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Papers by Gabriela Pino

Research paper thumbnail of Data from: The avalanche-like behaviour of large-scale haemodynamic activity from wakefulness to deep sleep

Research paper thumbnail of White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease

Journal of Psychiatric Research, 2020

Research paper thumbnail of El fascículo longitudinal inferior en la afasia progresiva primaria variante semántica

Neurología Argentina, 2012

Research paper thumbnail of Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Research paper thumbnail of Author Correction: Retrieval of retrained and reconsolidated memories are associated with a distinct neural network

Research paper thumbnail of Retrieval of retrained and reconsolidated memories are associated with a distinct neural network

Scientific Reports

Consolidated memories can persist from a single day to years, and persistence is improved by retr... more Consolidated memories can persist from a single day to years, and persistence is improved by retraining or retrieval-mediated plasticity. One retrieval-based way to strengthen memory is the reconsolidation process. Strengthening occurs simply by the presentation of specific cues associated with the original learning. This enhancement function has a fundamental role in the maintenance of memory relevance in animals everyday life. In the present study, we made a step forward in the identification of brain correlates imprinted by the reconsolidation process studying the long-term neural consequences when the strengthened memory is stable again. To reach such a goal, we compared the retention of pairedassociate memories that went through retraining process or were labilizated-reconsolidated. Using functional magnetic resonance imaging (fMRI), we studied the specific areas activated during retrieval and analyzed the functional connectivity of the whole brain associated with the event-related design. We used Graph Theory tools to analyze the global features of the network. We show that reconsolidated memories imprint a more locally efficient network that is better at exchanging information, compared with memories that were retrained or untreated. For the first time, we report a method to elucidate the neural footprints associated with a relevant function of memory reconsolidation. Consolidated memories can persist from 24 hours to years, depending on the saliency, intensity or emotionality of the information to be remembered 1. It is an accepted idea that the mechanisms responsible for making a memory long-lasting must persist to make the trace resistant to forgetting 2-5. It is possible to modify the persistence of a memory after consolidation simply by retraining or by the presentation of a reminder. A reminder is defined as a group of cues that evoke the original memory trace 6,7. An example of a reminder based way to strengthen memory is the reconsolidation process. That is, when consolidated memories are reactivated by the presentation of specific reminders, the retrieved memory enters in a period of labilization followed by a process of restabilization known as reconsolidation 8-10. Memory reconsolidation has a fundamental role in the maintenance of memory relevance 11. This process is in charge of modifying the strength and/or content of consolidated memories. It has been observed in animal models and in human experiments 12-15. Depending on the treatment used in the

Research paper thumbnail of F169. Brain Connectivity During Psychological Stress in Patients with Schizophrenia

Research paper thumbnail of Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Consolidated memories return to a labile state after the presentation of cues (reminders) associa... more Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated.

Research paper thumbnail of Data from: The avalanche-like behaviour of large-scale haemodynamic activity from wakefulness to deep sleep

Research paper thumbnail of White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease

Journal of Psychiatric Research, 2020

Research paper thumbnail of El fascículo longitudinal inferior en la afasia progresiva primaria variante semántica

Neurología Argentina, 2012

Research paper thumbnail of Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Research paper thumbnail of Author Correction: Retrieval of retrained and reconsolidated memories are associated with a distinct neural network

Research paper thumbnail of Retrieval of retrained and reconsolidated memories are associated with a distinct neural network

Scientific Reports

Consolidated memories can persist from a single day to years, and persistence is improved by retr... more Consolidated memories can persist from a single day to years, and persistence is improved by retraining or retrieval-mediated plasticity. One retrieval-based way to strengthen memory is the reconsolidation process. Strengthening occurs simply by the presentation of specific cues associated with the original learning. This enhancement function has a fundamental role in the maintenance of memory relevance in animals everyday life. In the present study, we made a step forward in the identification of brain correlates imprinted by the reconsolidation process studying the long-term neural consequences when the strengthened memory is stable again. To reach such a goal, we compared the retention of pairedassociate memories that went through retraining process or were labilizated-reconsolidated. Using functional magnetic resonance imaging (fMRI), we studied the specific areas activated during retrieval and analyzed the functional connectivity of the whole brain associated with the event-related design. We used Graph Theory tools to analyze the global features of the network. We show that reconsolidated memories imprint a more locally efficient network that is better at exchanging information, compared with memories that were retrained or untreated. For the first time, we report a method to elucidate the neural footprints associated with a relevant function of memory reconsolidation. Consolidated memories can persist from 24 hours to years, depending on the saliency, intensity or emotionality of the information to be remembered 1. It is an accepted idea that the mechanisms responsible for making a memory long-lasting must persist to make the trace resistant to forgetting 2-5. It is possible to modify the persistence of a memory after consolidation simply by retraining or by the presentation of a reminder. A reminder is defined as a group of cues that evoke the original memory trace 6,7. An example of a reminder based way to strengthen memory is the reconsolidation process. That is, when consolidated memories are reactivated by the presentation of specific reminders, the retrieved memory enters in a period of labilization followed by a process of restabilization known as reconsolidation 8-10. Memory reconsolidation has a fundamental role in the maintenance of memory relevance 11. This process is in charge of modifying the strength and/or content of consolidated memories. It has been observed in animal models and in human experiments 12-15. Depending on the treatment used in the

Research paper thumbnail of F169. Brain Connectivity During Psychological Stress in Patients with Schizophrenia

Research paper thumbnail of Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Consolidated memories return to a labile state after the presentation of cues (reminders) associa... more Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated.

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