Gülhadiye Avcu - Academia.edu (original) (raw)

Papers by Gülhadiye Avcu

Research paper thumbnail of A snapshot of pediatric inpatients and outpatients with COVID-19: a point prevalence study from Turkey

European Journal of Pediatrics

This multi-center point prevalence study evaluated children who were diagnosed as having coronavi... more This multi-center point prevalence study evaluated children who were diagnosed as having coronavirus disease 2019 (COVID-19). On February 2nd, 2022, inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in the study from 12 cities and 24 centers in Turkey. Of 8605 patients on February 2nd, 2022, in participating centers, 706 (8.2%) had COVID-19. The median age of the 706 patients was 92.50 months, 53.4% were female, and 76.7% were inpatients. The three most common symptoms of the patients with COVID-19 were fever (56.6%), cough (41.3%), and fatigue (27.5%). The three most common underlying chronic diseases (UCDs) were asthma (3.4%), neurologic disorders (3.3%), and obesity (2.6%). The SARS-CoV-2-related pneumoniae rate was 10.7%. The COVID-19 vaccination rate was 12.5% in all patients. Among patients aged over 12 years with access to the vaccine given by the Republic of Turkey Ministry of Health, the vaccination rate was 38.7%. Patients with UCDs presented with dyspnea and pneumoniae more frequently than those without UCDs (p < 0.001 for both). The rates of fever, diarrhea, and pneumoniae were higher in patients without COVID-19 vaccinations (p = 0.001, p = 0.012, and p = 0.027). Conclusion: To lessen the effects of the disease, all eligible children should receive the COVID-19 vaccine. The illness may specifically endanger children with UCDs. What is Known: • Children with COVID-19 mainly present with fever and cough, as in adults. • COVID-19 may specifically threaten children with underlying chronic diseases. What is New: • Children with obesity have a higher vaccination rate against COVID-19 than children without obesity. • Among unvaccinated children, fever and pneumoniae might be seen at a higher ratio than among vaccinated children.

Research paper thumbnail of A Review of a Diagnostic Tool: Galactomannan

Journal of Immunological Sciences, 2018

Invasive fungal infections, including invasive aspergillosis are associated with a high morbidity... more Invasive fungal infections, including invasive aspergillosis are associated with a high morbidity and mortality especially in immunocompromised patients. Diagnosis is often difficult due to several factors such as delay in clinical suspicion and the lack of spesific clinical findings. Galactomannan is a polysaccharide cell wall component of Aspergillus and galactomannan antigen detection has become widely used for diagnosis of invasive aspergillosis. Here, we tried to discuss the diagnostic value of the galactomannan test in the context of literature review.

Research paper thumbnail of Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines

Human Vaccines & Immunotherapeutics

Research paper thumbnail of COVID-19 Pandemisinde Enfeksiyon Kontrol Çalışmaları Çerçevesinde Çocuk Hastalarla Çalışan Sağlık Personeli Eğitimi

Journal of Pediatric Infection, 2020

Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare person... more Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n= 4457) received education on...

Research paper thumbnail of Education of Healthcare Personnel Working with Pediatric Patients During COVID-19 Pandemic within the Framework of Infection Control

Journal of Pediatric Infection, 2020

Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare person... more Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n= 4457) received education on...

Research paper thumbnail of Fever, Malaise and Arthralgia: Brucellosis or Salmonellosis in the Differential Diagnosis in an Endemic Area

Clinical and Experimental Dermatology, 2020

Bulgular: İki yıllık süreçte toplam 36 olgunun 30’u bruselloz, 6’sı salmonelloz tanısı almıştır. ... more Bulgular: İki yıllık süreçte toplam 36 olgunun 30’u bruselloz, 6’sı salmonelloz tanısı almıştır. Brusella tanısı alan 30 olgunun 20’si hayvan teması olduğunu ve 2 olgu dışında hepsi çiğ süt ve süt ürünü tüketimi olduğunu belirtmiştir. Salmonelloz tanısı alan 6 olgunun ise 2’sinin ailesi ise hayvancılıkla uğraşmakta olup, diğer olgularda enfeksiyon kaynağına dair bir gösterge bulunamamıştır. Ateş, halsizlik ve artralji en sık görülen semptomlar olup her iki hastalıkta hepatosplenomegali en sık görülen ekstraartiküler bulgudur. Bruselloz tanılı 17 olgudan 3’ünde relaps görülmüştür. İzlemde hemofagositoz gelişen ve kemoterapi ihtiyacı doğan bir olgu dışında tüm olgularda remisyon sağlanmıştır.

Research paper thumbnail of Ateş, Halsizlik ve Artralji: Endemik Bir Bölgede Ayırıcı Tanıda Bruselloz ve Salmonelloz

Clinical and Experimental Dermatology, 2020

Bruselloz ve salmonelloz ülkemizde endemik olarak görülen enfeksiyöz ve zoonotik hastalıklardır. ... more Bruselloz ve salmonelloz ülkemizde endemik olarak görülen enfeksiyöz ve zoonotik hastalıklardır. Bu çalışmada hastanemize ateş, halsizlik ve eklem ağrısı yakınması ile başvuran ve bu iki hastalık açısından tetkik edilerek biri ile tanı almış pediatrik olgular geriye dönük olarak incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Hastaların yaş, cinsiyet, çiğ süt ve süt ürünü tüketim öyküleri, klinik ve laboratuvar bulguları, organ tutuluşları, tedavi uygulamaları ve prognozları retrospektif olarak değerlendirilerek sunulmuştur. Bulgular: İki yıllık süreçte toplam 36 olgunun 30'u bruselloz, 6'sı salmonelloz tanısı almıştır. Brusella tanısı alan 30 olgunun 20'si hayvan teması olduğunu ve 2 olgu dışında hepsi çiğ süt ve süt ürünü tüketimi olduğunu belirtmiştir. Salmonelloz tanısı alan 6 olgunun ise 2'sinin ailesi ise hayvancılıkla uğraşmakta olup, diğer olgularda enfeksiyon kaynağına dair bir gösterge bulunamamıştır. Ateş, halsizlik ve artralji en sık görülen semptomlar olup her iki hastalıkta hepatosplenomegali en sık görülen ekstraartiküler bulgudur. Bruselloz tanılı 17 olgudan 3'ünde relaps görülmüştür. İzlemde hemofagositoz gelişen ve kemoterapi ihtiyacı doğan bir olgu dışında tüm olgularda remisyon sağlanmıştır. Sonuç: Her iki hastalığa yönelik eradikasyon programlarının uygulanması ve kontrol çabalarına rağmen özellikle bruselloz, endemisite göstermesi açısından ülkemizde hâlâ önemli bir sağlık sorunu olarak karşımıza çıkmaktadır.

Research paper thumbnail of Epidemiological Evaluation of Hospitalized Children With Respiratory Virus Infections

Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yat... more Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks PCR ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Hastalar ve Metod: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay / mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofaringeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için Multiplex PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94'ünde (% 83.3) en az bir solunum patojeni tespit edildi. Hastaların 29'unda (% 30.9) koenfeksiyon tespit edildi. RSV (% 28.7) en sık görülen patojendi ve RSV-Rhinovirus en sık görülen birliktelikti (% 31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p = 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu enfeksiyonu varlığı, hastalığın ciddiyeti (solunum skorlaması, oksijen hastanede kalış süresi, yoğun bakım ihtiyacı) ve laboratuvar bulguları açısından anlamlı fark saptanmadı. (p> 0.05). Sonuç: Hastaların% 83.3'ünde en az bir solunum yolu virüsü ve hastaların üçte birinde birden fazla solunum yolu virusu tespit edildi. RSV hem tek hem de çoklu virüs enfeksiyonlarında en sık rastlanan patojendi. Hastalığın şiddeti açısından tek virüs ve çoklu virüs enfeksiyonları arasında bir ilişki saptanmadı.

Research paper thumbnail of Nosocomial Non-fermentative gram negative bacteria bloodstream infections in children; Risk factors and clinical outcomes of carbapenem resistance

Journal of Infection and Chemotherapy, 2021

INTRODUCTION Non-fermentative Gram-negative bacterias (NFGNBs) are a major cause of life threaten... more INTRODUCTION Non-fermentative Gram-negative bacterias (NFGNBs) are a major cause of life threatening infections in hospitalized children. In this study, we aimed to evaluate the demographic and clinical characteristics of NFGNBs infections and identify the risk factors and outcomes of bloodstream infections (BSIs) caused by carbapenem-resistant (CR) NFGNBs infections. METHODS A retrospective cohort was designed to evaluate the patients with a BSI caused by NFGNBs between in January 2014 and December 2017. RESULTS A total of 131 episodes from 115 patients were evaluated. The mean age of the patients was 4.79±(4.74) year. The most commonly isolated NFGNBs species was Acinetobacter spp. (35.9%), Pseudomonas spp. (34.4%), and Stenotrophomonas maltophilia (13%). The rate of carbapenem-resistance was 38.2% in Acinetobacter spp. and 26.6% in Pseudomonas spp. The comparison of CR group with carbapenem-susceptible (CS) group showed statistical significance for the length of hospital stay prior to onset of infection and total hospital stay (P values were 0.001, 0.008). Based on the univariate analysis, requirement of mechanical ventilation, central venous catheter, nasogastric tube, Foley catheter, severe neutropenia (<100/mm3), prolonged neutropenia (≥14 days), prior intensive care unit admission and prior antimicrobial treatment (carbapenems, colistin, glycopeptide) were more common in carbapenem-resistant NFGNBs infections (P values are 0.001, 0.012, 0.000, 0.005, 0.042, 0.027, 0.007, 0.007). In patients with NFGNBs infections 14-day and 30-day mortality rates were %16.8 and 21.4%. CONCLUSION CR infections were more common in children with prolonged and severe neutropenia. Prior antimicrobial use and intensive care unit admission were more common in CR infections.

Research paper thumbnail of SARS-CoV-2 seropositivity among pediatric health care personnel just after the first peak of pandemic: A nationwide surveillance

International Journal of Infectious Diseases, 2021

Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to e... more Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to explore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future. Methods: We enrolled 4927 health care personnel working in pediatric units at 32 hospitals from 7 different regions of Turkey in a study to determine SARS Co-V-2 seroprevalence after the first peak of the COVID-19 pandemic. A point of care serologic lateral flow rapid test kit for immunoglobulin (Ig)M/IgG was used. Seroprevalence and its association with demographic characteristics and possible risk factors were analyzed. Results: SARS-CoV-2 seropositivity prevalence in health care personnel tested was 6.1%. Seropositivity was more common among those who did not universally wear protective masks (10.6% vs 6.1%). Having a COVID-19-positive co-worker increased the likelihood of infection. The least and the most experienced personnel were more likely to be infected. Most of the seropositive health care personnel (68.0%) did not suspect that they had previously had COVID-19. Conclusions: Health surveillance for health care personnel involving routine point-of-care nucleic acid testing and monitoring personal protective equipment adherence are suggested as important strategies to protect health care personnel from COVID-19 and reduce nosocomial SARS-CoV-2 transmission.

Research paper thumbnail of Rapid Detection of Specific Gram-negative Microorganisms Causing Bloodstream Infections in Children with the Microarray Method

The Journal of Pediatric Research, 2020

Hospital-acquired BSI caused by Gram-negative bacteria are increasing day by day and serious infe... more Hospital-acquired BSI caused by Gram-negative bacteria are increasing day by day and serious infections caused by multidrug-resistant bacteria are emerging (1). Moreover, ABS TRACT Aim: Bloodstream infections are serious conditions that can cause significant morbidity and mortality. Early recognition of the bacteria and targeted early treatment play an important role in prognosis. The Verigene Gram-negative blood culture nucleic acid test (BC-GN; Nanosphere, USA) is a new method that can accurately identify both Gram-negative bacteria and resistance genes within 2 hours. In this study, we aimed to determine the accuracy of this assay for the rapid identification of certain Gram-negative microorganisms in children with bloodstream infections and to compare with the conventional culture method.

Research paper thumbnail of 2272. Evaluation of Clinical Features, Carbapenem Resistance and Risk Factors of Klebsiella Species: A 4-Year Retrospective Study in Turkey

Open Forum Infectious Diseases, 2019

Background Gram-negative-resistant bacterial infections are increasing due to widespread use of a... more Background Gram-negative-resistant bacterial infections are increasing due to widespread use of antibiotics. Infections caused by Klebsiella spp. are an important part of healthcare-associated infections and cause morbidity and mortality. The aim of this study was to determine the epidemiological, clinical features, carbapenem resistance rates and risk factors of bloodstream infections of children with Klebsiella spp. Methods In this retropective study, medical records of 85 episodes of 75 patients caused by with Klebsiella spp. bacteriaemia who admitted to Ege University Faculty of Medicine, Pediatric Hospital in Turkey between 2014 and 2017 were evaluated. Conventional biochemical methods were performed using the automated systems of MALDİ-TOFF MS / VITEK 2 (Biomerieux, France). According to EUCAST recommendations, VITEK 2 (Biomerieux, France) automated microdilution method was used in sensitivity tests. Results The mean age of 85 episodes included in the study was 3.49 (±5.4) yea...

Research paper thumbnail of Solunum Yolu Virüs Enfeksiyonu Nedeni ile Hastaneye Yatan Çocukların Klinik ve Epidemiyolojik Olarak Değerlendirilmesi

Journal of Pediatric Infection, 2017

Objective: Respiratory virus infections are the most common cause of hospitalization particularly... more Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. The aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic characteristics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respiratory viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common coexistence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05). Özet Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks polimeraz zincir reaksiyonu (PCR) ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Gereç ve Yöntemler: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay/mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofarengeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için multipleks PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94 (%83.3)'ünde en az bir solunum patojeni tespit edildi. Hastaların 29 (%30.9)'unda koenfeksiyon tespit edildi. Respiratuar sinsityal virüs (RSV) (%28.7) en sık görülen patojendi ve RSV-rinovirüs en sık görülen birliktelikti (%31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p= 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu en

Research paper thumbnail of Clinical and Epidemiological Evaluation of Hospitalized Children with Respiratory Virus Infections

Journal of Pediatric Infection, 2017

Objective: Respiratory virus infections are the most common cause of hospitalization particularly... more Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. The aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic characteristics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respiratory viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common coexistence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05). Özet Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks polimeraz zincir reaksiyonu (PCR) ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Gereç ve Yöntemler: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay/mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofarengeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için multipleks PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94 (%83.3)'ünde en az bir solunum patojeni tespit edildi. Hastaların 29 (%30.9)'unda koenfeksiyon tespit edildi. Respiratuar sinsityal virüs (RSV) (%28.7) en sık görülen patojendi ve RSV-rinovirüs en sık görülen birliktelikti (%31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p= 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu enfeksiyonu varlığı, hastalığın ciddiyeti (solunum skorlaması, oksijen gereksinimi) hastanede kalış süresi, yoğun bakım ihtiyacı ve laboratuvar bulguları açısından anlamlı fark saptanmadı (p> 0.05).

Research paper thumbnail of Sağlıklı Obez Bir Çocukta İnsan Metapnömovirüs İlişkili Ciddi Seyirli Pnömoni

Journal of Pediatric Infection, 2017

Human metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause... more Human metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause respiratory tract infections in patients of all ages but HMPV related most severe diseases are seen in infants, the elderly population, immunocompromised people or those with chronic diseases. In this paper, we present a 6.5 year-old male patient with HMPV related acute respiratory distress syndrome (ARDS) who has no other risk factors excluding obesity for severe HMPV infection.

Research paper thumbnail of Prevalence of Bacterial Agents in Children with Acute Gastroenteritis in the Pediatric Emergency Department of Ege University School of Medicine

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection, 2016

Objective: Acute gastroenteritis is one of the main causes of morbidity and mortality in childhoo... more Objective: Acute gastroenteritis is one of the main causes of morbidity and mortality in childhood. Although rotavirus is reported to be the most common agent in diarrhea, infectious gastroenteritis due to enteric pathogenic bacteria is still widely seen in developing and underdeveloped countries. In this study, we aimed to determine the incidence of bacterial agents in children with acute gastroenteritis in Pediatric Emergency

Research paper thumbnail of An Infant Presenting with Facial Asymmetry

The Journal of Pediatric Research, 2016

Research paper thumbnail of Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia

Medical Mycology Case Reports, 2016

Invasive fungal infections are most commonly seen in immunocompromised patients and usually affec... more Invasive fungal infections are most commonly seen in immunocompromised patients and usually affect the respiratory system. Gastrointestinal system involvement of mucormycosis and invasive aspergillosis is rarely reported in childhood. Here we describe a 5 year old boy with acute lymphoblastic leukaemia who developed invasive fungal infection particularly affecting the lower gastrointestinal system to emphasise the difficulties in diagnosis and management of invasive fungal infections in immunocompromised patients.

Research paper thumbnail of Thanks to Trauma

Pediatric Emergency Care, 2015

PubMed ID: 26626903[No abstract available

Research paper thumbnail of Severe Human Metapneumovirus Pneumonia in a Healthy Obese Child

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection, 2016

Human Metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause... more Human Metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause respiratory tract infections in patients of all ages but HMPV releated most severe diseases are seen in infants, the elderly population, immunocompromised people or those with chronic diseases. In this paper, we present a 6.5 year-old male patient with HMPV related acute respiratory distress syndrome (ARDS) who has no other risk factors excluding obesity for severe HMPV infection.

Research paper thumbnail of A snapshot of pediatric inpatients and outpatients with COVID-19: a point prevalence study from Turkey

European Journal of Pediatrics

This multi-center point prevalence study evaluated children who were diagnosed as having coronavi... more This multi-center point prevalence study evaluated children who were diagnosed as having coronavirus disease 2019 (COVID-19). On February 2nd, 2022, inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in the study from 12 cities and 24 centers in Turkey. Of 8605 patients on February 2nd, 2022, in participating centers, 706 (8.2%) had COVID-19. The median age of the 706 patients was 92.50 months, 53.4% were female, and 76.7% were inpatients. The three most common symptoms of the patients with COVID-19 were fever (56.6%), cough (41.3%), and fatigue (27.5%). The three most common underlying chronic diseases (UCDs) were asthma (3.4%), neurologic disorders (3.3%), and obesity (2.6%). The SARS-CoV-2-related pneumoniae rate was 10.7%. The COVID-19 vaccination rate was 12.5% in all patients. Among patients aged over 12 years with access to the vaccine given by the Republic of Turkey Ministry of Health, the vaccination rate was 38.7%. Patients with UCDs presented with dyspnea and pneumoniae more frequently than those without UCDs (p < 0.001 for both). The rates of fever, diarrhea, and pneumoniae were higher in patients without COVID-19 vaccinations (p = 0.001, p = 0.012, and p = 0.027). Conclusion: To lessen the effects of the disease, all eligible children should receive the COVID-19 vaccine. The illness may specifically endanger children with UCDs. What is Known: • Children with COVID-19 mainly present with fever and cough, as in adults. • COVID-19 may specifically threaten children with underlying chronic diseases. What is New: • Children with obesity have a higher vaccination rate against COVID-19 than children without obesity. • Among unvaccinated children, fever and pneumoniae might be seen at a higher ratio than among vaccinated children.

Research paper thumbnail of A Review of a Diagnostic Tool: Galactomannan

Journal of Immunological Sciences, 2018

Invasive fungal infections, including invasive aspergillosis are associated with a high morbidity... more Invasive fungal infections, including invasive aspergillosis are associated with a high morbidity and mortality especially in immunocompromised patients. Diagnosis is often difficult due to several factors such as delay in clinical suspicion and the lack of spesific clinical findings. Galactomannan is a polysaccharide cell wall component of Aspergillus and galactomannan antigen detection has become widely used for diagnosis of invasive aspergillosis. Here, we tried to discuss the diagnostic value of the galactomannan test in the context of literature review.

Research paper thumbnail of Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines

Human Vaccines & Immunotherapeutics

Research paper thumbnail of COVID-19 Pandemisinde Enfeksiyon Kontrol Çalışmaları Çerçevesinde Çocuk Hastalarla Çalışan Sağlık Personeli Eğitimi

Journal of Pediatric Infection, 2020

Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare person... more Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n= 4457) received education on...

Research paper thumbnail of Education of Healthcare Personnel Working with Pediatric Patients During COVID-19 Pandemic within the Framework of Infection Control

Journal of Pediatric Infection, 2020

Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare person... more Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n= 4457) received education on...

Research paper thumbnail of Fever, Malaise and Arthralgia: Brucellosis or Salmonellosis in the Differential Diagnosis in an Endemic Area

Clinical and Experimental Dermatology, 2020

Bulgular: İki yıllık süreçte toplam 36 olgunun 30’u bruselloz, 6’sı salmonelloz tanısı almıştır. ... more Bulgular: İki yıllık süreçte toplam 36 olgunun 30’u bruselloz, 6’sı salmonelloz tanısı almıştır. Brusella tanısı alan 30 olgunun 20’si hayvan teması olduğunu ve 2 olgu dışında hepsi çiğ süt ve süt ürünü tüketimi olduğunu belirtmiştir. Salmonelloz tanısı alan 6 olgunun ise 2’sinin ailesi ise hayvancılıkla uğraşmakta olup, diğer olgularda enfeksiyon kaynağına dair bir gösterge bulunamamıştır. Ateş, halsizlik ve artralji en sık görülen semptomlar olup her iki hastalıkta hepatosplenomegali en sık görülen ekstraartiküler bulgudur. Bruselloz tanılı 17 olgudan 3’ünde relaps görülmüştür. İzlemde hemofagositoz gelişen ve kemoterapi ihtiyacı doğan bir olgu dışında tüm olgularda remisyon sağlanmıştır.

Research paper thumbnail of Ateş, Halsizlik ve Artralji: Endemik Bir Bölgede Ayırıcı Tanıda Bruselloz ve Salmonelloz

Clinical and Experimental Dermatology, 2020

Bruselloz ve salmonelloz ülkemizde endemik olarak görülen enfeksiyöz ve zoonotik hastalıklardır. ... more Bruselloz ve salmonelloz ülkemizde endemik olarak görülen enfeksiyöz ve zoonotik hastalıklardır. Bu çalışmada hastanemize ateş, halsizlik ve eklem ağrısı yakınması ile başvuran ve bu iki hastalık açısından tetkik edilerek biri ile tanı almış pediatrik olgular geriye dönük olarak incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Hastaların yaş, cinsiyet, çiğ süt ve süt ürünü tüketim öyküleri, klinik ve laboratuvar bulguları, organ tutuluşları, tedavi uygulamaları ve prognozları retrospektif olarak değerlendirilerek sunulmuştur. Bulgular: İki yıllık süreçte toplam 36 olgunun 30'u bruselloz, 6'sı salmonelloz tanısı almıştır. Brusella tanısı alan 30 olgunun 20'si hayvan teması olduğunu ve 2 olgu dışında hepsi çiğ süt ve süt ürünü tüketimi olduğunu belirtmiştir. Salmonelloz tanısı alan 6 olgunun ise 2'sinin ailesi ise hayvancılıkla uğraşmakta olup, diğer olgularda enfeksiyon kaynağına dair bir gösterge bulunamamıştır. Ateş, halsizlik ve artralji en sık görülen semptomlar olup her iki hastalıkta hepatosplenomegali en sık görülen ekstraartiküler bulgudur. Bruselloz tanılı 17 olgudan 3'ünde relaps görülmüştür. İzlemde hemofagositoz gelişen ve kemoterapi ihtiyacı doğan bir olgu dışında tüm olgularda remisyon sağlanmıştır. Sonuç: Her iki hastalığa yönelik eradikasyon programlarının uygulanması ve kontrol çabalarına rağmen özellikle bruselloz, endemisite göstermesi açısından ülkemizde hâlâ önemli bir sağlık sorunu olarak karşımıza çıkmaktadır.

Research paper thumbnail of Epidemiological Evaluation of Hospitalized Children With Respiratory Virus Infections

Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yat... more Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks PCR ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Hastalar ve Metod: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay / mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofaringeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için Multiplex PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94'ünde (% 83.3) en az bir solunum patojeni tespit edildi. Hastaların 29'unda (% 30.9) koenfeksiyon tespit edildi. RSV (% 28.7) en sık görülen patojendi ve RSV-Rhinovirus en sık görülen birliktelikti (% 31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p = 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu enfeksiyonu varlığı, hastalığın ciddiyeti (solunum skorlaması, oksijen hastanede kalış süresi, yoğun bakım ihtiyacı) ve laboratuvar bulguları açısından anlamlı fark saptanmadı. (p> 0.05). Sonuç: Hastaların% 83.3'ünde en az bir solunum yolu virüsü ve hastaların üçte birinde birden fazla solunum yolu virusu tespit edildi. RSV hem tek hem de çoklu virüs enfeksiyonlarında en sık rastlanan patojendi. Hastalığın şiddeti açısından tek virüs ve çoklu virüs enfeksiyonları arasında bir ilişki saptanmadı.

Research paper thumbnail of Nosocomial Non-fermentative gram negative bacteria bloodstream infections in children; Risk factors and clinical outcomes of carbapenem resistance

Journal of Infection and Chemotherapy, 2021

INTRODUCTION Non-fermentative Gram-negative bacterias (NFGNBs) are a major cause of life threaten... more INTRODUCTION Non-fermentative Gram-negative bacterias (NFGNBs) are a major cause of life threatening infections in hospitalized children. In this study, we aimed to evaluate the demographic and clinical characteristics of NFGNBs infections and identify the risk factors and outcomes of bloodstream infections (BSIs) caused by carbapenem-resistant (CR) NFGNBs infections. METHODS A retrospective cohort was designed to evaluate the patients with a BSI caused by NFGNBs between in January 2014 and December 2017. RESULTS A total of 131 episodes from 115 patients were evaluated. The mean age of the patients was 4.79±(4.74) year. The most commonly isolated NFGNBs species was Acinetobacter spp. (35.9%), Pseudomonas spp. (34.4%), and Stenotrophomonas maltophilia (13%). The rate of carbapenem-resistance was 38.2% in Acinetobacter spp. and 26.6% in Pseudomonas spp. The comparison of CR group with carbapenem-susceptible (CS) group showed statistical significance for the length of hospital stay prior to onset of infection and total hospital stay (P values were 0.001, 0.008). Based on the univariate analysis, requirement of mechanical ventilation, central venous catheter, nasogastric tube, Foley catheter, severe neutropenia (<100/mm3), prolonged neutropenia (≥14 days), prior intensive care unit admission and prior antimicrobial treatment (carbapenems, colistin, glycopeptide) were more common in carbapenem-resistant NFGNBs infections (P values are 0.001, 0.012, 0.000, 0.005, 0.042, 0.027, 0.007, 0.007). In patients with NFGNBs infections 14-day and 30-day mortality rates were %16.8 and 21.4%. CONCLUSION CR infections were more common in children with prolonged and severe neutropenia. Prior antimicrobial use and intensive care unit admission were more common in CR infections.

Research paper thumbnail of SARS-CoV-2 seropositivity among pediatric health care personnel just after the first peak of pandemic: A nationwide surveillance

International Journal of Infectious Diseases, 2021

Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to e... more Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to explore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future. Methods: We enrolled 4927 health care personnel working in pediatric units at 32 hospitals from 7 different regions of Turkey in a study to determine SARS Co-V-2 seroprevalence after the first peak of the COVID-19 pandemic. A point of care serologic lateral flow rapid test kit for immunoglobulin (Ig)M/IgG was used. Seroprevalence and its association with demographic characteristics and possible risk factors were analyzed. Results: SARS-CoV-2 seropositivity prevalence in health care personnel tested was 6.1%. Seropositivity was more common among those who did not universally wear protective masks (10.6% vs 6.1%). Having a COVID-19-positive co-worker increased the likelihood of infection. The least and the most experienced personnel were more likely to be infected. Most of the seropositive health care personnel (68.0%) did not suspect that they had previously had COVID-19. Conclusions: Health surveillance for health care personnel involving routine point-of-care nucleic acid testing and monitoring personal protective equipment adherence are suggested as important strategies to protect health care personnel from COVID-19 and reduce nosocomial SARS-CoV-2 transmission.

Research paper thumbnail of Rapid Detection of Specific Gram-negative Microorganisms Causing Bloodstream Infections in Children with the Microarray Method

The Journal of Pediatric Research, 2020

Hospital-acquired BSI caused by Gram-negative bacteria are increasing day by day and serious infe... more Hospital-acquired BSI caused by Gram-negative bacteria are increasing day by day and serious infections caused by multidrug-resistant bacteria are emerging (1). Moreover, ABS TRACT Aim: Bloodstream infections are serious conditions that can cause significant morbidity and mortality. Early recognition of the bacteria and targeted early treatment play an important role in prognosis. The Verigene Gram-negative blood culture nucleic acid test (BC-GN; Nanosphere, USA) is a new method that can accurately identify both Gram-negative bacteria and resistance genes within 2 hours. In this study, we aimed to determine the accuracy of this assay for the rapid identification of certain Gram-negative microorganisms in children with bloodstream infections and to compare with the conventional culture method.

Research paper thumbnail of 2272. Evaluation of Clinical Features, Carbapenem Resistance and Risk Factors of Klebsiella Species: A 4-Year Retrospective Study in Turkey

Open Forum Infectious Diseases, 2019

Background Gram-negative-resistant bacterial infections are increasing due to widespread use of a... more Background Gram-negative-resistant bacterial infections are increasing due to widespread use of antibiotics. Infections caused by Klebsiella spp. are an important part of healthcare-associated infections and cause morbidity and mortality. The aim of this study was to determine the epidemiological, clinical features, carbapenem resistance rates and risk factors of bloodstream infections of children with Klebsiella spp. Methods In this retropective study, medical records of 85 episodes of 75 patients caused by with Klebsiella spp. bacteriaemia who admitted to Ege University Faculty of Medicine, Pediatric Hospital in Turkey between 2014 and 2017 were evaluated. Conventional biochemical methods were performed using the automated systems of MALDİ-TOFF MS / VITEK 2 (Biomerieux, France). According to EUCAST recommendations, VITEK 2 (Biomerieux, France) automated microdilution method was used in sensitivity tests. Results The mean age of 85 episodes included in the study was 3.49 (±5.4) yea...

Research paper thumbnail of Solunum Yolu Virüs Enfeksiyonu Nedeni ile Hastaneye Yatan Çocukların Klinik ve Epidemiyolojik Olarak Değerlendirilmesi

Journal of Pediatric Infection, 2017

Objective: Respiratory virus infections are the most common cause of hospitalization particularly... more Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. The aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic characteristics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respiratory viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common coexistence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05). Özet Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks polimeraz zincir reaksiyonu (PCR) ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Gereç ve Yöntemler: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay/mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofarengeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için multipleks PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94 (%83.3)'ünde en az bir solunum patojeni tespit edildi. Hastaların 29 (%30.9)'unda koenfeksiyon tespit edildi. Respiratuar sinsityal virüs (RSV) (%28.7) en sık görülen patojendi ve RSV-rinovirüs en sık görülen birliktelikti (%31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p= 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu en

Research paper thumbnail of Clinical and Epidemiological Evaluation of Hospitalized Children with Respiratory Virus Infections

Journal of Pediatric Infection, 2017

Objective: Respiratory virus infections are the most common cause of hospitalization particularly... more Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. The aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic characteristics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respiratory viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common coexistence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05). Özet Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multipleks polimeraz zincir reaksiyonu (PCR) ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin tanımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgularını karşılaştırmaktır. Gereç ve Yöntemler: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların demografik özellikleri, başvurdukları ay/mevsim, klinik ve laboratuvar bulguları, yatış süresi, nazofarengeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için multipleks PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94 (%83.3)'ünde en az bir solunum patojeni tespit edildi. Hastaların 29 (%30.9)'unda koenfeksiyon tespit edildi. Respiratuar sinsityal virüs (RSV) (%28.7) en sık görülen patojendi ve RSV-rinovirüs en sık görülen birliktelikti (%31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p= 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu enfeksiyonu varlığı, hastalığın ciddiyeti (solunum skorlaması, oksijen gereksinimi) hastanede kalış süresi, yoğun bakım ihtiyacı ve laboratuvar bulguları açısından anlamlı fark saptanmadı (p> 0.05).

Research paper thumbnail of Sağlıklı Obez Bir Çocukta İnsan Metapnömovirüs İlişkili Ciddi Seyirli Pnömoni

Journal of Pediatric Infection, 2017

Human metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause... more Human metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause respiratory tract infections in patients of all ages but HMPV related most severe diseases are seen in infants, the elderly population, immunocompromised people or those with chronic diseases. In this paper, we present a 6.5 year-old male patient with HMPV related acute respiratory distress syndrome (ARDS) who has no other risk factors excluding obesity for severe HMPV infection.

Research paper thumbnail of Prevalence of Bacterial Agents in Children with Acute Gastroenteritis in the Pediatric Emergency Department of Ege University School of Medicine

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection, 2016

Objective: Acute gastroenteritis is one of the main causes of morbidity and mortality in childhoo... more Objective: Acute gastroenteritis is one of the main causes of morbidity and mortality in childhood. Although rotavirus is reported to be the most common agent in diarrhea, infectious gastroenteritis due to enteric pathogenic bacteria is still widely seen in developing and underdeveloped countries. In this study, we aimed to determine the incidence of bacterial agents in children with acute gastroenteritis in Pediatric Emergency

Research paper thumbnail of An Infant Presenting with Facial Asymmetry

The Journal of Pediatric Research, 2016

Research paper thumbnail of Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia

Medical Mycology Case Reports, 2016

Invasive fungal infections are most commonly seen in immunocompromised patients and usually affec... more Invasive fungal infections are most commonly seen in immunocompromised patients and usually affect the respiratory system. Gastrointestinal system involvement of mucormycosis and invasive aspergillosis is rarely reported in childhood. Here we describe a 5 year old boy with acute lymphoblastic leukaemia who developed invasive fungal infection particularly affecting the lower gastrointestinal system to emphasise the difficulties in diagnosis and management of invasive fungal infections in immunocompromised patients.

Research paper thumbnail of Thanks to Trauma

Pediatric Emergency Care, 2015

PubMed ID: 26626903[No abstract available

Research paper thumbnail of Severe Human Metapneumovirus Pneumonia in a Healthy Obese Child

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection, 2016

Human Metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause... more Human Metapneumovirus (HMPV) is a newly described virus of Paramyxoviridae family. HMPV can cause respiratory tract infections in patients of all ages but HMPV releated most severe diseases are seen in infants, the elderly population, immunocompromised people or those with chronic diseases. In this paper, we present a 6.5 year-old male patient with HMPV related acute respiratory distress syndrome (ARDS) who has no other risk factors excluding obesity for severe HMPV infection.