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Papers by GABRIELA FRANCISCA

Research paper thumbnail of SPACING BEHAVIOR OF MARINE OTTERS (LONTRA FELINA) IN RELATION TO LAND REFUGES AND FISHERY WASTE IN CENTRAL CHILE

Journal of Mammalogy, 2007

The marine otter (Lontra felina) is a little-known South American otter of conservation concern. ... more The marine otter (Lontra felina) is a little-known South American otter of conservation concern. We report the 1st detailed information on its activity patterns, home ranges, core areas, and territoriality from 6 otters radiotracked near a fishing village in central Chile. ...

Research paper thumbnail of A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

Annals of The Rheumatic Diseases, 2011

Research paper thumbnail of The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

Human Molecular Genetics, 2009

The aim of this study was to investigate the possible role of STAT4 gene in the genetic predispos... more The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent cohorts of European ancestry (The Netherlands, Germany, Sweden, Italy and USA), were included in the study. The rs7574865 polymorphism was selected as STAT4 genetic marker. We observed that the rs7574865 T allele was significantly associated with susceptibility to lcSSc in the Spanish population [P = 1.9 x 10(-5) odds ratio (OR) 1.61 95% confidence intervals (CI) 1.29-1.99], but not with dcSSc (P = 0.41 OR 0.84 95% CI 0.59-1.21). Additionally, a dosage effect was observed showing individuals with rs7574865 TT genotype higher risk for lcSSc (OR 3.34, P = 1.02 x 10(-7) 95% CI 2.11-5.31). The association of the rs7574865 T allele with lcSSc was confirmed in all the replication cohorts with different effect sizes (OR ranging between 1.15 and 1.86), as well as the lack of association of STAT4 with dcSSc. A meta-analysis to test the overall effect of the rs7574865 polymorphism showed a strong risk effect of the T allele for lcSSc susceptibility (pooled OR 1.54 95% CI 1.36-1.74; P < 0.0001). Our data show a strong and reproducible association of the STAT4 gene with the genetic predisposition to lcSSc suggesting that this gene seems to be one of the genetic markers influencing SSc phenotype.

Research paper thumbnail of Cholesterol and membrane phospholipid compositions modulate the leakage capacity of the swaposin domain from a potato aspartic protease ( StAsp-PSI

Biochimica Et Biophysica Acta-molecular and Cell Biology of Lipids, 2011

Research paper thumbnail of Utilidad clínica del tratamiento antibiótico de la guía de la Sociedad Chilena de Enfermedades Respiratorias para la neumonía comunitaria en adultos hospitalizados

Revista Medica De Chile, 2003

Background: The Chilean Society of Respiratory Diseases (SER) developed guidelines for the empiri... more Background: The Chilean Society of Respiratory Diseases (SER) developed guidelines for the empirical treatment of community acquired pneumonia (CAP). Aim: To evaluate the degree of adherence to antibiotic treatment recommended by SER guidelines and its ...

Research paper thumbnail of Genetic Diversity and Population Structure of Vibrio cholerae

Research paper thumbnail of Constraint-induced movement therapy for children with obstetric brachial plexus palsy: two single-case series

International Journal of Rehabilitation Research, 2009

Research paper thumbnail of A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort

Journal of Translational Medicine, 2010

Research paper thumbnail of Nasal Hyperreactivity to Methacholine Measured by Acoustic Rhinometry in Asymptomatic Allergic and Perennial Nonallergic Rhinitis

American Journal of Rhinology & Allergy, 2000

This study was carried out to assess nasal response to different doses of methacholine and to eva... more This study was carried out to assess nasal response to different doses of methacholine and to evaluate the diagnostic possibilities of this test. Thirty-seven patients with allergic rhinitis induced by pollen (out of season), 16 with nonallergic rhinitis, and 25 normal subjects were evaluated. After provocation with saline, increasing doses of methacholine, ranging from 0.5 to 16 mg/mL, were applied. Nasal obstruction was assessed by acoustic rhinometry 10 minutes after each dose, the minimum cross-sectional area and the nasal volume in both fossae were obtained. Ipratropium bromide was applied after the last dose of methacholine to evaluate reversibility. After methacholine challenge with 0.5, 1, 2, and 4 mg/mL there was a statistically significant decrease (p < 0.05) in nasal area and volume in a dose-dependent manner in patients with allergic and nonallergic rhinitis in comparison with controls. A ROC (receiver-operating characteristic) analysis showed that a decrease in nasal volume > or = 20% at methacholine concentration of 2 mg/mL is able to predict the presence of rhinitis (positive predicted value 93%, negative predicted value 79%) in 75% of subjects. The clinical relevance of this finding suggests that patients with symptomatic nonallergic rhinitis or even asymptomatic patients with allergic rhinitis out of pollen season present a nasal hyperreactivity to methacholine, and that a decrease of nasal volume > 20% by acoustic rhinometry after challenge with methacholine at 2 mg/mL is able to discriminate these patients from normal subjects. This method seems to be a suitable tool in the diagnosis of rhinitis.

Research paper thumbnail of Koala

Research paper thumbnail of SPACING BEHAVIOR OF MARINE OTTERS (LONTRA FELINA) IN RELATION TO LAND REFUGES AND FISHERY WASTE IN CENTRAL CHILE

Journal of Mammalogy, 2007

The marine otter (Lontra felina) is a little-known South American otter of conservation concern. ... more The marine otter (Lontra felina) is a little-known South American otter of conservation concern. We report the 1st detailed information on its activity patterns, home ranges, core areas, and territoriality from 6 otters radiotracked near a fishing village in central Chile. ...

Research paper thumbnail of A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

Annals of The Rheumatic Diseases, 2011

Research paper thumbnail of The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

Human Molecular Genetics, 2009

The aim of this study was to investigate the possible role of STAT4 gene in the genetic predispos... more The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent cohorts of European ancestry (The Netherlands, Germany, Sweden, Italy and USA), were included in the study. The rs7574865 polymorphism was selected as STAT4 genetic marker. We observed that the rs7574865 T allele was significantly associated with susceptibility to lcSSc in the Spanish population [P = 1.9 x 10(-5) odds ratio (OR) 1.61 95% confidence intervals (CI) 1.29-1.99], but not with dcSSc (P = 0.41 OR 0.84 95% CI 0.59-1.21). Additionally, a dosage effect was observed showing individuals with rs7574865 TT genotype higher risk for lcSSc (OR 3.34, P = 1.02 x 10(-7) 95% CI 2.11-5.31). The association of the rs7574865 T allele with lcSSc was confirmed in all the replication cohorts with different effect sizes (OR ranging between 1.15 and 1.86), as well as the lack of association of STAT4 with dcSSc. A meta-analysis to test the overall effect of the rs7574865 polymorphism showed a strong risk effect of the T allele for lcSSc susceptibility (pooled OR 1.54 95% CI 1.36-1.74; P < 0.0001). Our data show a strong and reproducible association of the STAT4 gene with the genetic predisposition to lcSSc suggesting that this gene seems to be one of the genetic markers influencing SSc phenotype.

Research paper thumbnail of Cholesterol and membrane phospholipid compositions modulate the leakage capacity of the swaposin domain from a potato aspartic protease ( StAsp-PSI

Biochimica Et Biophysica Acta-molecular and Cell Biology of Lipids, 2011

Research paper thumbnail of Utilidad clínica del tratamiento antibiótico de la guía de la Sociedad Chilena de Enfermedades Respiratorias para la neumonía comunitaria en adultos hospitalizados

Revista Medica De Chile, 2003

Background: The Chilean Society of Respiratory Diseases (SER) developed guidelines for the empiri... more Background: The Chilean Society of Respiratory Diseases (SER) developed guidelines for the empirical treatment of community acquired pneumonia (CAP). Aim: To evaluate the degree of adherence to antibiotic treatment recommended by SER guidelines and its ...

Research paper thumbnail of Genetic Diversity and Population Structure of Vibrio cholerae

Research paper thumbnail of Constraint-induced movement therapy for children with obstetric brachial plexus palsy: two single-case series

International Journal of Rehabilitation Research, 2009

Research paper thumbnail of A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort

Journal of Translational Medicine, 2010

Research paper thumbnail of Nasal Hyperreactivity to Methacholine Measured by Acoustic Rhinometry in Asymptomatic Allergic and Perennial Nonallergic Rhinitis

American Journal of Rhinology & Allergy, 2000

This study was carried out to assess nasal response to different doses of methacholine and to eva... more This study was carried out to assess nasal response to different doses of methacholine and to evaluate the diagnostic possibilities of this test. Thirty-seven patients with allergic rhinitis induced by pollen (out of season), 16 with nonallergic rhinitis, and 25 normal subjects were evaluated. After provocation with saline, increasing doses of methacholine, ranging from 0.5 to 16 mg/mL, were applied. Nasal obstruction was assessed by acoustic rhinometry 10 minutes after each dose, the minimum cross-sectional area and the nasal volume in both fossae were obtained. Ipratropium bromide was applied after the last dose of methacholine to evaluate reversibility. After methacholine challenge with 0.5, 1, 2, and 4 mg/mL there was a statistically significant decrease (p < 0.05) in nasal area and volume in a dose-dependent manner in patients with allergic and nonallergic rhinitis in comparison with controls. A ROC (receiver-operating characteristic) analysis showed that a decrease in nasal volume > or = 20% at methacholine concentration of 2 mg/mL is able to predict the presence of rhinitis (positive predicted value 93%, negative predicted value 79%) in 75% of subjects. The clinical relevance of this finding suggests that patients with symptomatic nonallergic rhinitis or even asymptomatic patients with allergic rhinitis out of pollen season present a nasal hyperreactivity to methacholine, and that a decrease of nasal volume > 20% by acoustic rhinometry after challenge with methacholine at 2 mg/mL is able to discriminate these patients from normal subjects. This method seems to be a suitable tool in the diagnosis of rhinitis.

Research paper thumbnail of Koala