G Sridhar - Academia.edu (original) (raw)

G Sridhar

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Research paper thumbnail of Poster Presentations - Peritoneal Transport and Ultrafiltration

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2008

Icodextrin Metabolism in a Rabbit Experimental Model Objectives: The study of icodextrin (ICO)-ba... more Icodextrin Metabolism in a Rabbit Experimental Model Objectives: The study of icodextrin (ICO)-based peritoneal dialysis (PD) solutions in animals is limited by high levels of serum α-amylase. Of the commonly used experimental animal species, rabbits have the lowest serum amylase levels (approximately 230 U/L), albeit significantly higher than circulating levels in humans (approximately 60 U/L). We studied ICO metabolism in rabbits to evaluate their potential as an experimental model for ICO solutions. Methods: New Zealand white rabbits (n=12-18) were intraperitoneally infused with 40 mL/kg 7.5% ICO (Extraneal PD solution: Baxter Healthcare BV, Utrecht, Netherlands). α-Amylase, total ICO, and individual ICO metabolites were assayed in blood and peritoneal effluent after dwell periods of 3-6 hours.

Research paper thumbnail of Poster Presentations - Peritoneal Transport and Ultrafiltration

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2008

Icodextrin Metabolism in a Rabbit Experimental Model Objectives: The study of icodextrin (ICO)-ba... more Icodextrin Metabolism in a Rabbit Experimental Model Objectives: The study of icodextrin (ICO)-based peritoneal dialysis (PD) solutions in animals is limited by high levels of serum α-amylase. Of the commonly used experimental animal species, rabbits have the lowest serum amylase levels (approximately 230 U/L), albeit significantly higher than circulating levels in humans (approximately 60 U/L). We studied ICO metabolism in rabbits to evaluate their potential as an experimental model for ICO solutions. Methods: New Zealand white rabbits (n=12-18) were intraperitoneally infused with 40 mL/kg 7.5% ICO (Extraneal PD solution: Baxter Healthcare BV, Utrecht, Netherlands). α-Amylase, total ICO, and individual ICO metabolites were assayed in blood and peritoneal effluent after dwell periods of 3-6 hours.

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