Gülşah Seydaoğlu - Academia.edu (original) (raw)
Papers by Gülşah Seydaoğlu
Cukurova Medical Journal
This study aims to examine the relationship of the preschool childhood masturbation with the pare... more This study aims to examine the relationship of the preschool childhood masturbation with the parental attitude as well as the relation of the same with the comorbidity and related stammering, tic disorders, nail biting, nocturnal enuresis (NE) and encopresis. Materials and Methods: In this study, parents of 105 preschool children (between the ages of 3-6) were interviewed. 50 out the 105 interviewed parents' children had have been with childhood masturbation (CM) and they are receiving professional consultancy or support services and these parents constitute the case group of this study. The control group was formed with the parents of 55 children. Research data were obtained by of the Personal Information Form filled by the parents, Parental Attitude Scale (PAS) and Comorbid Problems Determination Form prepared by the researcher. Results: Authoritarion parental attitude is discovered to be statistically higher than the case group with CM compared to the control group without such disorder. It has been detected that nail biting, NE and encopresis comorbidity is significantly higher in the case group with CM compared to the control group. Conclusion: There was a direct relationship between authoritarian parental attitudes and the CM that emerged in preschool childhood. Along with CM the rate of frequency of nail biting, NE and encopresis are higher than the control group. Amaç: Bu çalışmada okul öncesi dönemde çocukluk çağı masturbasyon bozukluğunun ebeveyn tutumları ile ilişkisinin ve kekemelik, tik bozukluğu, tırnak yeme, enürezis noktürna, enkoprezis ile komorbiditesinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 105 okul öncesi çocuğun (3-6 yaş) ebeveynleri ile görüşülmüştür. Görüşülen 105 ebeveynin 50'si çocuklarına Çocukluk çağı masturbayon (ÇÇM) bozukluğu tanısı konulan ve profesyonel danışmanlık veya destek hizmeti alan kişilerdir ve bu ebeveynler çalışmanın olgu grubunu oluşturmaktadır. Kontrol grubu 55 çocuğun ebeveynleri ile oluşturulmuştur. Araştırma verileri, ebeveynlerin doldurduğu Kişisel Bilgi Formu, Ebeveyn Tutum Ölçeği ve araştırmacı tarafından hazırlanan Alışkı Sorunları Belirleme Bilgi Formu kullanılarak elde edilmiştir. Bulgular: Otoriter ebeveyn tutumu ÇÇM bozukluğu olan olgu gurubunda, bu bozukluğun olmadığı kontrol grubuna göre istatistiksel olarak yüksek bulunmuştur. ÇÇM bozukluğu olan olgu grubunda, kontrol grubuna göre anlamlı düzeyde yüksek tırnak yeme, enürezis noktürna, enkoprezis komorbiditesi saptanmıştır. Sonuç: Otoriter ebeveyn tutumu ile okul öncesi çocukluk döneminde ortaya çıkan ÇÇM arasında doğrudan bir ilişki olduğu görülmüştür. ÇÇM ile birlikte tırnak yeme, enürezis noktürna, enkoprezis görülme sıklığı kontrol grubuna göre daha yüksektir.
Biomedical Research and Clinical Practice
Context: Nowadays, virtually everybody is exposed to radiofrequency radiation (RFR) from mobile p... more Context: Nowadays, virtually everybody is exposed to radiofrequency radiation (RFR) from mobile phone base station antennas or other sources. Despite many research efforts and public debate there is still great concern about the possible adverse effects of RFR on human health. The present study was designed as an attempt to correlate the effect of non-thermal radiation. Objective: The aim of this study was to evaluate the possible effects of in vitro 900 and 1800 MHz GSM-like (radiation from cell phones) exposure on chromosomes of human fetal cells (FCs). Materials and methods: We examined the induction of non-thermal effect following 3h, 6h and 12h exposure to 900 and 1800 MHz radiofrequency radiation (RF-EMR) in FCs and in control medium, which did not exposure of RF-EMR. Results: The results indicated that a significant difference of chromosomal aberrations (CAs) between medium grown cells the exposure of FCs to RF-EMR at 900 and 1800 MHz and unexposed cells, determined by the χ2 test (P < 0.001). We found CAs in 25.9% of cells exposed to RF radiation [such as fragility, gap, singlestrand breaks (SSB) and double-strand breaks (DSB)], and non-thermal RF-EMF caused delays in chromosome condensation, and a significant rise in CAs with increasing exposure time. Conclusion: Results of this study confirm that the GSM-like RF-EMR leads to significant direct genotoxic effects on human FCs in vitro culture, and RF-EMR had negative effects on human chromosomes, moreover these effects aggravated with exposure time. We concluded that mobile phone risks to human chromosomes and human health. However, we confirm that RF-EMR affects negatively the condensation of chromosomes. Our hope is that the knowledge of mobile phones safety can not only help guide the future design of these instruments, but also affect the selection of procedures in order to ensure safe, efficacious, and efficient system operation.
Cukurova Medical Journal
Öz Purpose: The aim of this study was toexplore the histopathologic subtypes of pediatric lymphom... more Öz Purpose: The aim of this study was toexplore the histopathologic subtypes of pediatric lymphomas and their relation with Ebstein-Barr virus infection in our region. Materials and Methods: In this retrospective study, 87 children including 36 cases with Hodgkin lymphoma and 51 cases with non-Hodgkin lymphoma were included in the study. The pathologic slides were used to investigate immunohistochemical staining with ebstein-barr virüs latent membrane protein-1 and in-situ hybridization. Results: The most common histopathological subtype in hodgkin lymphoma cases was mixed cellular classical hodgkin lymphoma (55.6%). The most common histopathological subtype in Non-Hodgkin lymphoma cases was Burkitt lymphoma (51.0%). Ebstein-Barr virüs latent membrane protein-1 was positive in 29 Hodgkin lymphoma. All non-Hodgkin lymphoma cases were stained negative with ımmunohistochemical. The positive staining rate of Hodgkin lymphoma cases with in-situ hybridization was 83.3% and this rate was 27.5% in non-Hodgkin lymphoma cases. The differences between groups for both staining methods were significant. Conclusion: The results of this study show that the distribution of histopatholojik subtypes of pediatric lymphomas similar to in developing countries. And we have observed that in-situ hybridization is more specific than immunohistochemistry because Ebstein-Barr virus positivity is more detected in in-situ hybridization. Amaç: Bu çalışmanın amacı bölgemizdeki pediatrik lenfomaların histopatolojik alt tiplerinin oranını ve bunların Ebstein-Barr virüs enfeksiyonu ile olan ilişkisini incelemektir. Gereç ve Yöntem: Hodgkin lenfoma tanısı alan 36 olgu ve non-hodgkin lenfoma tanısı alan 51 olgu retrospektif arşiv taraması yapılarak çalışmaya dahil edildi. Olgulara immünohistokimyasal olarak Ebstein-Barr virüs latent membran proteini-1 ve in-situ hibridizasyon uygulandı. Bulgular: Hodgkin lenfoma olgularında; en sık rastlanan histopatolojik alt tipler sırası ile mikst sellüler klasik hodgkin lenfoma (%55,6) idi. Non-Hodgkin lenfoma olgularında en sık rastlanan histopatolojik alt tip Burkitt lenfoma (%51) idi. Ebstein-Barr virüs latent membran proteini-1 ile 29 hodgkin lenfoma olgusunda pozitif iken non-hodgkin lenfoma olgularında immünohistokimya ile pozitif boyanma saptanmadı. Hodgkin lenfoma olgularında in situ hibridizasyon ile boyanma oranı % 83.,3 iken non-Hodgkin lenfoma olgularında bu oran % 27.5 idi.. Her iki boyama yöntemi için gruplar arasındaki fark istatistiksel olarak anlamlıydı. Sonuç: Bu çalışmada, olgularımızın histopatolojik dağılımlarının gelişmekte olan ülkelerdeki pediatrik lenfoma olguları ile benzer olduğunu göstermektedir. Aynı zamanda in situ hibridizasyon'da Ebstein-Barr virüs pozitifliği daha fazla olması nedeniyle in situ hibridizasyonun ebstein barr virüs tespitinde immünohistokimyadan daha spesifik olduğunu düşünmekteyiz.
Turkish Journal of Colorectal Disease
Enflamatuvar barsak hastalığı patogenezinde, serbest oksijen radikallerinin de aralarında bulundu... more Enflamatuvar barsak hastalığı patogenezinde, serbest oksijen radikallerinin de aralarında bulunduğu çeşitli etkenler tanımlanmıştır. Bu çalışmanın amacı glutamin (Gln) ile kombine edilen antioksidan N-asetilsisteinin (NAC) deneysel kolit modeli üzerindeki etkilerini incelemektir. Yöntem: Trinitrobenzeno sülfonik asit ile deneysel kolit modeli oluşturulduktan bir gün sonra ratlar randomize edilerek intraperitoneal NAC veya oral Gln + intraperitoneal NAC uygulandı. Tedavi sonrası ratlar sakrifiye edilerek, kolon hasarı makroskobik ve mikroskobik olarak değerlendirildi. Malonil dialdehid seviyesi ve süperoksit dismutaz aktivitesi biyokimyasal olarak analiz edildi. Bulgular: NAC veya Gln + NAC verilen gruplarda makroskobik olarak kolit grubuna göre daha iyi sonuçlar elde edildi. Histopatolojik olarak tedavi verilen tüm gruplarda kolit grubuna kıyasla anlamlı olarak daha düşük skorlar elde edildi. Biyokimyasal olarakta tedavi verilen tüm gruplarda kolit grubuna kıyasla daha iyi sonuçlar elde edildi. Sonuç: Deneyden elde edilen sonuçlara göre, NAC uygulanmasının deneysel kolit modeli üzerine olumlu etkili olduğu sonucuna varıldı.
Journal of Turkish Sleep Medicine
Obstrüktif Uyku Apne sendromu (OSAS), uyku sırasında üst solunum yolunun tekrarlayıcı kısmi ya da... more Obstrüktif Uyku Apne sendromu (OSAS), uyku sırasında üst solunum yolunun tekrarlayıcı kısmi ya da tam obstrüksiyonu, horlama ve gündüz aşırı uykululuk ile karakterize olan kronik bir hastalıktır. Hipertansiyon, kardiyovasküler ve serebrovasküler hastalıklar OSAS'de en sık karşılaşılan komorbit hastalıklardır (1-4).
Turkish thoracic journal, Jan 13, 2018
We aimed to obtain information about the characteristics of the ICUs in our country via a point p... more We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study. This cross-sectional study was planned by the Respiratory Failure and Intensive Care Assembly of Turkish Thoracic Society. A questionnaire was prepared and invitations were sent from the association's communication channels to reach the whole country. Data were collected through all participating intensivists between the October 26, 2016 at 08:00 and October 27, 2016 at 08:00. Data were collected from the 67 centers. Overall, 76.1% of the ICUs were managed with a closed system. In total, 35.8% (n=24) of ICUs were levels of care (LOC) 2 and 64.2% (n=43) were LOC 3. The median total numbers of ICU beds, LOC 2, and LOC 3 beds were 12 (8-23), 14 (10-25), and 12 (8-20), respectively. The median number of ventilators was 12 (7-21) and that of ventilators with non-invasive ventilation mode was 11 (6-20). The median numbers of patients per physician during day and night were...
Transcultural Psychiatry
The aims of this study were to develop a sexual orientation attitude scale and use it to investig... more The aims of this study were to develop a sexual orientation attitude scale and use it to investigate the attitudes of psychiatrists, other physicians and first year medical students toward homosexuals and homosexuality in Ankara, Turkey. A cross-sectional study was performed with three groups including psychiatrists (n = 147), non-psychiatric physicians (n = 224) and first year medical students (n = 280). A scale with 43 items consisting of four subscales (heterosexism, homophobia, homonegativity, neutrality) was developed which showed high internal consistency, validity and reliability in this sample of Turkish individuals. The internal consistency coefficients (Cronbach's alpha) for the subscales were 0.85-0.86, 0.95-0.95, 0.95-0.95, and 0.85-0.86, respectively. Being male, single, a graduate of a religious (Imam Hatip) or vocational high school, of rural origin, a student, more religious, heterosexual and studying at university hospitals were found to be related to higher s...
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, Jan 3, 2018
Recent reports have indicated an improved prognosis in sepsis with beta blocker agents; however, ... more Recent reports have indicated an improved prognosis in sepsis with beta blocker agents; however, the underlying action mechanism is still under debate. The aim of this study was to investigate the potential effect of propranolol on endothelial dysfunction in septic rats. The cecal ligation and puncture model (CLP) was used to generate sepsis. Adult male Wistar-Albino rats were divided into 4 groups: group 1 was a sham group, group 2 received sterile saline, group 3 received 10 mg/kg of propranolol 3 days before the intervention, and group 4 received 10 mg/kg of propranolol 30 min after CLP. Six rats from each group were sacrificed 24 h postoperatively. The remaining rats were followed for survival. We have also evaluated the effects on systemic inflammation, coagulation and the lung tissue with immunohistochemical and electron microscopic evaluation. Serum tumor necrosis factor alpha (TNF-α) and plasminogen activator inhibitor-1 (PAI-1) levels, as well as tissue TNF-α scores were el...
International Dental Research
Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers... more Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers (vascular endothelial growth factor (VEGF) and microvessel density (MVD) in enamel matrix derivative (EMD) treated retromolar soft tissues to gain further insights into the biological mechanisms involved in wound healing and EMD treatment. Methodology: In twenty healthy volunteers, gingival biopsies were obtained from the distal wedge operations of test (EMD-applied) and control sites. EMD was applied into the test sites during the operation. At the 15th post-operative day, the sample sites were re-entered and gingival tissue samples were obtained from both test and control sites. A total of 80 samples for each sites were analyzed by immunohistochemistry for inflammatory infiltrate, expression of VEGF and MVD. Results: Despite similar post-operative inflammatory infiltrate, it was found that EMD- applied sites had statistically higher VEGF-A and VEGF-C expression and MVD compared to the...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)
TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor a... more Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor activity. The main adverse effects are hand-foot syndrome, diarrhea, and dermatitis. In recent years, hypertriglyceridemia has been reported in patients treated with capecitabine. Dyslipidemia is a rare but important side effect of capecitabine. The aim of this study is to examine the changes in lipid levels during capecitabine treatment and to raise awareness of pharmacovigilance.
International archives of allergy and immunology, Jan 9, 2017
Although it is known that there has been an increase in asthma and allergic diseases among school... more Although it is known that there has been an increase in asthma and allergic diseases among school-aged children, results vary between countries. The aim of this study was to examine trends in the prevalence of these diseases in the city of Adana (south Turkey) over the last 20 years based on the results of 3 cross-sectional studies. Three cross-sectional surveys were performed 10 years apart in south Turkey. Here, we compare the surveys conducted among children between the ages of 6 and 14 years from 1994, 2004, and 2014. The participants were randomly chosen among children attending participating primary schools in Adana. The questionnaire in the first survey contained almost the same questions as the ISAAC. In the 2 latter surveys, we used the ISAAC questionnaire to investigate the prevalence of asthma and other allergic diseases. A total of 2,334 children in 1994, 3,728 children in 2004, and 3,209 children in 2014 were included in the final analysis. The results showed a statisti...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2016
International Journal of Gynecological Cancer, 2016
ObjectiveThe aim of this study is to evaluate the results of radical surgery in patients with sta... more ObjectiveThe aim of this study is to evaluate the results of radical surgery in patients with stage IB2 to IIA2 cervical cancer who were operated on at our center between 2002 and 2015.Materials and MethodsForty-seven cases of patients with stage IB2/IIA2 cervical cancer who underwent primary radical surgery between 2002 and 2015 were enrolled in this study. Patients’ files and pathological reports were retrospectively reviewed. Surgical, pathological, and clinical variables were analyzed and their impact on survival period was researched. Disease-free survival and overall survival periods were determined using the Kaplan-Meier test. The P value was considered significant if less than 0.05.ResultsType C2 radical hysterectomy with lymphadenectomy (5 pelvic, 42 pelvic and para-aortic) was performed for all of the 47 patients in accordance with the Querleu-Morrow classification. Thirty-three of the cases were stage Ib2 and 14 cases were IIa2. Five years of overall survival was 80%. Rec...
Am ma aç ç: : An ti ko li ner jik ilaç lar la ze hir len me ler acil ser vis ler de sık gö rü len... more Am ma aç ç: : An ti ko li ner jik ilaç lar la ze hir len me ler acil ser vis ler de sık gö rü len ve ya şa mı teh dit eden ze hir len me ler dir. Bu ilaç -la rın kalp hı zı de ği şik lik le ri, ri tim bo zuk luk la rı ve ile ti ge cik me le ri gi bi kalp üze ri ne cid di yan et ki le ri var dır. Ça lış ma mız da -ki amaç QTc≥0,45 olan tri sik lik an ti dep re san (TSA) ve TSA dı şı an ti ko li ner jik ilaç lar la ze hir len me ler de kalp üze ri ne olan di ğer olum suz et ki le rin ben zer özel lik te olup ol ma dı ğı nın be lir len me si ve stan dart NaH CO 3 te da vi si nin tüm an ti ko li ner jik ilaç ze hir len me le rin de QRS ge niş le me si dı şın da QTc uza ma sın da da et kin li ği nin kar şı laş tı rıl ma sı dır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : İle ri ye dö nük ola rak plan la nan va ka kon trol ni te li ğin de ki ça lış ma mı za 07.06.2005-30.11.2006 ta rih le ri ara sın da Çu ku ro va Üni ver si -te si Tıp Fa kül te si acil ser vi se TSA ve TSA d...
Annals of Indian Academy of Neurology, 2015
migraine headache. [6,7] Headache and sleep share a complex relationship since sleep disturbances... more migraine headache. [6,7] Headache and sleep share a complex relationship since sleep disturbances may trigger headaches, and headaches in turn may cause sleep abnormalities in these patients. Sleep patterns were attributed to significant variations in headache over time in 46% of tension-type and 60% of migraine patients. [7] Vgontzas et al. (2008) suggested that sleep disturbances in patients with migraine are not explained solely by chance association or on the basis of co-morbid depression and anxiety. [8] Rather, a biological basis underlying a common pathway for regulation of sleep and pathogenesis of migraine may exist. Since the mechanisms underlying migraine headache are still insufficiently understood, different of medications are used for migraine prophylaxis. Available guidelines commonly recommend beta-blockers or tricyclic antidepressants (TCA) as the first choice for migraine prophylaxis. [9] The efficacy of TCAs in migraine treatment has been shown to be independent of their antidepressant action. [10,11] Both amitriptyline and propranolol appear to have rapid eye movement (REM)suppressant effects, and disruption of REM sleep has been shown to trigger migraine attacks. [12] Disturbed sleep is associated with a reduction in pain threshold, presumably reflecting central sensitization and advocating further investigation into sleep disturbance as a potential modifiable risk factor for the prevention of headaches. Identification of
Turkiye Klinikleri Journal of Medical Sciences, 2013
ABSTRACT
Journal of clinical orthodontics : JCO, 2014
Cukurova Medical Journal
This study aims to examine the relationship of the preschool childhood masturbation with the pare... more This study aims to examine the relationship of the preschool childhood masturbation with the parental attitude as well as the relation of the same with the comorbidity and related stammering, tic disorders, nail biting, nocturnal enuresis (NE) and encopresis. Materials and Methods: In this study, parents of 105 preschool children (between the ages of 3-6) were interviewed. 50 out the 105 interviewed parents' children had have been with childhood masturbation (CM) and they are receiving professional consultancy or support services and these parents constitute the case group of this study. The control group was formed with the parents of 55 children. Research data were obtained by of the Personal Information Form filled by the parents, Parental Attitude Scale (PAS) and Comorbid Problems Determination Form prepared by the researcher. Results: Authoritarion parental attitude is discovered to be statistically higher than the case group with CM compared to the control group without such disorder. It has been detected that nail biting, NE and encopresis comorbidity is significantly higher in the case group with CM compared to the control group. Conclusion: There was a direct relationship between authoritarian parental attitudes and the CM that emerged in preschool childhood. Along with CM the rate of frequency of nail biting, NE and encopresis are higher than the control group. Amaç: Bu çalışmada okul öncesi dönemde çocukluk çağı masturbasyon bozukluğunun ebeveyn tutumları ile ilişkisinin ve kekemelik, tik bozukluğu, tırnak yeme, enürezis noktürna, enkoprezis ile komorbiditesinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 105 okul öncesi çocuğun (3-6 yaş) ebeveynleri ile görüşülmüştür. Görüşülen 105 ebeveynin 50'si çocuklarına Çocukluk çağı masturbayon (ÇÇM) bozukluğu tanısı konulan ve profesyonel danışmanlık veya destek hizmeti alan kişilerdir ve bu ebeveynler çalışmanın olgu grubunu oluşturmaktadır. Kontrol grubu 55 çocuğun ebeveynleri ile oluşturulmuştur. Araştırma verileri, ebeveynlerin doldurduğu Kişisel Bilgi Formu, Ebeveyn Tutum Ölçeği ve araştırmacı tarafından hazırlanan Alışkı Sorunları Belirleme Bilgi Formu kullanılarak elde edilmiştir. Bulgular: Otoriter ebeveyn tutumu ÇÇM bozukluğu olan olgu gurubunda, bu bozukluğun olmadığı kontrol grubuna göre istatistiksel olarak yüksek bulunmuştur. ÇÇM bozukluğu olan olgu grubunda, kontrol grubuna göre anlamlı düzeyde yüksek tırnak yeme, enürezis noktürna, enkoprezis komorbiditesi saptanmıştır. Sonuç: Otoriter ebeveyn tutumu ile okul öncesi çocukluk döneminde ortaya çıkan ÇÇM arasında doğrudan bir ilişki olduğu görülmüştür. ÇÇM ile birlikte tırnak yeme, enürezis noktürna, enkoprezis görülme sıklığı kontrol grubuna göre daha yüksektir.
Biomedical Research and Clinical Practice
Context: Nowadays, virtually everybody is exposed to radiofrequency radiation (RFR) from mobile p... more Context: Nowadays, virtually everybody is exposed to radiofrequency radiation (RFR) from mobile phone base station antennas or other sources. Despite many research efforts and public debate there is still great concern about the possible adverse effects of RFR on human health. The present study was designed as an attempt to correlate the effect of non-thermal radiation. Objective: The aim of this study was to evaluate the possible effects of in vitro 900 and 1800 MHz GSM-like (radiation from cell phones) exposure on chromosomes of human fetal cells (FCs). Materials and methods: We examined the induction of non-thermal effect following 3h, 6h and 12h exposure to 900 and 1800 MHz radiofrequency radiation (RF-EMR) in FCs and in control medium, which did not exposure of RF-EMR. Results: The results indicated that a significant difference of chromosomal aberrations (CAs) between medium grown cells the exposure of FCs to RF-EMR at 900 and 1800 MHz and unexposed cells, determined by the χ2 test (P < 0.001). We found CAs in 25.9% of cells exposed to RF radiation [such as fragility, gap, singlestrand breaks (SSB) and double-strand breaks (DSB)], and non-thermal RF-EMF caused delays in chromosome condensation, and a significant rise in CAs with increasing exposure time. Conclusion: Results of this study confirm that the GSM-like RF-EMR leads to significant direct genotoxic effects on human FCs in vitro culture, and RF-EMR had negative effects on human chromosomes, moreover these effects aggravated with exposure time. We concluded that mobile phone risks to human chromosomes and human health. However, we confirm that RF-EMR affects negatively the condensation of chromosomes. Our hope is that the knowledge of mobile phones safety can not only help guide the future design of these instruments, but also affect the selection of procedures in order to ensure safe, efficacious, and efficient system operation.
Cukurova Medical Journal
Öz Purpose: The aim of this study was toexplore the histopathologic subtypes of pediatric lymphom... more Öz Purpose: The aim of this study was toexplore the histopathologic subtypes of pediatric lymphomas and their relation with Ebstein-Barr virus infection in our region. Materials and Methods: In this retrospective study, 87 children including 36 cases with Hodgkin lymphoma and 51 cases with non-Hodgkin lymphoma were included in the study. The pathologic slides were used to investigate immunohistochemical staining with ebstein-barr virüs latent membrane protein-1 and in-situ hybridization. Results: The most common histopathological subtype in hodgkin lymphoma cases was mixed cellular classical hodgkin lymphoma (55.6%). The most common histopathological subtype in Non-Hodgkin lymphoma cases was Burkitt lymphoma (51.0%). Ebstein-Barr virüs latent membrane protein-1 was positive in 29 Hodgkin lymphoma. All non-Hodgkin lymphoma cases were stained negative with ımmunohistochemical. The positive staining rate of Hodgkin lymphoma cases with in-situ hybridization was 83.3% and this rate was 27.5% in non-Hodgkin lymphoma cases. The differences between groups for both staining methods were significant. Conclusion: The results of this study show that the distribution of histopatholojik subtypes of pediatric lymphomas similar to in developing countries. And we have observed that in-situ hybridization is more specific than immunohistochemistry because Ebstein-Barr virus positivity is more detected in in-situ hybridization. Amaç: Bu çalışmanın amacı bölgemizdeki pediatrik lenfomaların histopatolojik alt tiplerinin oranını ve bunların Ebstein-Barr virüs enfeksiyonu ile olan ilişkisini incelemektir. Gereç ve Yöntem: Hodgkin lenfoma tanısı alan 36 olgu ve non-hodgkin lenfoma tanısı alan 51 olgu retrospektif arşiv taraması yapılarak çalışmaya dahil edildi. Olgulara immünohistokimyasal olarak Ebstein-Barr virüs latent membran proteini-1 ve in-situ hibridizasyon uygulandı. Bulgular: Hodgkin lenfoma olgularında; en sık rastlanan histopatolojik alt tipler sırası ile mikst sellüler klasik hodgkin lenfoma (%55,6) idi. Non-Hodgkin lenfoma olgularında en sık rastlanan histopatolojik alt tip Burkitt lenfoma (%51) idi. Ebstein-Barr virüs latent membran proteini-1 ile 29 hodgkin lenfoma olgusunda pozitif iken non-hodgkin lenfoma olgularında immünohistokimya ile pozitif boyanma saptanmadı. Hodgkin lenfoma olgularında in situ hibridizasyon ile boyanma oranı % 83.,3 iken non-Hodgkin lenfoma olgularında bu oran % 27.5 idi.. Her iki boyama yöntemi için gruplar arasındaki fark istatistiksel olarak anlamlıydı. Sonuç: Bu çalışmada, olgularımızın histopatolojik dağılımlarının gelişmekte olan ülkelerdeki pediatrik lenfoma olguları ile benzer olduğunu göstermektedir. Aynı zamanda in situ hibridizasyon'da Ebstein-Barr virüs pozitifliği daha fazla olması nedeniyle in situ hibridizasyonun ebstein barr virüs tespitinde immünohistokimyadan daha spesifik olduğunu düşünmekteyiz.
Turkish Journal of Colorectal Disease
Enflamatuvar barsak hastalığı patogenezinde, serbest oksijen radikallerinin de aralarında bulundu... more Enflamatuvar barsak hastalığı patogenezinde, serbest oksijen radikallerinin de aralarında bulunduğu çeşitli etkenler tanımlanmıştır. Bu çalışmanın amacı glutamin (Gln) ile kombine edilen antioksidan N-asetilsisteinin (NAC) deneysel kolit modeli üzerindeki etkilerini incelemektir. Yöntem: Trinitrobenzeno sülfonik asit ile deneysel kolit modeli oluşturulduktan bir gün sonra ratlar randomize edilerek intraperitoneal NAC veya oral Gln + intraperitoneal NAC uygulandı. Tedavi sonrası ratlar sakrifiye edilerek, kolon hasarı makroskobik ve mikroskobik olarak değerlendirildi. Malonil dialdehid seviyesi ve süperoksit dismutaz aktivitesi biyokimyasal olarak analiz edildi. Bulgular: NAC veya Gln + NAC verilen gruplarda makroskobik olarak kolit grubuna göre daha iyi sonuçlar elde edildi. Histopatolojik olarak tedavi verilen tüm gruplarda kolit grubuna kıyasla anlamlı olarak daha düşük skorlar elde edildi. Biyokimyasal olarakta tedavi verilen tüm gruplarda kolit grubuna kıyasla daha iyi sonuçlar elde edildi. Sonuç: Deneyden elde edilen sonuçlara göre, NAC uygulanmasının deneysel kolit modeli üzerine olumlu etkili olduğu sonucuna varıldı.
Journal of Turkish Sleep Medicine
Obstrüktif Uyku Apne sendromu (OSAS), uyku sırasında üst solunum yolunun tekrarlayıcı kısmi ya da... more Obstrüktif Uyku Apne sendromu (OSAS), uyku sırasında üst solunum yolunun tekrarlayıcı kısmi ya da tam obstrüksiyonu, horlama ve gündüz aşırı uykululuk ile karakterize olan kronik bir hastalıktır. Hipertansiyon, kardiyovasküler ve serebrovasküler hastalıklar OSAS'de en sık karşılaşılan komorbit hastalıklardır (1-4).
Turkish thoracic journal, Jan 13, 2018
We aimed to obtain information about the characteristics of the ICUs in our country via a point p... more We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study. This cross-sectional study was planned by the Respiratory Failure and Intensive Care Assembly of Turkish Thoracic Society. A questionnaire was prepared and invitations were sent from the association's communication channels to reach the whole country. Data were collected through all participating intensivists between the October 26, 2016 at 08:00 and October 27, 2016 at 08:00. Data were collected from the 67 centers. Overall, 76.1% of the ICUs were managed with a closed system. In total, 35.8% (n=24) of ICUs were levels of care (LOC) 2 and 64.2% (n=43) were LOC 3. The median total numbers of ICU beds, LOC 2, and LOC 3 beds were 12 (8-23), 14 (10-25), and 12 (8-20), respectively. The median number of ventilators was 12 (7-21) and that of ventilators with non-invasive ventilation mode was 11 (6-20). The median numbers of patients per physician during day and night were...
Transcultural Psychiatry
The aims of this study were to develop a sexual orientation attitude scale and use it to investig... more The aims of this study were to develop a sexual orientation attitude scale and use it to investigate the attitudes of psychiatrists, other physicians and first year medical students toward homosexuals and homosexuality in Ankara, Turkey. A cross-sectional study was performed with three groups including psychiatrists (n = 147), non-psychiatric physicians (n = 224) and first year medical students (n = 280). A scale with 43 items consisting of four subscales (heterosexism, homophobia, homonegativity, neutrality) was developed which showed high internal consistency, validity and reliability in this sample of Turkish individuals. The internal consistency coefficients (Cronbach's alpha) for the subscales were 0.85-0.86, 0.95-0.95, 0.95-0.95, and 0.85-0.86, respectively. Being male, single, a graduate of a religious (Imam Hatip) or vocational high school, of rural origin, a student, more religious, heterosexual and studying at university hospitals were found to be related to higher s...
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, Jan 3, 2018
Recent reports have indicated an improved prognosis in sepsis with beta blocker agents; however, ... more Recent reports have indicated an improved prognosis in sepsis with beta blocker agents; however, the underlying action mechanism is still under debate. The aim of this study was to investigate the potential effect of propranolol on endothelial dysfunction in septic rats. The cecal ligation and puncture model (CLP) was used to generate sepsis. Adult male Wistar-Albino rats were divided into 4 groups: group 1 was a sham group, group 2 received sterile saline, group 3 received 10 mg/kg of propranolol 3 days before the intervention, and group 4 received 10 mg/kg of propranolol 30 min after CLP. Six rats from each group were sacrificed 24 h postoperatively. The remaining rats were followed for survival. We have also evaluated the effects on systemic inflammation, coagulation and the lung tissue with immunohistochemical and electron microscopic evaluation. Serum tumor necrosis factor alpha (TNF-α) and plasminogen activator inhibitor-1 (PAI-1) levels, as well as tissue TNF-α scores were el...
International Dental Research
Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers... more Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers (vascular endothelial growth factor (VEGF) and microvessel density (MVD) in enamel matrix derivative (EMD) treated retromolar soft tissues to gain further insights into the biological mechanisms involved in wound healing and EMD treatment. Methodology: In twenty healthy volunteers, gingival biopsies were obtained from the distal wedge operations of test (EMD-applied) and control sites. EMD was applied into the test sites during the operation. At the 15th post-operative day, the sample sites were re-entered and gingival tissue samples were obtained from both test and control sites. A total of 80 samples for each sites were analyzed by immunohistochemistry for inflammatory infiltrate, expression of VEGF and MVD. Results: Despite similar post-operative inflammatory infiltrate, it was found that EMD- applied sites had statistically higher VEGF-A and VEGF-C expression and MVD compared to the...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)
TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor a... more Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor activity. The main adverse effects are hand-foot syndrome, diarrhea, and dermatitis. In recent years, hypertriglyceridemia has been reported in patients treated with capecitabine. Dyslipidemia is a rare but important side effect of capecitabine. The aim of this study is to examine the changes in lipid levels during capecitabine treatment and to raise awareness of pharmacovigilance.
International archives of allergy and immunology, Jan 9, 2017
Although it is known that there has been an increase in asthma and allergic diseases among school... more Although it is known that there has been an increase in asthma and allergic diseases among school-aged children, results vary between countries. The aim of this study was to examine trends in the prevalence of these diseases in the city of Adana (south Turkey) over the last 20 years based on the results of 3 cross-sectional studies. Three cross-sectional surveys were performed 10 years apart in south Turkey. Here, we compare the surveys conducted among children between the ages of 6 and 14 years from 1994, 2004, and 2014. The participants were randomly chosen among children attending participating primary schools in Adana. The questionnaire in the first survey contained almost the same questions as the ISAAC. In the 2 latter surveys, we used the ISAAC questionnaire to investigate the prevalence of asthma and other allergic diseases. A total of 2,334 children in 1994, 3,728 children in 2004, and 3,209 children in 2014 were included in the final analysis. The results showed a statisti...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2016
International Journal of Gynecological Cancer, 2016
ObjectiveThe aim of this study is to evaluate the results of radical surgery in patients with sta... more ObjectiveThe aim of this study is to evaluate the results of radical surgery in patients with stage IB2 to IIA2 cervical cancer who were operated on at our center between 2002 and 2015.Materials and MethodsForty-seven cases of patients with stage IB2/IIA2 cervical cancer who underwent primary radical surgery between 2002 and 2015 were enrolled in this study. Patients’ files and pathological reports were retrospectively reviewed. Surgical, pathological, and clinical variables were analyzed and their impact on survival period was researched. Disease-free survival and overall survival periods were determined using the Kaplan-Meier test. The P value was considered significant if less than 0.05.ResultsType C2 radical hysterectomy with lymphadenectomy (5 pelvic, 42 pelvic and para-aortic) was performed for all of the 47 patients in accordance with the Querleu-Morrow classification. Thirty-three of the cases were stage Ib2 and 14 cases were IIa2. Five years of overall survival was 80%. Rec...
Am ma aç ç: : An ti ko li ner jik ilaç lar la ze hir len me ler acil ser vis ler de sık gö rü len... more Am ma aç ç: : An ti ko li ner jik ilaç lar la ze hir len me ler acil ser vis ler de sık gö rü len ve ya şa mı teh dit eden ze hir len me ler dir. Bu ilaç -la rın kalp hı zı de ği şik lik le ri, ri tim bo zuk luk la rı ve ile ti ge cik me le ri gi bi kalp üze ri ne cid di yan et ki le ri var dır. Ça lış ma mız da -ki amaç QTc≥0,45 olan tri sik lik an ti dep re san (TSA) ve TSA dı şı an ti ko li ner jik ilaç lar la ze hir len me ler de kalp üze ri ne olan di ğer olum suz et ki le rin ben zer özel lik te olup ol ma dı ğı nın be lir len me si ve stan dart NaH CO 3 te da vi si nin tüm an ti ko li ner jik ilaç ze hir len me le rin de QRS ge niş le me si dı şın da QTc uza ma sın da da et kin li ği nin kar şı laş tı rıl ma sı dır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : İle ri ye dö nük ola rak plan la nan va ka kon trol ni te li ğin de ki ça lış ma mı za 07.06.2005-30.11.2006 ta rih le ri ara sın da Çu ku ro va Üni ver si -te si Tıp Fa kül te si acil ser vi se TSA ve TSA d...
Annals of Indian Academy of Neurology, 2015
migraine headache. [6,7] Headache and sleep share a complex relationship since sleep disturbances... more migraine headache. [6,7] Headache and sleep share a complex relationship since sleep disturbances may trigger headaches, and headaches in turn may cause sleep abnormalities in these patients. Sleep patterns were attributed to significant variations in headache over time in 46% of tension-type and 60% of migraine patients. [7] Vgontzas et al. (2008) suggested that sleep disturbances in patients with migraine are not explained solely by chance association or on the basis of co-morbid depression and anxiety. [8] Rather, a biological basis underlying a common pathway for regulation of sleep and pathogenesis of migraine may exist. Since the mechanisms underlying migraine headache are still insufficiently understood, different of medications are used for migraine prophylaxis. Available guidelines commonly recommend beta-blockers or tricyclic antidepressants (TCA) as the first choice for migraine prophylaxis. [9] The efficacy of TCAs in migraine treatment has been shown to be independent of their antidepressant action. [10,11] Both amitriptyline and propranolol appear to have rapid eye movement (REM)suppressant effects, and disruption of REM sleep has been shown to trigger migraine attacks. [12] Disturbed sleep is associated with a reduction in pain threshold, presumably reflecting central sensitization and advocating further investigation into sleep disturbance as a potential modifiable risk factor for the prevention of headaches. Identification of
Turkiye Klinikleri Journal of Medical Sciences, 2013
ABSTRACT
Journal of clinical orthodontics : JCO, 2014