Gary Dorfman - Academia.edu (original) (raw)
Papers by Gary Dorfman
Clinical Cancer Research, 2008
Critical Care Medicine, Nov 1, 1988
Two potential errors of pulmonary artery wedge pressure measurement that have received little att... more Two potential errors of pulmonary artery wedge pressure measurement that have received little attention are improper anatomic referencing of the transducer and nondependent placement of the pulmonary artery catheter tip. Transducers are often referenced to the midaxillary line of the supine patient. We utilized CT of the chest to determine accurately the topographic location of the left atrium to evaluate the accuracy of referencing the transducer in this position and to investigate atrial location in the lateral decubitus positions vis-à-vis external landmarks, so that more accurate referencing could be performed with a pulmonary artery catheter tip in the dependent lung. A prospective group consisting of ten patients referred for chest CT as well as retrospective review of 40 chest CT scans served as the study population. This study demonstrated a discrepancy between the perceived midaxillary line and the true location of the midleft atrium. Lateral decubitus CT scanning revealed a more readily localizable surface anatomic landmark which consistently and accurately predicts midleft atrial location. In addition, the appropriate decubitus position guarantees dependent catheter tip placement (Zone 3).
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Jan 16, 2015
The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studi... more The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studies within the context of single- and multi-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of the imaging. The aim is to minimize intra- and inter-subject, intra- and inter-platform, inter-examination, and inter-institutional variability of primary and/or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The full document is available on line. The main subjects areas in the document are: Context of the imaging protocol within the clinical trial, Site selection, Qualification and training, Subject scheduling, Subject preparation, Imaging related substance preparation and administration, Imaging procedure, Image post-processing, Image analysis, Image interpretation, Archival and distribution of data, Quality control, and Im...
Radiology, 2011
Quantitative imaging biomarkers could speed the development of new treatments for unmet medical n... more Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often referred to as pathways) relate, nor is it clear which data need to be collected to support these different pathways most efficiently, given the time- and cost-intensive nature of doing so. The purpose of this article is to describe current thinking regarding these pathways emerging from diverse stakeholders interested and active in the definition, validation, and qualification of quantitative imaging biomarkers and to propose processes to facilitate the development and use of quantitative imaging biomarkers. A flexible framework is described that may be adapted for each imaging application, providing mechanisms that can be used to develop, assess, and evaluate relevant biomarkers. From this framework, processes can be mapped that would be applicable to both imaging product development and to quantitative imaging biomarker development aimed at increasing the effectiveness and availability of quantitative imaging. http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100800/-/DC1.
Journal of Computer Assisted Tomography, 1987
Peritoneal lavage and abdominal/pelvic CT are described in the radiologic and surgical literature... more Peritoneal lavage and abdominal/pelvic CT are described in the radiologic and surgical literature as alternative techniques in the evaluation of blunt abdominal trauma. The relative merits of each technique have been discussed, and it has been stated that postlavage CT is not useful because of the residual peritoneal fluid. A retrospective study of 48 patients who underwent postlavage CT was performed over 34 months. Despite residual lavage fluid, CT provided specific and clinically useful information in 58% of patients following peritoneal lavage. A variety of intraperitoneal and retroperitoneal traumatic lesions were imaged using postlavage CT. We conclude that postlavage CT is often clinically useful in the patient who has incurred blunt abdominal trauma, irrespective of the peritoneal lavage results.
Investigative Radiology, 1989
A questionnaire was administered to 238 students at four institutions before and after a radiolog... more A questionnaire was administered to 238 students at four institutions before and after a radiology clerkship to evaluate student attitudes regarding radiology as a career, radiologist expertise, and clerkship expectations. There was no statistically significant difference among the clerkships, although they varied in types of experience, geographic location, and size. After the clerkship, the students agreed more strongly that the radiologist should be involved in patient workup, screening of requests, interpretation of emergency room films, and consultations. A significant change in attitude could be identified after the four-week experience, indicating a desire for the radiologist to have a more active role as imaging consultant.
Investigative Radiology, 1990
Investigative Radiology, 1986
Critical Care Medicine, 1988
Two potential errors of pulmonary artery wedge pressure measurement that have received little att... more Two potential errors of pulmonary artery wedge pressure measurement that have received little attention are improper anatomic referencing of the transducer and nondependent placement of the pulmonary artery catheter tip. Transducers are often referenced to the midaxillary line of the supine patient. We utilized CT of the chest to determine accurately the topographic location of the left atrium to evaluate the accuracy of referencing the transducer in this position and to investigate atrial location in the lateral decubitus positions vis-à-vis external landmarks, so that more accurate referencing could be performed with a pulmonary artery catheter tip in the dependent lung. A prospective group consisting of ten patients referred for chest CT as well as retrospective review of 40 chest CT scans served as the study population. This study demonstrated a discrepancy between the perceived midaxillary line and the true location of the midleft atrium. Lateral decubitus CT scanning revealed a more readily localizable surface anatomic landmark which consistently and accurately predicts midleft atrial location. In addition, the appropriate decubitus position guarantees dependent catheter tip placement (Zone 3).
American Journal of Roentgenology, 1990
The user has requested enhancement of the downloaded file.
Semin Respir Crit Care Med, 1996
Archives of Surgery, Apr 1, 1990
The present case report details a previously unreported complication of subclavian vein catheteri... more The present case report details a previously unreported complication of subclavian vein catheterization, vertebral artery pseudoaneurysm. Attention to this problem was brought about in the patient by the development of stridor and dysphagia noted 5 days following placement of the subclavian catheter. A computed tomographic scan of the neck revealed a superior mediastinal, contrast-enhancing mass in the region of the right subclavian artery with a "bull's-eye" sign suggestive of a pseudoaneurysm. Arteriography subsequently proved the pseudoaneurysm to be of vertebral origin. The pseudoaneurysm was ligated via a neck incision together with a median sternotomy to obtain vascular control. The evaluation and treatment options of this problem are discussed.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Jan 16, 2015
The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studi... more The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studies within the context of single- and multi-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of the imaging. The aim is to minimize intra- and inter-subject, intra- and inter-platform, inter-examination, and inter-institutional variability of primary and/or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The full document is available on line. The main subjects areas in the document are: Context of the imaging protocol within the clinical trial, Site selection, Qualification and training, Subject scheduling, Subject preparation, Imaging related substance preparation and administration, Imaging procedure, Image post-processing, Image analysis, Image interpretation, Archival and distribution of data, Quality control, and Im...
Journal of Computed Tomography, 1988
Extracranial, cervical aneurysms and arterial thrombosis are uncommon entities. In most cases, th... more Extracranial, cervical aneurysms and arterial thrombosis are uncommon entities. In most cases, they have diagnostic clinical presentations. However, on occasion the history and physical findings do not clearly suggest their presence. In these cases, postcontrast computed tomography scans can aid in rapidly establishing the correct diagnosis by revealing a "bull's-eye" appearance within the mass (vessel lumen). The diagnosis is less difficult to make when the involved vessel is the carotid artery, because this artery is routinely identified on postcontrast computed tomography scans and the lesion can be easily placed along its course. The vascular origin of such a lesion is not usually evident on computed tomography if the process does not lie along the course of a major vessel. In these cases, the bull's-eye sign can establish the diagnosis so that prompt consideration can be given to angiography and therapy.
Investigative Radiology, 1992
The authors induced atherosclerotic occlusions in a rabbit model, using and comparing different e... more The authors induced atherosclerotic occlusions in a rabbit model, using and comparing different experimental methods. Lesions were induced in 40 femoral arteries in 20 rabbits. Four combinations of lesion induction methods were used: 1) drying of the endothelium with carbon dioxide gas; 2) gas-drying of the artery plus mechanical injury; 3) gas-drying plus induced thrombosis of the treated segment using thrombin; and 4) gas-drying, mechanical injury, and induced thrombosis. All rabbits were fed a high-fat, high-cholesterol diet for 1 to 2 months after lesion induction. Seventeen rabbits were available for follow-up. Sixty-eight percent (13 of 19) of femoral arteries treated with thrombin-induced thrombosis demonstrated atherosclerotic occlusions, compared with 27% of those that did not receive this treatment (4 of 15; P < .01). Thrombin-induced thrombotic occlusion of a segment of artery which has been de-endothelialized, followed by a high-fat, high cholesterol diet, results in a higher yield of experimental occlusive atherosclerosis in rabbits than is achievable by other methods.
Radiology, 2011
Quantitative imaging biomarkers could speed the development of new treatments for unmet medical n... more Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often referred to as pathways) relate, nor is it clear which data need to be collected to support these different pathways most effi ciently, given the timeand cost-intensive nature of doing so. The purpose of this article is to describe current thinking regarding these pathways emerging from diverse stakeholders interested and active in the defi nition, validation, and qualifi cation of quantitative imaging biomarkers and to propose processes to facilitate the development and use of quantitative imaging biomarkers. A fl exible framework is described that may be adapted for each imaging application, providing mechanisms that can be used to develop, assess, and evaluate relevant biomarkers. From this framework, processes can be mapped that would be applicable to both imaging product development and to quantitative imaging biomarker development aimed at increasing the effectiveness and availability of quantitative imaging. q RSNA, 2011 Supplemental material: http://radiology.rsna.org/lookup /suppl/
Journal of Vascular Surgery, 1987
A 58-year-old man with severe left lower extremity claudication and rest pain underwent percutane... more A 58-year-old man with severe left lower extremity claudication and rest pain underwent percutaneous transluminal angioplasty. A high-pressure balloon was inflated in an area of severe atherosclerotie narrowing. The patient complained of severe pain during inflation and had a vasovagal response. After balloon deflation, angiography displayed extravasation just inferior to the lower edge of the balloon. Immediate inflation of the balloon tamponaded the leak and allowed the patient's transfer to the operating room in stable condition. It is hypothesized that the new high-pressure balloons can overcome resistance in nondistensible arterial walls, causing rupture without balloon rupture. ( J V^sc SugG 1987;6:528-30.) Varying success rates for percutaneous transluminal angioplasty have been reported, with short,
Journal of Vascular and Interventional Radiology, 2004
Clinical Cancer Research, 2008
Critical Care Medicine, Nov 1, 1988
Two potential errors of pulmonary artery wedge pressure measurement that have received little att... more Two potential errors of pulmonary artery wedge pressure measurement that have received little attention are improper anatomic referencing of the transducer and nondependent placement of the pulmonary artery catheter tip. Transducers are often referenced to the midaxillary line of the supine patient. We utilized CT of the chest to determine accurately the topographic location of the left atrium to evaluate the accuracy of referencing the transducer in this position and to investigate atrial location in the lateral decubitus positions vis-à-vis external landmarks, so that more accurate referencing could be performed with a pulmonary artery catheter tip in the dependent lung. A prospective group consisting of ten patients referred for chest CT as well as retrospective review of 40 chest CT scans served as the study population. This study demonstrated a discrepancy between the perceived midaxillary line and the true location of the midleft atrium. Lateral decubitus CT scanning revealed a more readily localizable surface anatomic landmark which consistently and accurately predicts midleft atrial location. In addition, the appropriate decubitus position guarantees dependent catheter tip placement (Zone 3).
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Jan 16, 2015
The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studi... more The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studies within the context of single- and multi-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of the imaging. The aim is to minimize intra- and inter-subject, intra- and inter-platform, inter-examination, and inter-institutional variability of primary and/or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The full document is available on line. The main subjects areas in the document are: Context of the imaging protocol within the clinical trial, Site selection, Qualification and training, Subject scheduling, Subject preparation, Imaging related substance preparation and administration, Imaging procedure, Image post-processing, Image analysis, Image interpretation, Archival and distribution of data, Quality control, and Im...
Radiology, 2011
Quantitative imaging biomarkers could speed the development of new treatments for unmet medical n... more Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often referred to as pathways) relate, nor is it clear which data need to be collected to support these different pathways most efficiently, given the time- and cost-intensive nature of doing so. The purpose of this article is to describe current thinking regarding these pathways emerging from diverse stakeholders interested and active in the definition, validation, and qualification of quantitative imaging biomarkers and to propose processes to facilitate the development and use of quantitative imaging biomarkers. A flexible framework is described that may be adapted for each imaging application, providing mechanisms that can be used to develop, assess, and evaluate relevant biomarkers. From this framework, processes can be mapped that would be applicable to both imaging product development and to quantitative imaging biomarker development aimed at increasing the effectiveness and availability of quantitative imaging. http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100800/-/DC1.
Journal of Computer Assisted Tomography, 1987
Peritoneal lavage and abdominal/pelvic CT are described in the radiologic and surgical literature... more Peritoneal lavage and abdominal/pelvic CT are described in the radiologic and surgical literature as alternative techniques in the evaluation of blunt abdominal trauma. The relative merits of each technique have been discussed, and it has been stated that postlavage CT is not useful because of the residual peritoneal fluid. A retrospective study of 48 patients who underwent postlavage CT was performed over 34 months. Despite residual lavage fluid, CT provided specific and clinically useful information in 58% of patients following peritoneal lavage. A variety of intraperitoneal and retroperitoneal traumatic lesions were imaged using postlavage CT. We conclude that postlavage CT is often clinically useful in the patient who has incurred blunt abdominal trauma, irrespective of the peritoneal lavage results.
Investigative Radiology, 1989
A questionnaire was administered to 238 students at four institutions before and after a radiolog... more A questionnaire was administered to 238 students at four institutions before and after a radiology clerkship to evaluate student attitudes regarding radiology as a career, radiologist expertise, and clerkship expectations. There was no statistically significant difference among the clerkships, although they varied in types of experience, geographic location, and size. After the clerkship, the students agreed more strongly that the radiologist should be involved in patient workup, screening of requests, interpretation of emergency room films, and consultations. A significant change in attitude could be identified after the four-week experience, indicating a desire for the radiologist to have a more active role as imaging consultant.
Investigative Radiology, 1990
Investigative Radiology, 1986
Critical Care Medicine, 1988
Two potential errors of pulmonary artery wedge pressure measurement that have received little att... more Two potential errors of pulmonary artery wedge pressure measurement that have received little attention are improper anatomic referencing of the transducer and nondependent placement of the pulmonary artery catheter tip. Transducers are often referenced to the midaxillary line of the supine patient. We utilized CT of the chest to determine accurately the topographic location of the left atrium to evaluate the accuracy of referencing the transducer in this position and to investigate atrial location in the lateral decubitus positions vis-à-vis external landmarks, so that more accurate referencing could be performed with a pulmonary artery catheter tip in the dependent lung. A prospective group consisting of ten patients referred for chest CT as well as retrospective review of 40 chest CT scans served as the study population. This study demonstrated a discrepancy between the perceived midaxillary line and the true location of the midleft atrium. Lateral decubitus CT scanning revealed a more readily localizable surface anatomic landmark which consistently and accurately predicts midleft atrial location. In addition, the appropriate decubitus position guarantees dependent catheter tip placement (Zone 3).
American Journal of Roentgenology, 1990
The user has requested enhancement of the downloaded file.
Semin Respir Crit Care Med, 1996
Archives of Surgery, Apr 1, 1990
The present case report details a previously unreported complication of subclavian vein catheteri... more The present case report details a previously unreported complication of subclavian vein catheterization, vertebral artery pseudoaneurysm. Attention to this problem was brought about in the patient by the development of stridor and dysphagia noted 5 days following placement of the subclavian catheter. A computed tomographic scan of the neck revealed a superior mediastinal, contrast-enhancing mass in the region of the right subclavian artery with a "bull's-eye" sign suggestive of a pseudoaneurysm. Arteriography subsequently proved the pseudoaneurysm to be of vertebral origin. The pseudoaneurysm was ligated via a neck incision together with a median sternotomy to obtain vascular control. The evaluation and treatment options of this problem are discussed.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Jan 16, 2015
The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studi... more The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studies within the context of single- and multi-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of the imaging. The aim is to minimize intra- and inter-subject, intra- and inter-platform, inter-examination, and inter-institutional variability of primary and/or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The full document is available on line. The main subjects areas in the document are: Context of the imaging protocol within the clinical trial, Site selection, Qualification and training, Subject scheduling, Subject preparation, Imaging related substance preparation and administration, Imaging procedure, Image post-processing, Image analysis, Image interpretation, Archival and distribution of data, Quality control, and Im...
Journal of Computed Tomography, 1988
Extracranial, cervical aneurysms and arterial thrombosis are uncommon entities. In most cases, th... more Extracranial, cervical aneurysms and arterial thrombosis are uncommon entities. In most cases, they have diagnostic clinical presentations. However, on occasion the history and physical findings do not clearly suggest their presence. In these cases, postcontrast computed tomography scans can aid in rapidly establishing the correct diagnosis by revealing a "bull's-eye" appearance within the mass (vessel lumen). The diagnosis is less difficult to make when the involved vessel is the carotid artery, because this artery is routinely identified on postcontrast computed tomography scans and the lesion can be easily placed along its course. The vascular origin of such a lesion is not usually evident on computed tomography if the process does not lie along the course of a major vessel. In these cases, the bull's-eye sign can establish the diagnosis so that prompt consideration can be given to angiography and therapy.
Investigative Radiology, 1992
The authors induced atherosclerotic occlusions in a rabbit model, using and comparing different e... more The authors induced atherosclerotic occlusions in a rabbit model, using and comparing different experimental methods. Lesions were induced in 40 femoral arteries in 20 rabbits. Four combinations of lesion induction methods were used: 1) drying of the endothelium with carbon dioxide gas; 2) gas-drying of the artery plus mechanical injury; 3) gas-drying plus induced thrombosis of the treated segment using thrombin; and 4) gas-drying, mechanical injury, and induced thrombosis. All rabbits were fed a high-fat, high-cholesterol diet for 1 to 2 months after lesion induction. Seventeen rabbits were available for follow-up. Sixty-eight percent (13 of 19) of femoral arteries treated with thrombin-induced thrombosis demonstrated atherosclerotic occlusions, compared with 27% of those that did not receive this treatment (4 of 15; P < .01). Thrombin-induced thrombotic occlusion of a segment of artery which has been de-endothelialized, followed by a high-fat, high cholesterol diet, results in a higher yield of experimental occlusive atherosclerosis in rabbits than is achievable by other methods.
Radiology, 2011
Quantitative imaging biomarkers could speed the development of new treatments for unmet medical n... more Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often referred to as pathways) relate, nor is it clear which data need to be collected to support these different pathways most effi ciently, given the timeand cost-intensive nature of doing so. The purpose of this article is to describe current thinking regarding these pathways emerging from diverse stakeholders interested and active in the defi nition, validation, and qualifi cation of quantitative imaging biomarkers and to propose processes to facilitate the development and use of quantitative imaging biomarkers. A fl exible framework is described that may be adapted for each imaging application, providing mechanisms that can be used to develop, assess, and evaluate relevant biomarkers. From this framework, processes can be mapped that would be applicable to both imaging product development and to quantitative imaging biomarker development aimed at increasing the effectiveness and availability of quantitative imaging. q RSNA, 2011 Supplemental material: http://radiology.rsna.org/lookup /suppl/
Journal of Vascular Surgery, 1987
A 58-year-old man with severe left lower extremity claudication and rest pain underwent percutane... more A 58-year-old man with severe left lower extremity claudication and rest pain underwent percutaneous transluminal angioplasty. A high-pressure balloon was inflated in an area of severe atherosclerotie narrowing. The patient complained of severe pain during inflation and had a vasovagal response. After balloon deflation, angiography displayed extravasation just inferior to the lower edge of the balloon. Immediate inflation of the balloon tamponaded the leak and allowed the patient's transfer to the operating room in stable condition. It is hypothesized that the new high-pressure balloons can overcome resistance in nondistensible arterial walls, causing rupture without balloon rupture. ( J V^sc SugG 1987;6:528-30.) Varying success rates for percutaneous transluminal angioplasty have been reported, with short,
Journal of Vascular and Interventional Radiology, 2004