Gökhan Gök - Academia.edu (original) (raw)
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Papers by Gökhan Gök
Aquaculture, 2019
Ammonia tolerance of European sea bass (Dicentrarchus labrax) juveniles (1.1 ± 0.3 g) was investi... more Ammonia tolerance of European sea bass (Dicentrarchus labrax) juveniles (1.1 ± 0.3 g) was investigated by a series of acute toxicity experiments at different salinity levels (10, 20 and 30 ppt) at pH 8.0 and temperature 22°C. Oxygen consumption rates were also measured to determine the Standard Metabolism (SM) of the fish. The tolerance of the fish to total ammonia nitrogen (TAN) and unionized ammonia (NH 3) increased significantly with increasing salinity levels. The safe level for European sea bass was estimated to be 0.4, 1.0 and 1.6 mg L −1 for TAN and 0.02, 0.04 and 0.07 mg L −1 for NH 3 at 10, 20 and 30 ppt salinity levels, respectively. At any, each level, the SM of the fish increased with increasing TAN concentration (P < .01). The SM of the fish at 10, 20 and 30 ppt gradients is 284, 282 and 272 mg h −1 kg −1 , respectively at 0 mg L −1 TAN concentration (P < .01). This study indicates that European sea bass, a euryhaline teleost fish, has a low tolerance to ammonia at any salinity level.
Journal of Gastrointestinal Cancer, 2017
2018 26th Signal Processing and Communications Applications Conference (SIU), May 1, 2018
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2017
Öz Although metformin is a well tolerated anti-hyperglycemic drug it may cause lactic acidosis wh... more Öz Although metformin is a well tolerated anti-hyperglycemic drug it may cause lactic acidosis which has high mortality. In this paper we reported a renal transplant patient with lactic acidosis. Fifty-five year old renal transplant patient was admitted to our hospital with confusion and lactic acidosis. Her confusion improved dramatically after restoring blood glucose, supportive therapy and hemodialysis. Her obstructive ureteral stone was removed with ureteral catheterization. In follow up period her renal function was similar to baseline. In summary rapid diagnosis and also appropriate treatment including hemodialysis can prevent morbidity/ mortality in a patient with metformin associated lactic acidosis. Metformin users, especially renal transplant receivers who have high risk of acute renal failure, should be educated about the discontinuation of the drug when their urine volume decreased. Metformin iyi tolere edilen bir anti-hiperglisemik ilaç olmasına rağmen tedavisi sırasında mortalitesi yüksek laktik asidoza neden olabilir. Burada laktik asidoz ve böbrek yetersizliği gelişen bir böbrek nakil hastası rapor edilmiştir. Ellibeş yaşında böbrek nakil hastası hastanemize şuur bozukluğu, hipoglisemi ve laktik asidoz ile getirildi. Hastada postrenal akut böbrek yetersizliği saptandı. Hipoglisemi ve destek tedavisini takiben hemodiyaliz sonrası hastanın konfüzyonu dramatik olarak düzeldi. Üreteral taşın çıkarılmasından sonra böbrek fonksiyonları önceki değerlerde normal seyretti. Metformine bağlı gelişen laktik asidozda erken tanı ve geciktirilmeden hemodiyaliz dahil destek redavisi ile morbidite ve mortaliteyi önleyebilir. Ayrıca, akut böbrek yetersizliği gelisme riski yüksek transplant hastaları dahil metformin kullanan hastaların idrar azalması durumunda metformine ara vermesi konusunda eğitilmesi önemli olabilir.
Aquaculture, 2019
Ammonia tolerance of European sea bass (Dicentrarchus labrax) juveniles (1.1 ± 0.3 g) was investi... more Ammonia tolerance of European sea bass (Dicentrarchus labrax) juveniles (1.1 ± 0.3 g) was investigated by a series of acute toxicity experiments at different salinity levels (10, 20 and 30 ppt) at pH 8.0 and temperature 22°C. Oxygen consumption rates were also measured to determine the Standard Metabolism (SM) of the fish. The tolerance of the fish to total ammonia nitrogen (TAN) and unionized ammonia (NH 3) increased significantly with increasing salinity levels. The safe level for European sea bass was estimated to be 0.4, 1.0 and 1.6 mg L −1 for TAN and 0.02, 0.04 and 0.07 mg L −1 for NH 3 at 10, 20 and 30 ppt salinity levels, respectively. At any, each level, the SM of the fish increased with increasing TAN concentration (P < .01). The SM of the fish at 10, 20 and 30 ppt gradients is 284, 282 and 272 mg h −1 kg −1 , respectively at 0 mg L −1 TAN concentration (P < .01). This study indicates that European sea bass, a euryhaline teleost fish, has a low tolerance to ammonia at any salinity level.
Journal of Gastrointestinal Cancer, 2017
2018 26th Signal Processing and Communications Applications Conference (SIU), May 1, 2018
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2017
Öz Although metformin is a well tolerated anti-hyperglycemic drug it may cause lactic acidosis wh... more Öz Although metformin is a well tolerated anti-hyperglycemic drug it may cause lactic acidosis which has high mortality. In this paper we reported a renal transplant patient with lactic acidosis. Fifty-five year old renal transplant patient was admitted to our hospital with confusion and lactic acidosis. Her confusion improved dramatically after restoring blood glucose, supportive therapy and hemodialysis. Her obstructive ureteral stone was removed with ureteral catheterization. In follow up period her renal function was similar to baseline. In summary rapid diagnosis and also appropriate treatment including hemodialysis can prevent morbidity/ mortality in a patient with metformin associated lactic acidosis. Metformin users, especially renal transplant receivers who have high risk of acute renal failure, should be educated about the discontinuation of the drug when their urine volume decreased. Metformin iyi tolere edilen bir anti-hiperglisemik ilaç olmasına rağmen tedavisi sırasında mortalitesi yüksek laktik asidoza neden olabilir. Burada laktik asidoz ve böbrek yetersizliği gelişen bir böbrek nakil hastası rapor edilmiştir. Ellibeş yaşında böbrek nakil hastası hastanemize şuur bozukluğu, hipoglisemi ve laktik asidoz ile getirildi. Hastada postrenal akut böbrek yetersizliği saptandı. Hipoglisemi ve destek tedavisini takiben hemodiyaliz sonrası hastanın konfüzyonu dramatik olarak düzeldi. Üreteral taşın çıkarılmasından sonra böbrek fonksiyonları önceki değerlerde normal seyretti. Metformine bağlı gelişen laktik asidozda erken tanı ve geciktirilmeden hemodiyaliz dahil destek redavisi ile morbidite ve mortaliteyi önleyebilir. Ayrıca, akut böbrek yetersizliği gelisme riski yüksek transplant hastaları dahil metformin kullanan hastaların idrar azalması durumunda metformine ara vermesi konusunda eğitilmesi önemli olabilir.