Gabriela Rosado - Academia.edu (original) (raw)

Papers by Gabriela Rosado

Journal of Thoracic Oncology

Conclusion: Underexpression of SFTPC in tumor samples was independently associated with worse pro... more Conclusion: Underexpression of SFTPC in tumor samples was independently associated with worse prognosis.

European Respiratory Journal, Sep 1, 2012

European Journal of Surgical Oncology

As nutritional status plays an important role in outcomes after surgery, this study evaluated the... more As nutritional status plays an important role in outcomes after surgery, this study evaluated the association between preoperative nutritional status (NS) and postoperative outcomes after major resection for lung cancer. We identified 219 patients with a diagnosis of cancer who underwent pulmonary resection from 2010 to 2012. Preoperative NS was assessed by anthropometric and biological parameters, body mass index (BMI), and the Nutritional Risk Index (NRI). We stratified this population into 4 BMI groups: underweight, normal weight, overweight and obese and 4 NRI groups: well-nourished; mildly malnourished; moderately malnourished and severely malnourished. The outcomes measured were postoperative complications; 30-day postoperative mortality; hospital length of stay (LOS), overall survival (OS) and disease-free survival (DFS). We performed both unadjusted analysis and adjusted multivariable analysis, controlling for statistically significant variables. Mean BMI and NRI were, respectively, 26.5 ± 4.3 and 112.4 ± 3.3. There were no significant differences between BMI categories and resection type, pathological stage, or overall postoperative complications. By contrast, significant differences (p < 0.05) in postoperative complications were observed among the NRI groups. LOS was longer in underweight and/or malnourished patients. In terms of OS, we found no significant differences according to NRI and BMI; however, patients with underweight had significantly shorter DFS compared with patients with overweight and obesity (log-rank p-value = 0.001). NS as measured by the NRI is an independent predictor of the risk of postsurgical complications, regardless of clinicopathologic characteristics. NRI might therefore be an useful tool for identifying early-stage lung cancer patients at risk for postoperative complications.

Surg Endosc, 2010

To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic t... more To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis. From 2000 to 2008, 124 consecutive patients with primary spontaneous pneumothorax were operated; 105 were men (84.7%) and 19 were women (15.3%) with a mean age of 26.6 years (range 17-46 years). No mortality was recorded. Staging according to Vanderschueren's classification was as follows: stage I, 61 patients (45.9%); stage II, 39 patients (29.3%); stage III, 31 patients (23.3%); stage IV, two patients (1.5%). The overall rate of complications was 9% (12/133), corresponding to prolonged air leak in 9(6.7%) patients and hemothorax in 3(2.2%) patients. Four patients (3%) had recurrence requiring reoperation. There were no episodes of acute respiratory failure, pneumonia or subcutaneous emphysema following talc pleurodesis. Thoracoscopic pleural talc pleurodesis as a treatment for recurrent pneumothorax is easy, safe, and rapid, and causes minimal morbidity and mortality.

Cir Espan, 2010

La hiperhidrosis primaria (HP) es un exceso de sudoración sin causa aparente. La HP es más frecue... more La hiperhidrosis primaria (HP) es un exceso de sudoración sin causa aparente. La HP es más frecuente en mujeres y en palmas, plantas y axilas. Los tratamientos médicos no son efectivos. La cirugía consiste en eliminar/desconectar los ganglios simpáticos T2 (HP craneofacial y rubor facial), T3 (HP palmar) y T3–T4 (HP axilar). Las técnicas quirúrgicas son la resección/transección, la ablación mediante electrocoagulación, la neuropresión con clip y la radiofrecuencia, fundamentalmente. La anhidrosis se consigue en el 95% de los pacientes. Menos del 5% presenta complicaciones y estas son menores. El efecto secundario más temido es la sudoración refleja, que se presenta en un 48% de los pacientes. La sudoración refleja es más frecuente en espalda, tórax y abdomen y aparece independientemente de la técnica utilizada. Un 90% de los pacientes están muy satisfechos tras la cirugía. Actualmente, la cirugía del simpático torácico es el gold estándar para la HP.Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent in women and in palms, soles and axillae. Medical treatment is not effective. The objective of the surgery is to remove or to disconnect sympathetic ganglia T2 (craniofacial PH or facial blushing), T3 (palmar PH) and T3–T4 (axillary PH). The surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. Anhidrosis is achieved in 95% of the patients. The overall rate of complications is less than 5% and these are minor complications. The most important unwanted effect is reflex sweating, presented in 48% of the patients. Reflex sweating is more frequent in back, thorax and abdomen and it appears independently of the surgical technique. Ninety percent of the patients are very satisfied after surgery. Nowadays, thoracic sympathetic surgery is the gold standard for primary hyperhidrosis.

General Thoracic and Cardiovascular Surgery, 2011

The primary intranodal schwannoma is an uncommon variant of schwannomas and extremely rare. We re... more The primary intranodal schwannoma is an uncommon variant of schwannomas and extremely rare. We report the case of a 70-year-old woman who was found to have a soft tissue opacity in the right hemithorax on chest posteroanterior radiography and signifi cant uptake of 18 F-fl uorodeoxyglucose on positron emission tomography. We performed thoracoscopic resection, and a defi nitive diagnosis of intranodal schwannoma was made from the pathological fi ndings.

Cirugía Española (English Edition), 2010

Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent... more Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent in women and in palms, soles and axillae. Medical treatment is not effective. The objective of the surgery is to remove or to disconnect sympathetic ganglia T2 (craniofacial PH or facial blushing), T3 (palmar PH) and T3-T4 (axillary PH). The surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. Anhidrosis is achieved in 95% of the patients. The overall rate of complications is less than 5% and these are minor complications. The most important unwanted effect is reflex sweating, presented in 48% of the patients. Reflex sweating is more frequent in back, thorax and abdomen and it appears independently of the surgical technique. Ninety percent of the patients are very satisfied after surgery. Nowadays, thoracic sympathetic surgery is the gold standard for primary hyperhidrosis.

Surgical Endoscopy, 2012

Background Thoracoscopic bilateral sympathicolysis of the T3 sympathetic ganglia is an effective ... more Background Thoracoscopic bilateral sympathicolysis of the T3 sympathetic ganglia is an effective treatment for palmar hyperhidrosis, though not without potential complications and consequences such as Horner's syndrome.

Surgical Endoscopy, 2010

To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic t... more To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis. From 2000 to 2008, 124 consecutive patients with primary spontaneous pneumothorax were operated; 105 were men (84.7%) and 19 were women (15.3%) with a mean age of 26.6 years (range 17-46 years). No mortality was recorded. Staging according to Vanderschueren's classification was as follows: stage I, 61 patients (45.9%); stage II, 39 patients (29.3%); stage III, 31 patients (23.3%); stage IV, two patients (1.5%). The overall rate of complications was 9% (12/133), corresponding to prolonged air leak in 9(6.7%) patients and hemothorax in 3(2.2%) patients. Four patients (3%) had recurrence requiring reoperation. There were no episodes of acute respiratory failure, pneumonia or subcutaneous emphysema following talc pleurodesis. Thoracoscopic pleural talc pleurodesis as a treatment for recurrent pneumothorax is easy, safe, and rapid, and causes minimal morbidity and mortality.

Annals of Surgical Oncology, 2013

This study was designed to describe the characteristics and survival of NSCLC patients treated wi... more This study was designed to describe the characteristics and survival of NSCLC patients treated with surgery and single pN1 disease, multiple pN1, and single unsuspected pN2. In 2005-2009, we treated 378 lung cancer patients with surgery with radical intent; 152 cases were pN1 or pN2. We excluded patients with neoadjuvant treatment, incomplete resection, incomplete lymph node dissection, metastasis, cN2 disease, multiple pN2, SCLC, and lack of PET-CT. All patients were staged with TNM 2010. We included 72 patients: 21 single pN1, 26 multiple pN1, and 25 single unsuspected pN2. Statistical analysis included descriptive statistics, chi-square test, Kaplan-Meier, log-rank test, and Cox proportional hazard model. The sample included 62 men (86 %) and 10 women (14 %), mean age 64 ± 9 years. The three subgroups did not show statistically significant differences in the main characteristics. Adjuvant treatment was performed in 56 patients (78 %). The 5 year overall survival (OS) for single pN1 was 73 %; for multiple pN1, 34 %; and for single unsuspected pN2, 25 % (P = 0.15). The mean OS for single pN1 was 63 ± 6 months; median OS for multiple pN1 was 45 (range, 42-48) months and for single pN2 was 54 (range, 32-77) months. Multivariate analysis found the following negative prognostic factors of OS: for single pN1, age, female sex, and microscopic intratumoral lymphatic and vascular invasion; for multiple pN1, ≤10 lymph nodes resected. Patients with single pN1 had better OS than patients with multiple pN1. Patients with single unsuspected pN2 had OS similar to that of multiple pN1.

European Respiratory Journal, Sep 1, 2012

Number: 3493 Publication Number: P665 Abstract Group: 1.4. Interventional Pulmonology Keyword 1: ... more Number: 3493 Publication Number: P665 Abstract Group: 1.4. Interventional Pulmonology Keyword 1: Bronchoscopy Keyword 2: Airway management Keyword 3: Surgery Title: Optimizing the treatment of inflammatory tracheal stenosis according to a morphometric classification

Journal of Thoracic Oncology

Conclusion: Underexpression of SFTPC in tumor samples was independently associated with worse pro... more Conclusion: Underexpression of SFTPC in tumor samples was independently associated with worse prognosis.

European Respiratory Journal, Sep 1, 2012

European Journal of Surgical Oncology

As nutritional status plays an important role in outcomes after surgery, this study evaluated the... more As nutritional status plays an important role in outcomes after surgery, this study evaluated the association between preoperative nutritional status (NS) and postoperative outcomes after major resection for lung cancer. We identified 219 patients with a diagnosis of cancer who underwent pulmonary resection from 2010 to 2012. Preoperative NS was assessed by anthropometric and biological parameters, body mass index (BMI), and the Nutritional Risk Index (NRI). We stratified this population into 4 BMI groups: underweight, normal weight, overweight and obese and 4 NRI groups: well-nourished; mildly malnourished; moderately malnourished and severely malnourished. The outcomes measured were postoperative complications; 30-day postoperative mortality; hospital length of stay (LOS), overall survival (OS) and disease-free survival (DFS). We performed both unadjusted analysis and adjusted multivariable analysis, controlling for statistically significant variables. Mean BMI and NRI were, respectively, 26.5 ± 4.3 and 112.4 ± 3.3. There were no significant differences between BMI categories and resection type, pathological stage, or overall postoperative complications. By contrast, significant differences (p < 0.05) in postoperative complications were observed among the NRI groups. LOS was longer in underweight and/or malnourished patients. In terms of OS, we found no significant differences according to NRI and BMI; however, patients with underweight had significantly shorter DFS compared with patients with overweight and obesity (log-rank p-value = 0.001). NS as measured by the NRI is an independent predictor of the risk of postsurgical complications, regardless of clinicopathologic characteristics. NRI might therefore be an useful tool for identifying early-stage lung cancer patients at risk for postoperative complications.

Surg Endosc, 2010

To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic t... more To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis. From 2000 to 2008, 124 consecutive patients with primary spontaneous pneumothorax were operated; 105 were men (84.7%) and 19 were women (15.3%) with a mean age of 26.6 years (range 17-46 years). No mortality was recorded. Staging according to Vanderschueren's classification was as follows: stage I, 61 patients (45.9%); stage II, 39 patients (29.3%); stage III, 31 patients (23.3%); stage IV, two patients (1.5%). The overall rate of complications was 9% (12/133), corresponding to prolonged air leak in 9(6.7%) patients and hemothorax in 3(2.2%) patients. Four patients (3%) had recurrence requiring reoperation. There were no episodes of acute respiratory failure, pneumonia or subcutaneous emphysema following talc pleurodesis. Thoracoscopic pleural talc pleurodesis as a treatment for recurrent pneumothorax is easy, safe, and rapid, and causes minimal morbidity and mortality.

Cir Espan, 2010

La hiperhidrosis primaria (HP) es un exceso de sudoración sin causa aparente. La HP es más frecue... more La hiperhidrosis primaria (HP) es un exceso de sudoración sin causa aparente. La HP es más frecuente en mujeres y en palmas, plantas y axilas. Los tratamientos médicos no son efectivos. La cirugía consiste en eliminar/desconectar los ganglios simpáticos T2 (HP craneofacial y rubor facial), T3 (HP palmar) y T3–T4 (HP axilar). Las técnicas quirúrgicas son la resección/transección, la ablación mediante electrocoagulación, la neuropresión con clip y la radiofrecuencia, fundamentalmente. La anhidrosis se consigue en el 95% de los pacientes. Menos del 5% presenta complicaciones y estas son menores. El efecto secundario más temido es la sudoración refleja, que se presenta en un 48% de los pacientes. La sudoración refleja es más frecuente en espalda, tórax y abdomen y aparece independientemente de la técnica utilizada. Un 90% de los pacientes están muy satisfechos tras la cirugía. Actualmente, la cirugía del simpático torácico es el gold estándar para la HP.Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent in women and in palms, soles and axillae. Medical treatment is not effective. The objective of the surgery is to remove or to disconnect sympathetic ganglia T2 (craniofacial PH or facial blushing), T3 (palmar PH) and T3–T4 (axillary PH). The surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. Anhidrosis is achieved in 95% of the patients. The overall rate of complications is less than 5% and these are minor complications. The most important unwanted effect is reflex sweating, presented in 48% of the patients. Reflex sweating is more frequent in back, thorax and abdomen and it appears independently of the surgical technique. Ninety percent of the patients are very satisfied after surgery. Nowadays, thoracic sympathetic surgery is the gold standard for primary hyperhidrosis.

General Thoracic and Cardiovascular Surgery, 2011

The primary intranodal schwannoma is an uncommon variant of schwannomas and extremely rare. We re... more The primary intranodal schwannoma is an uncommon variant of schwannomas and extremely rare. We report the case of a 70-year-old woman who was found to have a soft tissue opacity in the right hemithorax on chest posteroanterior radiography and signifi cant uptake of 18 F-fl uorodeoxyglucose on positron emission tomography. We performed thoracoscopic resection, and a defi nitive diagnosis of intranodal schwannoma was made from the pathological fi ndings.

Cirugía Española (English Edition), 2010

Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent... more Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent in women and in palms, soles and axillae. Medical treatment is not effective. The objective of the surgery is to remove or to disconnect sympathetic ganglia T2 (craniofacial PH or facial blushing), T3 (palmar PH) and T3-T4 (axillary PH). The surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. Anhidrosis is achieved in 95% of the patients. The overall rate of complications is less than 5% and these are minor complications. The most important unwanted effect is reflex sweating, presented in 48% of the patients. Reflex sweating is more frequent in back, thorax and abdomen and it appears independently of the surgical technique. Ninety percent of the patients are very satisfied after surgery. Nowadays, thoracic sympathetic surgery is the gold standard for primary hyperhidrosis.

Surgical Endoscopy, 2012

Background Thoracoscopic bilateral sympathicolysis of the T3 sympathetic ganglia is an effective ... more Background Thoracoscopic bilateral sympathicolysis of the T3 sympathetic ganglia is an effective treatment for palmar hyperhidrosis, though not without potential complications and consequences such as Horner's syndrome.

Surgical Endoscopy, 2010

To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic t... more To review our experience of treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis. From 2000 to 2008, 124 consecutive patients with primary spontaneous pneumothorax were operated; 105 were men (84.7%) and 19 were women (15.3%) with a mean age of 26.6 years (range 17-46 years). No mortality was recorded. Staging according to Vanderschueren's classification was as follows: stage I, 61 patients (45.9%); stage II, 39 patients (29.3%); stage III, 31 patients (23.3%); stage IV, two patients (1.5%). The overall rate of complications was 9% (12/133), corresponding to prolonged air leak in 9(6.7%) patients and hemothorax in 3(2.2%) patients. Four patients (3%) had recurrence requiring reoperation. There were no episodes of acute respiratory failure, pneumonia or subcutaneous emphysema following talc pleurodesis. Thoracoscopic pleural talc pleurodesis as a treatment for recurrent pneumothorax is easy, safe, and rapid, and causes minimal morbidity and mortality.

Annals of Surgical Oncology, 2013

This study was designed to describe the characteristics and survival of NSCLC patients treated wi... more This study was designed to describe the characteristics and survival of NSCLC patients treated with surgery and single pN1 disease, multiple pN1, and single unsuspected pN2. In 2005-2009, we treated 378 lung cancer patients with surgery with radical intent; 152 cases were pN1 or pN2. We excluded patients with neoadjuvant treatment, incomplete resection, incomplete lymph node dissection, metastasis, cN2 disease, multiple pN2, SCLC, and lack of PET-CT. All patients were staged with TNM 2010. We included 72 patients: 21 single pN1, 26 multiple pN1, and 25 single unsuspected pN2. Statistical analysis included descriptive statistics, chi-square test, Kaplan-Meier, log-rank test, and Cox proportional hazard model. The sample included 62 men (86 %) and 10 women (14 %), mean age 64 ± 9 years. The three subgroups did not show statistically significant differences in the main characteristics. Adjuvant treatment was performed in 56 patients (78 %). The 5 year overall survival (OS) for single pN1 was 73 %; for multiple pN1, 34 %; and for single unsuspected pN2, 25 % (P = 0.15). The mean OS for single pN1 was 63 ± 6 months; median OS for multiple pN1 was 45 (range, 42-48) months and for single pN2 was 54 (range, 32-77) months. Multivariate analysis found the following negative prognostic factors of OS: for single pN1, age, female sex, and microscopic intratumoral lymphatic and vascular invasion; for multiple pN1, ≤10 lymph nodes resected. Patients with single pN1 had better OS than patients with multiple pN1. Patients with single unsuspected pN2 had OS similar to that of multiple pN1.

European Respiratory Journal, Sep 1, 2012

Number: 3493 Publication Number: P665 Abstract Group: 1.4. Interventional Pulmonology Keyword 1: ... more Number: 3493 Publication Number: P665 Abstract Group: 1.4. Interventional Pulmonology Keyword 1: Bronchoscopy Keyword 2: Airway management Keyword 3: Surgery Title: Optimizing the treatment of inflammatory tracheal stenosis according to a morphometric classification