Gabriel Lopez - Profile on Academia.edu (original) (raw)
Papers by Gabriel Lopez
Integrative Oncology Physician Consultations at a Comprehensive Cancer Center: Analysis of Demographic, Clinical and Patient Reported Outcomes
Journal of Cancer, 2017
Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-base... more Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the characteristics of patients seeking IO consultation. Methods: Patients presenting for an outpatient IO consultation completed a CAM use questionnaire, Measure Yourself Concerns and Wellbeing (MYCaW), Edmonton Symptom Assessment Scale (ESAS), Quality of Life Short Form 12 (SF-12), and post-consultation satisfaction item. Results: 2,474 new patient IO consultations were conducted from 9/2009 to 12/2013 and 2367 (96%) completed at least one measure. Most were female (69%); the most frequent cancer type was breast (29%); 38% had distant/advanced disease; 75% had used a CAM approach in prior 12 months. The most common concerns were seeking an integrative/holistic approach (34%), he...
Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins
Advanced materials (Deerfield Beach, Fla.), Jan 6, 2017
Strong, tough, stretchable, and self-adhesive hydrogels have been designed with intrinsically uns... more Strong, tough, stretchable, and self-adhesive hydrogels have been designed with intrinsically unstructured proteins. The extraordinary mechanical properties exhibited by these materials are enabled by an integration of toughening mechanisms that maintain high elasticity and dissipate mechanical energy within the protein networks.
Inpatient Acupuncture at a Major Cancer Center
Integrative cancer therapies, 2016
Use of complementary and integrative therapies is increasing among cancer patients, but data rega... more Use of complementary and integrative therapies is increasing among cancer patients, but data regarding the impact treatments such as acupuncture have in an inpatient oncology setting are limited. Patients who received acupuncture in an inpatient hospital environment between December 2014 and December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores were examined for each symptom using paired t tests. A total of 172 inpatients were treated with acupuncture in their hospital beds (257 visits). Thirty percent (n = 51) received at least one additional follow-up treatment (mean visits/patient = 1.5). Completion rate of the modified ESAS after acupuncture was 42%. The most common reasons for not completing the post-treatment ESAS were "patient too drowsy" or "patient fell asleep" (72%). For patients who reported a baseline symptom score ≥1, the greatest improvements (...
Hollow silica microspheres for buoyancy-assisted separation of infectious pathogens from stool
Journal of chromatography. A, Jan 30, 2016
Separation of cells and microorganisms from complex biological mixtures is a critical first step ... more Separation of cells and microorganisms from complex biological mixtures is a critical first step in many analytical applications ranging from clinical diagnostics to environmental monitoring for food and waterborne contaminants. Yet, existing techniques for cell separation are plagued by high reagent and/or instrumentation costs that limit their use in many remote or resource-poor settings, such as field clinics or developing countries. We developed an innovative approach to isolate infectious pathogens from biological fluids using buoyant hollow silica microspheres that function as "molecular buoys" for affinity-based target capture and separation by floatation. In this process, antibody functionalized glass microspheres are mixed with a complex biological sample, such as stool. When mixing is stopped, the target-bound, low-density microspheres float to the air/liquid surface, which simultaneously isolates and concentrates the target analytes from the sample matrix. The m...
Incorporation of silicone oil into elastomers enhances barnacle detachment by active surface strain
Biofouling, 2016
Silicone-oil additives are often used in fouling-release silicone coatings to reduce the adhesion... more Silicone-oil additives are often used in fouling-release silicone coatings to reduce the adhesion strength of barnacles and other biofouling organisms. This study follows on from a recently reported active approach to detach barnacles, which was based on the surface strain of elastomeric materials, by investigating a new, dual-action approach to barnacle detachment using Ecoflex®-based elastomers incorporated with poly(dimethylsiloxane)-based oil additives. The experimental results support the hypothesis that silicone-oil additives reduce the amount of substratum strain required to detach barnacles. The study also de-coupled the two effects of silicone oils (ie surface-activity and alteration of the bulk modulus) and examined their contributions in reducing barnacle adhesion strength. Further, a finite element model based on fracture mechanics was employed to qualitatively understand the effects of surface strain and substratum modulus on barnacle adhesion strength. The study demons...
Scientia Agropecuaria, Jun 19, 2010
En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo ... more En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo de extracción sobre el rendimiento de aceite esencial y el costo de producción. Se tuvieron en cuenta parámetros como la temperatura de vapor, la presión de extracción, la porosidad de lecho, flujo de vapor y temperatura de condensación. Fue utilizado un Diseño Compuesto Central Rotacional para evaluar las zonas óptimas de extracción y el costo que ocasionaría, buscando en todo momento aumentar los rendimientos y disminuir los gastos. Según este diseño, la extracción con menores costos de producción (0.57 Nuevos Soles por mL de aceite esencial) se alcanza cuando las hojas tienen una humedad entre 25 y 30% y se extraen con tiempos entre 98 y 126 min.
Logro de metas de prevención secunadaria, prescripción farmacológica y eventos cardiovasculares mayores en pacientes con enfermedad coronaria
Revista Medica De Chile, Jun 24, 2013
Creating cellular patterns using genetically engineered, gold- and cell-binding polypeptides
Biointerphases, Jan 27, 2016
Patterning cells on material surfaces is an important tool for the study of fundamental cell biol... more Patterning cells on material surfaces is an important tool for the study of fundamental cell biology, tissue engineering, and cell-based bioassays. Here, the authors report a simple approach to pattern cells on gold patterned silicon substrates with high precision, fidelity, and stability. Cell patterning is achieved by exploiting adsorbed biopolymer orientation to either enhance (gold regions) or impede (silicon oxide regions) cell adhesion at particular locations on the patterned surface. Genetic incorporation of gold binding domains enables C-terminal chemisorption of polypeptides onto gold regions with enhanced accessibility of N-terminal cell binding domains. In contrast, the orientation of polypeptides adsorbed on the silicon oxide regions limit the accessibility of the cell binding domains. The dissimilar accessibility of cell binding domains on the gold and silicon oxide regions directs the cell adhesion in a spatially controlled manner in serum-free medium, leading to the f...
Minimum spouting velocity under vacuum and high temperature in conical spouted beds
The Canadian Journal of Chemical Engineering, Aug 1, 2009
ABSTRACT
Drying Technology, Nov 30, 2011
Ipdps, 2005
Network access control mechanisms constitute an increasingly needed service, when communications ... more Network access control mechanisms constitute an increasingly needed service, when communications are becoming more and more ubiquitous thanks to some technologies such as wireless networks or Mobile IP. This paper presents a particular scenario where access rules are based not only on the identity of the different users but also on authorization data related to those users. In order to accomplish this general goal, it will be necessary to add to the traditional system-specific services for authentication and authorization, and also some entities able to manage the information related to identity, roles and permissions. Network access will be based on the 802.1X framework and the Authentication, Authorization, and Accounting (AAA) architecture, as they constitute the basis for most of the existing proposals for limiting the access to a restricted network. These proposals will be extended making use of an authorization infrastructure based on SAML statements, the RBAC model, and XACML as the main language for expressing authorization policies. The solution that we present in this paper is a consequence of an exhaustive and non-trivial analysis of the different mechanisms that could be used to provide this kind of service. As we will see, the correct integration ARTICLE IN PRESS www.elsevier.com/locate/jnca 1084-8045/$ -see front matter r
Scientia Agropecuaria, Jun 19, 2010
En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo ... more En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo de extracción sobre el rendimiento de aceite esencial y el costo de producción. Se tuvieron en cuenta parámetros como la temperatura de vapor, la presión de extracción, la porosidad de lecho, flujo de vapor y temperatura de condensación. Fue utilizado un Diseño Compuesto Central Rotacional para evaluar las zonas óptimas de extracción y el costo que ocasionaría, buscando en todo momento aumentar los rendimientos y disminuir los gastos. Según este diseño, la extracción con menores costos de producción (0.57 Nuevos Soles por mL de aceite esencial) se alcanza cuando las hojas tienen una humedad entre 25 y 30% y se extraen con tiempos entre 98 y 126 min.
J Pharmacol Exp Ther, 2004
We provide a detailed analysis of very weak fragments of modal logic. Our fragments lack connecti... more We provide a detailed analysis of very weak fragments of modal logic. Our fragments lack connectives that introduce non-determinism and they feature restrictions on the modal operators, which may lead to substantial reductions in complexity. Our main result is a general game-based characterization of the expressive power of our fragments over the class of finite structures.
Lab Chip, 2005
This report presents a study of electrokinetic transport in a series of integrated macro-to nanof... more This report presents a study of electrokinetic transport in a series of integrated macro-to nanofluidic chips that allow for controlled injection of molecular mixtures into high-density arrays of nanochannels. The high-aspect-ratio nanochannels were fabricated on a Si wafer using interferometric lithography and standard semiconductor industry processes, and are capped with a transparent Pyrex cover slip to allow for experimental observations. Confocal laser scanning microscopy was used to examine the electrokinetic transport of a negatively charged dye (Alexa 488) and a neutral dye (rhodamine B) within nanochannels that varied in width from 35 to 200 nm with electric field strengths equal to or below 2000 V m 21 . In the negatively charged channels, nanoconfinement and interactions between the respective solutes and channel walls give rise to higher electroosmotic velocities for the negatively charged dye than for the neutral dye, towards the negative electrode, resulting in an anomalous separation that occurs over a relatively short distance (,1 mm). Increasing the channel widths leads to a switch in the electroosmotic transport behavior observed in microscale channels, where neutral molecules move faster because the negatively charged molecules are slowed by the electrophoretic drag. Thus a clear distinction between ''nano-'' and ''microfluidic'' regimes is established. We present an analytical model that accounts for the electrokinetic transport and adsorption (of the neutral dye) at the channel walls, and is in good agreement with the experimental data. The observed effects have potential for use in new nano-separation technologies.
SWIFT White Paper: Identity as a Convergence Layer
Examination of moderators of expressive writing in patients with renal cell carcinoma: the role of depression and social support
Psycho-oncology, Jan 3, 2016
To identify groups most likely to benefit from an Expressive Writing (EW) intervention, we examin... more To identify groups most likely to benefit from an Expressive Writing (EW) intervention, we examined psychosocial variables as intervention moderators. We hypothesized that EW would be particularly effective for participants with high levels of depressive symptoms and social support at study entry. Patients (n = 277; 60.6% male) with kidney cancer were randomly assigned to either an expressive (EW) or neutral writing (NW) condition. Intervention outcomes included measures of depressive symptoms (CESD), cancer-related symptoms (MDASI), fatigue (BFI), and sleep disturbances (PSQI) assessed at baseline, 1, 4, and 10 months later. Moderators were measured at baseline. As hypothesized, depressive symptoms and social support moderated intervention efficacy. When examining both moderators simultaneously, EW appeared to be most effective in terms of cancer-related symptoms (p < 0.05) and depressive symptoms (p < 0.01) for participants with elevated depressive symptoms who received high...
J Therm Anal Calorim, 1982
The thermal treatment of the pentafluorophenyl derivatives M(C6Fs)eDxn [M = Pd (n = 2, 3) or Pt (... more The thermal treatment of the pentafluorophenyl derivatives M(C6Fs)eDxn [M = Pd (n = 2, 3) or Pt (n = 2); Dx = dioxane] leads to the formation of the new dioxane adducts M(C6Fs)2Dx (M = Pd, Pt) and Pt(C6Fs)2Dxl.n. Calculations of the order of reaction and the activation energy of some of the decomposition reactions are described. The values were determined by the Coats-Redfern and Freeman--Carroll methods. Structural data on the isolated intermediates were obtained by infrared spectroscopy and magnetic susceptibility measurements.
Nurse and patient characteristics predict communication about complementary and alternative medicine
Cancer, 2016
The aim of this study was to identify nurse factors (eg, knowledge, practices, and clinical habit... more The aim of this study was to identify nurse factors (eg, knowledge, practices, and clinical habits regarding complementary and alternative medicine [CAM] as well as demographic factors) and patient characteristics (eg, age, sex, and treatment status) associated with nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; CAM inquiry and referral patterns. Baseline data were collected with nurse/patient questionnaires about CAM use and knowledge as part of a multicenter CAM educational clinical trial. Frequencies and nested regression models were used to assess predictors of nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; inquiries about and referral to CAM therapies. Six hundred ninety-nine patients participated in the study. For patients, female sex (odds ratio [OR], 1.50; P = .019) and cancer recurrence (OR, 1.45; P = .05) were predictive of nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; inquiries about and referral to CAM therapies. A total of 175 nurses with a mean age of 45 years and a mean experience of 20 years participated; 79% were staff nurses, and 11% were nurse practitioners. Fifty-three percent asked at least 1 of their last 5 patients about CAM use; 42% referred patients to CAM therapy. Nurses who reported being &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;somewhat comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 2.70; P = .0001) or &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;very comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 3.88; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001) about discussing CAM, self-reported use of massage (OR, 2.20; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001), and had formal CAM education (OR, 4.14; P = .0001) were more likely to ask about CAM use. Nurses who reported being &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;somewhat comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 2.54; 95% confidence interval, 1.47-4.41; P = .0008) or &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;very comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 7.46; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .00001) and had formal CAM education (OR, 2.96; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001) were also more likely to refer patients to CAM therapies. Both patient and nurse characteristics were associated with discussions about CAM. Oncology institutions that prioritize evidence-based medicine should consider introducing CAM education to their nursing staff. Cancer 2016. © 2016 American Cancer Society.
Integrative Oncology Physician Consultations at a Comprehensive Cancer Center: Analysis of Demographic, Clinical and Patient Reported Outcomes
Journal of Cancer, 2017
Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-base... more Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the characteristics of patients seeking IO consultation. Methods: Patients presenting for an outpatient IO consultation completed a CAM use questionnaire, Measure Yourself Concerns and Wellbeing (MYCaW), Edmonton Symptom Assessment Scale (ESAS), Quality of Life Short Form 12 (SF-12), and post-consultation satisfaction item. Results: 2,474 new patient IO consultations were conducted from 9/2009 to 12/2013 and 2367 (96%) completed at least one measure. Most were female (69%); the most frequent cancer type was breast (29%); 38% had distant/advanced disease; 75% had used a CAM approach in prior 12 months. The most common concerns were seeking an integrative/holistic approach (34%), he...
Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins
Advanced materials (Deerfield Beach, Fla.), Jan 6, 2017
Strong, tough, stretchable, and self-adhesive hydrogels have been designed with intrinsically uns... more Strong, tough, stretchable, and self-adhesive hydrogels have been designed with intrinsically unstructured proteins. The extraordinary mechanical properties exhibited by these materials are enabled by an integration of toughening mechanisms that maintain high elasticity and dissipate mechanical energy within the protein networks.
Inpatient Acupuncture at a Major Cancer Center
Integrative cancer therapies, 2016
Use of complementary and integrative therapies is increasing among cancer patients, but data rega... more Use of complementary and integrative therapies is increasing among cancer patients, but data regarding the impact treatments such as acupuncture have in an inpatient oncology setting are limited. Patients who received acupuncture in an inpatient hospital environment between December 2014 and December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores were examined for each symptom using paired t tests. A total of 172 inpatients were treated with acupuncture in their hospital beds (257 visits). Thirty percent (n = 51) received at least one additional follow-up treatment (mean visits/patient = 1.5). Completion rate of the modified ESAS after acupuncture was 42%. The most common reasons for not completing the post-treatment ESAS were "patient too drowsy" or "patient fell asleep" (72%). For patients who reported a baseline symptom score ≥1, the greatest improvements (...
Hollow silica microspheres for buoyancy-assisted separation of infectious pathogens from stool
Journal of chromatography. A, Jan 30, 2016
Separation of cells and microorganisms from complex biological mixtures is a critical first step ... more Separation of cells and microorganisms from complex biological mixtures is a critical first step in many analytical applications ranging from clinical diagnostics to environmental monitoring for food and waterborne contaminants. Yet, existing techniques for cell separation are plagued by high reagent and/or instrumentation costs that limit their use in many remote or resource-poor settings, such as field clinics or developing countries. We developed an innovative approach to isolate infectious pathogens from biological fluids using buoyant hollow silica microspheres that function as "molecular buoys" for affinity-based target capture and separation by floatation. In this process, antibody functionalized glass microspheres are mixed with a complex biological sample, such as stool. When mixing is stopped, the target-bound, low-density microspheres float to the air/liquid surface, which simultaneously isolates and concentrates the target analytes from the sample matrix. The m...
Incorporation of silicone oil into elastomers enhances barnacle detachment by active surface strain
Biofouling, 2016
Silicone-oil additives are often used in fouling-release silicone coatings to reduce the adhesion... more Silicone-oil additives are often used in fouling-release silicone coatings to reduce the adhesion strength of barnacles and other biofouling organisms. This study follows on from a recently reported active approach to detach barnacles, which was based on the surface strain of elastomeric materials, by investigating a new, dual-action approach to barnacle detachment using Ecoflex®-based elastomers incorporated with poly(dimethylsiloxane)-based oil additives. The experimental results support the hypothesis that silicone-oil additives reduce the amount of substratum strain required to detach barnacles. The study also de-coupled the two effects of silicone oils (ie surface-activity and alteration of the bulk modulus) and examined their contributions in reducing barnacle adhesion strength. Further, a finite element model based on fracture mechanics was employed to qualitatively understand the effects of surface strain and substratum modulus on barnacle adhesion strength. The study demons...
Scientia Agropecuaria, Jun 19, 2010
En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo ... more En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo de extracción sobre el rendimiento de aceite esencial y el costo de producción. Se tuvieron en cuenta parámetros como la temperatura de vapor, la presión de extracción, la porosidad de lecho, flujo de vapor y temperatura de condensación. Fue utilizado un Diseño Compuesto Central Rotacional para evaluar las zonas óptimas de extracción y el costo que ocasionaría, buscando en todo momento aumentar los rendimientos y disminuir los gastos. Según este diseño, la extracción con menores costos de producción (0.57 Nuevos Soles por mL de aceite esencial) se alcanza cuando las hojas tienen una humedad entre 25 y 30% y se extraen con tiempos entre 98 y 126 min.
Logro de metas de prevención secunadaria, prescripción farmacológica y eventos cardiovasculares mayores en pacientes con enfermedad coronaria
Revista Medica De Chile, Jun 24, 2013
Creating cellular patterns using genetically engineered, gold- and cell-binding polypeptides
Biointerphases, Jan 27, 2016
Patterning cells on material surfaces is an important tool for the study of fundamental cell biol... more Patterning cells on material surfaces is an important tool for the study of fundamental cell biology, tissue engineering, and cell-based bioassays. Here, the authors report a simple approach to pattern cells on gold patterned silicon substrates with high precision, fidelity, and stability. Cell patterning is achieved by exploiting adsorbed biopolymer orientation to either enhance (gold regions) or impede (silicon oxide regions) cell adhesion at particular locations on the patterned surface. Genetic incorporation of gold binding domains enables C-terminal chemisorption of polypeptides onto gold regions with enhanced accessibility of N-terminal cell binding domains. In contrast, the orientation of polypeptides adsorbed on the silicon oxide regions limit the accessibility of the cell binding domains. The dissimilar accessibility of cell binding domains on the gold and silicon oxide regions directs the cell adhesion in a spatially controlled manner in serum-free medium, leading to the f...
Minimum spouting velocity under vacuum and high temperature in conical spouted beds
The Canadian Journal of Chemical Engineering, Aug 1, 2009
ABSTRACT
Drying Technology, Nov 30, 2011
Ipdps, 2005
Network access control mechanisms constitute an increasingly needed service, when communications ... more Network access control mechanisms constitute an increasingly needed service, when communications are becoming more and more ubiquitous thanks to some technologies such as wireless networks or Mobile IP. This paper presents a particular scenario where access rules are based not only on the identity of the different users but also on authorization data related to those users. In order to accomplish this general goal, it will be necessary to add to the traditional system-specific services for authentication and authorization, and also some entities able to manage the information related to identity, roles and permissions. Network access will be based on the 802.1X framework and the Authentication, Authorization, and Accounting (AAA) architecture, as they constitute the basis for most of the existing proposals for limiting the access to a restricted network. These proposals will be extended making use of an authorization infrastructure based on SAML statements, the RBAC model, and XACML as the main language for expressing authorization policies. The solution that we present in this paper is a consequence of an exhaustive and non-trivial analysis of the different mechanisms that could be used to provide this kind of service. As we will see, the correct integration ARTICLE IN PRESS www.elsevier.com/locate/jnca 1084-8045/$ -see front matter r
Scientia Agropecuaria, Jun 19, 2010
En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo ... more En el presente trabajo se estudiaron el efecto de la humedad de la hoja de eucalipto y el tiempo de extracción sobre el rendimiento de aceite esencial y el costo de producción. Se tuvieron en cuenta parámetros como la temperatura de vapor, la presión de extracción, la porosidad de lecho, flujo de vapor y temperatura de condensación. Fue utilizado un Diseño Compuesto Central Rotacional para evaluar las zonas óptimas de extracción y el costo que ocasionaría, buscando en todo momento aumentar los rendimientos y disminuir los gastos. Según este diseño, la extracción con menores costos de producción (0.57 Nuevos Soles por mL de aceite esencial) se alcanza cuando las hojas tienen una humedad entre 25 y 30% y se extraen con tiempos entre 98 y 126 min.
J Pharmacol Exp Ther, 2004
We provide a detailed analysis of very weak fragments of modal logic. Our fragments lack connecti... more We provide a detailed analysis of very weak fragments of modal logic. Our fragments lack connectives that introduce non-determinism and they feature restrictions on the modal operators, which may lead to substantial reductions in complexity. Our main result is a general game-based characterization of the expressive power of our fragments over the class of finite structures.
Lab Chip, 2005
This report presents a study of electrokinetic transport in a series of integrated macro-to nanof... more This report presents a study of electrokinetic transport in a series of integrated macro-to nanofluidic chips that allow for controlled injection of molecular mixtures into high-density arrays of nanochannels. The high-aspect-ratio nanochannels were fabricated on a Si wafer using interferometric lithography and standard semiconductor industry processes, and are capped with a transparent Pyrex cover slip to allow for experimental observations. Confocal laser scanning microscopy was used to examine the electrokinetic transport of a negatively charged dye (Alexa 488) and a neutral dye (rhodamine B) within nanochannels that varied in width from 35 to 200 nm with electric field strengths equal to or below 2000 V m 21 . In the negatively charged channels, nanoconfinement and interactions between the respective solutes and channel walls give rise to higher electroosmotic velocities for the negatively charged dye than for the neutral dye, towards the negative electrode, resulting in an anomalous separation that occurs over a relatively short distance (,1 mm). Increasing the channel widths leads to a switch in the electroosmotic transport behavior observed in microscale channels, where neutral molecules move faster because the negatively charged molecules are slowed by the electrophoretic drag. Thus a clear distinction between ''nano-'' and ''microfluidic'' regimes is established. We present an analytical model that accounts for the electrokinetic transport and adsorption (of the neutral dye) at the channel walls, and is in good agreement with the experimental data. The observed effects have potential for use in new nano-separation technologies.
SWIFT White Paper: Identity as a Convergence Layer
Examination of moderators of expressive writing in patients with renal cell carcinoma: the role of depression and social support
Psycho-oncology, Jan 3, 2016
To identify groups most likely to benefit from an Expressive Writing (EW) intervention, we examin... more To identify groups most likely to benefit from an Expressive Writing (EW) intervention, we examined psychosocial variables as intervention moderators. We hypothesized that EW would be particularly effective for participants with high levels of depressive symptoms and social support at study entry. Patients (n = 277; 60.6% male) with kidney cancer were randomly assigned to either an expressive (EW) or neutral writing (NW) condition. Intervention outcomes included measures of depressive symptoms (CESD), cancer-related symptoms (MDASI), fatigue (BFI), and sleep disturbances (PSQI) assessed at baseline, 1, 4, and 10 months later. Moderators were measured at baseline. As hypothesized, depressive symptoms and social support moderated intervention efficacy. When examining both moderators simultaneously, EW appeared to be most effective in terms of cancer-related symptoms (p < 0.05) and depressive symptoms (p < 0.01) for participants with elevated depressive symptoms who received high...
J Therm Anal Calorim, 1982
The thermal treatment of the pentafluorophenyl derivatives M(C6Fs)eDxn [M = Pd (n = 2, 3) or Pt (... more The thermal treatment of the pentafluorophenyl derivatives M(C6Fs)eDxn [M = Pd (n = 2, 3) or Pt (n = 2); Dx = dioxane] leads to the formation of the new dioxane adducts M(C6Fs)2Dx (M = Pd, Pt) and Pt(C6Fs)2Dxl.n. Calculations of the order of reaction and the activation energy of some of the decomposition reactions are described. The values were determined by the Coats-Redfern and Freeman--Carroll methods. Structural data on the isolated intermediates were obtained by infrared spectroscopy and magnetic susceptibility measurements.
Nurse and patient characteristics predict communication about complementary and alternative medicine
Cancer, 2016
The aim of this study was to identify nurse factors (eg, knowledge, practices, and clinical habit... more The aim of this study was to identify nurse factors (eg, knowledge, practices, and clinical habits regarding complementary and alternative medicine [CAM] as well as demographic factors) and patient characteristics (eg, age, sex, and treatment status) associated with nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; CAM inquiry and referral patterns. Baseline data were collected with nurse/patient questionnaires about CAM use and knowledge as part of a multicenter CAM educational clinical trial. Frequencies and nested regression models were used to assess predictors of nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; inquiries about and referral to CAM therapies. Six hundred ninety-nine patients participated in the study. For patients, female sex (odds ratio [OR], 1.50; P = .019) and cancer recurrence (OR, 1.45; P = .05) were predictive of nurses&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; inquiries about and referral to CAM therapies. A total of 175 nurses with a mean age of 45 years and a mean experience of 20 years participated; 79% were staff nurses, and 11% were nurse practitioners. Fifty-three percent asked at least 1 of their last 5 patients about CAM use; 42% referred patients to CAM therapy. Nurses who reported being &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;somewhat comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 2.70; P = .0001) or &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;very comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 3.88; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001) about discussing CAM, self-reported use of massage (OR, 2.20; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001), and had formal CAM education (OR, 4.14; P = .0001) were more likely to ask about CAM use. Nurses who reported being &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;somewhat comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 2.54; 95% confidence interval, 1.47-4.41; P = .0008) or &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;very comfortable&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (OR, 7.46; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .00001) and had formal CAM education (OR, 2.96; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001) were also more likely to refer patients to CAM therapies. Both patient and nurse characteristics were associated with discussions about CAM. Oncology institutions that prioritize evidence-based medicine should consider introducing CAM education to their nursing staff. Cancer 2016. © 2016 American Cancer Society.