GUEI-FEN CHIU - Academia.edu (original) (raw)

Papers by GUEI-FEN CHIU

Research paper thumbnail of 816 – Effects of Anti-Helicobacter Pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

Gastroenterology, 2019

cells that co-expressed intrinsic factor (marker of chief cells), YFP (lineage marker), and GSII ... more cells that co-expressed intrinsic factor (marker of chief cells), YFP (lineage marker), and GSII lectin (a marker for SPEM) was also significantly increased with wild-type H. pylori compared to uninfected mice (p<0.01) or mice infected with the cagE mutant (p<0.01). In conclusion, chronic H. pylori infection stimulates Lrig1-expressing progenitor activity in a cag-dependent manner and these cells give rise to a full spectrum of differentiated cells including chief cells, as well as SPEM. Thus, the cag pathogenicity island is a key mediator of epithelial progenitor cell responsiveness that develops following H. pylori infection and provides further insight into oncogenic events that develop in response to this pathogen.

Research paper thumbnail of Risk of Chronic Kidney Disease after Early and Late Helicobacter Pylori Eradication in Patients with Peptic Ulcer Disease: A Population-Based Cohort Study in Taiwan

Biology and Medicine, 2017

Background: Helicobacter pylori play a central role in the development of chronic gastritis, gast... more Background: Helicobacter pylori play a central role in the development of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. The risk of upper gastrointestinal bleeding in patients with chronic kidney disease (CKD) or end stage renal disease is reportedly higher than that in the general population. The effects of early and late H. pylori eradication on kidney disease rates warrant further investigation. Methods: We conducted a population-based study by using Taiwan's National Health Insurance Research Database of 1 million beneficiaries. The enrolled-date of this database is from January 1, 2000 to December 31, 2009. We compared the incidence and risk of CKD in 3,689 patients in the early H. pylori eradication cohort with those in 4,298 patients in the late H. pylori eradication cohort. Results: The adjusted hazard ratio (HR; 95% confidence interval (CI)=1.17-1.77) for subsequent CKD was 1.44fold higher in the late eradication cohort than in the early eradication cohort. In subgroup analysis, in patients aged 40-65 years, the HR was 1.55 (95% CI=1.14-2.10) and in those aged >65 years, the HR was 1.41 (95% CI=1.03-1.93). Conclusion: This nationwide population-based cohort study provides evidence that patients with late eradication of H. pylori are at higher risk of CKD than those with early eradication of H. pylori.

Research paper thumbnail of Is It Possible To Reduce the Risk of Hepatocellular Carcinoma by Taking Statin in Diabeties Mellitus Patients with HBV or HCV

Journal of Cancer Science & Therapy, 2017

Research paper thumbnail of Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease

Kidney international, Jan 5, 2015

The evidence on whether Chinese herbal medicines affect outcome in patients with chronic kidney d... more The evidence on whether Chinese herbal medicines affect outcome in patients with chronic kidney disease (CKD) is limited. Here we retrospectively explored the association of prescribed Chinese herbal medicine use and the risk of end-stage renal disease (ESRD) in patients with CKD. Patients with newly diagnosed CKD in the Taiwan National Health Insurance Research Database from 2000 to 2005 were categorized into new use or nonuse of prescribed Chinese herbal medicine groups. These patients were followed until death, dialysis initiation, or till the end of 2008. Among the 24,971 study patients, 11,351 were new users of prescribed Chinese herbal medicine after CKD diagnosis. Overall, after adjustment for confounding variables, the use group exhibited a significant 60% reduced ESRD risk (cause-specific hazard ratio 0.41, 95% confidence interval 0.37-0.46) compared with the nonuse group. The change was significantly large among patients using wind dampness-dispelling formulas (0.63, 0.51-...

Research paper thumbnail of Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Gastroenterology Research and Practice, 2013

Background. ChronicHelicobacter pyloriinfection and iron-deficiency anemia (IDA) are common in ad... more Background. ChronicHelicobacter pyloriinfection and iron-deficiency anemia (IDA) are common in adults. Although the most common causes of IDA usually arise from the gastrointestinal tract, the association between chronicHelicobacter pyloriinfection and anemia remains unclear.Aim. To evaluate the association of chronicHelicobacter pyloriinfection and IDA.Materials and Methods. We enrolled 882 patients from January 2010 to April 2013. The status ofHelicobacter pylori(H.p) infection was confirmed and blood samples from the same participants were taken on the same day to check the level of hemoglobin, serum iron, ferritin, and total iron-binding capacity (TIBC).Results. No significant difference was noted from the demographic data. The average level of hemoglobin (Hb) was not different between negative and positive groups, pos 13.57 g/dL versus neg 13.65 g/dL (P=0.699). Although the levels of serum IDA related parameters were expected in positive group (lower serum iron and ferritin and...

Research paper thumbnail of Effects of Anti–Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

Clinical Gastroenterology and Hepatology, 2018

Background & Aims: Helicobacter pylori induces immune tolerance and is associated with a lower ri... more Background & Aims: Helicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and inflammatory bowel diseases (IBD). We aimed to determine the effects of treatment for H pylori infection on the incidence of autoimmune disease and IBD. Methods: We collected data from the National Health Insurance Research Database in Taiwan on patients younger than 18 years old without a prior diagnosis of autoimmune disease or IBD. Patients with peptic ulcer disease (PUD) with treatment of H pylori infection (PUD+HPRx), PUD without H pylori treatment (PUD-HPRx), a urinary tract infection (UTI) treated with cephalosporin, or without PUD (controls) were matched for age, sex, insurance, and Charlson's comorbidity index score.

Research paper thumbnail of 816 – Effects of Anti-Helicobacter Pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

Gastroenterology, 2019

cells that co-expressed intrinsic factor (marker of chief cells), YFP (lineage marker), and GSII ... more cells that co-expressed intrinsic factor (marker of chief cells), YFP (lineage marker), and GSII lectin (a marker for SPEM) was also significantly increased with wild-type H. pylori compared to uninfected mice (p<0.01) or mice infected with the cagE mutant (p<0.01). In conclusion, chronic H. pylori infection stimulates Lrig1-expressing progenitor activity in a cag-dependent manner and these cells give rise to a full spectrum of differentiated cells including chief cells, as well as SPEM. Thus, the cag pathogenicity island is a key mediator of epithelial progenitor cell responsiveness that develops following H. pylori infection and provides further insight into oncogenic events that develop in response to this pathogen.

Research paper thumbnail of Risk of Chronic Kidney Disease after Early and Late Helicobacter Pylori Eradication in Patients with Peptic Ulcer Disease: A Population-Based Cohort Study in Taiwan

Biology and Medicine, 2017

Background: Helicobacter pylori play a central role in the development of chronic gastritis, gast... more Background: Helicobacter pylori play a central role in the development of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. The risk of upper gastrointestinal bleeding in patients with chronic kidney disease (CKD) or end stage renal disease is reportedly higher than that in the general population. The effects of early and late H. pylori eradication on kidney disease rates warrant further investigation. Methods: We conducted a population-based study by using Taiwan's National Health Insurance Research Database of 1 million beneficiaries. The enrolled-date of this database is from January 1, 2000 to December 31, 2009. We compared the incidence and risk of CKD in 3,689 patients in the early H. pylori eradication cohort with those in 4,298 patients in the late H. pylori eradication cohort. Results: The adjusted hazard ratio (HR; 95% confidence interval (CI)=1.17-1.77) for subsequent CKD was 1.44fold higher in the late eradication cohort than in the early eradication cohort. In subgroup analysis, in patients aged 40-65 years, the HR was 1.55 (95% CI=1.14-2.10) and in those aged >65 years, the HR was 1.41 (95% CI=1.03-1.93). Conclusion: This nationwide population-based cohort study provides evidence that patients with late eradication of H. pylori are at higher risk of CKD than those with early eradication of H. pylori.

Research paper thumbnail of Is It Possible To Reduce the Risk of Hepatocellular Carcinoma by Taking Statin in Diabeties Mellitus Patients with HBV or HCV

Journal of Cancer Science & Therapy, 2017

Research paper thumbnail of Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease

Kidney international, Jan 5, 2015

The evidence on whether Chinese herbal medicines affect outcome in patients with chronic kidney d... more The evidence on whether Chinese herbal medicines affect outcome in patients with chronic kidney disease (CKD) is limited. Here we retrospectively explored the association of prescribed Chinese herbal medicine use and the risk of end-stage renal disease (ESRD) in patients with CKD. Patients with newly diagnosed CKD in the Taiwan National Health Insurance Research Database from 2000 to 2005 were categorized into new use or nonuse of prescribed Chinese herbal medicine groups. These patients were followed until death, dialysis initiation, or till the end of 2008. Among the 24,971 study patients, 11,351 were new users of prescribed Chinese herbal medicine after CKD diagnosis. Overall, after adjustment for confounding variables, the use group exhibited a significant 60% reduced ESRD risk (cause-specific hazard ratio 0.41, 95% confidence interval 0.37-0.46) compared with the nonuse group. The change was significantly large among patients using wind dampness-dispelling formulas (0.63, 0.51-...

Research paper thumbnail of Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Gastroenterology Research and Practice, 2013

Background. ChronicHelicobacter pyloriinfection and iron-deficiency anemia (IDA) are common in ad... more Background. ChronicHelicobacter pyloriinfection and iron-deficiency anemia (IDA) are common in adults. Although the most common causes of IDA usually arise from the gastrointestinal tract, the association between chronicHelicobacter pyloriinfection and anemia remains unclear.Aim. To evaluate the association of chronicHelicobacter pyloriinfection and IDA.Materials and Methods. We enrolled 882 patients from January 2010 to April 2013. The status ofHelicobacter pylori(H.p) infection was confirmed and blood samples from the same participants were taken on the same day to check the level of hemoglobin, serum iron, ferritin, and total iron-binding capacity (TIBC).Results. No significant difference was noted from the demographic data. The average level of hemoglobin (Hb) was not different between negative and positive groups, pos 13.57 g/dL versus neg 13.65 g/dL (P=0.699). Although the levels of serum IDA related parameters were expected in positive group (lower serum iron and ferritin and...

Research paper thumbnail of Effects of Anti–Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

Clinical Gastroenterology and Hepatology, 2018

Background & Aims: Helicobacter pylori induces immune tolerance and is associated with a lower ri... more Background & Aims: Helicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and inflammatory bowel diseases (IBD). We aimed to determine the effects of treatment for H pylori infection on the incidence of autoimmune disease and IBD. Methods: We collected data from the National Health Insurance Research Database in Taiwan on patients younger than 18 years old without a prior diagnosis of autoimmune disease or IBD. Patients with peptic ulcer disease (PUD) with treatment of H pylori infection (PUD+HPRx), PUD without H pylori treatment (PUD-HPRx), a urinary tract infection (UTI) treated with cephalosporin, or without PUD (controls) were matched for age, sex, insurance, and Charlson's comorbidity index score.