G. Grisolia - Academia.edu (original) (raw)
Papers by G. Grisolia
BJOG: An International Journal of Obstetrics & Gynaecology, 2020
To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the ... more To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the antenatal imaging of the torcular herophili (TH) in the second trimester of pregnancy.
Ultrasound in Obstetrics & Gynecology, 2020
Results: We found an interaction effect in terms of an increase of connectivity strength between ... more Results: We found an interaction effect in terms of an increase of connectivity strength between the left thalamus and the left insular region in the fetus only for mothers with high PTB risk and with anxiety. Conclusions: The functional interplay between the insular region and the thalamus underpins salience attribution, which is a key cognitive asset for survival in the extrauterine environment. Accordingly functional synchronisation of these regions, as part of the Salience Network, has been previously reported already at birth. We report novel evidence showing how maternal mental states may impact on fetal functional neurodevelopment. We argue that maternal anxiety may influence functional connectivity patterns through the increase of fetal cerebral blood flow, stemming from reduced uteroplacental perfusion as a consequence of norepinephrine release.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 2013
J Obstet Gynaecol Can 2013;35(6):497 A 32-year-old woman underwent fetal echocardiography using H... more J Obstet Gynaecol Can 2013;35(6):497 A 32-year-old woman underwent fetal echocardiography using HDlive at 21 weeks’ gestation. Her previous baby had had a double outlet right ventricle. Voluson E8 ultrasound equipment with a volumetric RAB 4–8D MHz probe was used. The scan showed a normal four-chamber view of the heart with the pulmonary vein draining into the left atrium (Figure 1) and normal angiographic study of the left ventricle and ascending aorta (Figure 2). Additional structures also appeared normal. The newborn showed normal postnatal echocardiographic and cardiologic outcomes. HDlive differs from conventional rendering methods because it uses a fixed virtual light source that calculates the propagation of light through skin and tissue. Operators can freely select the light source at any angle relative to the ultrasound volume to enhance anatomical details.
Ultrasound in Obstetrics & Gynecology
4D Fetal Echocardiography>, 2012
Prenatal Diagnosis, 2013
To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW) that may... more To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW) that may facilitate the evaluation of cerebral midline structures at the second trimester anatomy scan. Fetal cerebral midline structures from 300 consecutive normal low-risk pregnant women were studied prospectively by 2D and 3D ultrasound between 19-23 weeks of gestation. All the newborn infants underwent pediatric follow-up and were considered normal up to 2 years of life. In addition, five confirmed pathologic cases were evaluated and the abnormal features using this technique are described in this clinical series. Off-line volume data sets displaying the corpus callosum and the cerebellar vermis anatomy were accurately reconstructed in 98.5% and 96% of cases from sagittal and axial planes, respectively. For pathological cases, an agreement rate of 0.96 and 0.91 for midsagittal and axial planes, respectively, was observed. This study demonstrates the feasibility of including 3D ultrasound as an adjunct technique for the evaluation of cerebral midline structures in the second trimester fetus. Future prospective studies will be necessary to evaluate if the application of this novel 3D reconstructing technique as a step forward following 2D second trimester screening scan will improve the prenatal detection of cerebral midline anomalies in the low-risk pregnant population.
Fetal Diagnosis and Therapy, 2013
The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increas... more The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increasing in recent time. We obtained three-dimensional data sets of the fetal face from 100 low-risk and 50 high-risk first-trimester fetuses to evaluate the offline reformatting accuracy of the retronasal triangle (RNT) using a novel reslicing technique. Adequate volume data sets for offline analysis were captured in 98% of cases. The RNT view was reformatted in 96% of cases by offline analysis. The secondary palate could be assessed in 93% by offline analysis and an abnormal RNT in the coronal plane was detected in 2 cases of lethal aneuploidy. The false-positive rate was 1.33% in the two studied groups. Abnormal RNT seems to be a valuable ultrasound marker for the early diagnosis of facial clefting. This novel reslicing technique has proven to be easy, fast and accurate, which suggest that this technology could be included in daily practice and integrated with other applications such as multiplanar mode and volume NT. Prospective studies are needed to confirm these promising results and to demonstrate if these diagnostic armamentarium tools will lead to a diagnostic enhancement of cleft lip and palate in early pregnancy.
Journal of Clinical Ultrasound, 2014
Abnormal intracranial translucency (IT) (fourth ventricle) and a Blake&am... more Abnormal intracranial translucency (IT) (fourth ventricle) and a Blake's pouch cyst with normal brain stem cavity may be valuable first-trimester call signs of defects in the skull base. Here, we report a case of presumptive two-dimensional sonographic diagnosis of occipital cephalocele that was posed at the time of 11-13 weeks aneuploidy scan. The two-dimensional sonographic finding elicited a detailed fetal neuroscan that was performed using either multiplanar mode or a novel three-dimensional reslicing and lightening technique. The use of three-dimensional sonographic software and offline "navigation" within the volume of interest enabled operators to capture a diagnostic snapshot of the condition, enhancing quality imaging and early detection of the encephalic lesion.
Ultrasound in Obstetrics & Gynecology
Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks... more Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks, birth weight of 3285 (1700-3750) grams, with a time of outcome of 6 (1.3-10) years. 69.2% of the masses were located on the left side, and were predominantly cystic (69.2%). In this series, there were no signs of polydramnious or fetal hydropsis. Associated malformations were found in 23% of the fetuses, being the cardiac malformation the more prevalent. Preterm delivery occurred in 23% of the pregnancies, as consequence of obstetrical complications as preeclampsia (7.6%), placenta previa (7.6%) and preterm rupture of membranes (7.6%). 15.4% of the fetuses had involution of the SRM during the pregnancy, one fetus had surgical treatment with a different diagnosis of the ultrasound and MRI. Of the 69.2% of the cases, the spontaneous resolution occurred in 30.7% during the first year of life and in 38.4% the masses presented without modifications or signs of regression since the neonatal period. Conclusions: Prenatal suprarenal masses are related with preterm labour and congenital heart defects. The spontaneous regression and the absence of modifications in the masses were a common long-term outcome of SRM. OP18. 02 Sonographic features of fetal hepatic hemangioma before and after birth
Archives of Gynecology and Obstetrics, 2013
American Journal of Neuroradiology, 2015
La Pediatria medica e chirurgica : Medical and surgical pediatrics
A retrospective study was performed over the children admitted to three regional pediatric burn u... more A retrospective study was performed over the children admitted to three regional pediatric burn units, over a 5-year period (1986-1990). Out of 695 pediatric patients, 270 (38.8%) were admitted with burns of the head and neck. This whole childhood age group (up to 14 years of age) was examined epidemiologically. The age group presenting the highest incidence was within 0-3 years (71%); scalds were involved in high percentage (68%) and many injuries occurred at home (93%). Epidemiological aspects of the report are discussed with particular consideration of preventive programs.
Annals of burns and fire disasters, Jan 31, 2005
This paper deals with specific aspects of paediatric burns in the acute phase and considers how t... more This paper deals with specific aspects of paediatric burns in the acute phase and considers how the treatment of burned children differs from that of burned adults. The epidemiology of paediatric burns is reviewed. Particular aspects of the treatment of burned children are presented, with regard to treatment at the site of the accident, first aid, resuscitation, and local treatment. The importance of the accurate assessment of paediatric burns is stressed.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Burns, including thermal injury, 1983
In many cases deep second degree and third degree burns cause severe scarring. The authors have r... more In many cases deep second degree and third degree burns cause severe scarring. The authors have reported here their experience of the treatment of hypertrophic scarring from burns carried out on 44 children with intralesional injections of a long-acting cortico-steroid (Triamcinolone hexacetonide) using the jet spray technique.
La Pediatria medica e chirurgica : Medical and surgical pediatrics
The burn injury is a typical pathology in which there is a possibility of opportunistic infection... more The burn injury is a typical pathology in which there is a possibility of opportunistic infections because the patients have a severe derangement in their defense. The authors examine etiology, pathogenesis, simptomatology, diagnosis, prophylaxis and therapy of these infections. The authors also report their own experience about these infections based on study of a group of burned children hospitalized in the pediatric surgery unit of A. Meyer hospital in Florence.
La Pediatria medica e chirurgica : Medical and surgical pediatrics
Localized burns to hands are very frequent in the paediatric group age. Toddlers are particularly... more Localized burns to hands are very frequent in the paediatric group age. Toddlers are particularly vulnerable. These burns have a favourable prognosis "quoad vitam" but often cause contracting scar deformity leading to loss of hand function. The authors report own experience in the last five years and emphasize the need for more severe prevention especially within the home environment to decrease the frequency of these simple but dangerous burns.
Ultrasound in Obstetrics & Gynecology, 2014
Child's Nervous System, 2014
A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum d... more A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum diagnosis and postnatal outcome
BJOG: An International Journal of Obstetrics & Gynaecology, 2020
To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the ... more To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the antenatal imaging of the torcular herophili (TH) in the second trimester of pregnancy.
Ultrasound in Obstetrics & Gynecology, 2020
Results: We found an interaction effect in terms of an increase of connectivity strength between ... more Results: We found an interaction effect in terms of an increase of connectivity strength between the left thalamus and the left insular region in the fetus only for mothers with high PTB risk and with anxiety. Conclusions: The functional interplay between the insular region and the thalamus underpins salience attribution, which is a key cognitive asset for survival in the extrauterine environment. Accordingly functional synchronisation of these regions, as part of the Salience Network, has been previously reported already at birth. We report novel evidence showing how maternal mental states may impact on fetal functional neurodevelopment. We argue that maternal anxiety may influence functional connectivity patterns through the increase of fetal cerebral blood flow, stemming from reduced uteroplacental perfusion as a consequence of norepinephrine release.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 2013
J Obstet Gynaecol Can 2013;35(6):497 A 32-year-old woman underwent fetal echocardiography using H... more J Obstet Gynaecol Can 2013;35(6):497 A 32-year-old woman underwent fetal echocardiography using HDlive at 21 weeks’ gestation. Her previous baby had had a double outlet right ventricle. Voluson E8 ultrasound equipment with a volumetric RAB 4–8D MHz probe was used. The scan showed a normal four-chamber view of the heart with the pulmonary vein draining into the left atrium (Figure 1) and normal angiographic study of the left ventricle and ascending aorta (Figure 2). Additional structures also appeared normal. The newborn showed normal postnatal echocardiographic and cardiologic outcomes. HDlive differs from conventional rendering methods because it uses a fixed virtual light source that calculates the propagation of light through skin and tissue. Operators can freely select the light source at any angle relative to the ultrasound volume to enhance anatomical details.
Ultrasound in Obstetrics & Gynecology
4D Fetal Echocardiography>, 2012
Prenatal Diagnosis, 2013
To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW) that may... more To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW) that may facilitate the evaluation of cerebral midline structures at the second trimester anatomy scan. Fetal cerebral midline structures from 300 consecutive normal low-risk pregnant women were studied prospectively by 2D and 3D ultrasound between 19-23 weeks of gestation. All the newborn infants underwent pediatric follow-up and were considered normal up to 2 years of life. In addition, five confirmed pathologic cases were evaluated and the abnormal features using this technique are described in this clinical series. Off-line volume data sets displaying the corpus callosum and the cerebellar vermis anatomy were accurately reconstructed in 98.5% and 96% of cases from sagittal and axial planes, respectively. For pathological cases, an agreement rate of 0.96 and 0.91 for midsagittal and axial planes, respectively, was observed. This study demonstrates the feasibility of including 3D ultrasound as an adjunct technique for the evaluation of cerebral midline structures in the second trimester fetus. Future prospective studies will be necessary to evaluate if the application of this novel 3D reconstructing technique as a step forward following 2D second trimester screening scan will improve the prenatal detection of cerebral midline anomalies in the low-risk pregnant population.
Fetal Diagnosis and Therapy, 2013
The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increas... more The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increasing in recent time. We obtained three-dimensional data sets of the fetal face from 100 low-risk and 50 high-risk first-trimester fetuses to evaluate the offline reformatting accuracy of the retronasal triangle (RNT) using a novel reslicing technique. Adequate volume data sets for offline analysis were captured in 98% of cases. The RNT view was reformatted in 96% of cases by offline analysis. The secondary palate could be assessed in 93% by offline analysis and an abnormal RNT in the coronal plane was detected in 2 cases of lethal aneuploidy. The false-positive rate was 1.33% in the two studied groups. Abnormal RNT seems to be a valuable ultrasound marker for the early diagnosis of facial clefting. This novel reslicing technique has proven to be easy, fast and accurate, which suggest that this technology could be included in daily practice and integrated with other applications such as multiplanar mode and volume NT. Prospective studies are needed to confirm these promising results and to demonstrate if these diagnostic armamentarium tools will lead to a diagnostic enhancement of cleft lip and palate in early pregnancy.
Journal of Clinical Ultrasound, 2014
Abnormal intracranial translucency (IT) (fourth ventricle) and a Blake&am... more Abnormal intracranial translucency (IT) (fourth ventricle) and a Blake's pouch cyst with normal brain stem cavity may be valuable first-trimester call signs of defects in the skull base. Here, we report a case of presumptive two-dimensional sonographic diagnosis of occipital cephalocele that was posed at the time of 11-13 weeks aneuploidy scan. The two-dimensional sonographic finding elicited a detailed fetal neuroscan that was performed using either multiplanar mode or a novel three-dimensional reslicing and lightening technique. The use of three-dimensional sonographic software and offline "navigation" within the volume of interest enabled operators to capture a diagnostic snapshot of the condition, enhancing quality imaging and early detection of the encephalic lesion.
Ultrasound in Obstetrics & Gynecology
Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks... more Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks, birth weight of 3285 (1700-3750) grams, with a time of outcome of 6 (1.3-10) years. 69.2% of the masses were located on the left side, and were predominantly cystic (69.2%). In this series, there were no signs of polydramnious or fetal hydropsis. Associated malformations were found in 23% of the fetuses, being the cardiac malformation the more prevalent. Preterm delivery occurred in 23% of the pregnancies, as consequence of obstetrical complications as preeclampsia (7.6%), placenta previa (7.6%) and preterm rupture of membranes (7.6%). 15.4% of the fetuses had involution of the SRM during the pregnancy, one fetus had surgical treatment with a different diagnosis of the ultrasound and MRI. Of the 69.2% of the cases, the spontaneous resolution occurred in 30.7% during the first year of life and in 38.4% the masses presented without modifications or signs of regression since the neonatal period. Conclusions: Prenatal suprarenal masses are related with preterm labour and congenital heart defects. The spontaneous regression and the absence of modifications in the masses were a common long-term outcome of SRM. OP18. 02 Sonographic features of fetal hepatic hemangioma before and after birth
Archives of Gynecology and Obstetrics, 2013
American Journal of Neuroradiology, 2015
La Pediatria medica e chirurgica : Medical and surgical pediatrics
A retrospective study was performed over the children admitted to three regional pediatric burn u... more A retrospective study was performed over the children admitted to three regional pediatric burn units, over a 5-year period (1986-1990). Out of 695 pediatric patients, 270 (38.8%) were admitted with burns of the head and neck. This whole childhood age group (up to 14 years of age) was examined epidemiologically. The age group presenting the highest incidence was within 0-3 years (71%); scalds were involved in high percentage (68%) and many injuries occurred at home (93%). Epidemiological aspects of the report are discussed with particular consideration of preventive programs.
Annals of burns and fire disasters, Jan 31, 2005
This paper deals with specific aspects of paediatric burns in the acute phase and considers how t... more This paper deals with specific aspects of paediatric burns in the acute phase and considers how the treatment of burned children differs from that of burned adults. The epidemiology of paediatric burns is reviewed. Particular aspects of the treatment of burned children are presented, with regard to treatment at the site of the accident, first aid, resuscitation, and local treatment. The importance of the accurate assessment of paediatric burns is stressed.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Burns, including thermal injury, 1983
In many cases deep second degree and third degree burns cause severe scarring. The authors have r... more In many cases deep second degree and third degree burns cause severe scarring. The authors have reported here their experience of the treatment of hypertrophic scarring from burns carried out on 44 children with intralesional injections of a long-acting cortico-steroid (Triamcinolone hexacetonide) using the jet spray technique.
La Pediatria medica e chirurgica : Medical and surgical pediatrics
The burn injury is a typical pathology in which there is a possibility of opportunistic infection... more The burn injury is a typical pathology in which there is a possibility of opportunistic infections because the patients have a severe derangement in their defense. The authors examine etiology, pathogenesis, simptomatology, diagnosis, prophylaxis and therapy of these infections. The authors also report their own experience about these infections based on study of a group of burned children hospitalized in the pediatric surgery unit of A. Meyer hospital in Florence.
La Pediatria medica e chirurgica : Medical and surgical pediatrics
Localized burns to hands are very frequent in the paediatric group age. Toddlers are particularly... more Localized burns to hands are very frequent in the paediatric group age. Toddlers are particularly vulnerable. These burns have a favourable prognosis "quoad vitam" but often cause contracting scar deformity leading to loss of hand function. The authors report own experience in the last five years and emphasize the need for more severe prevention especially within the home environment to decrease the frequency of these simple but dangerous burns.
Ultrasound in Obstetrics & Gynecology, 2014
Child's Nervous System, 2014
A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum d... more A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum diagnosis and postnatal outcome