem Prognosescore für trophoblastäre Erkrankungen der WHO nicht abgeschätzt werden kann. Therapeutisch empfohlen wird die Hysterektomie. Die Chemosensitivität ist gering und wegen der Seltenheit der Tumoren ist das geeignetste Chemotherapie-Schema nicht bekannt. Bei metastasierenden oder rezidivierenden PSTT hat sich das EP/EMA-Regime als am effektivsten erwiesen.
![Research paper thumbnail of [Spontaneous recanalization after vasectomy]](https://attachments.academia-assets.com/107955816/thumbnails/1.jpg)
](PubMed, Dec 1, 1993
Two cases of spontaneous recanalisation could be reoperated. The recanalisation was proved histol... more Two cases of spontaneous recanalisation could be reoperated. The recanalisation was proved histologically. The reasons were analysed. The own technique is presented: resection of at least two centimeters of the vas, ligature, electrocoagulation, proximally turning-up fixation of the end, distally immersing the end in a tobacco-pouch.
Cancer, Mar 1, 1997
The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients wit... more The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients with retroperitoneal tumors are male, and careful histologic evaluation reveals preinvasive intratubular germ cell neoplasia (ITGCN) or scars in the testis suggesting a so-called "burnt out" germ cell tumor. However, in the testes of patients with primary mediastinal germ cell tumors, no ITGCN has been described in the literature to date. The authors report the first case of simultaneous germ cell neoplasia in the mediastinum and the testis, providing further insights into the biology and origin of these lesions. The authors report the pathologic features and cytogenetic findings in an adult male with a mediastinal germ cell tumor and asymmetric testis. This patient died shortly after diagnosis. A locally invasive mediastinal nonseminomatous germ cell tumor was associated with ITGCN in one testis. Metastases were not present clinically or on autopsy during a detailed and systematic examination of retroperitoneal lymph nodes and other viscera. Neither an invasive germ cell tumor nor a scar was found in either testis (both testes were serially sectioned and entirely examined histologically). The findings of this study suggest that the mediastinal tumor is a primary neoplasm with concomitant in situ lesion in one testis, suggesting a more generalized defect of germ cell and thus providing new information about the unresolved issue of the histogenesis of extragonadal germ cell tumors. This article presents a review of the literature concerning the issues highlighted by this case and discusses the hypotheses regarding the development of extragonadal germ cell tumors.
PubMed, Mar 1, 1997
Background: The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of ... more Background: The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients with retroperitoneal tumors are male, and careful histologic evaluation reveals preinvasive intratubular germ cell neoplasia (ITGCN) or scars in the testis suggesting a so-called "burnt out" germ cell tumor. However, in the testes of patients with primary mediastinal germ cell tumors, no ITGCN has been described in the literature to date. The authors report the first case of simultaneous germ cell neoplasia in the mediastinum and the testis, providing further insights into the biology and origin of these lesions. Methods: The authors report the pathologic features and cytogenetic findings in an adult male with a mediastinal germ cell tumor and asymmetric testis. This patient died shortly after diagnosis. Results: A locally invasive mediastinal nonseminomatous germ cell tumor was associated with ITGCN in one testis. Metastases were not present clinically or on autopsy during a detailed and systematic examination of retroperitoneal lymph nodes and other viscera. Neither an invasive germ cell tumor nor a scar was found in either testis (both testes were serially sectioned and entirely examined histologically). Conclusions: The findings of this study suggest that the mediastinal tumor is a primary neoplasm with concomitant in situ lesion in one testis, suggesting a more generalized defect of germ cell and thus providing new information about the unresolved issue of the histogenesis of extragonadal germ cell tumors. This article presents a review of the literature concerning the issues highlighted by this case and discusses the hypotheses regarding the development of extragonadal germ cell tumors.
Stroke, Aug 1, 2000
Background-Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, b... more Background-Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder. Summary of Report-An extraordinary presentation of an extremely long-lasting, culture-negative endocarditis caused by Tropheryma whippelii is described, the clinical consequence of which has become apparent in recurrent strokes. Conclusions-Cardiac involvement of Whipple's disease should always be considered in culture and serologically negative endocarditis. The polymerase chain reaction technique may be a useful tool to confirm a presumed diagnosis of T whippelii endocarditis and consequently to apply an effective treatment regimen.
Seit 15 Jahren sind atypische Keimzellen als Vorlauferzellen von Hodenkeimzelltumoren beim Erwach... more Seit 15 Jahren sind atypische Keimzellen als Vorlauferzellen von Hodenkeimzelltumoren beim Erwachsenen bekannt. Sie werden von einzelnen Autoren als totipotente Ursprungszellen der Hodenkeimzelltumoren betrachtet. Wahrend die Morphologie dieser Zellen gut charakterisiert ist, sind Daten uber die Entstehung und die Steuerung des biologischen Verhaltens dieser Zellen noch unvollstandig. Die in der Literatur bekannten Daten und Erfahrungen aus dem Zurcher Untersuchungsgut werden dargestellt und therapeutische Implikationen erlautert.
The American Journal of Surgery, 1972
Abstract A case of villous adenoma of the duodenum is presented. These lesions are usually small ... more Abstract A case of villous adenoma of the duodenum is presented. These lesions are usually small and silent; when symptomatic, they are large, sessile, and easily detected radiologically. They are prone to spontaneous hemorrhage and malignant transformation. An early radiologic diagnosis and complete surgical extirpation of the lesion are frequently possible and may result in a favorable prognosis despite the ominous histologic appearance.
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2017
Mittlerweile jeder Fünfte leidet an einer gastroösophagealen Refluxerkrankung (GERD), Tendenz ste... more Mittlerweile jeder Fünfte leidet an einer gastroösophagealen Refluxerkrankung (GERD), Tendenz steigend. Die Entwicklung eines Barrett-Ösophagus ist eine mögliche und potentiell maligne Komplikation. Bei welchen GERD-Patienten ist eine endoskopische Diagnostik angezeigt, wann eine empirische Therapie ausreichend? Einleitung Die gastroösophageale Refluxerkrankung (GERD) zeigt eine Prävalenz von ca. 20% mit zunehmender Inzidenz. Eine benigne Komplikation von GERD ist die Refluxösophagitis mit ihren möglichen Folgen wie Ulkus oder peptische Striktur. Eine potentiell maligne Komplikation von GERD ist die Entwicklung eines Barrett-Ösophagus, der als Präkanzerose für die Entwicklung eines Adenokarzinoms des distalen Ösophagus (Barrett-Karzinom) anzusehen ist. In der westlichen Welt findet sich einerseits eine siebenfache Zunahme der Inzidenz des Adenokarzinoms des distalen Ösophagus, andererseits belegen neuere Studien ein relativ geringes individuelles Entartungsrisiko eines Barrett-Ösophagus ohne Dysplasie von lediglich 0,12-0,33% pro Jahr [1-4]. Vor diesem Hintergrund stellt sich die Frage nach sinnvoller evidenzbasierter Diagnostik und Therapie. Es gilt, Risikofaktoren für die Entwicklung eines Barrett-Ösophagus aus der Masse der Patienten mit GERD zu erkennen und diese gezielt einer Endoskopie zuzuführen. Nach bioptisch gesicherter Diagnose eines Barrett-Ösophagus erfolgt ein Abschätzen des individuellen Risikos einer malignen Transformation. Dabei kristallisieren sich zunehmend Faktoren für effiziente, endoskopische Überwachungsstrategien heraus. Frühzeitig entdeckt können dysplastische und mukosale frühkarzinomatöse Veränderungen effektiv und sicher kurativ mittels endoskopischer Resektions-und Ablationsverfahren behandelt werden, die mittlerweile als Therapie der ersten Wahl gelten. Gastroösophageale Refluxerkrankung Definition, Diagnostik und empirische Therapie GERD sollte anhand der Montreal-Klassifikation definiert werden, die den pathophysiologischen Prozess des gastroösophagealen Refluxes und die klinische Symptomatik unabhängig voneinander berücksichtigt. Die Diagnose von GERD kann somit einerseits allein anhand von Symptomen, Folgen oder Komplikationen von Reflux und andererseits durch apparativ gemessenen Reflux ohne Symptome gestellt werden. Sodbrennen ist neben Aufstossen und Regurgitationen das sensitivste Symptom von GERD [5, 6]. Vor dem Hintergrund explodierender Gesundheitskosten stellt sich die klinische Frage, bei welchen Patienten mit GERD eine endoskopische Diagnostik indiziert ist. Nach den aktuellen Studien können Patienten mit behandlungsbedürftigen, klassischen Refluxbeschwerden ohne Alarmzeichen oder Risikofaktoren
Journal of Clinical Pathology, 2006
Gastrointestinal Endoscopy, 2015
The online version of this article, along with updated information and services, is located on the
Swiss medical weekly, 2002
PRINCIPLES 10 to 15% of human colon cancers are associated with an inherited or somatic defect of... more PRINCIPLES 10 to 15% of human colon cancers are associated with an inherited or somatic defect of the DNA Mismatch Repair (MMR) system, which has evolved to correct biosynthetic errors such as nucleotide mis-incorporations or misalignments arising during DNA replication in the S phase of the cell-cycle. Although expression of the MMR genes was expected to be cell-cycle dependent, we and others observed that the MMR proteins hMSH2 and hMLH1 are expressed constitutively in proliferating cells. METHODS In this study we extend our observations to another essential MMR protein, hMSH6. We used immunohistochemistry to evaluate the expression pattern of this protein in human colorectal mucosa and tumours, as well as in synchronised HeLa-S3 cells, in which we analysed its steady-state levels during the cell-cycle. RESULTS We show that the immunohistochemical pattern of expression of hMSH6 in normal colorectal crypts and in colon cancers differs significantly from that of the other MMR protei...
BACKGROUND The protozoan Giardia lamblia (GL) and the bacterium Helicobacter pylori (HP) are comm... more BACKGROUND The protozoan Giardia lamblia (GL) and the bacterium Helicobacter pylori (HP) are common causes of gastrointestinal disease. Coinfection is common and has been reported in studies from Africa, Europe, North America and Asia, but data for Switzerland are scarce. AIM To investigate GL and HP prevalence and coinfection rate in gastrointestinal biopsies from the Zurich area of Switzerland. METHODS Cases were retrieved from the laboratory information system (Medica Institute of Clinical Pathology, Zurich, Switzerland). Histological slides of cases with GL were reviewed, as were the concurrent gastric biopsies, where available. RESULTS Between January 1, 2013 and December 31, 2020, GL was found in 88 (0.14%) of 62,402 patients with a small intestine biopsy and HP in 10,668 (15.5%) of 68,961 patients with a gastric biopsy. 74/88 (84.1%) of patients with GL had unremarkable small intestine biopsies, 13/88 (14.8%) had increased intraepithelial lymphocytes, 5/88 (5.7%) showed villo...
Purpose: A retrospective analysis to assess the prognostic and predictive clinical value of breas... more Purpose: A retrospective analysis to assess the prognostic and predictive clinical value of breast tumor ErbB-2 receptor expression quantified by enzyme immunoassay (EIA), to compare levels measured by EIA with ErbB-2 status determined by immunohistochemistry (IHC), and to correlate receptor content with levels of phosphorylated (Y1248-P) ErbB-2, a measure of functional tyrosine kinase activity. Materials and Methods: EIA quantification of ErbB-2 was performed on membrane extracts from 3,208 well-characterized primary breast cancers. Overall, relapse-free, distant disease-free, and local/regionalfree patient survival data were available on 1,123 of these tumors. IHC scoring for ErbB-2 status (HercepTest; DAKO, Glostrup, Denmark) was performed on adjacent sections of 151 cases, and receptor functionality was measured in 230 tumors by an antibody specific for phosphorylated (Y1248-P) ErbB-2. Results: Unlike nonmalignant breast tissues, breast tumors showed increased ErbB-2 levels in a...
Forum Médical Suisse ‒ Swiss Medical Forum, 2017
A l'heure actuelle, une personne sur cinq souffre de reflux gastro-oesophagien (RGO), avec une te... more A l'heure actuelle, une personne sur cinq souffre de reflux gastro-oesophagien (RGO), avec une tendance à la hausse. Le développement d'un oesophage de Barrett en est une complication possible et potentiellement maligne. Chez quels patients atteints de RGO un diagnostic endoscopique est-il indiqué? Quand un traitement empirique est-il suffisant?
BJU International, 2000
Objective To assess the reliability of the histological diagnosis of bladder cancer by assessing ... more Objective To assess the reliability of the histological diagnosis of bladder cancer by assessing the interobserver variability of staging and grading in pTa/pT1 tumours and evaluating the clinical signi®cance of discrepancies. Materials and methods All sections from 301 super®cial bladder carcinomas were reviewed by one pathologist. The prognostic relevance of grade and stage from both the initial and review diagnosis were determined in 128 patients for whom there was long-term follow-up information. Results There were signi®cant interobserver differences in both the grading and staging of tumours. From a total of 235 tumours that were initially considered pT1, the reviewer classi®ed 35% as pTa, 56% as pT1, 6% as pT1-(at least pT1), and 3% as pT2±4. In 39% of all biopsies there were interobserver differences in tumour grade. The prognostic signi®cance of grade and stage differed between the initial pathology report and the reviewer's diagnosis. The reviewer's staging allowed a better estimate of the risk of subsequent tumour progression than the initial staging. Progression was signi®cantly more common in 49 tumours in which the reviewer agreed with stage pT1 than in 29 tumours that were down-staged from pT1 to pTa (P = 0.0116). However, the initial tumour grade (P = 0.0386) but not the reviewer's grade (P = 0.2645) was signi®cantly linked to progression. Conclusions These results show that grading and staging by different pathologists have varying prognostic implications. If possible, biopsies from bladder tumours should be independently evaluated by two different pathologists before radical therapy is administered.
Praxis, Apr 1, 2008
Vorgestellt wird eine 32-jährige III-Para, bei welcher sich anlässlich der zweiten und der dritte... more Vorgestellt wird eine 32-jährige III-Para, bei welcher sich anlässlich der zweiten und der dritten Sectio caesarea eine stille Uterusruptur fand. Nach der dritten Sectio caesarea bestand in der Stillphase während fünf Monaten eine geringgradige uterine Blutung, dann stellte sich unter oraler Kontrazeption eine Amenorrhoe ein. Regelmässige klinische und sonographische Kontrollen zeigten negative Serum-β- HCG-Werte und eine retrovesikale Resistenz, die nach 18 Monaten an Grösse zunahm und symptomatisch wurde. Bei abgeschlossener Familienplanung erfolgte die abdominale Hysterektomie ohne Adnexektomie. Histologisch zeigte sich ein Placental site trophoblastic tumor (PSTT), ein seltener trophoblastärer Tumor mit malignem Potential, dessen Prognose abhängig ist vom primären Tumorstadium, dem Zeitintervall zwischen letzter Schwangerschaft und Erkrankung, dem Alter der Patientin sowie der Mitoserate, und dessen Verlauf mit dem Prognosescore für trophoblastäre Erkrankungen der WHO nicht abgeschätzt werden kann. Therapeutisch empfohlen wird die Hysterektomie. Die Chemosensitivität ist gering und wegen der Seltenheit der Tumoren ist das geeignetste Chemotherapie-Schema nicht bekannt. Bei metastasierenden oder rezidivierenden PSTT hat sich das EP/EMA-Regime als am effektivsten erwiesen.
PubMed, Dec 1, 1993
Two cases of spontaneous recanalisation could be reoperated. The recanalisation was proved histol... more Two cases of spontaneous recanalisation could be reoperated. The recanalisation was proved histologically. The reasons were analysed. The own technique is presented: resection of at least two centimeters of the vas, ligature, electrocoagulation, proximally turning-up fixation of the end, distally immersing the end in a tobacco-pouch.
Cancer, Mar 1, 1997
The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients wit... more The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients with retroperitoneal tumors are male, and careful histologic evaluation reveals preinvasive intratubular germ cell neoplasia (ITGCN) or scars in the testis suggesting a so-called "burnt out" germ cell tumor. However, in the testes of patients with primary mediastinal germ cell tumors, no ITGCN has been described in the literature to date. The authors report the first case of simultaneous germ cell neoplasia in the mediastinum and the testis, providing further insights into the biology and origin of these lesions. The authors report the pathologic features and cytogenetic findings in an adult male with a mediastinal germ cell tumor and asymmetric testis. This patient died shortly after diagnosis. A locally invasive mediastinal nonseminomatous germ cell tumor was associated with ITGCN in one testis. Metastases were not present clinically or on autopsy during a detailed and systematic examination of retroperitoneal lymph nodes and other viscera. Neither an invasive germ cell tumor nor a scar was found in either testis (both testes were serially sectioned and entirely examined histologically). The findings of this study suggest that the mediastinal tumor is a primary neoplasm with concomitant in situ lesion in one testis, suggesting a more generalized defect of germ cell and thus providing new information about the unresolved issue of the histogenesis of extragonadal germ cell tumors. This article presents a review of the literature concerning the issues highlighted by this case and discusses the hypotheses regarding the development of extragonadal germ cell tumors.
PubMed, Mar 1, 1997
Background: The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of ... more Background: The histogenesis of extragonadal germ cell tumors remains an enigma. The majority of patients with retroperitoneal tumors are male, and careful histologic evaluation reveals preinvasive intratubular germ cell neoplasia (ITGCN) or scars in the testis suggesting a so-called "burnt out" germ cell tumor. However, in the testes of patients with primary mediastinal germ cell tumors, no ITGCN has been described in the literature to date. The authors report the first case of simultaneous germ cell neoplasia in the mediastinum and the testis, providing further insights into the biology and origin of these lesions. Methods: The authors report the pathologic features and cytogenetic findings in an adult male with a mediastinal germ cell tumor and asymmetric testis. This patient died shortly after diagnosis. Results: A locally invasive mediastinal nonseminomatous germ cell tumor was associated with ITGCN in one testis. Metastases were not present clinically or on autopsy during a detailed and systematic examination of retroperitoneal lymph nodes and other viscera. Neither an invasive germ cell tumor nor a scar was found in either testis (both testes were serially sectioned and entirely examined histologically). Conclusions: The findings of this study suggest that the mediastinal tumor is a primary neoplasm with concomitant in situ lesion in one testis, suggesting a more generalized defect of germ cell and thus providing new information about the unresolved issue of the histogenesis of extragonadal germ cell tumors. This article presents a review of the literature concerning the issues highlighted by this case and discusses the hypotheses regarding the development of extragonadal germ cell tumors.
Stroke, Aug 1, 2000
Background-Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, b... more Background-Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder. Summary of Report-An extraordinary presentation of an extremely long-lasting, culture-negative endocarditis caused by Tropheryma whippelii is described, the clinical consequence of which has become apparent in recurrent strokes. Conclusions-Cardiac involvement of Whipple's disease should always be considered in culture and serologically negative endocarditis. The polymerase chain reaction technique may be a useful tool to confirm a presumed diagnosis of T whippelii endocarditis and consequently to apply an effective treatment regimen.
Seit 15 Jahren sind atypische Keimzellen als Vorlauferzellen von Hodenkeimzelltumoren beim Erwach... more Seit 15 Jahren sind atypische Keimzellen als Vorlauferzellen von Hodenkeimzelltumoren beim Erwachsenen bekannt. Sie werden von einzelnen Autoren als totipotente Ursprungszellen der Hodenkeimzelltumoren betrachtet. Wahrend die Morphologie dieser Zellen gut charakterisiert ist, sind Daten uber die Entstehung und die Steuerung des biologischen Verhaltens dieser Zellen noch unvollstandig. Die in der Literatur bekannten Daten und Erfahrungen aus dem Zurcher Untersuchungsgut werden dargestellt und therapeutische Implikationen erlautert.
The American Journal of Surgery, 1972
Abstract A case of villous adenoma of the duodenum is presented. These lesions are usually small ... more Abstract A case of villous adenoma of the duodenum is presented. These lesions are usually small and silent; when symptomatic, they are large, sessile, and easily detected radiologically. They are prone to spontaneous hemorrhage and malignant transformation. An early radiologic diagnosis and complete surgical extirpation of the lesion are frequently possible and may result in a favorable prognosis despite the ominous histologic appearance.
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2017
Mittlerweile jeder Fünfte leidet an einer gastroösophagealen Refluxerkrankung (GERD), Tendenz ste... more Mittlerweile jeder Fünfte leidet an einer gastroösophagealen Refluxerkrankung (GERD), Tendenz steigend. Die Entwicklung eines Barrett-Ösophagus ist eine mögliche und potentiell maligne Komplikation. Bei welchen GERD-Patienten ist eine endoskopische Diagnostik angezeigt, wann eine empirische Therapie ausreichend? Einleitung Die gastroösophageale Refluxerkrankung (GERD) zeigt eine Prävalenz von ca. 20% mit zunehmender Inzidenz. Eine benigne Komplikation von GERD ist die Refluxösophagitis mit ihren möglichen Folgen wie Ulkus oder peptische Striktur. Eine potentiell maligne Komplikation von GERD ist die Entwicklung eines Barrett-Ösophagus, der als Präkanzerose für die Entwicklung eines Adenokarzinoms des distalen Ösophagus (Barrett-Karzinom) anzusehen ist. In der westlichen Welt findet sich einerseits eine siebenfache Zunahme der Inzidenz des Adenokarzinoms des distalen Ösophagus, andererseits belegen neuere Studien ein relativ geringes individuelles Entartungsrisiko eines Barrett-Ösophagus ohne Dysplasie von lediglich 0,12-0,33% pro Jahr [1-4]. Vor diesem Hintergrund stellt sich die Frage nach sinnvoller evidenzbasierter Diagnostik und Therapie. Es gilt, Risikofaktoren für die Entwicklung eines Barrett-Ösophagus aus der Masse der Patienten mit GERD zu erkennen und diese gezielt einer Endoskopie zuzuführen. Nach bioptisch gesicherter Diagnose eines Barrett-Ösophagus erfolgt ein Abschätzen des individuellen Risikos einer malignen Transformation. Dabei kristallisieren sich zunehmend Faktoren für effiziente, endoskopische Überwachungsstrategien heraus. Frühzeitig entdeckt können dysplastische und mukosale frühkarzinomatöse Veränderungen effektiv und sicher kurativ mittels endoskopischer Resektions-und Ablationsverfahren behandelt werden, die mittlerweile als Therapie der ersten Wahl gelten. Gastroösophageale Refluxerkrankung Definition, Diagnostik und empirische Therapie GERD sollte anhand der Montreal-Klassifikation definiert werden, die den pathophysiologischen Prozess des gastroösophagealen Refluxes und die klinische Symptomatik unabhängig voneinander berücksichtigt. Die Diagnose von GERD kann somit einerseits allein anhand von Symptomen, Folgen oder Komplikationen von Reflux und andererseits durch apparativ gemessenen Reflux ohne Symptome gestellt werden. Sodbrennen ist neben Aufstossen und Regurgitationen das sensitivste Symptom von GERD [5, 6]. Vor dem Hintergrund explodierender Gesundheitskosten stellt sich die klinische Frage, bei welchen Patienten mit GERD eine endoskopische Diagnostik indiziert ist. Nach den aktuellen Studien können Patienten mit behandlungsbedürftigen, klassischen Refluxbeschwerden ohne Alarmzeichen oder Risikofaktoren
Journal of Clinical Pathology, 2006
Gastrointestinal Endoscopy, 2015
The online version of this article, along with updated information and services, is located on the
Swiss medical weekly, 2002
PRINCIPLES 10 to 15% of human colon cancers are associated with an inherited or somatic defect of... more PRINCIPLES 10 to 15% of human colon cancers are associated with an inherited or somatic defect of the DNA Mismatch Repair (MMR) system, which has evolved to correct biosynthetic errors such as nucleotide mis-incorporations or misalignments arising during DNA replication in the S phase of the cell-cycle. Although expression of the MMR genes was expected to be cell-cycle dependent, we and others observed that the MMR proteins hMSH2 and hMLH1 are expressed constitutively in proliferating cells. METHODS In this study we extend our observations to another essential MMR protein, hMSH6. We used immunohistochemistry to evaluate the expression pattern of this protein in human colorectal mucosa and tumours, as well as in synchronised HeLa-S3 cells, in which we analysed its steady-state levels during the cell-cycle. RESULTS We show that the immunohistochemical pattern of expression of hMSH6 in normal colorectal crypts and in colon cancers differs significantly from that of the other MMR protei...
BACKGROUND The protozoan Giardia lamblia (GL) and the bacterium Helicobacter pylori (HP) are comm... more BACKGROUND The protozoan Giardia lamblia (GL) and the bacterium Helicobacter pylori (HP) are common causes of gastrointestinal disease. Coinfection is common and has been reported in studies from Africa, Europe, North America and Asia, but data for Switzerland are scarce. AIM To investigate GL and HP prevalence and coinfection rate in gastrointestinal biopsies from the Zurich area of Switzerland. METHODS Cases were retrieved from the laboratory information system (Medica Institute of Clinical Pathology, Zurich, Switzerland). Histological slides of cases with GL were reviewed, as were the concurrent gastric biopsies, where available. RESULTS Between January 1, 2013 and December 31, 2020, GL was found in 88 (0.14%) of 62,402 patients with a small intestine biopsy and HP in 10,668 (15.5%) of 68,961 patients with a gastric biopsy. 74/88 (84.1%) of patients with GL had unremarkable small intestine biopsies, 13/88 (14.8%) had increased intraepithelial lymphocytes, 5/88 (5.7%) showed villo...
Purpose: A retrospective analysis to assess the prognostic and predictive clinical value of breas... more Purpose: A retrospective analysis to assess the prognostic and predictive clinical value of breast tumor ErbB-2 receptor expression quantified by enzyme immunoassay (EIA), to compare levels measured by EIA with ErbB-2 status determined by immunohistochemistry (IHC), and to correlate receptor content with levels of phosphorylated (Y1248-P) ErbB-2, a measure of functional tyrosine kinase activity. Materials and Methods: EIA quantification of ErbB-2 was performed on membrane extracts from 3,208 well-characterized primary breast cancers. Overall, relapse-free, distant disease-free, and local/regionalfree patient survival data were available on 1,123 of these tumors. IHC scoring for ErbB-2 status (HercepTest; DAKO, Glostrup, Denmark) was performed on adjacent sections of 151 cases, and receptor functionality was measured in 230 tumors by an antibody specific for phosphorylated (Y1248-P) ErbB-2. Results: Unlike nonmalignant breast tissues, breast tumors showed increased ErbB-2 levels in a...
Forum Médical Suisse ‒ Swiss Medical Forum, 2017
A l'heure actuelle, une personne sur cinq souffre de reflux gastro-oesophagien (RGO), avec une te... more A l'heure actuelle, une personne sur cinq souffre de reflux gastro-oesophagien (RGO), avec une tendance à la hausse. Le développement d'un oesophage de Barrett en est une complication possible et potentiellement maligne. Chez quels patients atteints de RGO un diagnostic endoscopique est-il indiqué? Quand un traitement empirique est-il suffisant?