Nidhya Ganesan - Academia.edu (original) (raw)

Papers by Nidhya Ganesan

Infection Epidemiology and Microbiology

Backgrounds: This study aimed to analyze the applicability of platelet parameters in assessing th... more Backgrounds: This study aimed to analyze the applicability of platelet parameters in assessing the severity of COVID-19 disease. Materials & Methods: Patients with RT-PCR confirmed COVID-19 in the Pathology department of a tertiary care hospital in south India from June to December 2020 were included in this study. Clinical details and laboratory parameters of these patients were obtained. The difference between the studied variables in two groups was assessed using independent t-test. The optimum cutoff value of platelet to lymphocyte ratio (PLR) to differentiate between the tested groups was estimated using ROC (receiver operator curve) analysis. Findings: This study was conducted on 218 COVID-19 patients, of whom 17.9% showed thrombocytopenia at the time of admission. Among the hematological parameters, PLR, absolute lymphocyte count (ALC), platelet distribution width (PDW), D-dimer, and erythrocyte sedimentation rate (ESR) were significantly different between the ICU (intensive care unit) and non-ICU groups. Increased PLR values were associated with the disease severity. Conclusion: PLR could be used as an additional biomarker in assessing the severity of COVID-19 disease, and a cutoff value of 210.27 is optimal to differentiate severe COVID-19 disease from its mild and moderate forms with 79% specificity.

Journal of the College of Community Physicians of Sri Lanka

Indian Journal of Pediatrics

Iranian Journal of Pediatric Hematology & Oncology

Background: Early diagnosis of neonatal sepsis is quite challenging. I/T ratio (immature to matur... more Background: Early diagnosis of neonatal sepsis is quite challenging. I/T ratio (immature to mature neutrophil ratio) is a highly sensitive marker of sepsis but is time-consuming and subjective. Off late, volume conductivity and scatter (VCS) of neutrophils are among the newer parameters available for screening a septic neonate. This study aimed to determine the correlation between the I/T ratio and VCS parameters in neonatal sepsis and estimate a cut-off value of VCS parameters to diagnose neonatal sepsis using receiver operating curve analysis. Materials and Methods: This prospective observational study was conducted by the Department of Pathology and Neonatology from April 2019 to March 2020 in a tertiary care center. A total of 110 newborns were included in this study and were divided into two groups (probable sepsis and sepsis). Data were collected from the hospital database, and analysis was done using SPSS software. Correlation between the I/T ratio and VCS parameters was done...

Pathology - Research and Practice

Turkish Journal of Pathology, 2020

Objective: Hemoptysis is the expectoration of blood or blood-streaked sputum from the tracheobron... more Objective: Hemoptysis is the expectoration of blood or blood-streaked sputum from the tracheobronchial tree. The etiology may derive from nonneoplastic conditions such as infections, chronic pulmonary diseases, and vasculitis or neoplastic causes. Sometimes a definitive cause for hemoptysis cannot be found after ample diagnostic workup. The role of biopsy in such cases is to help the clinician in arriving at the final diagnosis. Diffuse alveolar hemorrhage is the main histopathological finding in hemoptysis and it appears with diffuse chest infiltrates radiologically. Material and Method: A retrospective study of 2 years duration was conducted to identify the morphological spectrum of diseases presenting with hemoptysis. A total of 243 lung biopsies obtained by various methods were retrieved in this study period and 20 cases with hemoptysis of undetermined etiology were detected. Results: Based on imaging and histopathology findings, the etiological causes of hemoptysis were divided into hemoptysis with and without capillaritis or due to tumor/tumor-like lesions and due to miscellaneous conditions. The most common etiology was vasculitis followed by infections. Conclusion: Histopathology helps to detect the etiology, particularly in cases of hemoptysis due to non-immunologic causes. In immunologic cases, histopathological findings may support the diagnosis in correlation with the clinical/imaging features.

Frontiers of Medicine, 2015

Pulmonary alveolar microlithiasis is a rare disease characterized by intra-alveolar presence of m... more Pulmonary alveolar microlithiasis is a rare disease characterized by intra-alveolar presence of microliths. This study reports an interesting case of pulmonary alveolar microlithiasis and provides a systematic review of cases reported from India. A 23-year-old female presented with a history of cough, wheeze, chest pain, and episodic wheeze for five months. Pulmonary function tests demonstrated an obstructive pattern, and chest Xray showed fine micronodular opacities predominantly involving the middle and lower zones of both lungs. Transbronchial lung biopsy revealed the diagnosis. She responded well to inhaled steroid therapy. A systematic review of literature was performed and identified 73 cases of pulmonary alveolar microlithiasis reported from India. The mean (SD) age of the patients was 28.8 (14.9) years, with an almost equal male:female ratio. Many patients were asymptomatic at presentation. Breathlessness and cough were the most common symptoms, and the disease progressed into respiratory failure associated with cor pulmonale. About one-third of the cases were initially misdiagnosed and treated as pulmonary tuberculosis. Extra-pulmonary manifestations and comorbidities were also evident in our series. This systematic review helps to determine epidemiological and clinical characteristics of pulmonary alveolar microlithiasis. Further research is needed to elucidate the etiopathogenesis, diagnosis, and therapeutic options, which are beneficial in developing and identifying costeffective treatment for pulmonary alveolar microlithiasis.

IntroductIon Identifying malignant cells in effusion fluid is of paramount importance in staging ... more IntroductIon Identifying malignant cells in effusion fluid is of paramount importance in staging and management of cancers. Differentiating reactive from malignant cases in effusion fluid is difficult at many times. We need a simple, inexpensive, and reliable tool to identify them. Micronucleus (MN) test is a simple test which is done on routine staining, thus avoiding the need of expensive methods and the use of immunocytochemistry panels and flow cytometry.[1-5]

We aimed to describe peripheral blood phagocytosis of platelets as a possible underlying mechanis... more We aimed to describe peripheral blood phagocytosis of platelets as a possible underlying mechanism of thrombocytopenia during the acute phase of dengue virus infection in a young male. Furthermore, enhanced platelet phagocytosis through the apoptotic mechanism is also briefly highlighted.

Turkish Journal of Pathology

Saudi Journal of Pathology and Microbiology, Sep 30, 2019

Bacterial contamination of transfusion products, especially platelets are the most common cause o... more Bacterial contamination of transfusion products, especially platelets are the most common cause of transfusion associated morbidity and mortality. Minimizing bacterial contamination in blood products is a priority for safe transfusion practices. A prospective study was done comparing the efficiency of two different disinfectant techniques by studying the flora on donor's arm before and after disinfection. This study was undertaken as there are very few reports on this important transfusion protocol from Southern India. Mean number of colonies in post disinfection swab culture with 2% povidone iodine was found to be greater than that of 2.5% Chlorhexidine in 75% isopropyl alcohol. 2.5% chlorhexidine disinfection offers more effective reduction in bacterial contamination than 2% povidone iodine group.

Journal of Cytology, 2017

International Journal of Medical Laboratory Research

Pneumatosisintestinalis (PI) also called as pneumatosis coli/ pneumatosiscystoidesintestinalis) i... more Pneumatosisintestinalis (PI) also called as pneumatosis coli/ pneumatosiscystoidesintestinalis) is the presence of multiple gas/ air filled cysts in the bowel wall. The pathogenesis is poorly understood and is probably multifactorial. The presentation may be either an incidental diagnosis or may be associated with various gastrointestinal diseases. We report a case of 76-year-old male presented with intestinal obstruction symptoms, diagnosed to be small bowel PI associated with lymphangiectasia. In this report we emphasize the pathogenesis of PI due to lymphatic disruption.

The Journal of Obstetrics and Gynecology of India

Indian Journal of Hematology and Blood Transfusion, 2017