Fusun Ozmen - Academia.edu (original) (raw)

Papers by Fusun Ozmen

Frontiers in Pediatrics, Jul 27, 2023

Turkiye Klinikleri Medical Oncology - Special Topics, 2017

Advances in Therapy, 2015

Frontiers in Pediatrics, Dec 23, 2022

World Journal of Gastroenterology, 2013

Journal of Clinical Psychopharmacology, Feb 15, 2021

Annals of Laparoscopic and Endoscopic Surgery, Nov 1, 2020

Journal of Gastrointestinal Surgery, Mar 13, 2012

International Journal of Clinical Practice, Jan 25, 2021

Vitiligo is an autoimmune disease characterised by acquired loss of melanocytes. Although the pat... more Vitiligo is an autoimmune disease characterised by acquired loss of melanocytes. Although the pathogenesis of vitiligo remains unknown, oxidative stress and autoimmune dysregulations are considered to play a role.

Cytokine, May 1, 2022

This is the first study to have investigated the prognostic role of cytokines and soluble human l... more This is the first study to have investigated the prognostic role of cytokines and soluble human leukocyte antigen-G (sHLA-G) levels in pediatric leukemia patients who have undergone allogeneic stem cell transplantation (allo-SCT). Forty-one patients with acute leukemia (n = 28, acute lymphoblastic leukemia (ALL) and n = 13, acute myeloblastic leukemia) were recruited. Patients were examined at diagnosis (n = 26), in the pre-transplantation period (PreTx) (n = 26), on the day of transplantation (Tx0) (n = 41), and on post-transplantation Days 14 (PostTx14) (n = 41) and 28 (PostTx28) (n = 41). Serum levels of pro-inflammatory cytokines (interleukin [IL]-1, IL-2, IL-6, Tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10), and sHLA-G were measured by Enzyme-Linked ImmunoSorbent Assay. Median levels of all cytokines tested and sHLA-G were significantly higher at diagnosis and at the post-transplant time points than at PreTx (all p < 0.05). At the time of diagnosis (specifically ALL) and at PostTx14, elevated IL-4, IL-10, and/or sHLA-G were associated with higher post-transplant relapse rates (all p < 0.05). Elevated IL-2 and TNF-α at Tx0 were associated with lower survival rates (both p < 0.05). Levels of serum cytokines and sHLA-G may be useful predictors of survival and relapse in pediatric leukemia patients who undergo allo-SCT.

Objective: Early diagnosis of lung cancer is critical for successful treatment and improving the ... more Objective: Early diagnosis of lung cancer is critical for successful treatment and improving the outcome of patients. The cancer cells synthesize proteins as well as all of the other cells. Cancer may be recognised with these proteins profiles analysed with any methods. With SELDI-TOF-MS method, protein profiles can be obtained from serum, pleural fluid, urine and tissue samples. The goal of this study was to identified protein profiles and to distinguish lung cancer patients from healty individuals by serum protein profiles. Methods: 170 patients with lung cancer, 53 individuals with no evidence lung cancer but high risk for lung cancer and 47 healthy individuals totally 270 individuals were included in this study. Venous samples were taken from all cases. All of the serum samples were analyzed by SELDI-TOF-MS method for proteomics investigation. Results: SELDI-TOF spectra of patients with lung cancer, healthy control and high risk are shown for the most discriminatory peaks of 11480 m/z, 11547 m/z and 11679 m/z. View this table: Discriminatory proteomic features between lung cancers and healthy controls These proteomic features were present in only lung cancer group, but not in healthy control or high risk groups. Conclusion: SELDI-TOF-MS method can correctly distinguish patients with lung cancer from healthy individuals and SELDI-TOF-MS method may be a new tool in diagnosis and screening test for lung cancer.

Obesity Surgery, Sep 4, 2020

Background: Although excess weight loss is the targeted endpoint of the successfull procedure, ma... more Background: Although excess weight loss is the targeted endpoint of the successfull procedure, many patients might suffer from disturbed bowel habits and vitamin deficiencies. We aimed to evaluate exocrine pancreatic function after different procedures. Methods: 60(21M)patients aged 43(21-62)years who underwent bariatric surgery (sleeve gastrectomy(SG), mini-gastric bypass(MGB) or single anastomosis duodenal switch(SADS)) and 20(6M)healthy controls aged 33(22-56)y were included. Stool samples were collected for fecal elastase-1(FE1) levels (mg/g stool). 10 patients from each group were given pancreatic enzyme replacement therapy(PERT). Excess weight loss(EWL,%) and serum vitamin D levels were also measured.

Journal of Dermatological Treatment, Jun 21, 2021

BACKGROUND Alopecia areata (AA) is an autoimmune disease where autoimmune dysregulations along wi... more BACKGROUND Alopecia areata (AA) is an autoimmune disease where autoimmune dysregulations along with genetic susceptibility are hypothesized to play a role in pathogenesis. OBJECTIVE The aim of this study in to evaluate HLA-A, HLA-B, HLA-C, HLA-DQB1 and HLA-DRB1 profile and its relationship with clinical features in AA patients. MATERIALS AND METHODS Ninety-eight patients with AA and 100 healthy controls were included in the study. HLA-A, HLA-B, HLA-C, HLA-DQB1 and HLA-DRB1 frequencies were analyzed using polymerase chain reaction-sequence specific primers (PCR-SSP). RESULTS HLA-B*39 and HLA-HLA-DRB1*15 allele frequencies were increased (p = 0.022 and p = 0.023, respectively), HLA-A*11 and HLA-B*35 frequencies were decreased (p = 0.006 and p = 0.014, respectively) in AA patients. HLA-B*13 and HLA-DRB1*11 were associated with poor prognostic factors. A class I allele, HLA-B*13 was associated with recurrence (p = 0.023) and presence of nevus flammeus (p = 0.022), while the class II allele HLA-DRB1*11 was associated with widespread hair loss (diffuse or universal alopecia) (p = 0.026), presence of ophiasis (p = 0.049) and juvenile onset (p = 0.018). CONCLUSION Belonging to two different classes of HLA family, HLA-B*13 and HLA-DRB1*11 alleles identified separate set of risk factors. In addition to increasing the risk of AA, HLA alleles may affect the prognosis of the disease.

Thyroid

Background: Despite mass vaccination, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2... more Background: Despite mass vaccination, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced subacute thyroiditis (SAT) is rarely seen as a complication. The reason why some individuals are susceptible to developing vaccine-induced SAT is not known. SAT develops in genetically predisposed individuals who carry specific human leukocyte antigen (HLA) haplotypes. It is unknown whether specific HLA alleles are associated with SARS-CoV-2 vaccine-induced SAT. Objective: This study compared the HLA profiles of patients with SARS-CoV-2 vaccine-induced SAT to controls, to assess whether there is an association between specific HLA genotypes and development of SAT. The relationship between HLA genotypes and the clinical course of SARS-CoV-2 vaccine-induced SAT was also evaluated. Methods: A case-control study was conducted in a Turkish tertiary care center. Fourteen patients with SARS-CoV-2 vaccine-induced SAT and 100 healthy controls were included. HLA-A, HLA-B, HLA-C, HLA-DQB1, and HLA-DRB1 frequencies were analyzed by next-generation sequencing. Results: The frequencies of HLA-B*35 and HLA-C*04 alleles were significantly higher in SARS-CoV-2 vaccine-induced SAT cohort when compared with controls (HLA-B*35: 13 [93%] vs. 40 [40%], p < 0.001; HLA-C*04: 13 [93%] vs. 43 [43%], p < 0.001, respectively). More severe thyrotoxicosis was seen in patients having HLA-B*35 and HLA-C*04 homozygous alleles (free thyroxine: 4.47 ng/dL [3.77-5.18] vs. 1.41 ng/dL [1.22-2.63], p = 0.048). Inflammation tended to be more severe in homozygous patients (C-reactive protein: 28.2 mg/dL [13.6-42.9] vs. 4.8 [1.2-10.5], p = 0.07). Conclusions: The frequencies of HLA-B*35 and HLA-C*04 alleles were higher in SARS-CoV-2 vaccineinduced SAT compared with controls. Homozygosity for HLA-B*35 and HLA-C*04 was associated with thyrotoxicosis and a greater inflammatory reaction. Our findings should be confirmed in studies of other populations.

Cytokine, 2022

International Journal of Clinical Practice, 2021

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018

Background and objectives: Sarcoidosis is a systemic inflammatory disease of unknown etiology tha... more Background and objectives: Sarcoidosis is a systemic inflammatory disease of unknown etiology that involves any part of the body, mainly the lungs and thoracic lymph nodes. The clinical presentation is heterogeneous based on the degree and extent of organ involvement. The existence of variable clinical presentations and treatment responses suggest an important role of genetic predisposition. In genetic studies, sarcoidosis was found to be associated with several genes, but the strongest link was with HLA region. The aim of this study was to investigate the association of HLA class II alleles with the extent and course of disease in Turkish patients with sarcoidosis. Methods: The study included 103 patients with sarcoidosis and 100 unrelated healthy controls. HLA-DRB1 and HLA-DQB1 typing was performed by using Polymerase Chain Reaction-Sequence Specific Priming (PCR-SSP) method at low resolution level. Results: HLA-DRB1* and -DQB1* analysis revealed that while the frequency of HLA-DR...