Günter Burg - Academia.edu (original) (raw)
Papers by Günter Burg
Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a rol... more Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a role for the innate immune system in driving the autoimmune T cell cascade has been proposed, its nature remains elusive. We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)- � -producing cells, infiltrate the skin of psoriatic patients and become activated to produce
entinpsoriaticskin.WeidentifiedhighnumbersofPDCs in psoriatic skin lesions (up to 16% of the tota... more entinpsoriaticskin.WeidentifiedhighnumbersofPDCs in psoriatic skin lesions (up to 16% of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123. By contrast, PDCs were present at very low lev- els in atopic dermatitis and not detected in normal hu- man skin. Conclusions: This study shows that psoriasis can be driven by the innate immune system through TLR liga- tion.Furthermore,ourfindingthatlargenumbersofPDCs
Human Pathology, 1990
Intravascular lymphomatosis (IL) is a rare and potentially fatal multifocal intravascular prolife... more Intravascular lymphomatosis (IL) is a rare and potentially fatal multifocal intravascular proliferative disorder, most often involving the skin and the central nervous system. Originally considered an endothelial disorder, IL has recently been reclassified as an angiotropic lymphoma, most often of B-cell origin. We report immunocytochemical and ultrastructural findings in two patients with IL, both representing angiotropic T-cell lymphomas. In one patient, lesional tissue was examined by Southern blot analysis and monoclonal T-cell receptor rearrangement was found. As an additional feature in one patient, a myelosuppressive serum factor was demonstrated in peripheral blood progenitor cell cultures as the cause of underlying chronic anemia and leukopenia; this factor is thought to be a cytokine product of the lymphoma cells.
Archives of Dermatological Research, 1999
Background: Monitoring of psoralen concentration and time-course in PUVA patients is vital for ef... more Background: Monitoring of psoralen concentration and time-course in PUVA patients is vital for efficient PUVA therapy. Blood sampling is invasive and labour-intensive and thus unsuited for routine use and repeat measurements over the course of therapy. Objective: Psoralen pharmacokinetics in saliva were investigated and validated as a noninvasive, simple and biologically relevant alternative to measurements in blood. Methods: The
New England Journal of Medicine, 1991
... 1. Claudio Tripodo, Emilio Iannitto, Ada Maria Florena, Carlo Ennio Pucillo, Pier Paolo Picca... more ... 1. Claudio Tripodo, Emilio Iannitto, Ada Maria Florena, Carlo Ennio Pucillo, Pier Paolo Piccaluga, Vito Franco, Stefano Aldo Pileri ... Christine Bodemer, Jean Louis Stephan, François Sigaux, Françoise Le Deist, Simon Schraub, Elisabeth Ranfraing, Claude Griscelli, Nicole Brousse ...
Encyclopedia of Molecular Mechanisms of Disease, 2009
Encyclopedia of Molecular Mechanisms of Disease, 2009
Encyclopedia of Molecular Mechanisms of Disease, 2009
Background: Granulomatous cutaneous T-cell lympho- mas (CTCLs) are rare and represent a diagnosti... more Background: Granulomatous cutaneous T-cell lympho- mas (CTCLs) are rare and represent a diagnostic chal- lenge. Only limited data on the clinicopathological and prognostic features of granulomatous CTCLs are avail- able. We studied 19 patients with granulomatous CTCLs to further characterize the clinicopathological, therapeu- tic, and prognostic features. Observations: The group included 15 patients with granulomatous mycosis fungoides (GMF) and 4
Recent Results in Cancer Research, 2002
Mycosis fungoides is a clinicopathologic term which describes a neoplasm of cerebriform T lymphoc... more Mycosis fungoides is a clinicopathologic term which describes a neoplasm of cerebriform T lymphocytes that form plaques and tumors. We further suggest that mycosis fungoides arises in a background of chronic inflammation or as a response to chronic antigenic stimulation. Subsequently, a series of mutations results in the stepwise progression from eczematous patches, to plaques, tumors and eventual hematogenous dissemination. The pathogenetic process is driven by various, probably individually different, exogenous factors, e.g. environmental foreign antigens, bacterial superantigen, and/or endogenous factors, e.g. autocrine cytokine loops, CD40/CD40L and B7/CD28 interaction.
Results: Models of the TBI were developed to test the rela- tive contributions of patches, plaque... more Results: Models of the TBI were developed to test the rela- tive contributions of patches, plaques, and tumors to the total tumor burden and, hence, survival time. Weighting factors reflecting the severity of each skin lesion were tested and incorporated. The best prognostic correlation was a di- chotomized index with the following formula: TB I=1+ (patches 3 2) + (plaques
Dermatology, 2003
Background: Multiple eruptive dermatofibroma (MEDF) is a rare disorder seen in immunocompromised ... more Background: Multiple eruptive dermatofibroma (MEDF) is a rare disorder seen in immunocompromised patients, simulating Kaposi’s sarcoma (KS). Whereas KS is strongly associated with human herpesvirus 8 (HHV-8), the virus has never been detected in MEDF until now. Objective: To present a patient with MEDF who showed no signs of immunodeficiency but was seropositive for HHV-8 antibodies and demonstrated HHV-8 DNA
Onkologie, 2003
SummaryCutaneous lymphomas include various types of clonal lymphoproliferative disorders. The ade... more SummaryCutaneous lymphomas include various types of clonal lymphoproliferative disorders. The adequate treatment approach depends on the exact diagnosis and should be non-aggressive in most cases. In early stages, local approaches such as UV or radiotherapy are preferred. In advanced stages, systemic drugs such as interferon-α or bexarotene can be administered. Experimental approaches for cutaneous lymphomas include vaccination and gene therapy.
Dermatology, 1999
Mycosis fungoides is a cutaneous T-cell lymphoma (CTCL) usually observed in mid to late adulthood... more Mycosis fungoides is a cutaneous T-cell lymphoma (CTCL) usually observed in mid to late adulthood. It occurs only rarely during childhood. Follicular mucinosis is a chronic dermatosis involving the sebaceous glands and outer root sheaths. It is normally differentiated into a juvenile benign form and an adult form possibly associated with mycosis fungoides. We report a 12-year-old boy who presented
Primary cutaneous lymphomas are currently classified by the European Organization for Research an... more Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. In particular, differences in the classification of cutaneous T-cell lymphomas other than mycosis fungoides, Sé zary syndrome, and the group of primary cutaneous CD30 ؉ lymphoproliferative disorders and the classification and terminol-ogy of different types of cutaneous B-cell lymphomas have resulted in considerable debate and confusion. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. In this paper we describe the characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin, and discuss differences with the previous classification schemes. In addition, the relative frequency and survival data of 1905 patients with primary cutaneous lymphomas derived from Dutch and Austrian registries for primary cutaneous lymphomas are presented to illustrate the clinical significance of this new classification. (Blood. 2005;105:3768-3785)
Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a rol... more Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a role for the innate immune system in driving the autoimmune T cell cascade has been proposed, its nature remains elusive. We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)- � -producing cells, infiltrate the skin of psoriatic patients and become activated to produce
entinpsoriaticskin.WeidentifiedhighnumbersofPDCs in psoriatic skin lesions (up to 16% of the tota... more entinpsoriaticskin.WeidentifiedhighnumbersofPDCs in psoriatic skin lesions (up to 16% of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123. By contrast, PDCs were present at very low lev- els in atopic dermatitis and not detected in normal hu- man skin. Conclusions: This study shows that psoriasis can be driven by the innate immune system through TLR liga- tion.Furthermore,ourfindingthatlargenumbersofPDCs
Human Pathology, 1990
Intravascular lymphomatosis (IL) is a rare and potentially fatal multifocal intravascular prolife... more Intravascular lymphomatosis (IL) is a rare and potentially fatal multifocal intravascular proliferative disorder, most often involving the skin and the central nervous system. Originally considered an endothelial disorder, IL has recently been reclassified as an angiotropic lymphoma, most often of B-cell origin. We report immunocytochemical and ultrastructural findings in two patients with IL, both representing angiotropic T-cell lymphomas. In one patient, lesional tissue was examined by Southern blot analysis and monoclonal T-cell receptor rearrangement was found. As an additional feature in one patient, a myelosuppressive serum factor was demonstrated in peripheral blood progenitor cell cultures as the cause of underlying chronic anemia and leukopenia; this factor is thought to be a cytokine product of the lymphoma cells.
Archives of Dermatological Research, 1999
Background: Monitoring of psoralen concentration and time-course in PUVA patients is vital for ef... more Background: Monitoring of psoralen concentration and time-course in PUVA patients is vital for efficient PUVA therapy. Blood sampling is invasive and labour-intensive and thus unsuited for routine use and repeat measurements over the course of therapy. Objective: Psoralen pharmacokinetics in saliva were investigated and validated as a noninvasive, simple and biologically relevant alternative to measurements in blood. Methods: The
New England Journal of Medicine, 1991
... 1. Claudio Tripodo, Emilio Iannitto, Ada Maria Florena, Carlo Ennio Pucillo, Pier Paolo Picca... more ... 1. Claudio Tripodo, Emilio Iannitto, Ada Maria Florena, Carlo Ennio Pucillo, Pier Paolo Piccaluga, Vito Franco, Stefano Aldo Pileri ... Christine Bodemer, Jean Louis Stephan, François Sigaux, Françoise Le Deist, Simon Schraub, Elisabeth Ranfraing, Claude Griscelli, Nicole Brousse ...
Encyclopedia of Molecular Mechanisms of Disease, 2009
Encyclopedia of Molecular Mechanisms of Disease, 2009
Encyclopedia of Molecular Mechanisms of Disease, 2009
Background: Granulomatous cutaneous T-cell lympho- mas (CTCLs) are rare and represent a diagnosti... more Background: Granulomatous cutaneous T-cell lympho- mas (CTCLs) are rare and represent a diagnostic chal- lenge. Only limited data on the clinicopathological and prognostic features of granulomatous CTCLs are avail- able. We studied 19 patients with granulomatous CTCLs to further characterize the clinicopathological, therapeu- tic, and prognostic features. Observations: The group included 15 patients with granulomatous mycosis fungoides (GMF) and 4
Recent Results in Cancer Research, 2002
Mycosis fungoides is a clinicopathologic term which describes a neoplasm of cerebriform T lymphoc... more Mycosis fungoides is a clinicopathologic term which describes a neoplasm of cerebriform T lymphocytes that form plaques and tumors. We further suggest that mycosis fungoides arises in a background of chronic inflammation or as a response to chronic antigenic stimulation. Subsequently, a series of mutations results in the stepwise progression from eczematous patches, to plaques, tumors and eventual hematogenous dissemination. The pathogenetic process is driven by various, probably individually different, exogenous factors, e.g. environmental foreign antigens, bacterial superantigen, and/or endogenous factors, e.g. autocrine cytokine loops, CD40/CD40L and B7/CD28 interaction.
Results: Models of the TBI were developed to test the rela- tive contributions of patches, plaque... more Results: Models of the TBI were developed to test the rela- tive contributions of patches, plaques, and tumors to the total tumor burden and, hence, survival time. Weighting factors reflecting the severity of each skin lesion were tested and incorporated. The best prognostic correlation was a di- chotomized index with the following formula: TB I=1+ (patches 3 2) + (plaques
Dermatology, 2003
Background: Multiple eruptive dermatofibroma (MEDF) is a rare disorder seen in immunocompromised ... more Background: Multiple eruptive dermatofibroma (MEDF) is a rare disorder seen in immunocompromised patients, simulating Kaposi’s sarcoma (KS). Whereas KS is strongly associated with human herpesvirus 8 (HHV-8), the virus has never been detected in MEDF until now. Objective: To present a patient with MEDF who showed no signs of immunodeficiency but was seropositive for HHV-8 antibodies and demonstrated HHV-8 DNA
Onkologie, 2003
SummaryCutaneous lymphomas include various types of clonal lymphoproliferative disorders. The ade... more SummaryCutaneous lymphomas include various types of clonal lymphoproliferative disorders. The adequate treatment approach depends on the exact diagnosis and should be non-aggressive in most cases. In early stages, local approaches such as UV or radiotherapy are preferred. In advanced stages, systemic drugs such as interferon-α or bexarotene can be administered. Experimental approaches for cutaneous lymphomas include vaccination and gene therapy.
Dermatology, 1999
Mycosis fungoides is a cutaneous T-cell lymphoma (CTCL) usually observed in mid to late adulthood... more Mycosis fungoides is a cutaneous T-cell lymphoma (CTCL) usually observed in mid to late adulthood. It occurs only rarely during childhood. Follicular mucinosis is a chronic dermatosis involving the sebaceous glands and outer root sheaths. It is normally differentiated into a juvenile benign form and an adult form possibly associated with mycosis fungoides. We report a 12-year-old boy who presented
Primary cutaneous lymphomas are currently classified by the European Organization for Research an... more Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. In particular, differences in the classification of cutaneous T-cell lymphomas other than mycosis fungoides, Sé zary syndrome, and the group of primary cutaneous CD30 ؉ lymphoproliferative disorders and the classification and terminol-ogy of different types of cutaneous B-cell lymphomas have resulted in considerable debate and confusion. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. In this paper we describe the characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin, and discuss differences with the previous classification schemes. In addition, the relative frequency and survival data of 1905 patients with primary cutaneous lymphomas derived from Dutch and Austrian registries for primary cutaneous lymphomas are presented to illustrate the clinical significance of this new classification. (Blood. 2005;105:3768-3785)