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Papers by Gökhan Ulusoy
Sakarya Medical Journal
This study was designed to evaluate the box sale trends of insulin preparations and glucagon-like... more This study was designed to evaluate the box sale trends of insulin preparations and glucagon-like peptide-1 (Glp-1) analogs by their therapeutic categories in Turkey. Also, we aimed to project sale trends of these pharmaceuticals in next years. We analyzed the data before the covid-19 pandemic and made predictions based on these data. This study analyzed retail and hospital box sales of insulin preparations from 4 therapeutic categories (fast/short-acting, intermediate-acting, premix, long-acting) and Glp-1 analogs. Total box sales of the insulin preparations were increased by %13,30 in the period examined. While fast/short-acting and long-acting insulin box sales increased with a decreasing upward trend, intermediate-acting and premix insulin box sales decreased. Glp-1 analog sales increased rapidly in this period. Currently, newer pharmaceuticals have been entering Turkish market for diabetes treatment. Less insulin might be required if newer pharmaceuticals are more widely availa...
Anadolu Kliniği Tıp Bilimleri Dergisi, 2019
This study aimed to analyze the phytochemical components of a number of herbs and herbal teas use... more This study aimed to analyze the phytochemical components of a number of herbs and herbal teas used to improve breast milk production by gas chromatography/mass spectrometry (GC/MS). Materials and Methods: The methanolic extracts were prepared by the maceration method using a rotary evaporator. The essential oils were obtained by the Clevenger method. Results: The GC/MS analyses of the essential oils and methanol extracts of the medicinal herbs Foeniculum vulgare, Pimpinella anisum, Trigonella foenum graceum, Urtica dioica, and Nigella sativa, and their teas on the market were performed with high sensitivity. The chemical components identified were presented in detailed tables. Discussion and Conclusions: In our study possible pharmacological effects of the components identified were discussed in light of the literature. Our findings are guiding for further research on the pharmacologically active components of these herbs and herbal teas that may be used for breast milk enhancement or other medical purposes in the future.
Fundamental & Clinical Pharmacology, 2019
Potassium (K +) ion channel activity is an important determinant of vascular tone by regulating c... more Potassium (K +) ion channel activity is an important determinant of vascular tone by regulating cell membrane potential (MP). Activation of K + channels leads to membrane hyperpolarization and subsequently vasodilatation, while inhibition of the channels causes membrane depolarization and then vasoconstriction. So far five distinct types of K + channels have been identified in vascular smooth muscle cells (VSMCs); Ca +2-activated K + channels (BK Ca), voltage-dependent K + channels Accepted Article This article is protected by copyright. All rights reserved. (K V), ATP-sensitive K + channels (K ATP), inward rectifier K + channels (K ir), and tandem-two pore K + channels (K 2 P). The activity and expression of vascular K + channels are changed during major vascular diseases such as hypertension, pulmonary hypertension, hypercholesterolemia, atherosclerosis, and diabetes mellitus. The defective function of K + channels is commonly associated with impaired vascular responses and is likely to become as a result of changes in K + channels during vascular diseases. Increased K + channel function and expression may also help to compensate for increased abnormal vascular tone. There are many pharmacological and genotypic studies which were carried out on the subtypes of K + channels expressed in variable amounts in different vascular beds. Modulation of K + channel activity by molecular approaches and selective drug development may be a novel treatment modality for vascular dysfunction in the future. This review presents the basic properties, physiological functions, pathophysiological and pharmacological roles of the five major classes of K + channels that have been determined in VSMCs.
Sakarya Medical Journal
This study was designed to evaluate the box sale trends of insulin preparations and glucagon-like... more This study was designed to evaluate the box sale trends of insulin preparations and glucagon-like peptide-1 (Glp-1) analogs by their therapeutic categories in Turkey. Also, we aimed to project sale trends of these pharmaceuticals in next years. We analyzed the data before the covid-19 pandemic and made predictions based on these data. This study analyzed retail and hospital box sales of insulin preparations from 4 therapeutic categories (fast/short-acting, intermediate-acting, premix, long-acting) and Glp-1 analogs. Total box sales of the insulin preparations were increased by %13,30 in the period examined. While fast/short-acting and long-acting insulin box sales increased with a decreasing upward trend, intermediate-acting and premix insulin box sales decreased. Glp-1 analog sales increased rapidly in this period. Currently, newer pharmaceuticals have been entering Turkish market for diabetes treatment. Less insulin might be required if newer pharmaceuticals are more widely availa...
Anadolu Kliniği Tıp Bilimleri Dergisi, 2019
This study aimed to analyze the phytochemical components of a number of herbs and herbal teas use... more This study aimed to analyze the phytochemical components of a number of herbs and herbal teas used to improve breast milk production by gas chromatography/mass spectrometry (GC/MS). Materials and Methods: The methanolic extracts were prepared by the maceration method using a rotary evaporator. The essential oils were obtained by the Clevenger method. Results: The GC/MS analyses of the essential oils and methanol extracts of the medicinal herbs Foeniculum vulgare, Pimpinella anisum, Trigonella foenum graceum, Urtica dioica, and Nigella sativa, and their teas on the market were performed with high sensitivity. The chemical components identified were presented in detailed tables. Discussion and Conclusions: In our study possible pharmacological effects of the components identified were discussed in light of the literature. Our findings are guiding for further research on the pharmacologically active components of these herbs and herbal teas that may be used for breast milk enhancement or other medical purposes in the future.
Fundamental & Clinical Pharmacology, 2019
Potassium (K +) ion channel activity is an important determinant of vascular tone by regulating c... more Potassium (K +) ion channel activity is an important determinant of vascular tone by regulating cell membrane potential (MP). Activation of K + channels leads to membrane hyperpolarization and subsequently vasodilatation, while inhibition of the channels causes membrane depolarization and then vasoconstriction. So far five distinct types of K + channels have been identified in vascular smooth muscle cells (VSMCs); Ca +2-activated K + channels (BK Ca), voltage-dependent K + channels Accepted Article This article is protected by copyright. All rights reserved. (K V), ATP-sensitive K + channels (K ATP), inward rectifier K + channels (K ir), and tandem-two pore K + channels (K 2 P). The activity and expression of vascular K + channels are changed during major vascular diseases such as hypertension, pulmonary hypertension, hypercholesterolemia, atherosclerosis, and diabetes mellitus. The defective function of K + channels is commonly associated with impaired vascular responses and is likely to become as a result of changes in K + channels during vascular diseases. Increased K + channel function and expression may also help to compensate for increased abnormal vascular tone. There are many pharmacological and genotypic studies which were carried out on the subtypes of K + channels expressed in variable amounts in different vascular beds. Modulation of K + channel activity by molecular approaches and selective drug development may be a novel treatment modality for vascular dysfunction in the future. This review presents the basic properties, physiological functions, pathophysiological and pharmacological roles of the five major classes of K + channels that have been determined in VSMCs.