Gaurav Tiwari Gaurav Tiwari - Academia.edu (original) (raw)

Papers by Gaurav Tiwari Gaurav Tiwari

International Journal of Applied Pharmaceutics, 2018

Objective: A fast, specific, and sensitive high-performance liquid chromatographic method has bee... more Objective: A fast, specific, and sensitive high-performance liquid chromatographic method has been developed and validated for the quantitative determination of unchanged Ramipril (RAM) and Telmisartan (TEL) in animal plasma.Methods: Analytes were extracted from animal plasma, 250 µl of animal plasma sample were mixed with internal working standard (25 ngmL-1) with the further addition of chloroform (HPLC Grade, Merck). The clear organic layer was separated and reconstituted to 1 ml in mobile phase and analysed by HPLC. The method was validated and evaluated in terms of linearity, accuracy, precision, specificity, limit of detection and limit of quantitation.Results: Absorption maxima of TEL and RAM was found to be 270 and 273 nm respectively. TEL and RAM with their respective internal standards (I. S.) were found to be well separated from the co-eluted components and there were no interferences from the endogenous material. The limit of detection (LOD) and limit of quantitation (LO...

2016 IEEE International Conference on Advances in Electronics, Communication and Computer Technology (ICAECCT), 2016

In this paper, we proposed a number of new inverse highpass (IHP), inverse bandpass (IBP), and in... more In this paper, we proposed a number of new inverse highpass (IHP), inverse bandpass (IBP), and inverse lowpass (ILP) filters using second generation current conveyor (CCII) as building blocks. The proposed two topologies can be configured as one of the above mentioned inversed filter by the selection of appropriate admittance. To test the functionality of the proposed multifunction inverse filter, the circuit was simulated using PSPICE simulator software. In simulation of the circuits, the CCII circuit was designed using macro model of AD844 IC. The simulated results are well agreed with the theoretical results.

Current Drug Therapy, 2020

Background: The present study assessed the transdermal potential of transferosomes loaded with al... more Background: The present study assessed the transdermal potential of transferosomes loaded with allopurinol for the treatment of gout. Methods: Transferosomes of allopurinol were composed of different ratios of tween-80, soya lecithin and solvent using a thin-film hydration method. Transferosomes were characterized for Scanning Electron Microscopy (SEM), zeta potential, % entrapment efficiency (%EE), Fourier Transform Infrared Spectroscopy (FTIR), in-vitro drug release and kinetics as well as stability. Then, optimized formulation was incorporated in gel and evaluated for viscosity, pH, extrudability, homogeneity, skin irritation study, spreadability, ex vivo skin permeation study, flux, and stability. Results: SEM studies suggested that vesicles were spherical and zeta potential were in the range of -11.4 mV to -29.6 mV and %EE was 52.4- 83.87%. FTIR study revealed that there was no interaction between allopurinol and excipients during the preparation of transferosomes. The cumulati...

Analog Integrated Circuits and Signal Processing, 2018

International journal of pharmaceutical investigation

The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (EC... more The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. The modified quasi-emulsion solvent diffusion method was used to prepare microsponges. A 3(2) factorial design was employed to study the formulation and the effects of independent variables (volume of organic solvent and Eudragit-RS100 content) on dependent variables (particle size, %entrapment efficiency, and %cumulative drug release). The optimized microsponge (F4) was characterized by scanning electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. F4 was plugged along with the calcium pectinate beads in HPMC capsules coated with enteric polymer Eudragit-L100 (Ed-L100) and/or Eudragit-S100 (Ed-S100) in different proportions. An in vitro release study of ECHC was performed in simulated gastric fluid for 2 h, followed by simulated intestinal fluid for next 6 h a...

International Journal of Pharmaceutical Investigation, 2012

International Journal of Drug Delivery, 2010

Pharmaceutical Methods, 2010

Indian Journal of Dental Research, 2010

The aim of this study to develop the controlled delivery of combination drug(s) to periodontal po... more The aim of this study to develop the controlled delivery of combination drug(s) to periodontal pocket. In the present investigation mucoadhesive gel formulations were prepared using carboxy methylcellulose (CMC), methylcellulose (MC), hydroxyethylcellulose (HEC), polyvinylpirrolidone (PVP), polycarbophil (PC), and poloxamer. Each formulation was characterized in terms of polarizing light microscopy, gelation, gel melting, hardness, compressibility, adhesiveness, cohesiveness, syringeability, adhesion to a mucin disk, rheological studies, drug release, and antibacterial activities. Addition of CMC and PVP to the gel favored hexagonal phase formation. The gelation temperature was decreased linearly with an increasing concentration of drug(s), whereas, the melting temperature increased with the concentration of drug(s). Increasing the concentrations of each polymeric component significantly increased formulation hardness, compressibility, adhesiveness, mucoadhesion, and syringeability, yet a decreased cohesiveness. Increased time of contact between the formulation and mucin significantly increased the required force of detachment. Drug release from all formulations was non-diffusion controlled and significantly decreased as the concentration of the polymer was increased, due to the concomitant increased viscosity of the formulations and the swelling kinetics of PC, following contact with the dissolution fluid. Antibacterial studies revealed that a gel with 30% HEC had a growth inhibition zone on agar with all three strains. Formulations containing HEC exhibited superior physical characteristics for improved drug delivery to the periodontal pocket and are now the subject of long-term clinical investigations.

Chronicles of Young Scientists, 2012

Chronicles of Young Scientists, 2011

Brazilian Journal of Pharmaceutical Sciences, 2009

The present study investigated a novel extended release system of promethazine hydrochloride (PHC... more The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-distilled water and phosphate buffer (pH 7.4). Adsorption tests from drug solution to solid polymers were also performed. A selected solid dispersion system was developed into capsule dosage form and evaluated for in vitro dissolution studies. The progressive disappearance of drug peaks in thermotropic profiles of spray-dried dispersions were related to increasing amount of polymers, while SEM s...

Int J PharmTech Res, 2009

INTRODUCTION An ideal drug delivery system should be able to deliver an adequate amount of drug, ... more INTRODUCTION An ideal drug delivery system should be able to deliver an adequate amount of drug, preferably for an extended period of time for its optimum therapeutic activity. Most drugs are inherently not long lasting in the body and require multiple daily dosing to achieve the ...