Gopu Jaya prakash reddy - Academia.edu (original) (raw)
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Papers by Gopu Jaya prakash reddy
Poor aqueous solubility always has been a very challenging obstacle like Simvastatin needs to be ... more Poor aqueous solubility always has been a very challenging obstacle like Simvastatin needs to be enhanced by using Powder solution technology. The present research proving the Propylene glycol, Avicel PH 101 and Aerosil PH 200 suitable for the liquisolid tablets i.e. resulting highest dissolution rate due to the wettability , producing of the super saturated microenvironment around the tablets and good flow properties by changing the 5:1 to 10:1 excipient ratio (R). All Simvastatin liquisolid tablets were showing the highest dissolution rate (99.9%) within the 60 minutes comparison with the direct compressed tablets and marketed tablets.
American Journal of Phytomedicine and Clinical Therapeutics, Apr 18, 2015
Plants have been used in traditional medicine for several thousand years. India is perhaps the la... more Plants have been used in traditional medicine for several thousand years. India is perhaps the largest producer of medicinal herbs and is rightly called the "Botanical garden of the World". Ayurveda-The Indian traditional system of medicine claims to cure and control various diseases by means of herbal medicines. Murraya koneigii (Curry Leaves/Kadhi Patta/Mitha Nimba/Giri Nimba) is native to India and it is found almost everywhere in the Indian subcontinent excluding the higher levels of Himalayas. The curry tree is having many diseases protecting ingredients (natural compounds) which can be used as a natural source to make newer, alternative and innovative medicines. Curry leaves used traditionally as antiemetic, antidiarrhoeal, febrifuge and blood purifier. The whole plant is considered to be a tonic and stomachic. Curry leaves are found to be effective as antioxidant, antidiabetic, antibacterial, antihypertensive, cytotoxic and also in the treatment of bronchial respiratory difficulties. The leaves are used traditionally as a spice in curry and other eatables. The present review incorporates the description of M. koenigii, its phytochemical constituents and various pharmacological activities of isolated compounds as well as bioactivity of extract studies carried out by various numbers of laboratories.
Cheminform, 2010
Antibacterial and Antimycotics. Part 1. Synthesis and Activity of 2-Pyrazoline Derivatives.-In or... more Antibacterial and Antimycotics. Part 1. Synthesis and Activity of 2-Pyrazoline Derivatives.-In order to get more information about the structure-activity relationship of pyrazoline derivatives with the title biological activities, different types of compounds such as (IV) and (VII) are synthesized.
Poor aqueous solubility always has been a very challenging obstacle like Simvastatin needs to be ... more Poor aqueous solubility always has been a very challenging obstacle like Simvastatin needs to be enhanced by using Powder solution technology. The present research proving the Propylene glycol, Avicel PH 101 and Aerosil PH 200 suitable for the liquisolid tablets i.e. resulting highest dissolution rate due to the wettability , producing of the super saturated microenvironment around the tablets and good flow properties by changing the 5:1 to 10:1 excipient ratio (R). All Simvastatin liquisolid tablets were showing the highest dissolution rate (99.9%) within the 60 minutes comparison with the direct compressed tablets and marketed tablets.
American Journal of Phytomedicine and Clinical Therapeutics, Apr 18, 2015
Plants have been used in traditional medicine for several thousand years. India is perhaps the la... more Plants have been used in traditional medicine for several thousand years. India is perhaps the largest producer of medicinal herbs and is rightly called the "Botanical garden of the World". Ayurveda-The Indian traditional system of medicine claims to cure and control various diseases by means of herbal medicines. Murraya koneigii (Curry Leaves/Kadhi Patta/Mitha Nimba/Giri Nimba) is native to India and it is found almost everywhere in the Indian subcontinent excluding the higher levels of Himalayas. The curry tree is having many diseases protecting ingredients (natural compounds) which can be used as a natural source to make newer, alternative and innovative medicines. Curry leaves used traditionally as antiemetic, antidiarrhoeal, febrifuge and blood purifier. The whole plant is considered to be a tonic and stomachic. Curry leaves are found to be effective as antioxidant, antidiabetic, antibacterial, antihypertensive, cytotoxic and also in the treatment of bronchial respiratory difficulties. The leaves are used traditionally as a spice in curry and other eatables. The present review incorporates the description of M. koenigii, its phytochemical constituents and various pharmacological activities of isolated compounds as well as bioactivity of extract studies carried out by various numbers of laboratories.
Cheminform, 2010
Antibacterial and Antimycotics. Part 1. Synthesis and Activity of 2-Pyrazoline Derivatives.-In or... more Antibacterial and Antimycotics. Part 1. Synthesis and Activity of 2-Pyrazoline Derivatives.-In order to get more information about the structure-activity relationship of pyrazoline derivatives with the title biological activities, different types of compounds such as (IV) and (VII) are synthesized.