G. Launoy - Academia.edu (original) (raw)
Papers by G. Launoy
World Journal of Gastroenterology, 2004
European Journal of Public Health, 2018
Revue d'epidemiologie et de sante publique, 1997
Revue D Epidemiologie Et De Sante Publique, 2001
Revue D Epidemiologie Et De Sante Publique, 1997
European Journal of Cancer, 2015
Revue d'Épidémiologie et de Santé Publique, 2006
European journal of cancer (Oxford, England : 1990), Jan 6, 2015
Since 25years the EUROCARE study monitors the survival of cancer patients in Europe through centr... more Since 25years the EUROCARE study monitors the survival of cancer patients in Europe through centralised collection, quality check and statistical analysis of population-based cancer registries (CRs) data. The European population covered by the study increased remarkably in the latest round. The study design and statistical methods were also changed to improve timeliness and comparability of survival estimates. To interpret the EUROCARE-5 results on adult cancer patients better here we assess the impact of these changes on data quality and on survival comparisons. In EUROCARE-5 the survival differences by area were studied applying the complete cohort approach to data on nearly nine million cancer patients diagnosed in 2000-2007 and followed up to 2008. Survival time trends were analysed applying the period approach to data on about 10 million cancer cases diagnosed from 1995 to 2007 and followed up to 2008. Differently from EUROCARE-4, multiple primary cancers were included and rela...
European Journal of Cancer, 2015
Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, va... more Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (⩾15years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44years; 20% ⩾75years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.
Tobacco and Health, 1995
Examining the qualitative and quantitative evolution of tobacco consumption provides both a globa... more Examining the qualitative and quantitative evolution of tobacco consumption provides both a global appreciation of the effectiveness of preventive measures taken in the past, and an evaluation of the incidence of tobacco-linked diseases in future years. In France, several such studies have been based on data provided by SEITA (1). In addition, the French Agency on Health Education has repeatedly conducted point prevalence surveys in representative groups in the population which have provided valuable information, especially regarding smoking habits in young people (2,3). The aim of this study is to evaluate the quantitative and qualitative changes in men’s smoking habits in France over the past 50 years, whilst attempting to identify the behaviour of each individual generation.
Revue d'épidémiologie et de santé publique, 2002
In France, data on social environment influence on cancer management and prognosis are rare and n... more In France, data on social environment influence on cancer management and prognosis are rare and no study has been conducted on lung cancer. This study was designed to investigate the associations between place of residence and occupation class, and diagnosis, treatment and prognosis of lung cancer. The study population consisted of the 585 cases of lung cancer collected by the cancer registry of the Manche department (France) over a three-year period (1997-1999). Distribution of qualitative variables was tested using chi(2) test. Multivariate analysis were conducted using logistic regressions. Differences in actuarial survival were tested using log-rank test. Difference in diagnostic conditions did not demonstrate any prominence by social characteristics. People living in rural areas did however have a higher probability of therapeutic abstention than people living in urban areas (adjusted odds ratio=2.20 [1.18-4.10]). Similarly, people without any occupational activity had a probab...
Santé publique (Vandoeuvre-lès-Nancy, France), 1999
The preservation or the amelioration of the health of individuals and populations does not only d... more The preservation or the amelioration of the health of individuals and populations does not only depend on the activity of the medical profession. It largely depends on public health policies. Screening for cancers illustrates how difficult it is to organise an action of public health within a health care system of liberal tradition in France. Through the example of screening for colorectal cancer, this article proposes to identify the mechanisms by which the system of health care determines the methods of organisation of mass cancer screenings. Through interviews carried out among the organisers of five colorectal cancer screening campaigns, we identified three models on which French screening campaigns are based: an administrative model, a medical model and a mixed model. Each of these models represents a different adaptation of the organisation of mass screening to the health care system in place in France. The interests of the concerned professional groups confront each other and...
Gastroentérologie clinique et biologique, 1999
The objective of this work was to study the reporting of resected colonic carcinomas and to compa... more The objective of this work was to study the reporting of resected colonic carcinomas and to compare them with Consensus Guidelines published in January 1998. The study included 535 colonic carcinomas collected in 8 French registries in 1995, and chosen by drawing lots. For each report, the presence of the information requested by the Guidelines was looked for. Three synthetic variables were built: 2 scores and one qualitative at 2 classes. The influence of patients, tumour and health care system's characteristics was analysed on the 3 dependent variables. Some important variations were observed for information's percents in reporting. In monovariate analysis, scores were significantly influenced by cancer's sub-location, area of patient's residence, surgical center, type of laboratories and pathologist case volume. In multivariate analysis, significant heterogeneity in practices remained between geographical areas. Types of laboratories and pathologist case volume af...
La Revue du praticien, 1999
In developed countries there is a decreasing incidence of oesophageal cancers in males. In France... more In developed countries there is a decreasing incidence of oesophageal cancers in males. In France, a strong difference is still observed between northern and southern areas, incidence being twice in the former. Incidence is slightly increasing in females. For the past 20 years, the rate of adenocarcinoma of the lower third is growing, especially in North America. This trend is emerging in France, but remains at a lesser degree. Carcinomas of the lower oesophagus present clinical and epidemiological similarities with those of the cardia. This change could be explained by the increasing prevalence of gastro-oesophageal reflux. Alcohol and tobacco remain the main risk factors of squamous cell carcinoma. Aniseed aperitif, warm spirits and beer carry the highest risk. For tobacco, the risk is correlated to the duration of consumption and decreases after quitting.
Revue d'épidémiologie et de santé publique, 1989
1446 cases of colorectal cancer have been collected in the Registry of digestive tract tumours in... more 1446 cases of colorectal cancer have been collected in the Registry of digestive tract tumours in the "Department" of Calvados with the aim of studying the effect of residential location on cancer incidence. The risk-ratio was different in males and in females and between different types of urban areas. Using the urban category of "Zone de Peuplement Industriel ou Urbain" (ZPIU) increased the observed risk-ratio (1.6 for males, 1.2 for females), and enabled definition of homogeneous populations. This improved classification, thus allowed a more discriminating analysis of the effect of residential location on risk of cancer in both sexes.
Gastroentérologie clinique et biologique, 1992
Estimation of differences in the incidence of digestive cancers in France was made from incidence... more Estimation of differences in the incidence of digestive cancers in France was made from incidence data coming from 7 French departments covered by population-based registries. For some localizations, such as cancer of the pancreas, incidence variations could be explained by differences in recording techniques. But geographic variations clearly appeared for digestive tract cancers: the incidence of esophageal cancer is 4 to 5 fold less in the departments of Tarn and Haute-Garonne than in the department of Calvados. Conversely, the incidence of colorectal cancer is lower in the department of Calvados than in the others. For the entire country, the estimated number of digestive cancers is 46,300 cases per year. This number represents a third of all cancers in males and a fourth in females. Colorectal cancer (25,700 cases per year) is the most frequent of all cancers in both sexes. Cancer of the stomach (8,200 cases per year) is the second digestive cancer, equal to esophageal cancer in...
Revue d'Épidémiologie et de Santé Publique, 2007
Patients play an increasingly active role in the medical decision making process. Hence, methods ... more Patients play an increasingly active role in the medical decision making process. Hence, methods for eliciting public preferences have become essential tools for enlightening the choices of health authorities. Discrete choice modelling is the most recently applied technique in the field of health. This article deals with the principle, the strengths and the weaknesses of this method. Often used in English-speaking countries, the discrete choice method has several advantages over other elicitation methods since it allows estimation of marginal utilities. Compliance rates are also higher and more information is provided. Considering these qualities, further research should be undertaken on discrete choice modelling in France.
World Journal of Gastroenterology, 2004
European Journal of Public Health, 2018
Revue d'epidemiologie et de sante publique, 1997
Revue D Epidemiologie Et De Sante Publique, 2001
Revue D Epidemiologie Et De Sante Publique, 1997
European Journal of Cancer, 2015
Revue d'Épidémiologie et de Santé Publique, 2006
European journal of cancer (Oxford, England : 1990), Jan 6, 2015
Since 25years the EUROCARE study monitors the survival of cancer patients in Europe through centr... more Since 25years the EUROCARE study monitors the survival of cancer patients in Europe through centralised collection, quality check and statistical analysis of population-based cancer registries (CRs) data. The European population covered by the study increased remarkably in the latest round. The study design and statistical methods were also changed to improve timeliness and comparability of survival estimates. To interpret the EUROCARE-5 results on adult cancer patients better here we assess the impact of these changes on data quality and on survival comparisons. In EUROCARE-5 the survival differences by area were studied applying the complete cohort approach to data on nearly nine million cancer patients diagnosed in 2000-2007 and followed up to 2008. Survival time trends were analysed applying the period approach to data on about 10 million cancer cases diagnosed from 1995 to 2007 and followed up to 2008. Differently from EUROCARE-4, multiple primary cancers were included and rela...
European Journal of Cancer, 2015
Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, va... more Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (⩾15years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44years; 20% ⩾75years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.
Tobacco and Health, 1995
Examining the qualitative and quantitative evolution of tobacco consumption provides both a globa... more Examining the qualitative and quantitative evolution of tobacco consumption provides both a global appreciation of the effectiveness of preventive measures taken in the past, and an evaluation of the incidence of tobacco-linked diseases in future years. In France, several such studies have been based on data provided by SEITA (1). In addition, the French Agency on Health Education has repeatedly conducted point prevalence surveys in representative groups in the population which have provided valuable information, especially regarding smoking habits in young people (2,3). The aim of this study is to evaluate the quantitative and qualitative changes in men’s smoking habits in France over the past 50 years, whilst attempting to identify the behaviour of each individual generation.
Revue d'épidémiologie et de santé publique, 2002
In France, data on social environment influence on cancer management and prognosis are rare and n... more In France, data on social environment influence on cancer management and prognosis are rare and no study has been conducted on lung cancer. This study was designed to investigate the associations between place of residence and occupation class, and diagnosis, treatment and prognosis of lung cancer. The study population consisted of the 585 cases of lung cancer collected by the cancer registry of the Manche department (France) over a three-year period (1997-1999). Distribution of qualitative variables was tested using chi(2) test. Multivariate analysis were conducted using logistic regressions. Differences in actuarial survival were tested using log-rank test. Difference in diagnostic conditions did not demonstrate any prominence by social characteristics. People living in rural areas did however have a higher probability of therapeutic abstention than people living in urban areas (adjusted odds ratio=2.20 [1.18-4.10]). Similarly, people without any occupational activity had a probab...
Santé publique (Vandoeuvre-lès-Nancy, France), 1999
The preservation or the amelioration of the health of individuals and populations does not only d... more The preservation or the amelioration of the health of individuals and populations does not only depend on the activity of the medical profession. It largely depends on public health policies. Screening for cancers illustrates how difficult it is to organise an action of public health within a health care system of liberal tradition in France. Through the example of screening for colorectal cancer, this article proposes to identify the mechanisms by which the system of health care determines the methods of organisation of mass cancer screenings. Through interviews carried out among the organisers of five colorectal cancer screening campaigns, we identified three models on which French screening campaigns are based: an administrative model, a medical model and a mixed model. Each of these models represents a different adaptation of the organisation of mass screening to the health care system in place in France. The interests of the concerned professional groups confront each other and...
Gastroentérologie clinique et biologique, 1999
The objective of this work was to study the reporting of resected colonic carcinomas and to compa... more The objective of this work was to study the reporting of resected colonic carcinomas and to compare them with Consensus Guidelines published in January 1998. The study included 535 colonic carcinomas collected in 8 French registries in 1995, and chosen by drawing lots. For each report, the presence of the information requested by the Guidelines was looked for. Three synthetic variables were built: 2 scores and one qualitative at 2 classes. The influence of patients, tumour and health care system's characteristics was analysed on the 3 dependent variables. Some important variations were observed for information's percents in reporting. In monovariate analysis, scores were significantly influenced by cancer's sub-location, area of patient's residence, surgical center, type of laboratories and pathologist case volume. In multivariate analysis, significant heterogeneity in practices remained between geographical areas. Types of laboratories and pathologist case volume af...
La Revue du praticien, 1999
In developed countries there is a decreasing incidence of oesophageal cancers in males. In France... more In developed countries there is a decreasing incidence of oesophageal cancers in males. In France, a strong difference is still observed between northern and southern areas, incidence being twice in the former. Incidence is slightly increasing in females. For the past 20 years, the rate of adenocarcinoma of the lower third is growing, especially in North America. This trend is emerging in France, but remains at a lesser degree. Carcinomas of the lower oesophagus present clinical and epidemiological similarities with those of the cardia. This change could be explained by the increasing prevalence of gastro-oesophageal reflux. Alcohol and tobacco remain the main risk factors of squamous cell carcinoma. Aniseed aperitif, warm spirits and beer carry the highest risk. For tobacco, the risk is correlated to the duration of consumption and decreases after quitting.
Revue d'épidémiologie et de santé publique, 1989
1446 cases of colorectal cancer have been collected in the Registry of digestive tract tumours in... more 1446 cases of colorectal cancer have been collected in the Registry of digestive tract tumours in the "Department" of Calvados with the aim of studying the effect of residential location on cancer incidence. The risk-ratio was different in males and in females and between different types of urban areas. Using the urban category of "Zone de Peuplement Industriel ou Urbain" (ZPIU) increased the observed risk-ratio (1.6 for males, 1.2 for females), and enabled definition of homogeneous populations. This improved classification, thus allowed a more discriminating analysis of the effect of residential location on risk of cancer in both sexes.
Gastroentérologie clinique et biologique, 1992
Estimation of differences in the incidence of digestive cancers in France was made from incidence... more Estimation of differences in the incidence of digestive cancers in France was made from incidence data coming from 7 French departments covered by population-based registries. For some localizations, such as cancer of the pancreas, incidence variations could be explained by differences in recording techniques. But geographic variations clearly appeared for digestive tract cancers: the incidence of esophageal cancer is 4 to 5 fold less in the departments of Tarn and Haute-Garonne than in the department of Calvados. Conversely, the incidence of colorectal cancer is lower in the department of Calvados than in the others. For the entire country, the estimated number of digestive cancers is 46,300 cases per year. This number represents a third of all cancers in males and a fourth in females. Colorectal cancer (25,700 cases per year) is the most frequent of all cancers in both sexes. Cancer of the stomach (8,200 cases per year) is the second digestive cancer, equal to esophageal cancer in...
Revue d'Épidémiologie et de Santé Publique, 2007
Patients play an increasingly active role in the medical decision making process. Hence, methods ... more Patients play an increasingly active role in the medical decision making process. Hence, methods for eliciting public preferences have become essential tools for enlightening the choices of health authorities. Discrete choice modelling is the most recently applied technique in the field of health. This article deals with the principle, the strengths and the weaknesses of this method. Often used in English-speaking countries, the discrete choice method has several advantages over other elicitation methods since it allows estimation of marginal utilities. Compliance rates are also higher and more information is provided. Considering these qualities, further research should be undertaken on discrete choice modelling in France.