Gao Zhennan - Academia.edu (original) (raw)
Papers by Gao Zhennan
Journal of Healthcare Engineering, 2022
In literature, antiosteoporotic effects of Angelica sinensis root have been confirmed, but the im... more In literature, antiosteoporotic effects of Angelica sinensis root have been confirmed, but the impact of Angelica sinensis polysaccharide (ASP) on osteoblastic or adipogenic distinction of BMSCs is limited. This paper aimed to explore the role of ASP on proliferation and differentiation of rat BMSCs. Rat BMSCs were subjected to isolation and identification through flow cytometry. The proliferation of rat BMSCs under ASP was performed by CCK-8 kit. Measures of osteogenesis under different concentrations of ASP were detected by using alizarin red staining for mesenchymal cells differentiation and ALP activity assay to identify ALP activity. Quantitative RT-PCR was selected to identify osteoblastic or adipogenic biomarkers from a genetic perspective. Likewise, we have evaluated measures of indicators of Wnt/β-catenin signal. ASP significantly promoted the proliferation, increased osteogenesis, and decreased adipogenesis of rat BMSCs within the limit of 20–60 mg/L in a dose-dependent ma...
Advances in Petroleum Exploration and Development, 2017
Taking Dongying Formation, Palaeogene, B Oilfield in Bohai Bay Basin as an example, this paper di... more Taking Dongying Formation, Palaeogene, B Oilfield in Bohai Bay Basin as an example, this paper discusses research on coupling 3D geological model and reservoir numerical simulation results during oilfield development. 3D geological modeling technology and reservoir numerical simulation plays important roles in oilfield development nowadays. 3D geological modeling integrates the static information and data from cores, logs and seismic to approach the reality of reservoir as much as possible. Numerical simulation based on geological models, provides a way to use dynamic data by history matching production. Thus, static data from the subsurface reservoir and dynamic data from production are synthesized with the combination of 3D geological modeling and numerical simulation. At present, except upscaling, which connected these two steps, modeling and simulation are usually discussed and operated separately. This paper tried to find an approach to realize the couple of 3D geological model...
The LD5-2N block is a typical heavy oil reservoir in Bohai offshore oilfield, and the viscosity o... more The LD5-2N block is a typical heavy oil reservoir in Bohai offshore oilfield, and the viscosity of crude oil for this block at reservoir condition is about 10000mPa.s. Therefore, the conventional exploitation method of water flooding or chemical flooding will be not suitable for this block, and the thermal recovery should be considered. Using the method of numerical simulation, the steam assisted gravity drainage (SAGD) process for this block is investigated in this paper. Firstly, a sensitivity analysis process of reservoir properties and fluid parameters is con- ducted, e.g., reservoir thickness, oil viscosity, permeability, the vertical-horizontal permeability ratio etc. Then, on account of the shale cases in this block, an orthog- onal test is carried out to study the influences of shale barriers on SAGD process. Results indicate that the parameters of reservoir thickness, reservoir permeability have a significantly influence on the recovery rate of SAGD process. For a SAGD proc...
Industrial Crops and Products, 2021
Biomass Conversion and Biorefinery, 2021
Bioresource Technology, 2021
In this study, different metal-salt catalyzed pretreatment was presented to disorganize the obsti... more In this study, different metal-salt catalyzed pretreatment was presented to disorganize the obstinate structure by eliminating the majority of hemicellulose, fractional of lignin, and improve the enzymatic saccharification of sugarcane bagasse. With the accession of Tween 80 during enzymolysis, all metal-salt pretreated substrates presented higher glucose yields, especially for CuCl2. Furthermore, Tween 80 was added to the pretreatment, enhancing the elimination of hemicellulose and lignin, decreasing the degradation of sugars to inhibitors, and presenting superior performance on improving glucose yield. In addition, the maximum glucose yield of 88.0% was achieved by using Tween 80 concomitantly with AlCl3 pretreatment and enzymolysis. It was also found that adding Tween 80 during pretreatment or/and enzymolysis after 24 h could liberate the similar glucose without Tween 80 after 72 h. However, the enhancement of Tween 80 at 6 h was higher than that at 72 h.
International Journal of Nanomedicine, 2019
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumo... more Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor in the world. Studies in recent years have demonstrated that cancer stem cells (CSCs) are present in many tumor tissues, including HNSCC, and CSCs are the root cause of tumor recurrence and metastasis. Thus, taking new treatment measures to target the killing of CSCs that are resistant to chemotherapy and radiotherapy is key to the success of cancer treatment. Methods: We explored a method for preparing anti-CD44 antibody-modified superparamagnetic iron oxide nanoparticles (SPIONPs). Biocompatibility was evaluated by a CCK-8 assay. The CSCs were obtained by a 3D cell culture technique from Cal-27 (human oral squamous cell carcinoma) cells, and then the CSCs were identified by quantitative real-time polymerase chain reaction (qRT-PCR). The targeting efficiency of the CD44-SPIONPs to CSCs was confirmed by Prussian blue staining and visualized by laser scanning confocal microscopy (LSCM). Flow cytometry was used to detect the apoptosis of CSCs after alternating magnetic field (AMF) treatment. The efficacy of tumor growth inhibition by CD44-SPIONP-mediated magnetic hyperthermia therapy was evaluated with tumor xenografts in nude mice. Results: The CD44-SPIONPs exhibited no negative effect on CSCs, indicating good biocompatibility. After SPIONPs were cocultured with stem cells, the majority of CD44-SPIONPs labeled with FITC penetrated the cell membrane into the cytoplasm. After AMF treatment, CD44-SPIONPs induced CSCs to undergo programmed death. The inhibitory ratio of the treated group was 33.43%, and necrotic areas in the tumor tissue were mainly distributed around the magnetic fluid. Conclusion: These results demonstrate that it is possible to kill CSCs using targeted magnetic nanoparticles and an AMF and that magnetic fluid hyperthermia significantly inhibited the growth of grafted Cal-27 tumors in mice.
SPE Asia Pacific Oil and Gas Conference and Exhibition, 2018
After more than 20 years’ development, S oilfield has entered high water cut stage. The layer con... more After more than 20 years’ development, S oilfield has entered high water cut stage. The layer contradiction is prominent and the water flooding condition is complex, which result in the complex decentralized state of the remaining oil. In order to determine the remaining oil distribution to guide the comprehensive adjustment of the oilfield, the reservoir architecture analysis of delta front was conducted. Based on the core, seismic data, dense well logging data and production performance data, the reservoir architecture of delta front in Dongying group is characterized with hierarchy process, model guidance and numerical simulation methods. In the paper, the distribution style of interlayers in single mouth bar is discussed. The distribution feature of the remaining oil under the control of interlayers is analyzed. It shows that multiple main channels form continuous mouth bar complex and single mouth bar develops several accretions. Interlayers in single mouth bar express in two f...
Offshore Technology Conference, 2019
Bohai oilfield located at Bohai Bay of China mainly consists of complex clastic reservoirs. Reser... more Bohai oilfield located at Bohai Bay of China mainly consists of complex clastic reservoirs. Reservoir prediction is difficult especially in the deep depth oilfields because of low seismic resolution. In addition, how to quantitatively characterize the risk of new oilfield development and how to build a more elaborate model in the late period of oilfield development are particularly challenging. This paper developed an innovative workflow for complex clastic reservoir characterization of offshore oilfield. A modeling method based on sedimentary evolution simulation, which can provide modeling constraints, is proposed for deep depth oilfields. Through sedimentary evolution modeling and other information, reservoir and structure uncertainty are analyzed, then reserves scale and reservoir connectivity are evaluated through experimental design, geological modeling and streamline simulation; 3p models are selected lastly. A new method is proposed for building an elaborate model of old oil...
The Journal of Portfolio Management, 2019
In this article, by investigating return predictability across a transnational supply chain, the ... more In this article, by investigating return predictability across a transnational supply chain, the authors present new evidence supporting the hypothesis that value-relevant information diffuses gradually in financial markets because of limited attention from investors. They find that the corresponding trading strategy delivers superior abnormal return. Using a sample of supply chains between Chinese customers and US suppliers from 2009 to 2015 and corresponding financial and return data, the authors show that Chinese customer returns can predict US supplier future return at the firm level. A long–short portfolio strategy based on these findings yields significant abnormal monthly returns of 2.179% (equal-weighted portfolio) in the Fama–French five-factor model. The authors also employ Fama–MacBeth regression analysis and propensity score matching–matched sample analysis, and the conclusions continue to hold.
Fuel, 2018
In heavy oil reservoirs, steam channeling and steam override seriously decrease oil production an... more In heavy oil reservoirs, steam channeling and steam override seriously decrease oil production and the ultimate oil recovery during steam flooding. Aiming at the two problems, some experiments were carried out to analyze the EOR mechanisms through injecting foaming agents along with steam injection in heavy oil reservoirs. An orthogonal method was employed to analyze the multiple factors on foam's properties to optimize foaming agent for steam injection. Then a novel 2D-visualization experiment was carried out to quantitatively study the characteristics of steam channeling and the variation of sweep efficiency during steam or steam foams flooding. Based on the experimental results, many bubble's characteristics, such as migration, retention, regeneration and etc., were analyzed through the macroscopic and microscopic perspectives. The experimental results show that the Jamin effect increases the flow resistance of steam-phase in porous media to obviously enlarge the macro sweep efficiency and effectively increase micro oil displacement efficiency. On a macroscopic level, because of the unique structure, foams decrease steam override or steam channeling to improve sweep efficiency; on a microscopic level, due to the expansion effect of gas-phase, bubbles can desquamate the oil film on the pore wall and even the oil drop in the blind pore to decrease the residual oil saturation. In our experiments, the ultimate recovery of steam flooding can only reach 48.48%. However, the ultimate recovery of steam foams can reach 59.95%, which is 11.47% higher than steam flooding.
Financial Management, 2017
This paper examines the relationship between mutual fund managers' past professional backgrounds ... more This paper examines the relationship between mutual fund managers' past professional backgrounds and their portfolio performance, using Chinese mutual fund data from 2003 to 2016. We focus on managers with prior work experience either as industry analysts or as macro analysts, the two most common career paths for Chinese fund managers. We hypothesize that managers who worked as industry analysts exhibit superior stock-picking skills, while managers with a background as macro analysts are more skillful in timing the market. These hypotheses are supported by the data, even after controlling for observable fund and manager characteristics. Bootstrap analyses suggest that the significant difference in performance between these two types of managers cannot be attributed purely to luck.
International Journal of Oil, Gas and Coal Technology, 2015
Miscible gas injection processes are among the effective methods for enhanced oil recovery. Aimin... more Miscible gas injection processes are among the effective methods for enhanced oil recovery. Aiming at three different types of light oil reservoir, we study the feasibility of miscible gas flooding of light oil reservoirs using the method of physical simulation. Several slimtube displacement experiments with different injected gases are carried out at the various pressure levels. These injected gases include carbon dioxide, hydrocarbon gas and flue gas. Thus, the minimum miscibility pressures of gas-oil system are studied, and the influence of oil components, injected gas, and reservoir properties on MMP are also discussed. Thereafter, we do a survey on the multiple-parameter correlations of CO2-oil MMP prediction. Then, two models are selected to correct for accurately predicting the CO2-oil MMP in this reservoir. This study could be used as a tool for the successful design of miscible gas injection project to enhance crude oil recovery in light oil reservoirs. [Received: February 23, 2013; Accepted: June 6, 2013]
Journal of Coal Science and Engineering (China), 2008
The composition analysis of coal-derived light oil * GAO Zhen-nan(高振楠), LIU Li-lin(刘立麟), ZHU Xiao... more The composition analysis of coal-derived light oil * GAO Zhen-nan(高振楠), LIU Li-lin(刘立麟), ZHU Xiao-man(朱肖曼), LI Wen-bo(李文博)
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2002
The purpose of this study is to investigate the synergistic effects of human tumor necrosis facto... more The purpose of this study is to investigate the synergistic effects of human tumor necrosis factor-alpha (hTNF-alpha) transfection and interferon-gamma (IFN-gamma) on the growth of tongue carcinoma cells. The cultured Tca8113 tongue carcinoma cells was divided into 2 groups, one group was transferred with hTNF-alpha gene. Each of the 2 groups was then divided into 5 subgroups, and the subgroups were added IFN-gamma until the final IFN-gamma concentrations respectively were 0, 10, 100, and 1000 U/ml. After culturing for 48 hours, the survival rates of the all groups of cells were assayed by MTT enzymatic labeling technique, and the expression of hTNF-alpha in Tca8113 cells was observed with immunocytochemistry. IFN-gamma did not affect the growth of Tca8113 cells without hTNF-alpha, however, the transfection of hTNF-alpha with the above different concentrations of IFN-gamma synergistically inhibited the growth of Tca8113 cells, the concentrations of IFN-gamma were positively correlat...
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2002
The aim of this study was to investigate suppression effects of the transfection of human tumor n... more The aim of this study was to investigate suppression effects of the transfection of human tumor necrosis factor-alpha (hTNF-alpha) gene on tongue carcinoma cells. The shuttle plasmid containing hTNF-alpha gene was extracted and purified, then it was transferred into Tca8113 tongue carcinoma cells with cationic liposome DOSPER. The control group was only given equivalent liposomes, except the plasmid. After culturing for 24, 48, 72 and 96 hours, the expression of hTNF-alpha gene in Tca8113 cells was analysed by ELISA and, the survival rate of transferred cells was assayed by MTT enzymatic labeling technique. The transferred Tca8113 cells displayed significantly overexpression of hTNF-alpha (P < 0.05). The survival rate of the transferred Tca8113 cells was decreased significantly (P < 0.05). Transfection of hTNF-alpha gene in vitro mediated by cationic liposomes can induce the overexpression of hTNF-alpha and inhibit the growth of tongue carcinoma cells.
Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2005
To evaluate the results of two kinds of sinus lifting techniques with simultaneous implant placem... more To evaluate the results of two kinds of sinus lifting techniques with simultaneous implant placement. 31 maxillary sinus underwent two kinds of sinus lifting techniques and simultaneously 42 implants placement. The sinuses were observed 1, 3, 6 months after the surgery. There were no implants loose or lost; X ray examination showed well osseointegration and no maxillary sinusitis. All the patients finished implant prosthesis in 6 months postoperatively. Through 6-36 months' follow-up, clinical results were satisfactory. With properly handling of indication and the operation skill, the results of two kinds of maxillary sinus lifting techniques with bone grafting and simultaneously implants placement are both satisfactory.
Oral Oncology, 2007
The aim of the present study was to assess the anti-tumor effect of a defective adenovirus that e... more The aim of the present study was to assess the anti-tumor effect of a defective adenovirus that expresses soluble vascular endothelial growth factor (VEGF) receptor FLT-1 (AdsFLT-1) in combination with cisplatin (cis-diamminedichloroplatinum, DDP) on human tongue carcinoma Tca8113 cell xenografts that had been pre-established in nude mice. In vitro, Tca8113 cells secreted soluble FLT-1 (sFLT-1) after infection with AdsFLT-1, and the conditioned medium from AdsFLT-1-treated Tca8113 cells seemed to inhibit VEGF-induced proliferation of human umbilical vein endothelial cells. The combined effects of sFLT-1 gene therapy and DDP chemotherapy was then studied in well-established Tca8113 xenografts. The concentration of sFLT-1 in serum reached a peak 8 days after intratumoral injection of AdsFLT-1. In these tumors, AdsFLT-1 intratumoral injections had only a small effect. Interestingly, when the cells were also exposed to DDP chemotherapy, significantly higher (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05), and possibly synergistic, anti-tumoral effects were observed that were highly correlated to a marked reduction in intratumoral vascularization and an increase in tumor-cell apoptosis. Together, these data emphasize the potential of combining an anti-angiogenic gene therapy strategy with a destructive approach directed against the tumor cells to fight human tongue carcinoma.
International Journal of Cancer, 2004
Vesicular stomatitis virus (VSV) has been shown to replicate rapidly in vitro and kill selectivel... more Vesicular stomatitis virus (VSV) has been shown to replicate rapidly in vitro and kill selectively a variety of tumor cell lines. The present study was designed to determine whether gemcitabine potentiates the antitumor activity of VSV in vitro and in vivo. A549 human lung adenocarcinoma cells and LLC Lewis lung carcinoma cells were treated with VSV (0.1-10 plaque-forming units per cell) plus gemcitabine (20 nM to 20 microM). Mice bearing A549 or LLC were treated with VSV (5 x 10(4) to 1 x 10(8) plaque-forming units) daily for 5 days plus gemcitabine (5-125 mg/kg/day) once every 3 days for 4 times. Induction of apoptosis and effects on growth inhibition were assessed. The lung cancer cells treated with VSV plus gemcitabine displayed the apparently increased apoptotic cells compared with treatment with VSV or gemcitabine alone. The combined treatment with VSV plus gemcitabine induced the apparent antitumor activity with complete regression of the established lung cancer in both A549 and LLC lung cancer models and augmented the induction of apoptosis in lung cancer cells in vivo as well. This study suggests that the combined treatment with VSV plus gemcitabine may augment the induction of apoptosis in lung cancer cells in vitro and in vivo, and that the augmented antitumor activity in vivo may result from the increased induction of apoptosis in lung cancer cells. The present findings may be of importance to the further exploration of the potential application of this combined approach in the treatment of lung cancer.
Journal of Healthcare Engineering, 2022
In literature, antiosteoporotic effects of Angelica sinensis root have been confirmed, but the im... more In literature, antiosteoporotic effects of Angelica sinensis root have been confirmed, but the impact of Angelica sinensis polysaccharide (ASP) on osteoblastic or adipogenic distinction of BMSCs is limited. This paper aimed to explore the role of ASP on proliferation and differentiation of rat BMSCs. Rat BMSCs were subjected to isolation and identification through flow cytometry. The proliferation of rat BMSCs under ASP was performed by CCK-8 kit. Measures of osteogenesis under different concentrations of ASP were detected by using alizarin red staining for mesenchymal cells differentiation and ALP activity assay to identify ALP activity. Quantitative RT-PCR was selected to identify osteoblastic or adipogenic biomarkers from a genetic perspective. Likewise, we have evaluated measures of indicators of Wnt/β-catenin signal. ASP significantly promoted the proliferation, increased osteogenesis, and decreased adipogenesis of rat BMSCs within the limit of 20–60 mg/L in a dose-dependent ma...
Advances in Petroleum Exploration and Development, 2017
Taking Dongying Formation, Palaeogene, B Oilfield in Bohai Bay Basin as an example, this paper di... more Taking Dongying Formation, Palaeogene, B Oilfield in Bohai Bay Basin as an example, this paper discusses research on coupling 3D geological model and reservoir numerical simulation results during oilfield development. 3D geological modeling technology and reservoir numerical simulation plays important roles in oilfield development nowadays. 3D geological modeling integrates the static information and data from cores, logs and seismic to approach the reality of reservoir as much as possible. Numerical simulation based on geological models, provides a way to use dynamic data by history matching production. Thus, static data from the subsurface reservoir and dynamic data from production are synthesized with the combination of 3D geological modeling and numerical simulation. At present, except upscaling, which connected these two steps, modeling and simulation are usually discussed and operated separately. This paper tried to find an approach to realize the couple of 3D geological model...
The LD5-2N block is a typical heavy oil reservoir in Bohai offshore oilfield, and the viscosity o... more The LD5-2N block is a typical heavy oil reservoir in Bohai offshore oilfield, and the viscosity of crude oil for this block at reservoir condition is about 10000mPa.s. Therefore, the conventional exploitation method of water flooding or chemical flooding will be not suitable for this block, and the thermal recovery should be considered. Using the method of numerical simulation, the steam assisted gravity drainage (SAGD) process for this block is investigated in this paper. Firstly, a sensitivity analysis process of reservoir properties and fluid parameters is con- ducted, e.g., reservoir thickness, oil viscosity, permeability, the vertical-horizontal permeability ratio etc. Then, on account of the shale cases in this block, an orthog- onal test is carried out to study the influences of shale barriers on SAGD process. Results indicate that the parameters of reservoir thickness, reservoir permeability have a significantly influence on the recovery rate of SAGD process. For a SAGD proc...
Industrial Crops and Products, 2021
Biomass Conversion and Biorefinery, 2021
Bioresource Technology, 2021
In this study, different metal-salt catalyzed pretreatment was presented to disorganize the obsti... more In this study, different metal-salt catalyzed pretreatment was presented to disorganize the obstinate structure by eliminating the majority of hemicellulose, fractional of lignin, and improve the enzymatic saccharification of sugarcane bagasse. With the accession of Tween 80 during enzymolysis, all metal-salt pretreated substrates presented higher glucose yields, especially for CuCl2. Furthermore, Tween 80 was added to the pretreatment, enhancing the elimination of hemicellulose and lignin, decreasing the degradation of sugars to inhibitors, and presenting superior performance on improving glucose yield. In addition, the maximum glucose yield of 88.0% was achieved by using Tween 80 concomitantly with AlCl3 pretreatment and enzymolysis. It was also found that adding Tween 80 during pretreatment or/and enzymolysis after 24 h could liberate the similar glucose without Tween 80 after 72 h. However, the enhancement of Tween 80 at 6 h was higher than that at 72 h.
International Journal of Nanomedicine, 2019
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumo... more Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor in the world. Studies in recent years have demonstrated that cancer stem cells (CSCs) are present in many tumor tissues, including HNSCC, and CSCs are the root cause of tumor recurrence and metastasis. Thus, taking new treatment measures to target the killing of CSCs that are resistant to chemotherapy and radiotherapy is key to the success of cancer treatment. Methods: We explored a method for preparing anti-CD44 antibody-modified superparamagnetic iron oxide nanoparticles (SPIONPs). Biocompatibility was evaluated by a CCK-8 assay. The CSCs were obtained by a 3D cell culture technique from Cal-27 (human oral squamous cell carcinoma) cells, and then the CSCs were identified by quantitative real-time polymerase chain reaction (qRT-PCR). The targeting efficiency of the CD44-SPIONPs to CSCs was confirmed by Prussian blue staining and visualized by laser scanning confocal microscopy (LSCM). Flow cytometry was used to detect the apoptosis of CSCs after alternating magnetic field (AMF) treatment. The efficacy of tumor growth inhibition by CD44-SPIONP-mediated magnetic hyperthermia therapy was evaluated with tumor xenografts in nude mice. Results: The CD44-SPIONPs exhibited no negative effect on CSCs, indicating good biocompatibility. After SPIONPs were cocultured with stem cells, the majority of CD44-SPIONPs labeled with FITC penetrated the cell membrane into the cytoplasm. After AMF treatment, CD44-SPIONPs induced CSCs to undergo programmed death. The inhibitory ratio of the treated group was 33.43%, and necrotic areas in the tumor tissue were mainly distributed around the magnetic fluid. Conclusion: These results demonstrate that it is possible to kill CSCs using targeted magnetic nanoparticles and an AMF and that magnetic fluid hyperthermia significantly inhibited the growth of grafted Cal-27 tumors in mice.
SPE Asia Pacific Oil and Gas Conference and Exhibition, 2018
After more than 20 years’ development, S oilfield has entered high water cut stage. The layer con... more After more than 20 years’ development, S oilfield has entered high water cut stage. The layer contradiction is prominent and the water flooding condition is complex, which result in the complex decentralized state of the remaining oil. In order to determine the remaining oil distribution to guide the comprehensive adjustment of the oilfield, the reservoir architecture analysis of delta front was conducted. Based on the core, seismic data, dense well logging data and production performance data, the reservoir architecture of delta front in Dongying group is characterized with hierarchy process, model guidance and numerical simulation methods. In the paper, the distribution style of interlayers in single mouth bar is discussed. The distribution feature of the remaining oil under the control of interlayers is analyzed. It shows that multiple main channels form continuous mouth bar complex and single mouth bar develops several accretions. Interlayers in single mouth bar express in two f...
Offshore Technology Conference, 2019
Bohai oilfield located at Bohai Bay of China mainly consists of complex clastic reservoirs. Reser... more Bohai oilfield located at Bohai Bay of China mainly consists of complex clastic reservoirs. Reservoir prediction is difficult especially in the deep depth oilfields because of low seismic resolution. In addition, how to quantitatively characterize the risk of new oilfield development and how to build a more elaborate model in the late period of oilfield development are particularly challenging. This paper developed an innovative workflow for complex clastic reservoir characterization of offshore oilfield. A modeling method based on sedimentary evolution simulation, which can provide modeling constraints, is proposed for deep depth oilfields. Through sedimentary evolution modeling and other information, reservoir and structure uncertainty are analyzed, then reserves scale and reservoir connectivity are evaluated through experimental design, geological modeling and streamline simulation; 3p models are selected lastly. A new method is proposed for building an elaborate model of old oil...
The Journal of Portfolio Management, 2019
In this article, by investigating return predictability across a transnational supply chain, the ... more In this article, by investigating return predictability across a transnational supply chain, the authors present new evidence supporting the hypothesis that value-relevant information diffuses gradually in financial markets because of limited attention from investors. They find that the corresponding trading strategy delivers superior abnormal return. Using a sample of supply chains between Chinese customers and US suppliers from 2009 to 2015 and corresponding financial and return data, the authors show that Chinese customer returns can predict US supplier future return at the firm level. A long–short portfolio strategy based on these findings yields significant abnormal monthly returns of 2.179% (equal-weighted portfolio) in the Fama–French five-factor model. The authors also employ Fama–MacBeth regression analysis and propensity score matching–matched sample analysis, and the conclusions continue to hold.
Fuel, 2018
In heavy oil reservoirs, steam channeling and steam override seriously decrease oil production an... more In heavy oil reservoirs, steam channeling and steam override seriously decrease oil production and the ultimate oil recovery during steam flooding. Aiming at the two problems, some experiments were carried out to analyze the EOR mechanisms through injecting foaming agents along with steam injection in heavy oil reservoirs. An orthogonal method was employed to analyze the multiple factors on foam's properties to optimize foaming agent for steam injection. Then a novel 2D-visualization experiment was carried out to quantitatively study the characteristics of steam channeling and the variation of sweep efficiency during steam or steam foams flooding. Based on the experimental results, many bubble's characteristics, such as migration, retention, regeneration and etc., were analyzed through the macroscopic and microscopic perspectives. The experimental results show that the Jamin effect increases the flow resistance of steam-phase in porous media to obviously enlarge the macro sweep efficiency and effectively increase micro oil displacement efficiency. On a macroscopic level, because of the unique structure, foams decrease steam override or steam channeling to improve sweep efficiency; on a microscopic level, due to the expansion effect of gas-phase, bubbles can desquamate the oil film on the pore wall and even the oil drop in the blind pore to decrease the residual oil saturation. In our experiments, the ultimate recovery of steam flooding can only reach 48.48%. However, the ultimate recovery of steam foams can reach 59.95%, which is 11.47% higher than steam flooding.
Financial Management, 2017
This paper examines the relationship between mutual fund managers' past professional backgrounds ... more This paper examines the relationship between mutual fund managers' past professional backgrounds and their portfolio performance, using Chinese mutual fund data from 2003 to 2016. We focus on managers with prior work experience either as industry analysts or as macro analysts, the two most common career paths for Chinese fund managers. We hypothesize that managers who worked as industry analysts exhibit superior stock-picking skills, while managers with a background as macro analysts are more skillful in timing the market. These hypotheses are supported by the data, even after controlling for observable fund and manager characteristics. Bootstrap analyses suggest that the significant difference in performance between these two types of managers cannot be attributed purely to luck.
International Journal of Oil, Gas and Coal Technology, 2015
Miscible gas injection processes are among the effective methods for enhanced oil recovery. Aimin... more Miscible gas injection processes are among the effective methods for enhanced oil recovery. Aiming at three different types of light oil reservoir, we study the feasibility of miscible gas flooding of light oil reservoirs using the method of physical simulation. Several slimtube displacement experiments with different injected gases are carried out at the various pressure levels. These injected gases include carbon dioxide, hydrocarbon gas and flue gas. Thus, the minimum miscibility pressures of gas-oil system are studied, and the influence of oil components, injected gas, and reservoir properties on MMP are also discussed. Thereafter, we do a survey on the multiple-parameter correlations of CO2-oil MMP prediction. Then, two models are selected to correct for accurately predicting the CO2-oil MMP in this reservoir. This study could be used as a tool for the successful design of miscible gas injection project to enhance crude oil recovery in light oil reservoirs. [Received: February 23, 2013; Accepted: June 6, 2013]
Journal of Coal Science and Engineering (China), 2008
The composition analysis of coal-derived light oil * GAO Zhen-nan(高振楠), LIU Li-lin(刘立麟), ZHU Xiao... more The composition analysis of coal-derived light oil * GAO Zhen-nan(高振楠), LIU Li-lin(刘立麟), ZHU Xiao-man(朱肖曼), LI Wen-bo(李文博)
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2002
The purpose of this study is to investigate the synergistic effects of human tumor necrosis facto... more The purpose of this study is to investigate the synergistic effects of human tumor necrosis factor-alpha (hTNF-alpha) transfection and interferon-gamma (IFN-gamma) on the growth of tongue carcinoma cells. The cultured Tca8113 tongue carcinoma cells was divided into 2 groups, one group was transferred with hTNF-alpha gene. Each of the 2 groups was then divided into 5 subgroups, and the subgroups were added IFN-gamma until the final IFN-gamma concentrations respectively were 0, 10, 100, and 1000 U/ml. After culturing for 48 hours, the survival rates of the all groups of cells were assayed by MTT enzymatic labeling technique, and the expression of hTNF-alpha in Tca8113 cells was observed with immunocytochemistry. IFN-gamma did not affect the growth of Tca8113 cells without hTNF-alpha, however, the transfection of hTNF-alpha with the above different concentrations of IFN-gamma synergistically inhibited the growth of Tca8113 cells, the concentrations of IFN-gamma were positively correlat...
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2002
The aim of this study was to investigate suppression effects of the transfection of human tumor n... more The aim of this study was to investigate suppression effects of the transfection of human tumor necrosis factor-alpha (hTNF-alpha) gene on tongue carcinoma cells. The shuttle plasmid containing hTNF-alpha gene was extracted and purified, then it was transferred into Tca8113 tongue carcinoma cells with cationic liposome DOSPER. The control group was only given equivalent liposomes, except the plasmid. After culturing for 24, 48, 72 and 96 hours, the expression of hTNF-alpha gene in Tca8113 cells was analysed by ELISA and, the survival rate of transferred cells was assayed by MTT enzymatic labeling technique. The transferred Tca8113 cells displayed significantly overexpression of hTNF-alpha (P < 0.05). The survival rate of the transferred Tca8113 cells was decreased significantly (P < 0.05). Transfection of hTNF-alpha gene in vitro mediated by cationic liposomes can induce the overexpression of hTNF-alpha and inhibit the growth of tongue carcinoma cells.
Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2005
To evaluate the results of two kinds of sinus lifting techniques with simultaneous implant placem... more To evaluate the results of two kinds of sinus lifting techniques with simultaneous implant placement. 31 maxillary sinus underwent two kinds of sinus lifting techniques and simultaneously 42 implants placement. The sinuses were observed 1, 3, 6 months after the surgery. There were no implants loose or lost; X ray examination showed well osseointegration and no maxillary sinusitis. All the patients finished implant prosthesis in 6 months postoperatively. Through 6-36 months' follow-up, clinical results were satisfactory. With properly handling of indication and the operation skill, the results of two kinds of maxillary sinus lifting techniques with bone grafting and simultaneously implants placement are both satisfactory.
Oral Oncology, 2007
The aim of the present study was to assess the anti-tumor effect of a defective adenovirus that e... more The aim of the present study was to assess the anti-tumor effect of a defective adenovirus that expresses soluble vascular endothelial growth factor (VEGF) receptor FLT-1 (AdsFLT-1) in combination with cisplatin (cis-diamminedichloroplatinum, DDP) on human tongue carcinoma Tca8113 cell xenografts that had been pre-established in nude mice. In vitro, Tca8113 cells secreted soluble FLT-1 (sFLT-1) after infection with AdsFLT-1, and the conditioned medium from AdsFLT-1-treated Tca8113 cells seemed to inhibit VEGF-induced proliferation of human umbilical vein endothelial cells. The combined effects of sFLT-1 gene therapy and DDP chemotherapy was then studied in well-established Tca8113 xenografts. The concentration of sFLT-1 in serum reached a peak 8 days after intratumoral injection of AdsFLT-1. In these tumors, AdsFLT-1 intratumoral injections had only a small effect. Interestingly, when the cells were also exposed to DDP chemotherapy, significantly higher (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05), and possibly synergistic, anti-tumoral effects were observed that were highly correlated to a marked reduction in intratumoral vascularization and an increase in tumor-cell apoptosis. Together, these data emphasize the potential of combining an anti-angiogenic gene therapy strategy with a destructive approach directed against the tumor cells to fight human tongue carcinoma.
International Journal of Cancer, 2004
Vesicular stomatitis virus (VSV) has been shown to replicate rapidly in vitro and kill selectivel... more Vesicular stomatitis virus (VSV) has been shown to replicate rapidly in vitro and kill selectively a variety of tumor cell lines. The present study was designed to determine whether gemcitabine potentiates the antitumor activity of VSV in vitro and in vivo. A549 human lung adenocarcinoma cells and LLC Lewis lung carcinoma cells were treated with VSV (0.1-10 plaque-forming units per cell) plus gemcitabine (20 nM to 20 microM). Mice bearing A549 or LLC were treated with VSV (5 x 10(4) to 1 x 10(8) plaque-forming units) daily for 5 days plus gemcitabine (5-125 mg/kg/day) once every 3 days for 4 times. Induction of apoptosis and effects on growth inhibition were assessed. The lung cancer cells treated with VSV plus gemcitabine displayed the apparently increased apoptotic cells compared with treatment with VSV or gemcitabine alone. The combined treatment with VSV plus gemcitabine induced the apparent antitumor activity with complete regression of the established lung cancer in both A549 and LLC lung cancer models and augmented the induction of apoptosis in lung cancer cells in vivo as well. This study suggests that the combined treatment with VSV plus gemcitabine may augment the induction of apoptosis in lung cancer cells in vitro and in vivo, and that the augmented antitumor activity in vivo may result from the increased induction of apoptosis in lung cancer cells. The present findings may be of importance to the further exploration of the potential application of this combined approach in the treatment of lung cancer.