Guilherme Dabus - Academia.edu (original) (raw)
Uploads
Papers by Guilherme Dabus
Techniques in vascular and interventional radiology, 2012
Journal of NeuroInterventional Surgery, 2013
‘Time is brain’ is a slogan that has been used by stroke advocacy groups to raise public awarenes... more ‘Time is brain’ is a slogan that has been used by stroke advocacy groups to raise public awareness that stroke is a medical emergency which requires timely treatment.1 Similarly, the acronym FAST (face, arm, speech, time) has been advertised as an easy way to remember the most common stroke symptoms and the need to act quickly.2 The time dependent nature of brain injury following an ischemic event has been characterized in animal experiments. Early studies have shown that brain tissue gradually undergoes irreversible damage following an acute ischemic stroke. These studies suggest that infarct growth can be described by a logarithmic or a sigmoidal function. The rate at which tissue transitions from reversible to irreversible injury is dependent on the depth of the ischemia; with mild reductions in cerebral blood flow, brain tissue remains viable for a relatively long duration, whereas cerebral injury becomes irreversible rapidly when cerebral blood flow is severely impaired (figure 1).3 ,4 Another factor that determines the rate at which tissue undergoes irreversible ischemic injury is the type of tissue that is involved. For example, gray matter, which has a higher metabolic demand, is more susceptible to ischemia than white matter.5 The average rate of neuronal loss in humans is estimated to be 1.9 million neurons per minute during the first 10 h after stroke onset.1 These data indicate that stroke treatments aimed at restoring blood flow are most effective when they are initiated early. Figure 1 Schematic representation of infarct volume evolution. A schematic representation of the evolution of infarct volume is shown for three hypothetical scenarios: the patient with a severe reduction in cerebral blood flow (CBF) (purple line) experiences rapid expansion of the infarct, which reaches its final volume early; moderate growth is seen in the patient with a …
Radiologia Brasileira, 2007
OBJETIVO: Avaliar o valor prognóstico da distensão de alças intestinais observada em radiografias... more OBJETIVO: Avaliar o valor prognóstico da distensão de alças intestinais observada em radiografias na evolução e mortalidade de neonatos com enterocolite necrosante. MATERIAIS E MÉTODOS: Nas radiografias de abdome de 53 pacientes obtidas no momento da suspeita diagnóstica de enterocolite necrosante, foi realizada a medida do diâmetro da alça mais distendida (AD), assim como a distância entre a borda superior da primeira vértebra lombar e a borda inferior da segunda (L1-L2), a distância entre as bordas laterais dos pedículos da primeira vértebra lombar (L1), e foram estabelecidas as associações entre AD/L1-L2 e AD/L1. Esta medida foi considerada como possível determinante de potenciais complicações, intervenção cirúrgica e mortalidade. RESULTADOS: Os pacientes que necessitaram de tratamento cirúrgico, aqueles que tiveram complicações durante a evolução e aqueles que morreram da doença tiveram a relação entre AD e AD/L1-L2 maiores (p < 0,05). Os valores de AD/L1 e a localização da a...
Sao Paulo Medical Journal, 2003
Percutaneous cholecystostomy offers a potentially important type of therapy for critically ill pa... more Percutaneous cholecystostomy offers a potentially important type of therapy for critically ill patients with acute cholecystitis who present high risk when undergoing laparotomy or laparoscopy under general anesthesia. It offers a distinct advantage for these kinds of patients by avoiding the risks of the surgical intervention. Percutaneous cholecystostomy is a safe and effective minimally invasive procedure with a high success rate and low procedure-related complications. It should be considered not only in temporary management of calculous cholecystitis, but also in definitive treatment in cases of acalculous cholecystitis.
Journal of Pediatric Surgery, 1988
The authors present a literature review on pulmonary embolism and conclude that pulmonary embolec... more The authors present a literature review on pulmonary embolism and conclude that pulmonary embolectomy is indicated in patients in whom thrombolytic therapy is contraindicated, or in those who are so compromised that a trial of medical management is not warranted and in those deteriorating on thrombolytic therapy. They state that patients with acute massive pulmonary emboli should be transferred to a center with full cardiopulmonary bypass capabilities.
Arquivos de Neuro-Psiquiatria, 2009
Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal ... more Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent - crisis (not controlled). MR studies, in addition to help in diagno...
Techniques in vascular and interventional radiology, 2012
Journal of NeuroInterventional Surgery, 2013
‘Time is brain’ is a slogan that has been used by stroke advocacy groups to raise public awarenes... more ‘Time is brain’ is a slogan that has been used by stroke advocacy groups to raise public awareness that stroke is a medical emergency which requires timely treatment.1 Similarly, the acronym FAST (face, arm, speech, time) has been advertised as an easy way to remember the most common stroke symptoms and the need to act quickly.2 The time dependent nature of brain injury following an ischemic event has been characterized in animal experiments. Early studies have shown that brain tissue gradually undergoes irreversible damage following an acute ischemic stroke. These studies suggest that infarct growth can be described by a logarithmic or a sigmoidal function. The rate at which tissue transitions from reversible to irreversible injury is dependent on the depth of the ischemia; with mild reductions in cerebral blood flow, brain tissue remains viable for a relatively long duration, whereas cerebral injury becomes irreversible rapidly when cerebral blood flow is severely impaired (figure 1).3 ,4 Another factor that determines the rate at which tissue undergoes irreversible ischemic injury is the type of tissue that is involved. For example, gray matter, which has a higher metabolic demand, is more susceptible to ischemia than white matter.5 The average rate of neuronal loss in humans is estimated to be 1.9 million neurons per minute during the first 10 h after stroke onset.1 These data indicate that stroke treatments aimed at restoring blood flow are most effective when they are initiated early. Figure 1 Schematic representation of infarct volume evolution. A schematic representation of the evolution of infarct volume is shown for three hypothetical scenarios: the patient with a severe reduction in cerebral blood flow (CBF) (purple line) experiences rapid expansion of the infarct, which reaches its final volume early; moderate growth is seen in the patient with a …
Radiologia Brasileira, 2007
OBJETIVO: Avaliar o valor prognóstico da distensão de alças intestinais observada em radiografias... more OBJETIVO: Avaliar o valor prognóstico da distensão de alças intestinais observada em radiografias na evolução e mortalidade de neonatos com enterocolite necrosante. MATERIAIS E MÉTODOS: Nas radiografias de abdome de 53 pacientes obtidas no momento da suspeita diagnóstica de enterocolite necrosante, foi realizada a medida do diâmetro da alça mais distendida (AD), assim como a distância entre a borda superior da primeira vértebra lombar e a borda inferior da segunda (L1-L2), a distância entre as bordas laterais dos pedículos da primeira vértebra lombar (L1), e foram estabelecidas as associações entre AD/L1-L2 e AD/L1. Esta medida foi considerada como possível determinante de potenciais complicações, intervenção cirúrgica e mortalidade. RESULTADOS: Os pacientes que necessitaram de tratamento cirúrgico, aqueles que tiveram complicações durante a evolução e aqueles que morreram da doença tiveram a relação entre AD e AD/L1-L2 maiores (p < 0,05). Os valores de AD/L1 e a localização da a...
Sao Paulo Medical Journal, 2003
Percutaneous cholecystostomy offers a potentially important type of therapy for critically ill pa... more Percutaneous cholecystostomy offers a potentially important type of therapy for critically ill patients with acute cholecystitis who present high risk when undergoing laparotomy or laparoscopy under general anesthesia. It offers a distinct advantage for these kinds of patients by avoiding the risks of the surgical intervention. Percutaneous cholecystostomy is a safe and effective minimally invasive procedure with a high success rate and low procedure-related complications. It should be considered not only in temporary management of calculous cholecystitis, but also in definitive treatment in cases of acalculous cholecystitis.
Journal of Pediatric Surgery, 1988
The authors present a literature review on pulmonary embolism and conclude that pulmonary embolec... more The authors present a literature review on pulmonary embolism and conclude that pulmonary embolectomy is indicated in patients in whom thrombolytic therapy is contraindicated, or in those who are so compromised that a trial of medical management is not warranted and in those deteriorating on thrombolytic therapy. They state that patients with acute massive pulmonary emboli should be transferred to a center with full cardiopulmonary bypass capabilities.
Arquivos de Neuro-Psiquiatria, 2009
Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal ... more Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent - crisis (not controlled). MR studies, in addition to help in diagno...